Article
Oncology
Tobias Niedermaier, Thomas Heisser, Anton Gies, Feng Guo, Efrat L. Amitay, Michael Hoffmeister, Hermann Brenner
Summary: The incidence and prevalence of colorectal cancer and its precursors are higher in males than in females in many countries, but the reasons for this difference are not fully understood. The male excess risk of colorectal cancer is partially explained by medical, lifestyle, and dietary factors, which account for 47% of the risk. The risk of advanced neoplasia increases in males from the proximal colon to the distal colon and rectum, with different proportions of excess risk explained by covariates in different segments of the colon.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Mercedes Vanaclocha-Espi, Josefa Ibanez, Ana Molina-Barcelo, Maria Jose Valverde-Roig, Andreu Nolasco, Francisco Perez-Riquelme, Mariola de la Vega, Isabel Portillo, Dolores Salas
Summary: The study on fecal immunological tests indicates that selecting optimal cut-off values for different age and sex groups can improve colorectal cancer screening sensitivity, reduce the need for further testing after negative results, but also lead to an increase in false positive diagnoses.
Review
Gastroenterology & Hepatology
Yoon Suk Jung, Jung Ho Park, Chan Hyuk Park
Summary: This study found no significant difference in the risk of metachronous colorectal neoplasia between serrated polyps and conventional adenomas, supporting current surveillance guidelines. Patients with both serrated polyps and high-risk adenomas may have an increased risk, warranting further investigation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lucia Medina-Prado, Carolina Mangas-Sanjuan, Sandra Baile-Maxia, Alejandro A. Martinez-Roca, Oscar Murcia, Sara Zarraquinos, Elena Rodriguez-Camacho, Adrian Hugo Aginagalde, Cristina Alvarez-Urturi, Maria J. Valverde-Roig, Pedro Zapater, Luis Bujanda, Dolores Salas, Isabel Portillo, Maria Pellise, Joaquin Cubiella, Rodrigo Jover
Summary: The study aimed to evaluate the risks of colorectal cancer, advanced adenomas, and advanced serrated polyps at 1-year surveillance colonoscopy in patients with multiple or large adenomas. Results showed low detection rates of colorectal cancer, advanced adenomas, and advanced serrated polyps among high-risk patients, with risk factors being the number of adenomas and polyps in a proximal location at baseline.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Gastroenterology & Hepatology
Eun Hyo Jin, Kyungdo Han, Dong Ho Lee, Cheol Min Shin, Joo Hyun Lim, Yoon Jin Choi, Kichul Yoon
Summary: The study found that obesity and metabolic syndrome are associated with an increased risk of earlier-onset colorectal cancer, particularly left-sided colon cancer. Individuals with metabolic syndrome and obesity have a higher risk of developing colorectal cancer before the age of 50, highlighting the importance of preventive interventions for this population.
Article
Gastroenterology & Hepatology
Thomas F. Imperiale, Joanne K. Daggy, Timothy D. Imler, Eric A. Sherer, Charles J. Kahi, Jason Larson, Jon Cardwell, Cynthia S. Johnson, Dennis J. Ahnen, Fadi Antaki, Christopher Ashley, Gyorgy Baffy, Jason A. Dominitz, Jason Hou, Mark A. Korsten, Anil Nagar, Kittichai Promrat, Douglas J. Robertson, Sameer Saini, Amandeep Shergill, Walter E. Smalley
Summary: The study found that age and race were associated with the prevalence of advanced neoplasia and colorectal cancer in Veterans, with higher overall prevalence in Blacks but not during screenings. Men had a higher risk for advanced neoplasia, while women had a higher proportion of proximal colorectal cancer.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Article
Oncology
Coral Arnau-Collell, Anna Diez-Villanueva, Beatriz Bellosillo, Josep M. Auge, Jenifer Munoz, Elisabe Guino, Leticia Moreira, Anna Serradesanferm, Isabel Tora-Rocamora, Laia Bonjoch, Gemma Ibanez-Sanz, Mireia Obon-Santacana, Ferran Moratalla-Navarro, Rebeca Sanz-Pamplona, Carmen Marquez Marquez, Rebeca Rueda Miret, Rocio Perez Berbegal, Gabriel Piquer Velasco, Cristina Hernandez Rodriguez, Antoni CRIPREV Consortium, Jaume Grau, Antoni Castells, Josep M. Borras, Xavier Bessa, Victor Moreno, Sergi Castellvi-Bel
