Article
Chemistry, Physical
Donald R. Griffin, Maani M. Archang, Chen-Hsiang Kuan, Westbrook M. Weaver, Jason S. Weinstein, An Chieh Feng, Amber Ruccia, Elias Sideris, Vasileios Ragkousis, Jaekyung Koh, Maksim Plikus, Dino Di Carlo, Tatiana Segura, Philip O. Scumpia
Summary: The study aimed to slow MAP scaffold degradation by changing the chirality of peptides, but unexpectedly, D-peptide crosslinked MAP scaffolds led to accelerated degradation in vivo, promoting tissue regeneration and enhancing wound healing. D-MAP triggered an immune response against D-chiral peptides and intact adaptive immune system was crucial for skin regeneration induced by the hydrogel.
Review
Cell Biology
Huiting Wu, Wei Liang, Meng Han, Yonghuan Zhen, Lixia Chen, Hua Li, Yang An
Summary: The high incidence, low healing rate, and economic burden of wounds worldwide pose a significant challenge in clinical practice. Wound healing is regulated by various cytokines and growth factors, and understanding their mechanisms is essential for improving treatment. Recent studies have shown that lactate, as an epigenetic regulator, plays a role in wound healing through gene expression regulation and posttranslational modifications. This article reviews the progress in lactate and lactylation research in wound healing, including its involvement in immune regulation, inflammation control, proliferative remodeling, and the potential of lactate therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nyemkuna Fortingo, Samuel Melnyk, Sarah H. Sutton, Mitchell A. Watsky, Wendy B. Bollag
Summary: Inflammation plays a complex role in corneal wound healing. While acute inflammation is necessary to prevent infection, chronic or excessive inflammation can delay healing and worsen outcomes. Reductions in severe or chronic inflammation lead to better corneal clarity, thickness, and healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yen-Hsi Lin, Yen-Chin Chen, Kuo-Sheng Cheng, Po-Jui Yu, Jiun-Ling Wang, Nai-Ying Ko
Summary: This study found a positive correlation between higher periwound temperatures and better wound healing, as well as a link between higher malnutrition scores and poor wound healing. Multivariate analysis showed that changes in periwound temperature can be a useful indicator for predicting pressure ulcer healing outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
David M. Chesko, Traci A. Wilgus
Summary: This review summarizes the roles of different immune cell types in cutaneous wound healing, with a focus on data from animal studies targeting specific cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Bogdan Purcareanu, Manuela Diana Ene, Alina Morosan, Dan Eduard Mihaiescu, Mihai Alexandru Florea, Adelina Ghica, Roxana Andreea Nita, Veronica Drumea, Mihai Alexandru Grigoroscuta, Andrei Kuncser, Petre Badica, Laura Olariu
Summary: The treatment of wounds remains a challenge for healthcare professionals, and the development of biocompatible and efficient medicines is a goal. Mesoporous materials loaded with bioactive compounds from natural extracts have potential for wound treatment. In this study, MCM-41-type mesoporous material was synthesized and characterized. The desorption degree of the natural extracts was monitored, and the active ingredients in the composite materials were quantified. The evaluation of the biological composites' activity on the wound site revealed their re-epithelializing properties.
Article
Pharmacology & Pharmacy
Hasan Turkez, Ozge Caglar Yildirim, Sena Oner, Abdurrahim Kadi, Abdulkadir Mete, Mehmet Enes Arslan, Irfan Oguz Sahin, Omer Erkan Yapca, Adil Mardinoglu
Summary: Complications of chronic non-healing wounds have led to the development of nanotechnology-based therapies using ALA conjugated hBN and B4C nanoparticles to accelerate wound healing and prevent infections. Through experimental analysis, it was found that ALA-conjugated hBN nanoparticles exhibited the highest wound healing potential and antimicrobial activity compared to ALA-B4C. Furthermore, the conjugation of ALA enhanced the wound healing and antimicrobial properties of hBN and B4C nanoparticles.
