Review
Cell Biology
Anna Waskiel-Burnat, Marta Osinska, Anna Salinska, Leszek Blicharz, Mohamad Goldust, Malgorzata Olszewska, Lidia Rudnicka
Summary: Alopecia areata is characterized by dysregulation of various systemic cytokines including Th1, Th2, and Th17. The severity and duration of the disease are positively correlated with elevated levels of certain cytokines, while others may serve as potential predictors of therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Xin-Zi Emily Tang, Shu Xuan Tan, Shawn Hoon, Gene W. Yeo
Summary: This study evaluated antibody and T cell responses to the Cas13d protein (RfxCas13d) from Ruminococcus flavefaciens in healthy donors. It found that most donors have antibodies and CD4 and CD8 T cell responses to RfxCas13d, similar to other Cas9 proteins. In addition, RfxCas13d-responsive T cells could produce inflammatory cytokines. These findings are important for the development of RfxCas13d for therapy.
Review
Virology
Faith H. N. Howard, Amy Kwan, Natalie Winder, Amina Mughal, Cristal Collado-Rojas, Munitta Muthana
Summary: The number of emerging and re-emerging viral diseases has increased globally in recent decades. Host factors such as age, ethnicity, and underlying pathologies can affect the immune response and the outcome following viral infection.
Article
Food Science & Technology
Jin Yuan, Xiaoqian Xu, Zhongliang Wang, Ping Tong, Xuanyi Meng, Yong Wu, Xin Li, Jinyan Gao, Hongbing Chen
Summary: This study aimed to characterize the differentiations of naive Th cells stimulated with different doses of Staphylococcus aureus enterotoxin B (SEB). The results showed that the balance of Th1/Th2 could be dominated by the doses of SEB stimulation, with a higher dose inducing more Th1 cells and a lower Th2/Th1 ratio. This finding complements the existing knowledge about SEB as a superantigen and has implications for managing S. aureus colonization and SEB contamination in food.
Article
Biochemistry & Molecular Biology
Vafa Baradaran Rahimi, Saeideh Saadat, Pouria Rahmanian Devin, Ali Jebalbarezy, Maryam Moqaddam, Mohammad Hossein Boskabady, Vahid Reza Askari
Summary: Crocetin, a natural compound derived from Crocus sativus, has immunoregulatory and anti-inflammatory properties, which allow it to modulate the immune response in human lymphocytes. It can decrease pro-inflammatory cytokines and increase anti-inflammatory cytokines, promoting a shift towards a Th1 and Treg dominant response.
Article
Medicine, Research & Experimental
Le Lv, Ziyang Chen, Wenhui Bai, Jiahui Hao, Zhengang Heng, Caijin Meng, Lin Wang, Xianglan Luo, Xinmiao Wang, Yanjun Cao, Jiao He
Summary: This study aimed to explore the efficacy of THDCA on ulcerative colitis and to reveal its mechanisms of action. The results showed that THDCA can significantly alleviate colitis and exert its effects by regulating the Th1/Th2 and Th17/Treg balance.
Article
Dermatology
Yong-Zhi Ji, Xiang-Lin Mei, Li-Li Jia, Shi-Rui Liu
Summary: The study found that CD4(+)T cell apoptosis and conversion of Th1/Th2-type cytokines play important roles in sporotrichosis, contributing to the progression of the disease.
DERMATOLOGIC THERAPY
(2021)
Article
Pharmacology & Pharmacy
Abdolkarim Hosseini, Hadi Esmaeili Gouvarchin Ghaleh, Hossein Aghamollaei, Mahdi Fasihi Ramandi, Gholamhossein Alishiri, Alireza Shahriary, Kazem Hassanpour, Mahdi Tat, Gholamreza Farnoosh
Summary: Studies have shown that melatonin can be used as a medicinal adjuvant to treat COVID-19 by reducing and controlling inflammatory cytokines through regulating the expression of Th1 and Th2 regulatory genes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Virology
Svetlana Atasheva, Dmitry M. Shayakhmetov
Summary: The expression of cytokines and chemokines in response to adenovirus infection is tightly regulated by the innate immune system. Cytokine-mediated toxicity compromises the safety of adenovirus-based vectors, limiting their utility for gene therapy applications. Further research is needed to understand the mechanisms triggering cytokine storm and develop intervention approaches to mitigate its severity.
