Article
Medicine, Research & Experimental
Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Marcella Ramos Sant'Ana, Guilherme Francisco Peruca, Chadi Pellegrini Anaruma, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, Diego Gomes de Melo, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Leandro Pereira de Moura
Summary: The study showed that short-term combined training can reduce glucose levels and fatty liver, improve hepatic insulin sensitivity, and reduce complications caused by fatty liver.
Article
Medicine, Research & Experimental
Gabriela V. Moreira, Layanne C. C. Araujo, Gilson M. Murata, Sandro L. Matos, Carla R. O. Carvalho
Summary: Nonalcoholic fatty liver disease (NAFLD), often associated with obesity, is a common liver disease worldwide. The gut-liver axis is considered the main pathway for NAFLD development. An exploratory study showed that a kombucha probiotic has beneficial effects on reducing metabolic abnormalities caused by diet-induced obesity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Mary P. Moore, Rory P. Cunningham, Grace M. Meers, Sarah A. Johnson, Andrew A. Wheeler, Rama R. Ganga, Nicole M. Spencer, James B. Pitt, Alberto Diaz-Arias, Ahmed I. A. Swi, Ghassan M. Hammoud, Jamal A. Ibdah, Elizabeth J. Parks, R. Scott Rector
Summary: Compromised hepatic FAO and mitochondrial turnover are intimately linked to increasing NAFLD severity in patients with obesity.
Article
Immunology
Zhihua Ren, Samuel Kumi Okyere, Lei Xie, Juan Wen, Jiayi Wang, Zhengli Chen, Xueqin Ni, Junliang Deng, Yanchun Hu
Summary: This study investigated the ameliorative effects of Bacillus toyonensis-SAU-20 (B. toyo SAU-20) on insulin resistance and hepatic steatosis in type 2 diabetic mice. Results showed that B. toyo SAU-20 significantly suppressed the elevation of glucose, lipid profile, lipogenic genes, and pro-inflammatory cytokines in T2DM mice. Additionally, B. toyo SAU-20 improved liver morphology, dyslipidemia, oxidative stress, and inflammation. These findings suggest that B. toyo SAU-20 alleviates insulin resistance and hepatic steatosis by improving lipid profiles, antioxidant status, and downregulating lipogenic genes and pro-inflammatory cytokines expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yaru Li, Xueqin Chen, Yulu Chen, Dongsheng Yu, Ran Jiang, Xinhui Kou, Liang Sheng, Yang Liu, Yu Song
Summary: Berberine improves TNF-alpha-induced hepatic insulin resistance by inhibiting MEKK1 and MEK1/2.
Article
Cell Biology
Yaru Li, Xueqin Chen, Yulu Chen, Dongsheng Yu, Ran Jiang, Xinhui Kou, Liang Sheng, Yang Liu, Yu Song
Summary: The study demonstrates that berberine improves TNF-alpha-induced hepatic insulin resistance by inhibiting MEKK1 and MEK1/2. Molecular docking confirms the interaction between berberine and these targets.
