Article
Immunology
David A. Anderson, Feiya Ou, Sunkyung Kim, Theresa L. Murphy, Kenneth M. Murphy
Summary: Genetic and reporter analysis in myeloid progenitor populations reveals that the transition from Myc to Mycl expression during dendritic cell development is controlled by the transcription factor IRF8. The switch occurs at the stage of initial specification from common dendritic cell progenitors for cDC1s and from common lymphoid progenitors for pDCs, with high levels of IRF8 and interaction with PU.1 playing a crucial role in this process.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yuhong Luo, Yuqing Gao, Weiwei Liu, Yuan Yang, Jie Jiang, Ying Wang, Wei Tang, Shoumei Yang, Lulu Sun, Jie Cai, Xiaozhen Guo, Shogo Takahashi, Kristopher W. Krausz, Aijuan Qu, Lei Chen, Cen Xie, Frank J. Gonzalez
Summary: This study reveals that PRMT5 is an epigenetic executor of MYC, leading to repression of the transcriptional regulation of downstream genes that promote hepatocellular carcinogenesis. Through PRMT5 inhibition a mechanism-based therapeutic strategy for MYC-driven HCC is highlighted, which synergistically suppresses proliferation and enhances antitumor immunity, providing an opportunity to mitigate the resistance of immune-cold tumor to ICT.
Article
Oncology
Duygu Kuzuoglu-Ozturk, Ozlem Aksoy, Christin Schmidt, Robin Lea, Jon D. Larson, Ryan R. L. Phelps, Nicole Nasholm, Megan Holt, Adrian Contreras, Miller Huang, Shannon Wong-Michalak, Hao Shao, Robert Wechsler-Reya, Joanna J. Phillips, Jason E. Gestwicki, Davide Ruggero, William A. Weiss
Summary: Deregulation of N-myc is a major cause of malignant brain tumors in children. This study characterizes the translatome of medulloblastoma and reveals that N-myc drives selective translation of transcripts promoting protein homeostasis. These findings identify a hidden molecular program promoting medulloblastoma formation and suggest potential new therapies for clinical use.
Article
Chemistry, Multidisciplinary
Haitao Qin, Wangshui Cai, Shuang Wang, Ting Guo, Guigen Li, Hongjian Lu
Summary: The study introduces a versatile and novel method for excising N-atoms from N-heterocycles, which can be used to synthesize various cyclic products using readily available substrates. Additionally, examples are provided for nitrogen excision from natural products and synthesis of chiral O-heterocycles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Jhon R. Enterina, Susmita Sarkar, Laura Streith, Jaesoo Jung, Britni M. Arlian, Sarah J. Meyer, Hiromu Takematsu, Changchun Xiao, Troy A. Baldwin, Lars Nitschke, Mark J. Shlomchick, James C. Paulson, Matthew S. Macauley
Summary: Germinal centers are critical for antibody affinity maturation, and glycan remodeling plays a key role in maintaining B cells in the germinal center. Downregulation of CD22 ligands on B cells in the germinal center leads to increased apoptosis, reduced production of memory B cells and plasma cells, and delayed affinity maturation of antibodies. These defects are CD22 dependent.
Article
Gastroenterology & Hepatology
Marina Serra, Mario Di Matteo, Jens Serneels, Rajesh Pal, Sarah Trusso Cafarello, Martina Lanza, Carlos Sanchez-Martin, Matthias Evert, Alessandra Castegna, Diego Francesco Calvisi, Massimiliano Mazzone, Amedeo Columbano
Summary: The study shows that Ldha deletion significantly impairs mouse HCC development, suggesting lactate dehydrogenase as a potential target to enhance the efficacy of current therapeutic options.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Leigh A. Bumpous, Kylie C. Moe, Jing Wang, Logan A. Carver, Alexandria G. Williams, Alexander S. Romer, Jesse D. Scobee, Jack N. Maxwell, Cheyenne A. Jones, Dai H. Chung, William P. Tansey, Qi Liu, April M. Weissmiller
Summary: The MYC family of oncoprotein transcription factors is overexpressed in over 50% of malignancies. The chromatin regulator WDR5 acts as a cofactor for MYC proteins and facilitates their recruitment to chromatin. This study focuses on N-MYC amplified neuroblastoma and demonstrates that WDR5 can facilitate the recruitment of N-MYC to genes associated with protein synthesis and other biological processes. The findings reveal WDR5 as a universal MYC recruiter and highlight the potential coregulation of novel biological functions by N-MYC and WDR5 in sustaining neuroblastoma.
