Article
Virology
Marta Canuti, Emilie Bouchard, Bruce Rodrigues, Hugh G. Whitney, Marti Hopson, Cornelia Gilroy, Garry Stenson, Suzanne C. Dufour, Andrew S. Lang, Joost T. P. Verhoeven
Summary: Newlavirus is a newly discovered fox protoparvovirus in Canada, with a high prevalence in foxes from Newfoundland and Labrador. It is not found in samples from other carnivores, indicating foxes may be the natural reservoir of this virus. Further studies should investigate its distribution due to its high prevalence and diversity.
Article
Infectious Diseases
Jade Ghosn, Lionel Piroth, Olivier Epaulard, Paul Le Turnier, France Mentre, Delphine Bachelet, Cedric Laouenan
Summary: One fourth of individuals hospitalized for COVID-19 still experienced three or more persistent symptoms at six months after admission. Factors independently associated with the presence of three or more symptoms at month 6 included female gender, having three or more symptoms at admission, and ICU admission/transfer during the acute phase. Further longitudinal follow-up of severe COVID-19 patients is needed for better understanding of the long-term persistence of symptoms.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Asma Gholami, Dariush Minai-Tehrani, Leif A. Eriksson
Summary: Alzheimer's disease is a progressive neurodegenerative disorder that affects the elderly population worldwide. Deficiency of acetylcholine and butyrylcholine due to the overexpression of AChE and BChE enzymes can lead to impaired neuron communication. In this study, Ondansetron, a drug used for preventing chemotherapy-induced nausea and vomiting, is found to be a potent inhibitor of cholinesterase enzymes. Molecular docking and dynamics simulations demonstrate its higher efficacy compared to Rivastigmine and Tacrine. In vitro studies confirm its inhibitory activity on AChE and BChE, making it a potential therapeutic option for AD treatment.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Klefah A. K. Musa, Leif A. Eriksson
Summary: Computational quantum chemistry methods were used to investigate the photodegradation mechanism and photochemical properties of benoxaprofen, a non-steroid anti-inflammatory drug. The drug was found to absorb UV radiation and undergo spontaneous decarboxylation under light excitation. The photochemical properties of benoxaprofen were similar to other photolabile non-steroidal anti-inflammatory drugs.
Article
Chemistry, Medicinal
Shohei Tsuchihashi, Kazuma Nakashima, Yuta Tarumizu, Hiroaki Ichikawa, Hiroki Jinda, Hiroyuki Watanabe, Masahiro Ono
Summary: PSMA is a promising target for radiotherapy in metastatic castration-resistant prostate cancer. PNT-DA1 is a newly designed agent that enhances tumor uptake, and [Ac-225]Ac-PNT-DA1 has superior antitumor effects compared to current gold standard therapies. The combination of [In-111]In-PNT-DA1 and [Ac-225]Ac-PNT-DA1 holds promise for PSMA-targeted radiotheranostics.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Hongfeng Gu, Wenxin Yan, Yong Wang, Wenbo Xu, Lei Huang, Jieping Yang, Bingxin Zhai, Hong Wang, Yupei Su, Qihua Zhu, Beibei Liu, Haiping Hao, Yi Zou, Yungen Xu
Summary: PARP7 is a negative regulator in type I interferon signaling and its overexpression in cancers can suppress type I interferon signaling and innate immune response. A novel PARP7 inhibitor, I-1, has been discovered with high potency and selectivity. It acts as an immune activator through PARP7 inhibition in the tumor microenvironment, highlighting its potential as a tumor immunotherapeutic agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Hematology
Jing Wang, Yongxiang Gao, Lan Chen, Yugang Guo, Siyi Hu, Liansheng Cheng, Weihua Xiao, Jiyuan Ke, Zhongliang Zhu, Liwen Niu
Summary: Agkisacucetin, a novel antithrombotic drug candidate isolated from the venom of Deinagkistrodon acutus, specifically recognizes the platelet surface receptor to block thrombosis. The crystal structure reveals that Agkisacucetin primarily contacts GPIb alpha at specific regions to inhibit platelet function.
Article
Dentistry, Oral Surgery & Medicine
Jong-Hoon Kim, Ha-Neul Lee, Seong-Kyeong Bae, Dong-Ha Shin, Bon-Hwan Ku, Ho-Yong Park, Tae-Sook Jeong
Summary: Arazyme, a metalloprotease produced from Serratia proteamaculans HY-3, showed strong proteolytic activities over a wide range of temperature and pH. It demonstrated efficient denture cleaning and antimicrobial effects, inhibiting the growth of major oral opportunistic pathogens, such as C. albicans, with more than 80% inhibition at a concentration of 250 mg/mL. Arazyme has potential as a biological oral health care agent and a source for developing novel denture care products.