Summary: This study is the first investigation analyzing polygenic risk score (PRS) in a two-step colorectal cancer screening program. The results showed that PRS could improve the accuracy of current colorectal cancer screening, especially for higher at-risk subgroups. However, the capacity of PRS is limited and should be complemented by additional biomarkers.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Gastroenterology & Hepatology
Martin C. S. Wong, Eman Yee-man Leung, Sam C. C. Chun, Yunyang Deng, Thomas Lam, Raymond S. Y. Tang, Junjie Huang
Summary: This study compared the recurrence rate of advanced colorectal neoplasia (ACN) among individuals who received surveillance colonoscopy at different time intervals in a large Chinese population. The results showed that a 7-10 year surveillance period after baseline non-advanced adenoma (NAA) was polypectomized had a small effect in preventing ACN recurrence.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Wei-Chun Cheng, Po-Jun Chen, Jui-Wen Kang, Wei-Ying Chen, Bor-Shyang Sheu
Summary: The study identified risk factors associated with advanced colorectal neoplasia (AN) in subjects with negative Fecal Immunochemical Test (FIT), including age, gender, smoking history, and metabolic syndrome. For FIT-negative cases, colonoscopy screening should be considered for male patients over 50 years old with a history of smoking and metabolic syndrome to detect AN.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Zhen Yuan, Shuyuan Wang, Zhaoce Liu, Yanfei Liu, Yuqi Wang, Youkui Han, Weifeng Gao, Xinyu Liu, Hongzhou Li, Qinghuai Zhang, Hong Ma, Junying Wang, Xiaomeng Wei, Xipeng Zhang, Wei Cui, Chunze Zhang
Summary: This study developed a scoring system to achieve more efficient risk stratification and improve adherence to colonoscopy in high-risk individuals identified in initial CRC screening. Analysis found that male sex, older age, high body mass index, smoking, and alcohol intake were associated with advanced colorectal neoplasia. The scoring model showed excellent discriminatory capacity.
BMC GASTROENTEROLOGY
(2022)
Review
Health Care Sciences & Services
Yoon Suk Jung, Jung Ho Park, Chan Hyuk Park
Summary: Patients under the age of 50 who have undergone polypectomy have a lower risk of metachronous advanced colorectal neoplasia (ACRN) compared to older patients (>= 50 years), indicating that they do not require more intensive surveillance and can have extended surveillance intervals.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ningjian Wang, Yuefeng Yu, Ying Sun, Haojie Zhang, Yuying Wang, Chi Chen, Xiao Tan, Bin Wang, Yingli Lu
Summary: This study investigated the risk factor profiles for atrial fibrillation (AF) based on age and genetic risk groups in a UK Biobank cohort. The results showed significant associations between most cardiometabolic factors and clinical comorbidities with age, and between low LDL cholesterol, renal dysfunction, cardiovascular disease, and genetic risk. Cardiometabolic factors and clinical comorbidities made the largest contributions to AF cases, with age and genetic risk determining the proportions of each factor.
EUROPEAN HEART JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Frank W. Chen, Liu Yang, Vivy T. Cusumano, Michelle C. Chong, Jonathan K. Lin, Diana Partida, Folasade P. May
Summary: The study found that compared to TO-CRC patients, EO-CRC patients were more likely to have advanced-stage disease, rectal tumors, and a family history. However, EO-CRC patients had a lower risk of developing metachronous advanced neoplasia, suggesting that shorter surveillance intervals may not be necessary for EO-CRC patients.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Manuel Sanchez-Garcia, Ana De La Rosa-Caceres, Sara Stasik-O'Brien, Juan Jose Mancheno-Barba, Oscar M. Lozano, Carmen Diaz-Batanero
Summary: This study aimed to develop normative data for the Spanish version of the IDAS-II, finding that women generally score higher than men on certain scales and significant differences in scores based on age groups. Norms provided in this work complement existing data and can assist clinical professionals in decision-making.
FRONTIERS IN PSYCHOLOGY
(2021)