Article
Immunology
Nai-Hsiang Chung, Ying-Chin Chen, Shiu-Ju Yang, Yu-Ching Lin, Horng-Yunn Dou, Lily Hui-Ching Wang, Ching-Len Liao, Yen-Hung Chow
Summary: A series of recombinant adenoviruses expressing SARS-CoV-2 spike protein were tested for their efficacy in preventing SARS-CoV-2 infection through intranasal or subcutaneous immunization in a rodent model. The study found that intranasal delivery induced higher antibody responses compared to subcutaneous injection, and pre-existing antibodies did not affect the antibody responses. The antibody responses induced by intranasal immunization were dominated by humoral immunity, while subcutaneous immunization primarily activated cellular immunity. The results demonstrate that intranasal administration of adenovirus vaccines is safe and effective in preventing SARS-CoV-2 infections.
Article
Immunology
Ling -Yu Chang, Jing Shan, Xin-Xin Hou, Da-Jin Li, Xiao-Qiu Wang
Summary: Endometriosis is a chronic disorder associated with infertility and pelvic pain, commonly believed to be estrogen-dependent. Recent studies have shown a correlation between immune system disorders and endometriosis, particularly involving the dysregulation of T helper cells leading to a shift towards Th2 immune response. This review aims to explore the mechanisms behind the development of endometriosis, including cytokines, chemokines, signal pathways, transcription factors, and other factors associated with Th1/Th2 immune response, as well as discussing current treatment approaches and potential therapeutic targets.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Veronique Corbiere, Eleonora E. Lambert, Marine Rodesch, Jacqueline A. M. van Gaans-van den Brink, Alicja Misiak, Elles Simonetti, Anne Van Praet, Audrey Godefroid, Dimitri A. Diavatopoulos, Cecile A. C. M. van Els, Francoise Mascart
Summary: This study developed a two-step assay for evaluating the immunogenicity of pertussis vaccines. It involved stimulating fresh whole blood with pertussis antigens, cryopreserving the stimulated cells, and later analyzing cytokine production using flow cytometry. The assay demonstrated high reproducibility and sensitivity, allowing for the accurate quantification of pertussis antigen-specific Th1, Th2, and Th17-type CD4(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Yuqian Yan, Shuping Jing, Liqiang Feng, Jing Zhang, Zhiwei Zeng, Min Li, Shan Zhao, Junxian Ou, Wendong Lan, Wenyi Guan, Xiaowei Wu, Jianguo Wu, Donald Seto, Qiwei Zhang
Summary: HAdVs cause a large number of ARD cases with severe morbidity and mortality, and HAdV-3 is the most common type causing outbreaks. This study constructed a novel recombinant and attenuated adenovirus vaccine candidate against HAdV-3, showing promising safety and efficacy in experiments.
Article
Agriculture, Dairy & Animal Science
Fatih R. Istanbullugil, Ali Risvanli, Ruslan Salikov, Metin Bayraktar, Nariste Kadiraliyeva, Aidai Zhunushova, Oznur Yilmaz, Burak F. Yuksel, Mert Turanli, Muhammet Uz, Mirbek I. Asinbekovic
Summary: This study investigates the relationship between Th1/Th2 cytokine balance and milk composition in Kyrgyz mares and foals. It is found that there is no Th1/Th2 polarization in mare's milk on the day of foal's birth and day 10, but there is Th1 polarization on day 5 and Th2 polarization on day 20. Correlation analysis shows that there is a positive correlation between IL-5 level and protein ratio on day 10, and a positive correlation between IL-2 level and fat rate as well as non-fat dry matter ratio on day 20.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Food Science & Technology
Sinan Chen, Yifei Xu, Ni Cheng, Feng Li, Haoan Zhao, Naisheng Bai, Hesham R. El-Seedi, Wei Cao
Summary: The study found that FBPE has a relieving effect on colitis, by regulating immune function, reducing inflammatory response, and restoring the immune system.