Article
Agriculture, Multidisciplinary
J. R. Oliveira, J. M. O. Andrade, D. de F. Lelis, A. F. Paraiso, A. M. B. de Paula, A. L. S. Guimaraes, J. P. Lima, J. Cota, D. da Costa, S. H. S. Santos
Summary: The aim of this study was to evaluate the impact of Madagascar cockroach flour on body composition, biochemistry, and inflammation in the liver of obese mice. The results showed that the group treated with HFD-CF had lower levels of fasting glucose, total cholesterol, triglycerides, and pyruvic transaminase/aspartate aminotransferase compared to the HFD group. Additionally, the HFD+CF group exhibited reduced levels of liver interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) expression. These findings suggest that Madagascar cockroach flour may serve as a beneficial dietary supplement to improve biochemical and inflammatory alterations caused by obesity.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Article
Gastroenterology & Hepatology
Ying Wu, Ai-Hong Yin, Jun-Tao Sun, Wei-Hua Xu, Chun-Qing Zhang
Summary: ACE2 overexpression inhibits HSC activation and promotes cell apoptosis by regulating HSC autophagy through the AMPK/mTOR pathway, thereby alleviating liver fibrosis and hepatic sinusoidal remodeling.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Plant Sciences
Chengliang Wang, Liying Ren, Shankang Chen, Huihui Zheng, Yifan Yang, Tieguang Gu, Yuhao Li, Chunxia Wang
Summary: The study revealed that Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance in rats by regulating the ACE2/Ang (1–7)/Mas axis-mediated anti-inflammatory pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carlos Perez-Monter, Alejandro Alvarez-Arce, Natalia Nuno-Lambarri, Ivonne Escalona-Nandez, Eva Juarez-Hernandez, Norberto C. Chavez-Tapia, Misael Uribe, Varenka J. Barbero-Becerra
Summary: Supplementing inulin in a classic obesity and fatty liver model mice can effectively prevent hepatic steatosis and reshape the composition of intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Helena Leal, Joao Cardoso, Patricia Valerio, Marta Quatorze, Vitor Carmona, Janete Cunha-Santos, Luis Pereira de Almeida, Claudia Pereira, Claudia Cavadas, Pedro Gomes
Summary: The protein SIRT2 is found to play a role in the regulation of hepatic lipid metabolism and its activation might be a therapeutic strategy against obesity and its metabolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marcelo Paradiso Marinovic, Celso Pereira Batista Sousa-Filho, Fernanda Aparecida Heleno Batista, Thayna Mendonca Avelino, Bruno Cogliati, Ana Carolina Migliorini Figueira, Rosemari Otton, Alice Cristina Rodrigues
Summary: This study demonstrates that green tea can improve non-alcoholic fatty liver disease (NAFLD), and this improvement is dependent on the action of adiponectin in the liver. The researchers found that catechins in green tea can reduce hepatic steatosis in a PPAR alpha-dependent manner.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xiyue Shen, Kai Luo, Juntao Yuan, Junling Gao, Bingqing Cui, Zhuoran Yu, Zhongbing Lu
Summary: DDAH1 is an important regulator of ADMA levels in NAFLD patients and plays a role in the development of NAFLD. Knockout of hepatic Ddah1 exacerbates liver steatosis and insulin resistance, while overexpression of DDAH1 attenuates NAFLD in mice. DDAH1 affects NF-KB signaling, lipid metabolism, and immune system processes in fatty livers, and reduces S100A11 expression via NF-KB, JNK, and oxidative stress-dependent manner. Strategies to increase DDAH1 activity or decrease S100A11 expression could be potential therapies for NAFLD.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Plant Sciences
Laxmi Sen Thakuri, Chul Min Park, Hyeon-A Kim, Hyung Jung Kim, Jin Woo Park, Jong Cheol Park, Dong Young Rhyu
Summary: Red seaweed has a long history in traditional Asian medicine and has been used to address various conditions. This study investigated the effects of a specific red seaweed extract on liver injury and lipid and glucose dysregulation, finding promising results.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Cell Biology
Songhua Zhang, Aryanna Sousa, Mengqui Lin, Ayako Iwano, Rishubh Jain, Bing Ma, Chang Min Lee, Jin Wook Park, Suchitra Kamle, Rolf Carlson, Ghun Geun Lee, Jack A. Elias, Jack R. Wands
Summary: The recently discovered human glycoprotein Chi3L1 has been found to potentially play a role in inflammation, tissue remodeling, and visceral fat accumulation. Inhibition of the Chi3L1 gene could reduce lipid accumulation and improve insulin signaling in the liver. High-fat diet induced increased Chi3L1 expression in the liver, while anti-Chi3L1 monoclonal antibodies partially restored insulin signaling and decreased hepatic lipid accumulation.
Article
Gastroenterology & Hepatology
Eline H. van den Berg, Jose L. Flores-Guerrero, Erwin Garcia, Margery A. Connelly, Vincent E. de Meijer, Stephan J. L. Bakker, Hans Blokzijl, Robin P. F. Dullaart
Summary: Plasma betaine levels are elevated in cirrhotic patients in parallel with disease severity and decrease after liver transplantation. The association with TMAO levels is not significant.