Article
Nutrition & Dietetics
Ting-Yun Lin, Ming-Ying Wu, Huan-Sheng Chen, Szu-Chun Hung, Paik-Seong Lim
Summary: The study aimed to develop and validate an equation for obtaining appendicular skeletal muscle mass (ASM) from Body Composition Monitor (BCM) among hemodialysis patients. The equation provided by BCM was found to be applicable for assessing ASM in hemodialysis patients. Low ASM predicted by the BCM equation was associated with significantly worse overall survival among CKD patients but not hemodialysis patients. The model showed high sensitivity and specificity as a diagnostic tool for sarcopenia.
CLINICAL NUTRITION
(2021)
Article
Cell Biology
Zefeng Chen, Dexu Ren, Jinyu Lv, Yuxin Xu, Mengru Xie, Xingbei He, Wen Shi, Qilan Qian, Aixin Jing, Xinhui Ma, Jingting Qin, Yuanyuan Ding, Ting Geng, Jinming Ma, Wei Liu, Shunfang Liu, Jing Ji
Summary: RNF31, a component of the LUBAC complex, promotes carcinogenesis by enhancing cell proliferation, invasion and inhibiting apoptosis in various cancers. The specific molecular mechanism by which RNF31 exerts these effects is still unclear. Our study shows that RNF31 plays an important role in maintaining c-Myc protein levels in cancer cells by extending its half-life and reducing its ubiquitination.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Yang Yang, Yu Yan, Jiaxin Yin, Ni Tang, Kai Wang, Luyi Huang, Jie Hu, Zhongqi Feng, Qingzhu Gao, Ailong Huang
Summary: Hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). The RNA N-6-methyladenosine (m(6)A) reader, YTH domain 2 (YTHDF2), plays a critical role in HCC progression. The increased O-GlcNAcylation of YTHDF2 upon HBV infection enhances its protein stability and oncogenic activity, promoting cell cycle progression and HBV-related HCC tumorigenesis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Gurudutt Dubey, Shruti Awari, Tejender Singh, Subash C. Sahoo, Prasad Bharatam
Summary: Six compounds with MIC -> N+<- NHC coordination interactions were synthesized and studied. Computational and analysis results suggest the formation of coordination bonds with specific bond lengths and bond dissociation energies between MIC and N+ center.
Article
Plant Sciences
Yalikunjiang Aizezi, Huazhang Shu, Linlin Zhang, Hongming Zhao, Yang Peng, Hongxia Lan, Yinpeng Xie, Jian Li, Yichuan Wang, Hongwei Guo, Kai Jiang
Summary: The apical hook plays a crucial role in protecting the delicate shoot apical meristem of dicot seedlings during early seedling development. Its development is regulated by multiple phytohormones and environmental factors, with cytokinin being identified as a key factor promoting apical hook development in Arabidopsis thaliana. Ethylene signaling and light signaling are integrated by cytokinin through EIN3/EIL1 and PIFs transcription factors, respectively, to dynamically regulate apical hook development.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Review
Medicine, Research & Experimental
Jianan Xu, Yuanyuan Sun, Weineng Fu, Shuang Fu
Summary: Myc target 1 (MYCT1), located at 6q25.2, is a crucial player in cancer development with widely distributed expression in cells and variable subcellular localization across different cancer types. It is regulated by multiple transcription factors and aberrant expression of MYCT1 impacts key biological processes and tumor immune responses in cancer cells. Despite some debated functions, MYCT1 holds undeniable significance in cancer development. This review aims to comprehensively examine the relationship between MYCT1 and cancer, providing valuable insights for cancer diagnosis and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Inorganic & Nuclear
Vit Kremlacek, Martin Hejda, Elena Rychagova, Sergey Ketkov, Roman Jambor, Ales Ruzicka, Libor Dostal
Summary: In this study, the C=C bond in selected N-alkyl/aryl-maleimides is activated by organopnictogen(I) compounds, resulting in bridged bicyclic [2.2.1] products with endo and exo orientations. The reversibility of C=C bond activation is found to depend on the E atom and the structure of the ligand. Structural elucidation of the addition products is achieved through multinuclear NMR and single-crystal X-ray diffraction analysis.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Cell Biology
Corinna Schreiner, Bianka Kernl, Petra Dietmann, Ricarda J. Riegger, Michael Kuehl, Susanne J. Kuehl
Summary: In this study, the researchers used Xenopus laevis as a model organism to investigate the role of Rpl5 in embryonic development. They showed that Rpl5 knockdown resulted in defects in cranial cartilage, eye formation, and brain development, similar to the clinical manifestations of Diamond Blackfan anemia (DBA). Further analyses revealed that Rpl5 functions through a common signaling pathway with c-Myc and Tp53, and that apoptosis is one of the main reasons for the observed phenotypes. This study provides new insights into the molecular background of ribosomopathies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)