Article
Immunology
Rafaela Vaz Sousa Pereira, Mostafa EzEldeen, Estefania Ugarte-Berzal, Erik Martens, Bert Malengier-Devlies, Jennifer Vandooren, Jan Jeroen Vranckx, Patrick Matthys, Ghislain Opdenakker
Summary: This study found that using physiological fibrin hydrogels in skin wound healing in mice can modulate immune cells and molecules, leading to faster wound repair. The hydrogels can reduce neutrophil numbers, increase non-classical Ly6Clow monocytes and resolutive macrophage populations, and decrease the expression of pro-inflammatory cytokines. Additionally, the hydrogels can increase the counts of dermal endothelial cells, fibroblasts, and keratinocytes, promote keratinocyte migration, and accelerate wound healing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Environmental
Li Wang, Yinghui Zhong, Qianqian Wu, Yu Wang, Ruoqi Tang, Silu Zhou, Jingde Yang, Qiming Liu, Guoxin Shi, Yanan Tang, Xianglong Meng, Kexin Chen, Xianqiang Yan, Xuelei Liu, Jing Zhan, Thomas M. Roberts, Song Liang, Jiaao Yu, Zhenning Liu
Summary: Two types of spermidine-functionalized biomaterials have been fabricated and shown to inhibit inflammatory responses and promote wound healing through in vitro and in vivo experiments. The findings of the proteomic analysis suggest possible mechanisms underlying these effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Medicine, General & Internal
Jessica Balikji, Maarten M. Hoogbergen, Johan Garssen, Joris C. Verster
Summary: The current study investigated the immune fitness and immune-related complaints of individuals with wound infection, slow healing wounds, or both. The findings showed that individuals with impaired wound healing reported poorer immune fitness and more immune-related complaints compared to healthy participants. These results emphasize the importance of further immune biomarkers analysis in supporting patient-reported outcome measures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Dorthe Seidel, Rolf Lefering
Summary: This study compared the resource utilization of NPWT and CWT in patients with SAWHI after surgery. The results showed that although the treatment length was shorter in the NPWT group, the hospitalization time was shorter in the CWT group. In addition, there were fewer outpatient participants in the NPWT group, but the dressing changes and wound-related procedures took less time per participant.
Review
Health Care Sciences & Services
Tatiana Bolgeo, Antonio Maconi, Menada Gardalini, Denise Gatti, Roberta Di Matteo, Marco Lapidari, Yaroslava Longhitano, Gabriele Savioli, Andrea Piccioni, Christian Zanza
Summary: Critically ill patients are prone to skin wounds, which have negative impacts on their quality of life, medication plans, and hospital stays. Cold atmospheric plasma (CAP) has been suggested as a potential solution to reduce wound contamination and promote healing. This review examines how CAP works, its mechanisms, and its applications in critical care settings, with a focus on its success in treating bedsores and potential implications for healthcare.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Polymer Science
Xiguang Yang, Dandan Guo, Xiaotian Ji, Changying Shi, Juntao Luo
Summary: Imbalanced immune regulation can lead to abnormal wound healing, such as chronic unhealing wounds or hypertrophic scar formation. However, by reducing the levels of inflammatory factors, normal wound healing can be facilitated. A versatile telodendrimer (TD) nanotrap (NT) platform has been developed to efficiently bind biomolecular proteins. By conjugating TD NT in a biocompatible hydrogel resin, topical application for cytokine scavenging becomes possible. The TD NT hydrogel is able to effectively modulate immune responses and attenuate local inflammation.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Xavier Alvarez, Andreia Alves, Maximiano P. Ribeiro, Massimo Lazzari, Paula Coutinho, Ana Otero
Summary: Exopolysaccharides (EPS) produced by cyanobacteria have potential biomedical applications, such as new wound dressings. Addition of acetate ions to the culture medium can stimulate EPS production, leading to gel formation and promotion of fibroblast migration and proliferation. These Nostoc EPS hydrogels show promising properties for skin injury treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Carolini Mendes, Anand Thirupathi, Maria E. A. B. Correa, Yaodong Gu, Paulo C. L. Silveira
Summary: This paper explores the application of metallic nanoparticles in the treatment of chronic wounds, highlighting their advantages in drug delivery, antimicrobial activity, and healing acceleration, as well as the safety and applicability of metallic nanoparticles produced through green synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Caroline V. Palmer, Andrew H. Baird
DISEASES OF AQUATIC ORGANISMS
(2018)
Review
Biotechnology & Applied Microbiology
Cassie R. Bakshani, Ana L. Morales-Garcia, Mike Althaus, Matthew D. Wilcox, Jeffrey P. Pearson, John C. Bythell, J. Grant Burgess
NPJ BIOFILMS AND MICROBIOMES
(2018)
Article
Marine & Freshwater Biology
Reia Guppy, Barbara Brown, John C. Bythell
Article
Biodiversity Conservation
R. Puschendorf, M. Wallace, M. M. Chayarria, A. J. Crawford, F. Wynne, M. Knight, D. H. Janzen, W. Hallwachs, Cv Palmer, S. J. Price
ANIMAL CONSERVATION
(2019)
Review
Ecology
Renata Ferrari, Liam Lachs, Daniel R. Pygas, Adriana Humanes, Brigitte Sommer, Will F. Figueira, Alasdair J. Edwards, John C. Bythell, James R. Guest
Summary: Ecosystem restoration relies on clear and measurable goals with standardized monitoring methods. Photogrammetry, using images to reconstruct landscapes and organisms, has the potential to enhance restoration success rates.
TRENDS IN ECOLOGY & EVOLUTION
(2021)
Article
Environmental Sciences
Liam Lachs, John C. Bythell, Holly K. East, Alasdair J. Edwards, Peter J. Mumby, William J. Skirving, Blake L. Spady, James R. Guest
Summary: Increasingly intense marine heatwaves threaten marine ecosystems, with mass coral bleaching causing catastrophic coral mortality. Fine-tuning coral bleaching prediction algorithms can improve accuracy of predictions and reduce detrimental impacts on coral reefs.