LIVER INTERNATIONAL
(2023)
Article
Surgery
Simone Augustinus, Anouk E. J. A. Latenstein, Bert R. Bonsing, Olivier Busch, Bas Groot Koerkamp, Ignace H. J. T. E. de Hingh, Vincent de Meijer, I. Quintus C. Molenaar, Hjalmar van Santvoort, Judith H. de Vos-Geelen, Casper G. van Eijck, Marc Besselink, Dutch Pancreatic Canc Grp
Summary: This study aimed to assess the clinical impact and risk factors of chyle leak (CL) after pancreatoduodenectomy. The nationwide Dutch Pancreatic Cancer Audit was used to include consecutive patients from all 19 centers. The rate of CL was 7.0% and it was associated with prolonged hospital stay. Vascular resection and open surgery were identified as predictors of CL.
Article
Surgery
Jelle L. van Dongen, Jacob G. van Dam, Marc A. Besselink, Bert Bonsing, Koop R. Bosscha, Olivier M. Busch, Ronald van Dam, Sebastiaan Festen, Erwin H. van der Harst, Ignace de Hingh, Geert Kazemier, Mike S. L. E. Liem, Vincent de Meijer, Jan S. D. Mieog, Izaak. Q. A. Molenaar, Gijs C. Patijn, Hjalmar H. van Santvoort, Jan Wijsman, Martijn W. J. Stommel, Fennie F. Wit, Roeland De Wilde, Casper H. J. van Eijck, Bas Groot Koerkamp, Dutch Pancreat Canc Grp
Summary: The objective of this study is to develop a fistula risk score for auditing and comparing postoperative pancreatic fistula (POPF) after pancreatoduodenectomy among hospitals. The study used data from the nationwide Dutch Pancreatic Cancer Audit and performed multivariable logistic regression analysis for case-mix adjustment. The fistula risk score was successful in case-mix adjustment and enables fair comparisons of POPF rates among hospitals.
Article
Surgery
J. Annelie Suurmeijer, Anne Claire A. Henry, Bert Bonsing, Koop M. Bosscha, Ronald H. van Dam, Casper F. van Eijck, Michael Gerhards, Erwin H. van der Harst, Ignace P. de Hingh, Martijn Intven, Geert W. Kazemier, Johanna J. Wilmink, Daan Lips, Fennie E. Wit, Vincent de Meijer, I. Quintus A. Molenaar, Gijs P. Patijn, George van der Schelling, Martijn W. J. R. Stommel, Olivier Busch, Bas Groot C. Koerkamp, Hjalmar G. van Santvoort, Marc Besselink, Dutch Pancreat Canc Grp
Summary: This study describes the outcome after pancreatic surgery in the first 6 years of a nationwide audit in the Netherlands. The results showed improvements in failure to rescue (FTR) and in-hospital mortality after pancreatoduodenectomy (PD), despite operating on more high-risk patients. Collaborative efforts may have contributed to these improvements.
Article
Gastroenterology & Hepatology
Muyiwa Awoniyi, Jeremy Wang, Billy Ngo, Vik Meadows, Jason Tam, Amba Viswanathan, Yunjia Lai, Stephanie Montgomery, Morgan Farmer, Martin Kummen, Louise Thingholm, Christoph Schramm, Corinna Bang, Andre Franke, Kun Lu, Huiping Zhou, Jasmohan S. Bajaj, Phillip B. Hylemon, Jenny Ting, Yury Popov, Johannes Roksund Hov, Heather L. Francis, Ryan Balfour Sartor
Summary: By studying the microbial composition in germ-free and antibiotic-treated mice and PSC patients, we identified different bacterial species with functional protective and detrimental effects in these animals and patients, which are associated with clinical risk scores. These findings are important for the development of personalized therapeutic approaches.
