Article
Plant Sciences
Jennifer Stander, Aleyo Chabeda, Edward P. Rybicki, Ann E. Meyers
Summary: The West Nile virus is a globally disseminated Flavivirus that causes encephalitis outbreaks in human and horse populations, posing a major public health threat. Utilizing plants as biofactories for vaccine production may offer a cost-effective and safer alternative to current vaccine manufacturing methods.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md Asad Ullah, Yusha Araf, Sowmen Das, Mohammad Jakir Hosen
Summary: This study attempted to design potential multivalent and multipathogenic vaccines against DENV and ZIKV using an immunoinformatics approach. Three vaccines were initially designed, with V3 identified as the best vaccine construct through molecular docking analysis. In silico validation studies indicated that V3 might be stable and generate a substantial immune response, but further in vivo and in vitro validation is needed to confirm the safety and efficacy of the suggested vaccine constructs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Immunology
Xuelian Han, Zhuming Cai, Yulong Dai, He Huang, Xiangwen Cao, Yuan Wang, Yingying Fang, Gang Liu, Min Zhang, Yuhang Zhang, Binhui Yang, Wei Xue, Guangyu Zhao, Wanbo Tai, Min Li
Summary: The artificially exposed surface areas in subunit vaccines reduce their efficacy, but this can be overcome by tightly packed oligomerization. This study validates the importance of burying these exposed surfaces in vaccine design using the envelope protein domain III of Japanese encephalitis virus as a candidate.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Materials Science, Biomaterials
Rafiq Ahmad Khan, Farhan Ahmed, Sumbul Afroz, Nooruddin Khan
Summary: This study introduced a new strategy of encapsulating the EDIII domain of all serotypes of DENV into PLGA nanoparticles, and the tetravalent nano formulation combined with TLR agonists showed enhanced immunological efficacy, triggering robust antibody responses and improved production of serotype-specific neutralizing antibodies.
BIOMATERIALS SCIENCE
(2022)
Review
Medicine, Research & Experimental
Wen-Hung Wang, Aspiro Nayim Urbina, Chih-Yen Lin, Zih-Syuan Yang, Wanchai Assavalapsakul, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: The development of dengue vaccines is crucial in preventing and controlling the global health threat caused by Dengue virus. Current approved vaccines have demonstrated low efficacy in certain populations, leading to ongoing investigation and development of novel strategies for dengue vaccines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Tomohiro Kotaki, Yurie Nagai, Atsushi Yamanaka, Eiji Konishi, Masanori Kameoka
Summary: This study focused on developing a Japanese encephalitis (JE) vaccine that does not induce antibody-dependent enhancement (ADE) of dengue virus (DENV) infection. By introducing a mutation at the 106th amino acid residue of the JEV E protein, the modified JE vaccine was able to significantly reduce the production of cross-reactive ADE-prone antibodies against DENV.
Review
Immunology
Mohd Ishtiaq Anasir, Chit Laa Poh
Summary: Dengue is a significant burden on the healthcare system in tropical and subtropical regions, with no effective vaccine currently available. This review discusses the identification of B-cell epitopes in the envelope protein of dengue and the therapeutic potential of monoclonal antibodies. These findings can inform the development of dengue therapies in the future.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2022)
Article
Virology
Michelle Felicia Lee, Mohd Ishtiaq Anasir, Chit Laa Poh
Summary: Dengue infections pose a critical threat to public health worldwide, and there is an urgent need to develop effective antivirals. Peptides designed to target the DENV envelope protein show promise as antiviral candidates. Among the twelve peptides designed, four exhibited potent inhibitory effects against multiple DENV serotypes. Peptide 3 demonstrated the best overall antiviral activity, while peptide 5F showed particular efficacy against DENV-4 during post-infection treatment.
Article
Biochemistry & Molecular Biology
Baoling Ying, Suzanne M. Scheaffer, Bradley Whitener, Chieh-Yu Liang, Oleksandr Dmytrenko, Samantha Mackin, Kai Wu, Diana Lee, Laura E. Avena, Zhenlu Chong, James Brett Case, LingZhi Ma, Thu T. M. Kim, Caralyn E. Sein, Angela Woods, Daniela Montes Berrueta, Gwo-Yu Chang, Guillaume Stewart-Jones, Isabella Renzi, Yen-Ting Lai, Agata Malinowski, Andrea Carfi, Sayda M. Elbashir, Darin K. Edwards, Larissa B. Thackray, Michael S. Diamond
Summary: The study showed that current vaccination can enhance protection against Omicron infections, but different vaccines have varying efficacy, which requires further investigation.
