Article
Biochemistry & Molecular Biology
Nathalia M. Pinheiro, Rosana Banzato, Iolanda Tiberio, Marco A. M. Prado, Vania F. Prado, Ayman K. Hamouda, Carla M. Prado
Summary: In acute lung injury, inflammatory markers are significantly elevated in cholinergic-deficient mice compared to wild-type, but treatment with the selective alpha 7 nicotinic receptor agonist PNU 282987 can restore the response and reduce lung inflammation. The anti-inflammatory effects of the lung cholinergic system are associated with an increase in the level of alpha 7 nicotinic receptors, suggesting potential clinical applications for treating acute lung injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
David Dahlgren, Olof Nylander, Markus Sjoblom
Summary: This study elucidates the impact of nicotinic and muscarinic receptor signaling on the regulation of duodenal mucosal permeability in response to luminal hypotonicity. A complex enteric intramural excitatory neural reflex involving both receptor subtypes mediates the increase in mucosal permeability induced by luminal hypotonicity.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Physiology
Kai Su, Jianguo Wang, Yang Lv, Ming Tian, You-Yang Zhao, Richard D. Minshall, Guochang Hu
Summary: Mechanical ventilation can lead to lung injury, but this study suggests that YAP expression in endothelial cells can reduce inflammation and edema formation, playing a protective role in ventilator-induced lung injury.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
X. Zhang, W. W. Qin, F. G. Ma, L. X. Sun, W. Han
Summary: This study examined the effects of Leptin on key receptors in the immune system in ventilator-induced lung injury (VILI) in rats. The results showed that Leptin could alleviate lung inflammation induced by VILI and regulate the levels of NLRP3, NLRC4, and NLRC3.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Respiratory System
Yang Zhang, Lulu Jiang, Tianfeng Huang, Dahao Lu, Yue Song, Lihui Wang, Ju Gao
Summary: The study found that Piezo1 affects the development and progression of VILI through promotion of RhoA/ROCK1 signaling. Inhibition of Piezo1 can alleviate VILI-induced pathologic changes and lung water content and protein leakage, improve the 7-day mortality rate in the model rats.
RESPIRATORY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Roberta Piovesana, Adam J. Reid, Ada Maria Tata
Summary: The communication between neurons and glial cells has been well-documented in various stages of development and disease. Neurotransmitters, especially acetylcholine, play a significant role in regulating the development and physiology of glial cells. This review focuses on the contribution of neurotransmitter receptors, particularly the M2 muscarinic receptor and the alpha 7 nicotinic receptor, in influencing the phenotype and functioning of Schwann cells. Understanding these interactions can help identify potential therapeutic targets for pathological conditions involving glial cells.
Article
Sport Sciences
Jie Yan, Changping Gu, Ge Liu, Yaqiang Zhang, Li Yang, Tao Zhao, Cuicui Cao, Liang Zhao, Guanghan Wu, Yuelan Wang
Summary: Mechanical ventilation and cyclic stretching can cause damage to mitochondrial function and cell junctions in the lungs. However, aerobic exercise before ventilation or AMPK activation can improve mitochondrial function and cell junction dysfunction. Sirt1 plays a protective role by inhibiting mitochondrial damage.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Pharmacology & Pharmacy
Jaromir Myslivecek
Summary: Social species form organizations to support individuals, as isolation may be a stressor. When studying the effects of social isolation on cholinergic signaling, it is important to consider the differences in isolation schemes and receptor subtypes.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Jun-Min Yang, Xiao-Yu Yang, Jian-Hua Wan
Summary: Cholinergic signaling plays a crucial role in the development and progression of pancreatic diseases by stimulating pancreatic cells and reducing pain and inflammation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Medicinal
Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed, Eman K. Rashwan, Abdel-Gawad S. Shalkami, Ayman M. Mahmoud
Summary: The study showed that the natural NADPH oxidase inhibitor acetovanillone (AV) can protect rats from acute lung injury (ALI) induced by cyclophosphamide (CP) by attenuating oxidative stress and enhancing Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Neurosciences
Paul F. Kramer, Samuel G. Brill -Weil, Alex C. Cummins, Renshu Zhang, Gisela A. Camacho-Hernandez, Amy H. Newman, Mark A. G. Eldridge, Bruno B. Averbeck, Zayd M. Khaliq
Summary: The transmission from striatal cholinergic interneurons (CINs) can control dopamine release through nicotinic acetylcholine receptors (nAChRs). This transmission primarily occurs through non-synaptic volume transmission and can convert synaptic input into spiking, providing distinct signaling.
Article
Respiratory System
Masako Kawai, Erquan Zhang, Jane Chanda Kabwe, Amphone Okada, Junko Maruyama, Hirofumi Sawada, Kazuo Maruyama
Summary: In this study, rats with monocrotaline-induced pulmonary hypertension were found to have reduced damage from high tidal volume ventilation compared to normal rats. The findings suggest that structural changes in hypertensive pulmonary vasculature may protect against ventilator-induced lung injury, regardless of the type of pulmonary hypertension.
BMC PULMONARY MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Roberta Piovesana, Michael Sebastian Salazar Intriago, Luciana Dini, Ada Maria Tata
Summary: Neurological pathologies lead to neuroinflammation, which can exacerbate neuronal and glial cell damage. Targeting neuroinflammation may reduce brain injury and rescue neuronal and glial cell functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lulu Jiang, Yang Zhang, Dahao Lu, Tianfeng Huang, Keshi Yan, Wenjun Yang, Ju Gao
Summary: This study found that excessive mechanical stretch during ARDS induces the activation of Piezo1 channel and its downstream target, calpain, leading to the disassembly of endothelial adherens junctions and further facilitating lung endothelial barrier breakdown and increased vascular permeability.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Yang Zhao, Huaxin Sun, Kai Li, Luxiang Shang, Xiaoyan Liang, Hang Yang, Zhenyu Dong, Jiasuoer Xiaokereti, Shuai Shang, Qina Zhou, Xianhui Zhou, Ling Zhang, Yanmei Lu, Baopeng Tang
Summary: Activation of the cholinergic anti-inflammatory pathway prevents ventricular remodeling in chronic heart failure by protecting myocardial mitochondrial injuries, reducing inflammation, attenuating cardiac fibrosis, and improving mitochondrial function, ultimately improving ischemic ventricular remodeling.
MEDIATORS OF INFLAMMATION
(2021)