Article
Immunology
Yunda Huang, Guido Ferrari, Galit Alter, Donald N. Forthal, John C. Kappes, George K. Lewis, J. Christopher Love, Bhavesh Borate, Linda Harris, Kelli Greene, Hongmei Gao, Tran B. Phan, Gary Landucci, Brittany A. Goods, Karen G. Dowell, Hao D. Cheng, Chris Bailey-Kellogg, David C. Montefiori, Margaret E. Ackerman
JOURNAL OF IMMUNOLOGY
(2016)
Article
Mathematical & Computational Biology
Peter B. Gilbert, Holly E. Janes, Yunda Huang
STATISTICS IN MEDICINE
(2016)
Article
Immunology
Yunda Huang, Lily Zhang, Darren Jolliffe, Arnt-Ove Hovden, Mats Okvist, Giuseppe Pantaleo, Maja A. Sommerfelt
Article
Virology
Ying Huang, Carlos DiazGranados, Holly Janes, Yunda Huang, Allan C. deCamp, Barbara Metch, Shannon Grant, Brittany Sanchez, Sanjay Phogat, Marguerite Koutsoukos, Niranjan Kanesa-Thasan, Patricia Bourguignon, Alix Collard, Susan Buchbinder, Georgia D. Tomaras, Julie McElrath, Glenda Gray, James G. Kublin, Lawrence Corey, Peter B. Gilbert
CURRENT OPINION IN VIROLOGY
(2016)
Article
Immunology
Jue Hou, Shuhui Wang, Manxue Jia, Dan Li, Ying Liu, Zhengpeng Li, Hong Zhu, Huifang Xu, Meiping Sun, Li Lu, Zhinan Zhou, Hong Peng, Qichen Zhang, Shihong Fu, Guodong Liang, Lena Yao, Xuesong Yu, Lindsay N. Carpp, Yunda Huang, Julie McElrath, Steve Self, Yiming Shao
JOURNAL OF IMMUNOLOGY
(2017)
Article
Medicine, Research & Experimental
Yunda Huang, Lily Zhang, Julie Ledgerwood, Nicole Grunenberg, Robert Bailer, Abby Isaacs, Kelly Seaton, Kenneth H. Mayer, Edmund Capparelli, Larry Corey, Peter B. Gilbert
Article
Immunology
Yunda Huang, Lily Zhang, Holly Janes, Nicole Frahm, Abby Isaacs, Jerome H. Kim, David Montefiori, M. Julie McElrath, Georgia D. Tomaras, Peter B. Gilbert
Article
Multidisciplinary Sciences
Susan P. Buchbinder, Nicole A. Grunenberg, Brittany J. Sanchez, Kelly E. Seaton, Guido Ferrari, M. Anthony Moody, Nicole Frahm, David C. Montefiori, Christine M. Hay, Paul A. Goepfert, Lindsey R. Baden, Harriet L. Robinson, Xuesong Yu, Peter B. Gilbert, M. Juliana McElrath, Yunda Huang, Georgia D. Tomaras
Article
Medicine, Research & Experimental
Stephen C. De Rosa, Srilatha Edupuganti, Yunda Huang, Xue Han, Marnie Elizaga, Edith Swann, Laura Polakowski, Spyros A. Kalams, Michael C. Keefer, Janine Maenza, Yiwen Lu, Megan C. Wise, Jian Yan, Matthew P. Morrow, Amir S. Khan, Jean D. Boyer, Laurent Humeau, Scott White, Michael Pensiero, Niranjan Y. Sardesai, Mark L. Bagarazzi, David B. Weiner, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, Lawrence Corey, M. Juliana McElrath
Article
Biotechnology & Applied Microbiology
Yunda Huang, Lily Zhang, Amanda Eaton, Nonhlanhla N. Mkhize, Lindsay N. Carpp, Erika Rudnicki, Allan DeCamp, Michal Juraska, April Randhawa, Adrian McDermott, Julie Ledgerwood, Philip Andrew, Shelly Karuna, Srilatha Edupuganti, Nyaradzo Mgodi, Myron Cohen, Lawrence Corey, John Mascola, Peter B. Gilbert, Lynn Morris, David C. Montefiori