Article
Radiology, Nuclear Medicine & Medical Imaging
Babs G. Sibinga Mulder, Marjory Koller, Evelien W. Duiker, Arantza Farina Sarasqueta, Jakobus Burggraaf, Vincent E. de Meijer, Alexander L. Vahrmeijer, Frederik J. H. Hoogwater, Bert A. Bonsing, Gooitzen M. van Dam, J. Sven D. Mieog, Bobby K. Pranger
Summary: Tumor visualization with near-infrared fluorescence (NIRF) imaging using bevacizumab-IRDye800CW is feasible and safe for pancreatic cancer surgery. However, it is necessary to find a more tumor-specific tracer than bevacizumab-IRDye800CW for better differentiation of pancreatic cancer from normal or inflamed pancreatic tissue.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Hedayatullah Esmati, Marieke van Rosmalen, Patrick F. van Rheenen, Marieke T. de Boer, Aad P. van den Berg, Hubert P. J. van der Doef, Michel Rayar, Ruben H. J. de Kleine, Robert J. Porte, Vincent E. de Meijer, Henkjan J. Verkade
Summary: The Eurotransplant (ET) allocation prioritization for patients with biliary atresia (BA) younger than 2 years has significantly reduced the waitlist mortality by decreasing the proportion of deceased donor liver transplantations (DDLT) and increasing the proportion of living donor liver transplantations (LDLT). The waitlist mortality decreased from 6.7% to 2.3% after the implementation of the new allocation rule, and the median waitlist duration also decreased.
LIVER TRANSPLANTATION
(2023)
Editorial Material
Oncology
Jacob K. de Bakker, J. Annelie Suurmeijer, Jurgen G. J. Toennaer, Bert A. Bonsing, Olivier R. Busch, Casper H. van Eijck, Ignace H. de Hingh, Vincent E. de Meijer, I. Quintus Molenaar, Hjalmar C. van Santvoort, Martijn W. Stommel, Sebastiaan Festen, Erwin van der Harst, Gijs Patijn, Daan J. Lips, Marcel Den Dulk, Koop Bosscha, Marc G. Besselink, Geert Kazemier
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jacob K. K. de Bakker, J. Annelie Suurmeijer, Jurgen G. J. Toennaer, Bert A. A. Bonsing, Olivier R. R. Busch, Casper H. H. van Eijck, Ignace H. H. de Hingh, Vincent E. E. de Meijer, I. Quintus Molenaar, Hjalmar C. C. van Santvoort, Martijn W. W. Stommel, Sebastiaan Festen, Erwin van der Harst, Gijs Patijn, Daan J. J. Lips, Marcel Den Dulk, Koop Bosscha, Marc G. G. Besselink, Geert Kazemier
Summary: Pancreatoduodenectomy for duodenal adenocarcinoma is associated with higher rates of major complications, pancreatic fistula, re-interventions, and in-hospital mortality compared with patients undergoing pancreatoduodenectomy for other cancers.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Diren Beyoglu, Pinzhu Huang, Disha Skelton-Badlani, Christine Zong, Yury V. Popov, Jeffrey R. Idle
Summary: We studied the metabolic reprogramming in liver fibrosis progression using different hepatotoxins in mice. The administration of carbon tetrachloride (CCl4), thioacetamide (TAA), or a high-fat diet resulted in similar metabolic changes during fibrogenesis. Hepatic glucose, galactose, fructose, and glucuronic acid were diminished, while ascorbate and collagen prolyl 4-hydroxylase increased. Recovery from high-fat diet challenge showed reversed changes. The hijacking of glucose and galactose metabolism for ascorbate synthesis was mediated by increased aldose reductase Akr1b3 transcription.
Article
Gastroenterology & Hepatology
Merlijn U. J. E. Graus, Ignace H. J. T. de Hingh, Marc G. Besselink, Marco J. Bruno, Johanna W. Wilmink, Vincent E. de Meijer, Marie -Louise F. van Velthuysen, Liselot B. J. Valkenburg-van Iersel, Lydia G. M. van der Geest, Judith de Vos-Geelen, D. P. C. G. C. O. V. I. D. Canc N. L. Consortium
Summary: This nationwide study found a minor impact of the COVID-19 pandemic on pancreatic cancer care and outcome. The Dutch health care system was apparently able to maintain essential care for patients with pancreatic cancer.
