期刊
PLOS ONE
卷 6, 期 5, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0019457
关键词
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资金
- Deutsche Lungenstiftung e.V. (Hannover, Germany)
- Else Kroner-Fresenius Stiftung (Bad Homburg, Germany)
- Deutsche Gesellschaft fur Padiatrische Infektiologie (DGPI) (Bremen, Germany)
Parvoviruses are single stranded DNA viruses that replicate in a so called rolling-hairpin mechanism, a variant of the rolling circle replication known for bacteriophages like phi X174. The replication intermediates of parvoviruses thus are concatemers of head-to-head or tail-to-tail structure. Surprisingly, in case of the novel human bocavirus, neither head-to-head nor tail-to-tail DNA sequences were detected in clinical isolates; in contrast head-to-tail DNA sequences were identified by PCR and sequencing. Thereby, the head-to-tail sequences were linked by a novel sequence of 54 bp of which 20 bp also occur as conserved structures of the palindromic ends of parvovirus MVC which in turn is a close relative to human bocavirus.
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