Article
Biochemistry & Molecular Biology
Nima Khalighinejad, Sanjay Manohar, Masud Husain, Matthew F. S. Rushworth
Summary: Decision-making involves choosing actions, as well as determining when and whether to initiate them. Different brain regions, such as DRN, BF, and ACC, contribute to different stages of decision-making, with 5-HT and ACh playing complementary roles.
Article
Neurosciences
Tomonobu Kato, Yasue Mitsukura, Keitaro Yoshida, Masaru Mimura, Norio Takata, Kenji F. Tanaka
Summary: Dorsal raphe (DR) 5-HT neurons play a crucial role in regulating sleep-wake transitions. The activity of these neurons fluctuates during the sleep-wake cycle, with slow oscillatory signals during non-rapid eye movement (NREM) sleep and cessation during rapid eye movement (REM) sleep. The oscillatory activity of DR 5-HT neurons is associated with EEG power fluctuation, and optogenetic manipulation of these neurons can induce or prolong specific sleep states.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Ao Li, Rui Li, Pengrong Ouyang, Huihui Li, Sa Wang, Xinxin Zhang, Dan Wang, Mingzi Ran, Guangchao Zhao, Qianzi Yang, Zhenghua Zhu, Hailong Dong, Haopeng Zhang
Summary: The dorsal raphe nucleus serotonergic neurons play a regulatory role in general anesthesia, as activation can facilitate emergence from anesthesia partly through 5-HT 1A and 2C receptors. By assessing neuronal activities, researchers found that Fos expression and calcium activity are significantly decreased during general anesthesia.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Endocrinology & Metabolism
Iltan Aklan, Nilufer Sayar-Atasoy, Fei Deng, Hyojin Kim, Yavuz Yavuz, Jacob Rysted, Connor Laule, Debbie Davis, Yulong Li, Deniz Atasoy
Summary: This study investigated the role of downstream neural circuits of serotonergic neurons in regulating feeding in rats. Using optogenetics and other methods, the researchers found that these circuits interact with satiety hormones, revealing the regulatory mechanisms of these hormones.
MOLECULAR METABOLISM
(2023)
Article
Behavioral Sciences
Kenji Doya, Kayoko W. Miyazaki, Katsuhiko Miyazaki
Summary: Recent advances in molecular tools have provided detailed data on serotonergic neuromodulation, showing substantial differences in signaling and effects depending on projection targets. It is conjectured that the evolution of serotonergic neuromodulation originated from signaling the time and resource available for action, learning, and development.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Arnauld Belmer, Ronan Depoortere, Kate Beecher, Adrian Newman-Tancredi, Selena E. Bartlett
Summary: This study demonstrates that stimulating the 5-HT1A receptor can reduce ethanol binge-drinking behavior and withdrawal-induced anxiety. Using a combination of pharmacological and chemogenetic approaches, the researchers identified the involvement of 5-HT1A autoreceptors and 5-HT neuronal function in regulating ethanol intake. They also discovered a serotonergic microcircuit originating from the MRN and projecting to the DG that specifically affects and modulates long-term ethanol consumption.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Franck Aby, Louis-Etienne Lorenzo, Zoe Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stephane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe De Deurwaerdere, Antoine G. Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves De Koninck, Pascal Fossat
Summary: Research has shown that serotonin (5-HT) neurons have a pain-relieving effect in mice who have not experienced pain before, but become pain-promoting in neuropathic pain models. An imbalance in spinal KCC2 function turns this pain relief into pain promotion, but KCC2 enhancers can restore the pain-relieving effect. Additionally, combining selective serotonin reuptake inhibitors (SSRIs) with KCC2 enhancers can effectively relieve pain hypersensitivity caused by nerve injury.
Article
Neurosciences
Andrew H. Cooper, Naomi S. Hedden, Pranav Prasoon, Yanmei Qi, Bradley K. Taylor
Summary: Following tissue injury, latent sensitization can be maintained in remission by the activity of μ-opioid receptors in the spinal cord. This sensitization is mediated by serotonergic neurons in the rostral ventral medulla that convey pronociceptive input to the spinal cord. The 5-HT3 receptor signaling in the dorsal horn and the activity of μ-opioid receptors in the rostral ventral medulla play opposing roles in maintaining this sensitization.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Kanza M. Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E. Dailey, Catherine A. Marcinkiewcz
Summary: Adolescent alcohol use can permanently alter brain function and lead to poor health outcomes in adulthood. Emerging evidence suggests that alcohol use can predispose individuals to pain disorders or exacerbate existing pain conditions, but the underlying neural mechanisms are currently unknown.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Behavioral Sciences
Ross A. McDevitt, Rosa Anna M. Marino, Hugo A. Tejeda, Antonello Bonci
Summary: Serotonin plays a crucial role in cue-reward learning in mice, as serotonin reuptake inhibitors can reduce lever pressing behavior, and alterations in serotonin levels in different brain regions can impact behavioral responses.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Sen Li, Ikuo Otsuka, Takaki Tanifuji, Satoshi Okazaki, Tadasu Horai, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto
Summary: Previous evidence has shown increased ribosomal DNA (rDNA) content in the blood of patients with schizophrenia (SCZ) among European populations. This study investigated rDNA copy number (rDNAcn) of SCZ in East Asian populations, as well as in blood and brain tissues. The results showed that patients with SCZ had significantly increased rDNAcn in both blood and brain tissues compared to controls. These findings replicate previous observations in Europeans and provide new insights into the molecular mechanisms underlying SCZ pathophysiology.
Article
Physiology
Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J. Homma, Shinji Yamaguchi
Summary: Serotonin is a neurotransmitter that plays an important role in regulating mental states and processing emotions in mammals. This study conducted a molecular dissection of serotonergic neurons in the brainstem of birds and found heterogeneity among these neurons. These findings contribute to a better understanding of the correspondence between bird and mammalian serotonergic neurons.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Tsogbadrakh Bayasgalan, Andrea Csemer, Adrienn Kovacs, Krisztina Pocsai, Balazs Pal
Summary: The study investigated the proportion and topographical organization of serotonergic neurons possessing M-current in DR and MR, as well as the electrophysiological parameters of neurons influenced by this current. Findings suggest that M-current strongly impacts firing properties of certain serotonergic neuronal subpopulations.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Amina Benhadda, Celia Delhaye, Imane Moutkine, Xavier Marques, Marion Russeau, Corentin Le Magueresse, Anne Roumier, Sabine Levi, Luc Maroteaux
Summary: Many psychiatric diseases are associated with dysfunction of serotonin (5-HT) neurons. This study shows that 5-HT1A and 5-HT2B receptors can form heterodimers and co-cluster at the plasma membrane of dendrites. Stimulation of these receptors prevents 5-HT1A receptor internalization and increases 5-HT2B receptor membrane clustering, regulating the excitability of serotonergic neurons.
Article
Neurosciences
Yuki Higuchi, Tomoaki Tada, Taiga Nakachi, Hiroyuki Arakawa
Summary: This study investigated the alterations in 5-HT signaling and functionality in BTBR mice and their contribution to abnormal behaviors. Results showed a reduced number of 5-HT neurons in the median raphe of BTBR mice and decreased responsiveness to the 5-HT1A receptor agonist buspirone. Additionally, blunted c-Fos responses in the BLA and Hipp regions of BTBR mice were associated with a lack of anxiety-like behavior.