Article
Biochemistry & Molecular Biology
Anna Krzyzewska, Marta Baranowska-Kuczko, Anna Jastrzab, Irena Kasacka, Hanna Kozlowska
Summary: CBD has antioxidant and anti-inflammatory effects in the treatment of pulmonary hypertension. It can be used as an adjuvant therapy for pulmonary hypertension, but further research is needed to confirm its effectiveness.
Article
Chemistry, Medicinal
Tomas Jasenovec, Dominika Radosinska, Marta Kollarova, Norbert Vrbjar, Peter Balis, Simona Trubacova, Ludovit Paulis, Lubomira Tothova, Ivana Shawkatova, Jana Radosinska
Summary: The objective of this study was to characterize monocrotaline-induced pulmonary arterial hypertension in a rat model and analyze the effects of bosentan. The study confirmed the effects of monocrotaline on lungs, heart, and pulmonary arterial pressure. Activation of the alternative pathway of the renin-angiotensin system and modifications of erythrocyte Na,K-ATPase enzyme kinetics were observed. Bosentan exhibited antioxidant effects and beneficial hemodynamic effects in PAH condition.
Article
Pharmacology & Pharmacy
Ahmad Beik, Hamid Najafipour, Siyavash Joukar, Soodeh Rajabi, Maryam Iranpour, Zeinab Kordestani
Summary: The study found that perillyl alcohol has protective and therapeutic effects on experimental pulmonary arterial hypertension (PAH), by inhibiting cellular proliferation, oxidative stress, and inflammation. It may serve as a new therapeutic target for the treatment of PAH.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Xiao-Qing Sun, Eva L. Peters, Ingrid Schalij, Julie Birkmose Axelsen, Stine Andersen, Kondababu Kurakula, Maria Catalina Gomez-Puerto, Robert Szulcek, Xiaoke Pant, Denielli da Silva Goncalves Bos, Roy E. J. Schiepers, Asger Andersen, Marie-Jose Goumans, Anton Vonk Noordegraaf, Willem J. van der Laarse, Frances S. de Man, Harm Jan Bogaard
Summary: MAO-A plays a significant role in the progression of PAH, and inhibiting MAO-A may be a potential treatment for PAH and RV failure.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Telli Gokcen, Kazkayasi Inci, Ergonul E. Inci, Onder Sevgen, Uma Serdar
Summary: This study aimed to investigate the effects of allopurinol on the pathological changes in a rat model of pulmonary hypertension (PH) induced by monocrotaline (MCT). The results showed that allopurinol could reverse the pathological changes caused by oxidative stress and high uric acid levels, and improve pulmonary arterial relaxation and basal lung perfusion pressure.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Cristina Campos-Carraro, Patrick Turck, Bruna Gazzi de Lima-Seolin, Rayane Brinck Teixeira, Alexsandra Zimmer, Alex Sander da Rosa Araujo, Adriane Bello-Klein
Summary: The study aimed to investigate the effects of copaiba oil on oxidative stress, pulmonary vascular resistance (PVR), and mean pulmonary arterial pressure (mPAP) in a model of pulmonary arterial hypertension (PAH). The results showed that copaiba oil attenuated PAH damage by reducing right ventricular hypertrophy, PVR, mPAP, and increasing antioxidant enzyme activities. Additionally, copaiba oil increased nitric oxide synthase activity and decreased NADPH oxidase activity.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaori Kato, Masato Tsutsui, Shingo Noguchi, Yukitoshi Iha, Keisuke Naito, Takaaki Ogoshi, Chinatsu Nishida, Masahiro Tahara, Hirotaka Yamashita, Ke-Yong Wang, Yumiko Toyohira, Nobuyuki Yanagihara, Hiroaki Masuzaki, Hiroaki Shimokawa, Akihide Tanimoto, Kazuhiro Yatera
Summary: The complete disruption of all three NOS genes in mice results in spontaneous pulmonary emphysema in juvenile mice, possibly through down-regulation of the Wnt/beta-catenin signaling pathway. This study demonstrates a novel preventive role of the endogenous NO/NOS system in the occurrence of pulmonary emphysema.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Chao Tang, Yunmei Luo, Sha Li, Bo Huang, Shangfu Xu, Lisheng Li
Summary: Inflammation plays a significant role in the pathogenesis of PAH. The study found that PAH induced by MCT progresses from an acute inflammatory phase to a chronic inflammatory phase, with changes in pro-inflammatory cytokines and macrophage ratios in the lung. The PI3K/Akt signaling pathway is also related to the progression of PAH and inflammation characteristics induced by MCT.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoming Li, Xiang Zhang, Xiaozhi Hou, Xin Bing, Fangyuan Zhu, Xinhao Wu, Na Guo, Hui Zhao, Fenglei Xu, Ming Xia
Summary: This study found that DEC1 expression was increased in rat models of OSA-associated PAH. In vitro experiments showed that DEC1 overexpression exacerbated oxidative stress and inflammatory responses, and promoted cell proliferation in PASMCs. These results suggest that hypoxia-induced DEC1 inhibits PPARγ, which is an important mechanism in the development of PAH.