Article
Microbiology
Guntur Fibriansah, Elisa X. Y. Lim, Jan K. Marzinek, Thiam-Seng Ng, Joanne L. Tan, Roland G. Huber, Xin-Ni Lim, Valerie S. Y. Chew, Victor A. Kostyuchenko, Jian Shi, Ganesh S. Anand, Peter J. Bond, James E. Crowe, Shee-Mei Lok
Summary: Dengue virus has four serotypes (DENV1-4) with different strains within each serotype. The virus can exhibit smooth or bumpy surface morphologies at 37 degrees C, depending on the strain. High-affinity therapeutic antibodies are able to neutralize diverse morphologies of dengue virus.
Article
Immunology
Hong-Jyun Huang, Martyr Yang, Hsin-Wei Chen, Shuying Wang, Chih-Peng Chang, Tzong-Shiann Ho, Yu-San Kao, Sen-Mao Tien, Hsing-Han Lin, Po-Chun Chang, Yen-Chung Lai, Yu-Peng Hsiao, Yi-Ling Liu, Chiao-Hsuan Chao, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin, Shu-Wen Wan
Summary: This study developed a modified DENV vaccine candidate with enhanced features by combining modifications of two DENV proteins. The vaccine candidate showed protective effects against DENV infection in a mouse model, indicating its potential clinical application.
Article
Fisheries
Tianwen Lin, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: In this study, recombinant proteins were used as subunit vaccine candidates for the immunization of pearl gentian grouper. The results showed that the recombinant S-domain, P-domain, and CP protein were highly immunogenic and provided good protection against NNV in the vaccinated fish.
Review
Microbiology
Rogier W. Sanders, John P. Moore
Summary: Most viral vaccines work by inducing neutralizing antibodies against the virus envelope or spike glycoproteins, which are engineered for stability and presentation of key epitopes to optimize vaccine performance. This technique emerged during HIV-1 Env vaccine development and has been widely applied to other viral vaccines, including SARS-CoV-2.
CELL HOST & MICROBE
(2021)
Review
Immunology
Lianpan Dai, George F. Gao
Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Immunology
Te-Sheng Lien, Der-Shan Sun, Shih-Che Hung, Wen-Sheng Wu, Hsin-Hou Chang
Summary: The study shows that the dengue virus envelope protein domain III can induce neutrophil NETosis processes, and inhibition of Nlrp3 inflammasome can suppress this process, providing a new molecular target for treating dengue-induced inflammatory pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
J. F. S. Amorim, A. S. Azevedo, S. M. Costa, G. F. Trindade, C. A. Basilio-de-Oliveira, A. J. S. Goncalves, N. G. Salomao, K. Rabelo, R. Amaral, L. H. M. Geraldo, F. R. S. Lima, R. Mohana-Borges, M. V. Paes, A. M. B. Alves
SCIENTIFIC REPORTS
(2019)
Article
Virology
Filipe Vieira Santos de Abreu, Anielly Ferreira-de-Brito, Adriana de Souza Azevedo, Jose Henrique Rezende Linhares, Vanessa de Oliveira Santos, Emily Hime Miranda, Maycon Sebastiao Alberto Santos Neves, Lena Yousfi, Ieda Pereira Ribeiro, Alexandre Araujo Cunhad dos Santos, Edmilson dos Santos, Taissa Pereira dos Santos, Danilo Simonini Teixeira, Marcelo Quintela Gomes, Camilla Bayma Fernandes, Andrea Marques Vieira da Silva, Monique da Rocha Queiroz Lima, Christophe Paupy, Alessandro Pecego Martins Romano, Ana Paula Dinis Ano Bom, Luzia Maria de Oliveira-Pinto, Sara Moutailler, Monique de Albuquerque Motta, Marcia Goncalves Castro, Myrna Cristina Bonaldo, Sheila Maria Barbosa de Lima, Ricardo Lourenco-de-Oliveira
Article
Cell Biology
Kissila Rabelo, Antonio Jose da Silva Goncalves, Luiz Jose de Souza, Anna Paula Sales, Sheila Maria Barbosa de Lima, Gisela Freitas Trindade, Bianca Torres Ciambarella, Natalia Recardo Amorim Tasmo, Bruno Lourenco Diaz, Jorge Jose de Carvalho, Marcia Pereira de Oliveira Duarte, Marciano Viana Paes
Article
