Article
Biochemistry & Molecular Biology
Sumeet Manandhar, Amy Scott-Thomas, Michael Harrington, Priyanka Sinha, Anna Pilbrow, Arthur Mark Richards, Vicky Cameron, Madhav Bhatia, Stephen T. Chambers
Summary: This study measured the concentrations of hydrogen sulfide (H2S) and substance P (SP) in the peripheral blood of patients with Escherichia coli or Klebsiella pneumoniae bacteraemia. The study found that the concentrations of H2S and SP varied with the site of infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Maofang Zhao, Yuan Cheng, Xiaoxuan Wang, Xiaoying Cui, Xiaojing Cheng, Qian Fu, Yilin Song, Peiquan Yu, Yi Liu, Yinghua Yu
Summary: This study identified that HFD-induced hypothalamic inflammation plays a critical role in the development of obesity. Restoration of hydrogen sulfide (H2S) levels could be a potential therapeutic approach to prevent obesity.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanling Zhao, Han Yan, Xue Liang, Zhenyu Zhang, Xuan Wang, Nianwei Shi, Weihong Bian, Qing Di, He Huang
Summary: Activation of astrocytes is inhibited by H2S, which leads to a reduction in the release of neuroinflammatory factors. H2S regulates NF-kappa B activation and S-sulfhydration of P-gp, thereby inhibiting the biosynthesis and secretion of proinflammatory factors by astrocytes. The findings suggest that H2S may have potential clinical value in developing new therapeutic strategies against neurodegenerative diseases.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Thanasekaran Jayakumar, Ming-Ping Wu, Joen-Rong Sheu, Chih-Wei Hsia, Periyakali Saravana Bhavan, Manjunath Manubolu, Chi-Li Chung, Chih-Hsuan Hsia
Summary: Pterostilbene (PTE), a natural stilbenoid found in grapes and berries, exhibits anti-inflammatory properties by attenuating NF-kappa B/ERK signaling pathways and enhancing antioxidant defense mechanisms. It significantly reduces NO production and expression of inflammatory factors, while inhibiting ERK activation and blocking phosphorylation and nuclear translocation of p65NF-kappa B.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bin Li, Lei Zhang, Lei Zhu, Yongqiang Cao, Zhimin Dou, Qin Yu
Summary: The study revealed the significant role of HDAC5 in intestinal sepsis by inhibiting Ghrelin and related signaling pathways to promote intestinal inflammation and cell apoptosis.
Article
Immunology
Rong Hu, Libo Chen, Xiaolong Chen, Zhong Xie, Chao Xia, Yong Chen
Summary: Aloperine has been shown to inhibit osteoclast activity and formation mediated by RANKL, indicating its potential as a new drug for the prevention and treatment of postmenopausal osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Hisatake Matsumoto, Brendon P. Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gurkan, Erik Malmstrom, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van 't Veer, Tom van der Poll
Summary: The study indicates that HIVEP1 acts as a negative regulator of NF-κB in monocytes, inhibiting the proinflammatory response induced by bacterial agonists. Dysregulation of HIVEP1 leads to significant changes in the monocyte transcriptome and modulation of NF-κB responsive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jisu Jeon, Yeji Lee, Hyeonseung Yu, Unhwan Ha
Summary: The study found that Pseudomonas aeruginosa DnaK induces production of Pentraxin 3, mediated through intracellular signals transmitted by the Toll-like receptor 4 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jianhua Li, Jiamin Ma, Mengyu Li, Jing Tao, Jiayi Chen, Chengye Yao, Shanglong Yao
Summary: The study demonstrates that GYY4137 inhibits the activation of the NLRP3 inflammasome by blocking the PDGFR beta/Akt/NF-kappa B pathway, which contributes to the treatment of CLP-induced ALI in mice.