Article
Medicine, Research & Experimental
Anna Krzyzewska, Marta Baranowska-Kuczko, Irena Kasacka, Hanna Kozlowska
Summary: Cannabidiol (CBD) is a plant-derived drug that is safe and well-tolerated, with anti-proliferative properties. It has been found to reduce pulmonary hypertension (PH) caused by monocrotaline (MCT) by decreasing right ventricular systolic pressure, pulmonary vascular hypertrophy, and right ventricular remodeling. Chronic administration of CBD in MCT-treated rats resulted in decreased levels of profibrotic parameters and mast cells in the lung tissue. These findings suggest that CBD may be used as an adjuvant therapy for PH, but further clinical trials are needed to confirm this.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Paula Poyatos, Miquel Gratacos, Kay Samuel, Ramon Orriols, Olga Tura-Ceide
Summary: Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Several studies have shown evidence of the critical role of oxidative stress in PH pathophysiology.
Article
Immunology
Mengqing Liu, Yi Ling, Yue Zhang, Lulu Liu, Yue Qiu, Yi Liu, Yanyan Yin
Summary: This study found that EPA1 plays an important role in the depressive-like behaviors induced by chronic unpredictable mild stress (CUMS), and the mechanism may be related to NLRP1 inflammasome-driven inflammatory response, regulation of calcium ion homeostasis and ROS generation, and alleviation of synaptic function damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lin Huang, Huayang Li, Suiqing Huang, Shunjun Wang, Quan Liu, Li Luo, Shuangjiao Gan, Guangguo Fu, PeiYun Zou, Guangxian Chen, Zhongkai Wu
Summary: The study demonstrates that notopterol can improve lung pathology, alleviate pulmonary arterial hypertension and cardiac dysfunction in PAH rats, exerting its effects through anti-inflammatory and anti-proliferative mechanisms.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lei Yang, Jinglin Tian, Jun Wang, Jie Zeng, Ting Wang, Boya Lin, John Linneman, Li Li, Yanqin Niu, Deming Gou, Yunhui Zhang
Summary: In this study, it was found that EP300 expression was increased in the MCT-induced PH model in rats, and knockdown of EP300 exacerbated PH and promoted the proliferation of PASMCs. Furthermore, EGR1 upregulated the expression of EP300 and provided protection from MCT-induced PH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zeba Farooqui, Razia Sultana Mohammad, Mustafa F. Lokhandwala, Anees Ahmad Banday
Summary: In this study, mice treated with Nrf2 inhibitor ML385 and pro-oxidant BSO exhibited exacerbated hypertension, increased oxidative stress, and renal dysfunction. Compared to mice treated with only BSO, co-treatment with ML385 and BSO showed increased activity of phase II antioxidant enzyme and significant alterations in inflammatory cytokine levels.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk
JOURNAL OF LIPID RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk
JOURNAL OF LIPID RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Xinzhi Li, Liudmila L. Mazaleuskaya, Laurel L. Ballantyne, Hu Meng, Garret A. FitzGerald, Colin D. Funk
Article
Biochemistry & Molecular Biology
Di Shao, Chunxiang Yao, Maya H. Kim, Jessica Fry, Richard A. Cohen, Catherine E. Costello, Reiko Matsui, Francesca Seta, Mark E. McComb, Markus M. Bachschmid
Article
Biochemistry & Molecular Biology
Weimin Yu, Li Xiao, Yumei Que, Siqi Li, Lili Chen, Pingping Hu, Rui Xiong, Francesca Seta, Hao Chen, Xiaoyong Tong
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Review
Physiology
Enkhjargal Budbazar, Francisca Rodriguez, Jose M. Sanchez, Francesca Seta
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Jeff Arni C. Valisno, Joel May, Kuldeep Singh, Eric Y. Helm, Lisia Venegas, Enkhjargal Budbazar, Jena B. Goodman, Christopher J. Nicholson, Dorina Avram, Richard A. Cohen, Gary F. Mitchell, Kathleen G. Morgan, Francesca Seta
Summary: The study reveals that BCL11B is expressed in vascular smooth muscle and regulates vascular stiffness. RNA sequencing in Bcl11b null mice identified changes in signaling pathways leading to increased arterial stiffness and cardiovascular damage.