Article
Medicine, General & Internal
Joeri Lambrecht, Mustafa Porsch-Oezcueruemez, Jan Best, Fabian Jost-Brinkmann, Christoph Roderburg, Muenevver Demir, Frank Tacke, Raphael Mohr
Summary: The study introduces a novel serological scoring tool, the APAC score, which consists of age, sPDGFR beta, AFP, and creatinine, and can identify HCC patients in cirrhotic population with high accuracy. The APAC score outperforms the GALAD score and is independent of disease etiology, including alcohol, viral infection, and NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Youssef Snoussi, Ines Sifaoui, Ahmed M. Khalil, Arvind K. Bhakta, Oleg Semyonov, Pavel S. Postnikov, Laurent Michely, Remy Pires, Stephane Bastide, Jose Enrique-Pinero Barroso, Jacob Lorenzo Morales, Mohamed M. Chehimi
Summary: This study describes a simple method to prepare silver-loaded biochar and demonstrates its highly effective antiparasitic activity against certain tropical diseases. The method has the potential to convert agricultural waste into effective nanomaterials for tropical disease treatment.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Umber Zaman, Shahid Ullah Khan, Awatif A. Hendi, Khalil Ur Rehman, Syed Badshah, Moamen S. Refat, Amnah Mohammed Alsuhaibani, Kalim Ullah, Abdul Wahab
Summary: In this study, a new acid phosphatase (ACP) from C. oxyacantha was isolated and characterized for the first time. The enzyme exhibited specific activity and physicochemical properties that distinguish it from other plant ACPs, providing insights into the role of ACP in C. oxyacantha.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Jacob M. Furlon, Spencer J. Mitchell, Chris Bailey-Kellogg, Karl E. Griswold
Summary: This study identified six new anti-C. difficile lysins and compared them to highly active lysins from existing literature. Results showed significant differences in expression level, antibacterial activity, selectivity, spore killing ability, and thermal stability among the enzymes, highlighting the need for a balanced assessment of lysin properties to find candidates with true clinical potential.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Vaha Akbary Moghaddam, Vesal Kasmaeifar, Zainab Mahmoodi, Hossein Ghafouri, Omid Saberi, Asadollah Mohammadi
Summary: A novel derivative of sulfamethoxazole named ZM-093 was synthesized and characterized through experimental and computational analysis, showing significant inhibitory effect against the cancer-related protein HSP70, potentially through binding to its substrate-binding domain. Additionally, a new method for evaluating the inhibitory activity of ligands to HSP70 based on protonography was introduced.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Dairy & Animal Science
Christian Bauer, Marat Kuibagarov, Lyudmila A. Lider, Dinara M. Seitkamzina, Zhanbolat A. Suranshiyev
Summary: This study conducted a serological study to investigate the occurrence of bovine hypodermosis in Kazakhstan. The results showed a high prevalence of this disease in the country.
Article
Environmental Sciences
Fuyong Liu, Yuran Su, Chuang Ma, Pan Xie, Jihong Zhao, Hongzhong Zhang
Summary: The combination of a novel immobilization agent SiO2@Fe3O4@C-COOH with traditional immobilization agents demonstrated a higher efficiency in immobilizing Pb in contaminated soil, significantly reducing its bioavailability.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lina Reslan, Nischay Mishra, Marc Finianos, Kimberley Zakka, Amanda Azakir, Cheng Guo, Riddhi Thakka, Ghassan Dbaibo, W. Ian Lipkin, Hassan Zaraket
Summary: G12 rotaviruses are becoming a significant cause of severe diarrhea globally. Seven human G12P[6] rotavirus strains were identified in Lebanon, showing genetic diversity and potential evolutionary links to Southeast Asian and North American strains. This study highlights the importance of ongoing surveillance and further research on emerging rotavirus strains for public health preparedness.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Virology
Endrya do Socorro Foro Ramos, Ulisses Alves Rosa, Geovani de Oliveira Ribeiro, Fabiola Villanova, Flavio Augusto de Padua Milagres, Rafael Brustulin, Vanessa dos Santos Morais, Mayara Bertanhe, Roberta Marcatti, Emerson Luiz Lima Araujo, Steven S. Witkin, Eric Delwart, Adriana Luchs, Antonio Charlys da Costa, Elcio Leal
Summary: A study in Brazil reported the complete genome sequences of nine echoviruses obtained by next-generation sequencing, revealing diverse echovirus genotypes in the Brazilian environment. Phylogenetic analysis showed significant differences in the E1 and E29 strains in Brazil compared to global strains.