Article
Environmental Sciences
Adriana Humanes, Elizabeth A. Beauchamp, John C. Bythell, Mitch K. Carle, Jamie R. Craggs, Alasdair J. Edwards, Yimnang Golbuu, Liam Lachs, Helios M. Martinez, Pawel Palmowski, Faith Paysinger, Janna L. Randle, Eveline van der Steeg, Michael Sweets, Achim Treumann, James R. Guest
Summary: Coral cover on tropical reefs has declined in the last three decades due to climate change, destructive fishing, pollution, and land use change. Effective coastal management and conservation strategies, along with drastic reductions in greenhouse gas emissions, are necessary to slow this decline. Selective breeding and rearing of coral colonies from eggs to mature stages is technically feasible at small scales, but challenges remain in scaling up these efforts for restoration initiatives.
FRONTIERS IN MARINE SCIENCE
(2021)
Editorial Material
Immunology
Nikki Traylor-Knowles, William E. Browne, Laura D. Mydlarz, Caroline V. Palmer, Benyamin Rosental
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thibault Bouderlique, Julian Petersen, Louis Faure, Daniel Abed-Navandi, Anass Bouchnita, Benjamin Mueller, Murtazo Nazarov, Lukas Englmaier, Marketa Tesarova, Pedro R. Frade, Tomas Zikmund, Till Koehne, Jozef Kaiser, Kaj Fried, Christian Wild, Olga Pantos, Andreas Hellander, John Bythell, Igor Adameyko
Summary: Research has revealed that corals can connect individual polyps and form a coral colony through complex liquid flow networks on the surface and branching flow systems inside the colony. These networks and systems play important roles in the growth, nutrient supply, and symbiont transfer of corals.
Article
Biology
Adriana Humanes, Liam Lachs, Elizabeth A. Beauchamp, John C. Bythell, Alasdair J. Edwards, Yimnang Golbuu, Helios M. Martinez, Pawel Palmowski, Achim Treumann, Eveline van der Steeg, Ruben van Hooidonk, James R. Guest
Summary: Coral reefs are facing unprecedented mass bleaching and mortality events due to marine heatwaves and climate change. Individual variation in heat tolerance suggests potential for coral adaptation. By exposing corals to experimental heatwaves, researchers found that the most-tolerant corals required double the heat stress dosage compared to the least-tolerant corals to induce bleaching. Under an ambitious emissions scenario, these differences in coral heat tolerance thresholds may delay the onset of annual bleaching and mortality conditions by up to 17 years. However, this delay is limited to only 10 years under a high emissions scenario. The results highlight the substantial variability in coral heat tolerance and the need for coral adaptation and ambitious emissions reductions.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Caroline Palmer, Carlos Jimenez, Giovanni Bassey, Eleazar Ruiz, Tatiana Villalobos Cubero, Maria Marta Chavarria Diaz, Xavier A. Harrison, Robert Puschendorf
Summary: The study documents coral cover and composition in relation to sea surface temperature (SST) over the past 25 years in marginal reefs of Costa Rica's Eastern Tropical Pacific. A catastrophic coral die-off event occurred in 2009, driven by SST minima and likely by extreme harmful algal blooms, leading to a shift in coral composition and a lack of recovery in the subsequent decade. This highlights the need for resilience-based management and restoration strategies in the face of ongoing coral reef declines.
Article
Biology
Liam Lachs, Adriana Humanes, Daniel R. Pygas, John C. Bythell, Peter J. Mumby, Renata Ferrari, Will F. Figueira, Elizabeth Beauchamp, Holly K. East, Alasdair J. Edwards, Yimnang Golbuu, Helios M. Martinez, Brigitte Sommer, Eveline van der Steeg, James R. Guest
Summary: As marine species adapt to climate change, their heat tolerance will be under strong selection, but trade-offs between heat tolerance and other traits may compromise adaptation. The study focused on reef-building corals and found no trade-offs between heat tolerance and fecundity or growth. Surprisingly, faster-growing corals tended to bleach and die at higher levels of heat stress. Overall, this suggests that some high-performing corals excel across multiple traits and trade-offs may not be major barriers to adaptation or evolution interventions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Liam Lachs, Simon D. D. Donner, Peter J. J. Mumby, John C. C. Bythell, Adriana Humanes, Holly K. K. East, James R. R. Guest
Summary: Recurrent mass bleaching events pose a threat to coral reefs and their future. However, this study suggests that the thermal tolerance of coral assemblages in a remote Pacific coral reef system has been increasing, leading to less severe bleaching impacts. Future climate projections indicate that further increases in thermal tolerance could substantially reduce bleaching trajectories, highlighting the importance of reducing carbon emissions.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Caroline Palmer
FRONTIERS IN MARINE SCIENCE
(2018)
Review
Biology
John C. Bythell, Barbara E. Brown, Thomas B. L. Kirkwood
BIOLOGICAL REVIEWS
(2018)