Pharmacology & Pharmacy
Noemi R. Gardinali, Renato S. Marchevsky, Jaqueline M. Oliveira, Marcelo Pelajo-Machado, Tatiana Kugelmeier, Marcio P. Castro, Aline C. A. Silva, Douglas P. Pinto, Lais B. Fonseca, Leandro S. Vilhena, Heliana M. Pereira, Sheila M. B. Lima, Emily H. Miranda, Gisela F. Trindade, Jose H. R. Linhares, Stephanie A. Silva, Juliana Gil Melgaco, Ada M. B. Alves, Julio Moran, Maria C. C. Silva, Romulo J. Soares-Bezerra, Andreza Soriano, Gentil A. Bentes, Fernanda O. Bottino, Sarah Beatriz Salvador Castro Faria, Rafael F. Nudelman, Claudia A. A. Lopes, Javier A. S. Perea, Klena Sarges, Marcia C. R. Andrade, Marcia C. V. A. Motta, Marcos S. Freire, Thiago M. L. Souza, Jonas Schmidt-Chanasit, Marcelo A. Pinto
ANTIVIRAL RESEARCH
(2020)
Article
Immunology
Valeria Valim, Ketty Lysie Libardi Lira Machado, Samira Tatiyama Miyamoto, Arthur Dalmaso Pinto, Priscila Costa Martins Rocha, Erica Vieira Serrano, Valquiria Garcia Dinis, Sonia Alves Gouvea, Joao Gabriel Fragoso Dias, Ana Carolina Campi-Azevedo, Andrea Teixeira-Carvalho, Vanessa Peruhype-Magalhaes, Ismael Artur da Costa-Rocha, Sheila Maria Barbosa de Lima, Emily Hime Miranda, Gisela Freitas Trindade, Maria de Lourdes de Sousa Maia, Maria Bernadete Renoldi de Oliveira Gavi, Lidia Balarini da Silva, Ruben Horst Duque, Ana Paula Espindula Gianordoli, Thays Zanon Casagrande, Karine Gadioli Oliveira, Bruna Costa da Mata Moura, Fernanda Nicole-Batista, Luiza Correa Rodrigues, Thalles Brandao Clemente, Enan Sales Magalhaes, Maria de Fatima Bissoli, Maria da Penha Gomes Gouvea, Lauro Ferreira Silva Pinto-Neto, Carolina Zorzanelli Costa, Raquel Altoe Giovelli, Leticia Resende Brandao, Elizandra Tomazela Laurenti Polito, Ingrid de Oliveira Koehlert, Brunela Passos Borjaille, Daniela Bergamim Pereira, Laiza Hombre Dias, Daniela Linhares Merlo, Luiz Fellipe Favoreto Genelhu, Flavia Zon Pretti, Maryella dos Santos Giacomin, Ana Paula Neves Burian, Francieli Fontana Sutile Tardetti Fantinato, Gecilmara Salviato Pileggi, Licia Maria Henrique da Mota, Olindo Assis Martins-Filho
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Ismael Artur da Costa-Rocha, Ketty Lysie Libardi Lira Machado, Ana Carolina Campi-Azevedo, Andrea Teixeira-Carvalho, Vanessa Peruhype-Magalhaes, Sheila Maria Barbosa de Lima, Emily Hime Miranda, Gisela Freitas Trindade, Thays Zanon Casagrande, Samira Tatiyama Miyamoto, Savio Carvalho Deotti, Rafaela Villa Real Barbosa, Priscila Costa Martins Rocha, Erica Vieira Serrano, Valquiria Garcia Dinis, Sonia Alves Gouvea, Maria Bernadete Renoldi de Oliveira Gavi, Lidia Balarini da Silva, Ruben Horst Duque, Ana Paula Espindula Gianordoli, Maria de Fatima Bissoli, Maria da Penha Gomes Gouvea, Lauro Ferreira da Silva Pinto-Neto, Ana Paula Neves Burian, Francieli Fontana Sutile Tardetti Fantinato, Gecilmara Salviato Pileggi, Licia Maria Henrique da Mota, Valeria Valim, Olindo Assis Martins-Filho
Summary: This study revealed that patients with autoimmune diseases have lower neutralizing antibody response after yellow fever vaccination, with differences in biomarker responses compared to healthy controls. Some patients exhibited distinct IFN-gamma responses at the peak of viremia, which may impact the immune response.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Laise Rodrigues Reis, Ismael Artur da Costa-Rocha, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhaes, Jordana Grazziela Coelho-Dos-Reis, Christiane Costa-Pereira, Dayane Andriotti Otta, Larissa Chaves Freire, Sheila Maria Barbosa de Lima, Adriana de Souza Azevedo, Waleska Dias Schwarcz, Ana Paula Dinis Ano Bom, Andrea Marques Vieira da Silva, Alessandro Fonseca de Souza, Thalita da Matta de Castro, Clara Lucy de Vasconcellos Ferroco, Ana Maria Bispo de Filippis, Fernanda de Bruycker Nogueira, Akira Homma, Carla Magda Domingues, Eduardo Sergio Soares Sousa, Luiz Antonio Bastos Camacho, Maria de Lourdes de Souza Maia, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho
Summary: This study investigated the influence of pre-existing flavivirus immunity and age on the immunity provided by 17DD-YF vaccination. The results showed that there were differences in flavivirus seropositivity rates at baseline between children and adults. Pre-existing flavivirus seropositivity had an impact on the cellular immune response. Additionally, adults had higher levels of YF-neutralizing antibodies after primary vaccination compared to younger children, but antibody levels declined more rapidly in children. These findings suggest that age affects the duration of the cellular immune response following 17DD-YF vaccination.
Article
Infectious Diseases
Adriana Coracini Tonacio, Tatiana do Nascimento Pedrosa, Eduardo Ferreira Borba, Nadia Emi Aikawa, Sandra Gofinet Pasoto, Julio Cesar Rente Ferreira Filho, Marilia Mantovani Sampaio Barros, Elaine Pires Leon, Suzete Cleusa Ferreira Spina Lombardi, Alfredo Mendrone Junior, Adriana de Souza Azevedo, Waleska Dias Schwarcz, Ricardo Fuller, Emily Figueiredo Neves Yuki, Michelle Remiao Ugolini Lopes, Rosa Maria Rodrigues Pereira, Percival Degrava Sampaio Barros, Danieli Castro Oliveira de Andrade, Ana Cristina de Medeiros-Ribeiro, Julio Cesar Bertacini de Moraes, Samuel Katsuyuki Shinjo, Renata Miossi, Alberto Jose da Silva Duarte, Marta Heloisa Lopes, Esper Georges Kallas, Clovis Artur Almeida da Silva, Eloisa Bonfa
Summary: The study found that fractional-dose yellow fever vaccine in autoimmune rheumatic disease patients with low immunosuppression resulted in a high rate of seroconversion, slightly lower than controls, with longer but less intense viremia. It was immunogenic, safe, and did not induce flares in patients, making it potentially useful in yellow fever outbreak situations and for individuals living or traveling to endemic areas.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Nadia Emi Aikawa, Verena Andrade Balbi, Eduardo Ferreira Borba, Adriana Coracini Tonacio, Adriana Maluf Elias Sallum, Lucia Maria Arruda Campos, Katia Tomie Kozu, Margarete Borges Vendramini, Nicole Fontoura, Adriana de Souza Azevedo, Waleska Dias Schwarcz, Ana Marli Christovam Sartori, Leila Antonangelo, Clovis Artur Silva, Eloisa Bonfa
Summary: This study found that 17DD YFV is safe and immunogenic in JARD patients with stable disease and receiving low immunosuppressive treatment. This research may contribute to recommendations for patients living/traveling to endemic areas.
Article
Immunology
Thays Zanon Casagrande, Ismael Artur Da Costa-Rocha, Maria Bernadete Renoldi de Oliveira Gavi, Samira Tatiyama Miyamoto, Priscila Costa Martins, Erica Vieira Serrano, Valquiria Garcia Dinis, Ketty Lysie Libardi Lira Machado, Sonia Alves Gouvea, Larissa Carvalho Caser, Ana Carolina Campi-Azevedo, Andrea Teixeira-Carvalho, Vanessa Peruhype-Magalhaes, Maria de Fatima Bissoli, Maria da Penha Gomes Gouvea, Sheila Maria Barbosa de Lima, Emily Hime Miranda, Gisela Freitas Trindade, Danielle Grillo Pacheco Lyra, Ana Paula Neves Burian, Lauro Ferreira da Silva Pinto Neto, Licia Maria Henrique da Mota, Olindo Assis Martins-Filho, Valeria Valim
Summary: The study found that the use of biological DMARDs impacts the response to the 17DD-YF vaccine, even after planned washout. Additionally, the immunogenicity of 17DD-YF vaccination in patients with SpA may be determined by previous biological DMARD therapy, inflammatory status prior to vaccination, and impairment of the IFN-γ/IL-10 axis at the peak of viremia.