Article
Virology
Geovani de Oliveira Ribeiro, Danielle Elise Gill, Edcelha Soares D. Athaide Ribeiro, Fred Julio Costa Monteiro, Vanessa S. Morais, Roberta Marcatti, Marlisson Octavio da S. Rego, Emerson Luiz Lima Araujo, Steven S. Witkin, Fabiola Villanova, Xutao Deng, Ester Cerdeira Sabino, Eric Delwart, Elcio Leal, Antonio Charlys da Costa
Summary: This study analyzed the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapa, identifying DENV-1 BR4 lineage introduced possibly from other states in northern Brazil around early 2010. Unique amino acid substitutions were found in the DENV-1 isolates from Amapa, indicating the potential of this new lineage to drive outbreaks of dengue in the Amazon region.
Article
Virology
Alvin Hui, Eda Altan, Nathan Slovis, Caitlin Fletcher, Xutao Deng, Eric Delwart
Summary: Through viral metagenomics, a new species of Circovirus, equine circovirus 1 (EqCV1), was identified in a pregnant mare with fever and hepatitis. EqCV1 showed similarities to pig circoviruses and elk circovirus, indicating its evolutionary relationship. Further studies are needed to determine the disease-causing potential of EqCV1 and its prevalence in different equine populations.
Article
Virology
Eda Altan, Alvin Hui, Yanpeng Li, Patricia Pesavento, Javier Asin, Beate Crossley, Xutao Deng, Francisco A. Uzal, Eric Delwart
Summary: A study conducted viral metagenomics analysis on six foals with interstitial pneumonia from Southern California, identifying new equine copiparvovirus and other previously uncharacterized viruses in the samples. The study also detected multiple infections of different viruses in some of the foals, highlighting the potential complexity of viral infections in these cases.
Article
Microbiology
Sarah Hulsey Stubbs, Marjorie Cornejo Pontelli, Nischay Mishra, Changhong Zhou, Juliano de Paula Souza, Rosa Maria Mendes Viana, W. Ian Lipkin, David M. Knipe, Eurico Arruda, Sean P. J. Whelan
Summary: Oropouche virus (OROV) infection can lead to severe febrile illness and potentially progress to meningitis or encephalitis. Researchers developed a chimeric vesicular stomatitis virus (VSV) bearing OROV glycoproteins, which elicited a strong neutralizing antibody response in mice and showed potential in reducing viral loads, suggesting targeting OROV glycoproteins could be an effective vaccination strategy against OROV infection.
Article
Microbiology
Fabiola Villanova, Roberta Marcatti, Mayara Bertanhe, Vanessa dos Santos Morais, Flavio Augusto de Padua Milagres, Rafael Brustulin, Emerson Luiz Lima Araujo, Roozbeh Tahmasebi, Steven S. Witkin, Xutao Deng, Eric Delwart, Ester Cerdeira Sabino, Cassio Hamilton Abreu-Junior, Elcio Leal, Antonio Charlys da Costa
Summary: Squash mosaic virus (SqMV) has been identified in various plants globally, including in multiple states in Brazil. The study found SqMV in human feces collected in Tocantins, with no evidence of related symptoms. Analysis showed a presence of multiple viruses in fecal samples from diarrhea patients, with at least 4 known to cause gastrointestinal symptoms.
Article
Biochemistry & Molecular Biology
Xiaoyu Che, Mady Hornig, Michaeline Bresnahan, Camilla Stoltenberg, Per Magnus, Pal Suren, Siri Mjaaland, Ted Reichborn-Kjennerud, Ezra Susser, W. Ian Lipkin
Summary: This study suggests that immune activation may be a risk factor for autism spectrum disorders (ASDs) and identifies potential immune biomarkers for early diagnosis. The findings highlight the importance of gestational immunopathology in ASD and reveal sex-specific differences.
