Review
Immunology
Jiashu Han, Mengwei Wu, Ziwen Liu
Summary: Interferon-gamma (IFN-γ) is crucial for determining immunotherapy responsiveness. It promotes immune cell activation and tumor cell apoptosis, but tumor cells can develop IFN-γ resistance, acquiring stemness characteristics and expressing immunosuppressive molecules. This review summarizes the potential mechanisms of IFN-γ resistance and highlights the importance of elucidating these mechanisms to improve immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Ahmed M. Mostafa, Hesham A. Saafan, Ahmed S. Al-Tawashi, Muhannad H. Kasem, Ahmed M. Alaa, Mahmoud M. Eltobgy, Ahmed S. Moubarak, Manar M. Gharib, Mohamed A. Awwad, Hazem M. Omar, Marwa O. El-Derany
Summary: This study aimed to investigate the association between haplotypes in IL-17A receptor rs2275913 and rs3819024 and development of HCC in CHC patients treated with either triple therapy or with dual therapy. The results showed that the presence of G-G haplotype in IL-17A was inversely associated with HCC development in patients receiving triple therapy. High serum AFP levels were directly associated with HCC development in patients receiving triple therapy.
Article
Virology
Chia-Min Wu, Fu-Hsiung Su, Chih-Hsin Muo, Jou-Chen Huang, Meei-Maan Wu, Chih-Ching Yeh
Summary: This study found that patients with HCV infection treated with PegIFN/RBV therapy had a significantly increased risk of retinopathy, particularly retinal hemorrhage.
Article
Immunology
Jia Jia, Yunyun Zhang, Hao Zhang, Zhidong Chen, Liwen Chen, Qiang Zhou, Xiongwen Lv, Qin Wang
Summary: This study aimed to investigate the correlation between serum hepcidin levels and the curative effect of interferon-alpha therapy in patients with chronic hepatitis B. The results showed that patients with higher early-on treatment hepcidin levels were more likely to experience a decline in HBsAg and HBV DNA levels. Additionally, changes in serum hepcidin levels could predict the therapeutic effect of interferon-alpha.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yu Liu, Hui Chen, Zhi-Ying Xu
Summary: This is a case of a patient who developed ischemic colitis during pegylated interferon-alpha (PEG-IFN-alpha) therapy. The patient presented with acute lower abdominal pain and haematochezia while receiving PEG-IFN-alpha monotherapy for chronic hepatitis B. Diagnosis was confirmed through colonoscopy and biopsies, and treatment involved discontinuation of PEG-IFN-alpha and symptomatic management. The patient recovered and subsequent colonoscopy showed normal findings.
Article
Immunology
Lea Meyer, Isoline Duquenois, Stacy Gellenoncourt, Marie Pellerin, Ailona Marcadet-Hauss, Nicole Pavio, Virginie Doceul
Summary: Hepatitis E virus (HEV) is a common cause of enterically transmitted acute hepatitis worldwide. Swine are the main reservoir of zoonotic HEV and can control the virus pathogenesis. Interferon-stimulated genes (ISGs) can restrict the replication of HEV.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yadong Wang, Yangyang Hu, Xing Zhang, Yue Luo, Luyuan Ma, Jingjing Lu, Qianfei Liang, Chengjun Xu, Caiyan Zhao, Calvin Q. Pan
Summary: This study investigated the relationship between IP-10 and treatment response in patients with CHC treated with direct-acting antiviral agents. The results showed that IP-10 levels decreased gradually during the treatment and baseline IP-10 level and the decline at 12 weeks were independent predictors of SVR.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Virology
Yi-Wen Huang, Albert Qin, Chan-Yen Tsai, Pei-Jer Chen
Summary: Ropeginterferon alfa-2b is a promising treatment option for MPN and chronic viral hepatitis due to its favorable pharmacokinetic profile and demonstrated efficacy in clinical studies. Administered once every two weeks, it has shown to be well-tolerated and effective in treating chronic hepatitis B, C, and D.
Article
Pharmacology & Pharmacy
Ming-Han Hsieh, Tzu-Yu Kao, Ting-Hui Hsieh, Chun-Chi Kao, Cheng-Yuan Peng, Hsueh-Chou Lai, Po-Heng Chuang, Jung-Ta Kao
Summary: SVR lowers the risk of liver histological progression but does not guarantee fibrosis clearance. For SVR cases, those with baseline F >= 2 or without significantly declined follow-up AST levels should be specifically monitored. As for non-SVR cases, those with a higher baseline AST or glucose level should preferentially receive retreatment.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Infectious Diseases
Anuja Pandit, Nirav Bhalani, B. L. Shashi Bhushan, Parshottam Koradia, Shweta Gargiya, Vinay Bhomia, Kevinkumar Kansagra
Summary: The study evaluated the efficacy and safety of PEG IFN-α2b with SOC in treating moderate COVID-19, showing a significant clinical improvement on day 15 likely due to faster viral reduction compared to SOC. Subjects in the PEG IFN-α2b plus SOC group had a higher rate of negative RT-PCR results on day 7 and day 14 compared to the SOC group.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
Bingxin Lei, Hongxiao Song, Fengchao Xu, Qi Wei, Fei Wang, Guangyun Tan, Haichun Ma
Summary: This review examines the role of long non-coding RNAs (lncRNAs) in HBV infection-related pathways, which not only complement the regulatory mechanisms of related pathways but also provide new potential therapeutic targets.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Rebecca L. Casazza, Drake T. Philip, Helen M. Lazear
Summary: IFN-lambda has antiviral effects during pregnancy, but its effects depend on the gestational stage. Infection with ZIKV earlier in pregnancy enhances transplacental transmission. IFN-lambda signaling in maternal tissues causes fetal resorption and intrauterine growth restriction in dams with robust ZIKV infection. Maternal IFN-lambda signaling also contributes to pregnancy pathology induced by poly(I.C) treatment.
Article
Pharmacology & Pharmacy
Jia Hou, Chao Dong, Jiaxuan Chen, Haitao Chen, Rong Na, Bin Zhou, Jinlin Hou, De-Ke Jiang
Summary: ZHX2 and PGS have the potential to predict the response to PegIFN alpha treatment in HBeAg-positive CHB patients.
ANTIVIRAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Hafiza Rida Farooq Chudhary, Amjad Ali, Sadia Bibi, Muhammad Waqas, Shazia Rafique, Muhammad Idrees, Sobia Ahsan Halim, Magda H. Abdellattif, Ajmal Khan, Ahmed Al-Harrasi
Summary: HCV is a global public health problem with a high number of infections worldwide. It is a leading cause of liver cancer due to the frequent occurrence of HCV infection, especially in those with HCV cirrhosis. This study analyzed the transcriptional analysis of the TP53 gene in HCV-infected patients treated with different antiviral therapies. The results showed that TP53 expression was significantly upregulated in patients with virological responses and HCC, and sofosbuvir + daclatasvir treatment had a significant impact on TP53 expression.
Article
Multidisciplinary Sciences
Laurent Gole, Feng Liu, Kok Haur Ong, Longjie Li, Hao Han, David Young, Gabriel Pik Liang Marini, Aileen Wee, Jingmin Zhao, Huiying Rao, Weimiao Yu, Lai Wei
Summary: This study utilized image analysis to predict the irreversibility of liver fibrosis in hepatitis C patients. The researchers found that collagen aggregation pattern and thickness were strongly associated with the reversibility of fibrosis. These findings have important implications for early prediction and treatment of hepatitis C.
SCIENTIFIC REPORTS
(2023)