Article
Virology
Paolla Beatriz A. Pinto, Tamiris A. C. Barros, Lauro M. Lima, Agatha R. Pacheco, Maysa L. Assis, Bernardo A. S. Pereira, Antonio J. S. Goncalves, Adriana S. Azevedo, Ana Gisele C. Neves-Ferreira, Simone M. Costa, Ada M. B. Alves
Summary: In this study on dengue disease, a bicistronic plasmid pNS1/E/D2 encoding DENV2 envelope (E) and non-structural 1 (NS1) proteins was constructed. Vaccination with pNS1/E/D2 or pcTPANS1 + pE1D2 induced immune responses against NS1 and E proteins in mice, and provided protection against DENV2.
Article
Virology
Tamiris Azamor, Ingrid Siciliano Horbach, Danielle Brito e Cunha, Juliana Gil Melgaco, Andrea Marques Vieira da Silva, Luciana Neves Tubarao, Adriana de Souza Azevedo, Renata Tourinho Santos, Nathalia dos Santos Alves, Thiago Lazari Machado, Jane Silva, Alessandro Fonseca de Souza, Camilla Bayma, Vanessa Pimenta Rocha, Ana Beatriz Teixeira Frederico, Brenda de Moura Dias, Bruno Pimenta Setatino, Caio Bidueira Denani, Samir Pereira da Costa Campos, Waleska Dias Schwarcz, Michel Vergne Sucupira, Edinea Pastro Mendes, Edimilson Domingos da Silva, Sheila Maria Barbosa de Lima, Ana Paula Dinis Ano Bom, Sotiris Missailidis
Summary: The study investigated immune responses to the ChAdOx1 nCoV-19 vaccine in COVID-19 and non-COVID-19 individuals, revealing significant differences in immune responses post-vaccination, with COVID-19 patients showing higher antibody levels and memory B cells. Vaccination was found to enhance IFN-γ production and impact the activation of T CD4+ naive cells in naive individuals.
Article
Immunology
Valeria Valim, Olindo Assis Martins-Filho, Maria da Penha Gomes Gouvea, Luiz Antonio Bastos Camacho, Daniel Antunes Maciel Villela, Sheila Maria Barbosa de Lima, Adriana Souza Azevedo, Lauro Ferreira Pinto Neto, Carla Magda Allan Santos Domingues, Nesio Fernandes de Medeiros Junior, Isac Ribeiro Moulaz, Laiza Hombre Dias, Samira Tatiyama Miyamoto, Andrea Teixeira-Carvalho, Jose Geraldo Mill
Summary: This study evaluated the effectiveness, safety, and immunogenicity of a half dose of ChAdOx1 nCoV-19 vaccine compared to the full dose. The results showed that the half dose was as effective and safe as the full dose, with no significant difference in preventing new cases. The immune response in individuals who were already seropositive at baseline suggests that the half dose may serve as a booster dose schedule.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Patricia P. Garcez, Andre Guasti, Nina Ventura, Luiza Mendonca Higa, Felipe Andreiuolo, Gabriella Pinheiro A. de Freitas, Liane de Jesus Ribeiro, Richard Araujo Maia, Sheila Maria Barbosa de Lima, Adriana de Souza Azevedo, Waleska Dias Schwarcz, Elena Cristina Caride, Leila Chimelli, Luiz Gustavo Dubois, Orlando da Costa Ferreira Junior, Amilcar Tanuri, Vivaldo Moura-Neto, Paulo Niemeyer
Summary: During a Zika virus outbreak in Brazil, a glioblastoma patient showed symptoms similar to an arbovirus-like infection, and after the infection resolved, the glioblastoma regressed without recurrence. This clinical response has continued for 6 years.
FRONTIERS IN MEDICINE
(2023)