MOLECULAR PSYCHIATRY
(2022)
Article
Virology
Eric Delwart, Michael J. Tisza, Eda Altan, Yanpeng Li, Xutao Deng, Dennis J. Hartigan-O'Connor, Amir Ardeshir
Summary: The recent changes in treatment have reduced the lethality of idiopathic chronic diarrhea (ICD), but it still remains a common cause of death in rhesus macaques. Comparison of viral metagenomics in fecal swabs from ICD animals and healthy controls did not find any strong associations between specific viruses and ICD.
Article
Virology
Endrya do Socorro Foro Ramos, Geovani de Oliveira Ribeiro, Fabiola Villanova, Flavio Augusto de Padua Milagres, Rafael Brustulin, Emerson Luiz Lima Araujo, Ramendra Pati Pandey, V. Samuel Raj, Xutao Deng, Eric Delwart, Adriana Luchs, Antonio Charlys da Costa, Elcio Leal
Summary: Metagenomics based on NGS was used to characterize the enteric virome of 250 individuals with gastroenteritis in northeastern and northern Brazil. The study revealed common viral sequences associated with GI, as well as emerging human viruses and viral contigs from various sources. This approach proved to be a powerful tool for detecting and characterizing a wide range of viruses in clinical GI samples.
Article
Virology
Eric Delwart, David Merriam, Amir Ardeshir, Eda Altan, Yanpeng Li, Xutao Deng, Dennis J. Hartigan-O'Connor
Summary: Idiopathic chronic diarrhea (ICD) is a common clinical problem in captive rhesus macaques, and viral metagenomics analysis revealed the presence of multiple viruses in the digestive tract tissues of animals with ICD. The distribution of viral reads varied between different gut tissues from the same animal, and in situ hybridization showed staining for both RNA and DNA viruses in the distal colon. The location of enteric viral nucleic acid differed widely between different viral families and along the length of the digestive tract.
Article
Virology
Fabiola Villanova, Flavio Augusto de Padua Milagres, Rafael Brustulin, Emerson Luiz Lima Araujo, Ramendra Pati Pandey, V. Samuel Raj, Xutao Deng, Eric Delwart, Adriana Luchs, Antonio Charlys da Costa, Elcio Leal
Summary: Putative replication-associated protein (REP) and capsid-like (CAP) proteins from CRESS DNA have been found in samples from various eukaryotic groups, but their life cycles and significance in diseases are not well-established. In this study, two full-length CRESS DNA genomes were analyzed from children with acute gastroenteritis in Brazil. The genomes showed similarity to a prior CRESS DNA sequence from a monkey in the United States, indicating a diverse group of porprismacoviruses in South America. The finding of closely related sequences in humans and monkeys highlights the zoonotic potential of these viruses.
Article
Virology
Geovani de Oliveira Ribeiro, Danielle Elise Gill, Endrya do Socorro Foro Ramos, Fabiola Villanova, Edcelha Soares D'Athaide Ribeiro, Fred Julio Costa Monteiro, Vanessa S. Morais, Marlisson Octavio da S. Rego, Emerson Luiz Lima Araujo, Ramendra Pati Pandey, V. Samuel Raj, Xutao Deng, Eric Delwart, Antonio Charlys da Costa, Elcio Leal
Summary: The simultaneous transmission of two lineages of CHIKV was discovered in Brazil. The Asian lineage was restricted to the Amazon region, while the East-Central-South-African lineage expanded across the country. Despite similar climatic conditions and mosquito vector frequencies, the spread of CHIKV differed between states.
Article
Virology
Endrya do Socorro Foro Ramos, Wandercleyson Uchoa Abreu, Luis Reginaldo Ribeiro Rodrigues, Luis Fernando Marinho, Vanessa dos Santos Morais, Fabiola Villanova, Ramendra Pati Pandey, Emerson Luiz Lima Araujo, Xutao Deng, Eric Delwart, Antonio Charlys da Costa, Elcio Leal
Summary: A new CHPV, a recently characterized genus of the Parvoviridae family, was identified in bat samples in North Brazil. The sequences of this CHPV are likely a new species within the genus Chaphamaparvovirus, showing a high level of specificity between CHPV and its hosts.
Article
Virology
Yanpeng Li, Eda Altan, Gabriel Reyes, Brian Halstead, Xutao Deng, Eric Delwart
Summary: This study characterized the virome in guano from various bat species in Northern California, identifying novel viral genomes and detecting sequences of known viruses in other bat species. The presence of canine and mouse parvoviruses in bat guano suggests contamination by carnivores and rodents. Further research is needed to fully understand the viral diversity in bats and the potential for cross-species transmission.
JOURNAL OF VIROLOGY
(2021)