CIRCULATION RESEARCH
(2021)
Review
Virology
Colin D. Funk, Craig Laferriere, Ali Ardakani
Summary: The SARS-CoV-2 virus has caused a devastating global pandemic with millions infected and dead. Efforts have been made to develop vaccines, with several in advanced stages of clinical trials and receiving emergency use authorization. The global vaccine rollout is crucial in ending the pandemic.
Article
Geriatrics & Gerontology
Yandan Wang, Erik Taylor, Basilis Zikopoulos, Francesca Seta, Nasi Huang, James A. Hamilton, Kathleen M. Kantak, Kathleen G. Morgan
Summary: This study reveals that the thalamus is the most vulnerable brain region in aging-induced vascular damage in the mouse model, with magnetic resonance imaging data documenting the timeline of damage accumulation and histological data showing that the majority of damage accumulates in specific thalamic nuclei.
NEUROBIOLOGY OF AGING
(2021)
Article
Cardiac & Cardiovascular Systems
Yuxiang Zhou, Xueping Wan, Kerstin Seidel, Mo Zhang, Jena B. Goodman, Francesca Seta, Naomi Hamburg, Jingyan Han
Summary: This study utilized a mouse model of atherosclerosis to show that aging and an atherogenic diet activate different aortic UPR pathways, leading to distinct vascular responses. Compared with dietary intervention, aging is associated with impaired endoplasmic reticulum protein folding and increased aortic apoptosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Editorial Material
Physiology
Francisca Rodriguez, Francesca Seta
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Anastasia Gkousioudi, Xunjie Yu, Jacopo Ferruzzi, Juncheng Qian, Richard D. Wainford, Francesca Seta, Yanhang Zhang
Summary: This study investigated the effects of diet-induced metabolic syndrome and aging on the biomechanical properties of mouse common carotid arteries. The results showed that aging is a dominant factor affecting arterial remodeling, while high fat high sucrose diet accelerates arterial remodeling but is eventually overshadowed by aging.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nicholas Milkovich, Anastasia Gkousioudi, Francesca Seta, Bela Suki, Yanhang Zhang
Summary: The study proposes a new index, harmonic distortion (HD), to characterize blood pressure waveform (BPW) and its relationship with other measures of arterial stiffness. The results show that HD is sensitive to changes in blood pressure and arterial stiffness, suggesting its potential as a noninvasive measure of arterial stiffness.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Anastasia Gkousioudi, Taisiya Sigaeva, Xunjie Yu, Francesca Seta, Richard Wainford, Yanhang Zhang
Summary: Healthy arteries adapt to mechanical stimuli to maintain mechanical homeostasis, but aging may disrupt this homeostasis. Our study found that aging leads to uneven unfolding of elastic lamellae, resulting in uneven lamellar stretching, increased stress gradient, and a shift in load-bearing to the adventitia.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D. Funk, Jian Zhang, Ying Yu
BRITISH JOURNAL OF PHARMACOLOGY
(2018)