Article
Pharmacology & Pharmacy
Yadong Li, Li Zhang, Ping Zhang, Zhiying Hao
Summary: The study demonstrated that dehydrocorydaline (Deh) alleviates sepsis-induced cardiomyocyte injury by inhibiting the TRAF6/NF-kappa B pathway, showing anti-inflammatory and anti-oxidative stress properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Cheng Yao-Jun, Tian Xin-Lei, Zeng Ya-Zhi, Lan Nan, Guo Ling-Feng, Liu Ke-Feng, Fang Hui-Long, Fan Hong-Ye, Peng Zhong-Lu
Summary: The study demonstrated that esculetin has anti-inflammatory and protective effects on early sepsis by relieving lung injury and inhibiting the production of inflammatory factors, as well as attenuating NF-kappa B and STAT1/STAT3 signaling pathways. These findings suggest that esculetin may serve as a potential therapeutic agent for early sepsis by rebalancing the innate immune response in macrophages.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Medicine, Research & Experimental
Francisca B. M. Sousa, Gabriella Pacheco, Ana P. Oliveira, Lucas A. D. Nicolau, Andre L. F. Lopes, Hygor Ferreira-Fernandes, Giovanny R. Pinto, Jand V. R. Medeiros
Summary: The study demonstrated that hydrogen sulfide (H2S) can protect against cholera toxin (CT) by preserving villus and crypt morphology in mice. This protective effect is likely achieved at least in part by reducing the activity of NF-kappa B and PGE2.
Article
Pharmacology & Pharmacy
Meisong Zhu, Qiang Xu, Xinmin Yang, Haibo Zhan, Bin Zhang, Xuqiang Liu, Min Dai
Summary: This study found that Vindoline (Vin) extracted from Catharanthus roseus can suppress the progression of osteoarthritis (OA) by inhibiting osteoclastogenesis and stabilizing the extracellular matrix (ECM) of articular cartilage. This provides molecular-level evidence for the potential of Vin in the treatment of OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Ming-Yu Jin, Xiao-Yong Wu, Mei-Ying Li, Xiao-Tong Li, Ri-Ming Huang, Yuan-Ming Sun, Zhen-Lin Xu
Summary: Noni fruit polysaccharides (NFP) exhibit anti-inflammatory effects in a DSS-induced IBD mouse model by regulating intestinal microecological balance and inhibiting inflammatory signaling pathways. NFP upregulates beneficial acids and downregulates harmful acids, suggesting its potential as a cost-effective intervention for preventing and treating IBD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Analytical
Seng Koon Lim, Peng Chen, Fook Loy Lee, Shabbir Moochha, Bo Liedberg
ANALYTICAL CHEMISTRY
(2015)
Article
Cardiac & Cardiovascular Systems
Boon Yew Tan, Rita Yu Yin Yong, Hector Barajas-Martinez, Robert Dumaine, Ying Xia Chew, Pavandip Singh Wasan, Chi Keong Ching, Kah Leng Ho, Linda Seo Hwee Gan, Nathalie Morin, Alicia Poh Leng Chong, Shiao Hui Yap, Jia Ling Neo, Eric Peng Huat Yap, Shabbir Moochhala, Daniel Thuan Tee Chong, Weien Chow, Swee Chong Seow, Dan Hu, Mahesh Uttamchandani, Wee Siong Teo
Article
Hematology