Article
Gastroenterology & Hepatology
Martijn P. D. Haring, Robbert J. de Haas, Frederike G. I. van Vilsteren, Joost M. Klaase, Evelien W. Duiker, Hans Blokzijl, Koert P. de Jong, Vincent E. de Meijer, Frans J. C. Cuperus
Summary: This study examined the variation in clinical management of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) in Europe. The survey found inconsistencies in the diagnosis and treatment of FNH and HCA, particularly in the management during pregnancy. The study suggests further research and the development of consistent guidelines to optimize the management of patients with benign liver tumors.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Surgery
Jesse Groen, Nynke Michiels, Marc G. Besselink, Koop Bosscha, Olivier R. Busch, Ronald van Dam, Casper H. J. van Eijck, Bas Groot Koerkamp, Erwin van der Harst, Ignace H. de Hingh, Tom M. Karsten, Daan J. Lips, Vincent E. de Meijer, Isaac Q. Molenaar, Vincent B. Nieuwenhuijs, Daphne Roos, Hjalmar C. van Santvoort, Jan H. Wijsman, Fennie Wit, Babs M. Zonderhuis, Judith de Vos-Geelen, Martin N. Wasser, Bert A. Bonsing, Martijn W. J. Stommel, Dutch Pancreatic Canc Grp
Summary: This study explores the potential causes and consequences of practice variation in venous resection during pancreatoduodenectomy for pancreatic cancer in the Netherlands. Among 1,311 patients undergoing pancreatoduodenectomy, 27% had a venous resection. The study found that patient and tumor characteristics did not fully explain the practice variation between centers, and the clinical outcomes of venous resection might be related to the volume of the procedure.
Meeting Abstract
Gastroenterology & Hepatology
Shixian Hu, J. Casper Swarte, Yanni Li, Johannes Bjork, Ranko Gacesa, Arnau Vich Vila, Rianne Douwes, Valerie Collij, Alexander Kurilshikov, Aadrian Post, Marjolein A. Y. Klaassen, Michele F. Eisenga, Antonio W. Gomes-Neto, Daan Kremer, Bernadien H. Jansen, Tim J. Knobbe, Stefan P. Berger, Jan-Stephan F. Sanders, M. Rebecca Heiner-Fokkema, Robert J. Porte, Frans J. C. Cuperus, Vincent E. Demeijer, Cisca Wijmenga, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Hans Blokzijl, Stephan J. L. Bakker, Rinse Weersma
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Martijn P. D. Haring, Arthur K. E. Elfrink, Christiaan A. J. Oudmaijer, Paul C. M. Andel, Alicia Furumaya, Nenke de Jong, Colin J. J. M. Willems, Thijs Huits, Julie M. L. Sijmons, Eric J. T. Belt, Koop Bosscha, Esther C. J. Consten, Marielle M. E. Coolsen, Peter van Duijvendijk, Joris Erdmann, Paul Gobardhan, Robbert J. de Haas, Tjarda van Heek, Hwai-Ding Lam, Wouter K. G. Leclercq, Mike S. L. Liem, Hendrik A. Marsman, Gijs A. Patijn, Turkan Terkivatan, Babs M. Zonderhuis, Izaak Quintus Molenaar, Wouter W. te Riele, Jeroen Hagendoorn, Alexander F. M. Schaapherder, Jan N. M. IJzermans, Carlijn Buis, Joost M. Klaase, Koert P. de Jong, Vincent E. de Meijer
Summary: This study analyzed the indications and outcomes of surgery for hepatocellular adenomas (HCAs) of different sizes. The results showed that small HCA surgeries were mainly indicated by suspicion of malignancy, while large HCA surgeries were mainly indicated by tumor size. Male sex, tumor size <50 mm, and lack of hepatobiliary contrast-enhanced magnetic resonance imaging were identified as independent risk factors for postoperative change in tumor diagnosis.
HEPATOLOGY COMMUNICATIONS
(2023)