Junyun Lai, Wei Jian Tan, Chien Tei Too, Joanna Ai Ling Choo, Lan Hiong Wong, Fatimah Bte Mustafa, Nalini Srinivasan, Angeline Pei Chiew Lim, Youjia Zhong, Nicholas R. J. Gascoigne, Brendon J. Hanson, Soh Ha Chan, Jianzhu Chen, Paul A. MacAry
Article
Immunology
Yen Leong Chua, Ka Hang Liong, Chiung-Hui Huang, Hok Sum Wong, Qian Zhou, Say Siong Ler, Yafang Tang, Chin Pei Low, Hui Yu Koh, I. -Chun Kuo, Yongliang Zhang, W. S. Fred Wong, Hong Yong Peh, Hwee Ying Lim, Moyar Qing Ge, Angela Haczku, Veronique Angeli, Paul A. MacAry, Kaw Yan Chua, David M. Kemeny
JOURNAL OF IMMUNOLOGY
(2016)
Article
Transplantation
Linda Shavit, Lucia Chen, Fayha Ahmed, Pietro Manuel Ferraro, Shabbir Moochhala, Steven B. Walsh, Robert Unwin
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2016)
Review
Oncology
Fenggang Yu, Wei Jian Tan, Yanan Lu, Paul A. MacAry, Kwok Seng Loh
Article
Urology & Nephrology
Linda Shavit, Daniela Girfoglio, Alex Kirkham, Darrell Allen, Pietro Manuel Ferraro, Shabbir Moochhala, Robert Unwin
Article
Chemistry, Analytical
Meng-Che Tu, Hari Krishna Svm, Alahakoon Thilini, Lim Tse Loong Wallace, Shabbir Moochhala, Umit Hakan Yildiz, Al. Palaniappan, Bo Liedberg
SENSORS AND ACTUATORS B-CHEMICAL
(2017)
Article
Cardiac & Cardiovascular Systems
Boon Yew Tan, Luokai Wang, Mahesh Uttamchandani, Hector Barajas-Martinez, Robert Dumaine, Nathalie Morin, Chi Keong Ching, Kah Leng Ho, Daniel Thuan Tee Chong, Weien Chow, Eric Peng Huat Yap, Shabbir Moochhala, Dan Hu, Rita Yu Yin Yong, Wee Siong Teo
JOURNAL OF ELECTROCARDIOLOGY
(2018)
Article
Urology & Nephrology
Pietro Manuel Ferraro, Miguel Angel Arrabal-Polo, Giovambattista Capasso, Emanuele Croppi, Adamasco Cupisti, Thomas Ernandez, Daniel G. Fuster, Juan Antonio Galan, Felix Grases, Ewout J. Hoorn, Felix Knauf, Emmanuel Letavernier, Nilufar Mohebbi, Shabbir Moochhala, Kremena Petkova, Agnieszka Pozdzik, John Sayer, Christian Seitz, Pasquale Strazzullo, Alberto Trinchieri, Giuseppe Vezzoli, Corrado Vitale, Liffert Vogt, Robert J. Unwin, Olivier Bonny, Giovanni Gambaro
Article
Microbiology
Ryan Yuki Huang, Deron Raymond Herr, Shabbir Moochhala
Article
Biochemistry & Molecular Biology
Anna Karen Carrasco Laserna, Yiyang Lai, Guihua Fang, Rajaseger Ganapathy, Mohamed Shirhan Bin Mohamed Atan, Jia Lu, Jian Wu, Mahesh Uttamchandani, Shabbir M. Moochhala, Sam Fong Yau Li
Proceedings Paper
Engineering, Electrical & Electronic
Wee Jin Koh, Shabbir M. Moochhala
2018 JOINT IEEE INTERNATIONAL SYMPOSIUM ON ELECTROMAGNETIC COMPATIBILITY AND 2018 IEEE ASIA-PACIFIC SYMPOSIUM ON ELECTROMAGNETIC COMPATIBILITY (EMC/APEMC)
(2018)
Meeting Abstract
Immunology
J. Lai, W. J. Tan, C. T. Too, J. A. L. Choo, L. H. Wong, F. Mustafa, N. Srinivasan, A. P. C. Lim, Y. Zhong, N. Gascoigne, B. Hanson, S. H. Chan, J. Chen, P. Macary
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Article
Rheumatology
Shaun M. Flint, Vojislav Jovanovic, Boon Wee Teo, Anselm Mak, Julian Thumboo, Eoin F. McKinney, James C. Lee, Paul MacAry, David M. Kemeny, David R. W. Jayne, Kok Yong Fong, Paul A. Lyons, Kenneth G. C. Smith