Summary: The study evaluated the efficacy of VRC01 for HIV-1 prevention and used statistical methods to predict its neutralization ability against viruses. The pharmacokinetics/pharmacodynamics joint modeling approach showed the best predictive performance, while simpler methods 1 and 2 performed comparably for predicting ID80 titers.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biochemical Research Methods
Bryan T. Mayer, Allan C. deCamp, Yunda Huang, Joshua T. Schiffer, Raphael Gottardo, Peter B. Gilbert, Daniel B. Reeves
Summary: Broadly neutralizing antibodies (bNAbs) are a promising drug for the prevention and treatment of HIV. However, due to differences in breadth, potency, and in vivo longevity, it is important to optimize the composition and dose ratio of combination bNAb therapies to enhance efficacy.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peter B. Gilbert, Yunda Huang, Allan C. deCamp, Shelly Karuna, Yuanyuan Zhang, Craig A. Magaret, Elena E. Giorgi, Bette Korber, Paul T. Edlefsen, Raabya Rossenkhan, Michal Juraska, Erika Rudnicki, Nidhi Kochar, Ying Huang, Lindsay N. Carpp, Dan H. Barouch, Nonhlanhla N. Mkhize, Tandile Hermanus, Prudence Kgagudi, Valerie Bekker, Haajira Kaldine, Rutendo E. Mapengo, Amanda Eaton, Elize Domin, Carley West, Wenhong Feng, Haili Tang, Kelly E. Seaton, Jack Heptinstall, Caroline Brackett, Kelvin Chiong, Georgia D. Tomaras, Philip Andrew, Bryan T. Mayer, Daniel B. Reeves, Magdalena E. Sobieszczyk, Nigel Garrett, Jorge Sanchez, Cynthia Gay, Joseph Makhema, Carolyn Williamson, James I. Mullins, John Hural, Myron S. Cohen, Lawrence Corey, David C. Montefiori, Lynn Morris
Summary: By integrating serum concentration and in vitro inhibitory concentration, the PT80 biomarker can guide the effective prevention of HIV-1 acquisition. The PT80 biomarker can be used to predict HIV-1 prevention efficacy and is proposed as a tool for evaluating bNAb regimens and candidate vaccines.
Article
Multidisciplinary Sciences
Youyi Fong, Yunda Huang, David Benkeser, Lindsay N. Carpp, German Anez, Wayne Woo, Alice McGarry, Lisa M. Dunkle, Iksung Cho, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Flora Castellino, Christos J. Petropoulos, Andrew Leith, Deanne Haugaard, Bill Webb, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars W. P. van der Laan, Nima S. Hejazi, April K. Randhawa, Michele P. Andrasik, James G. Kublin, Julia Hutter, Maryam Keshtkar-Jahromi, Tatiana H. Beresnev, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Julie A. Ake, Cynthia L. Gay, Karen L. Kotloff, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert
Summary: In the PREVENT-19 phase 3 trial, the NVX-CoV2373 vaccine's effectiveness against COVID-19 was assessed using markers such as spike IgG, RBD IgG, and nAb ID50. The study found that higher concentrations of these markers were associated with lower COVID-19 risk and higher vaccine efficacy. The results suggest that these markers could be used across different vaccine platforms to guide decision-making on vaccine approval and usage.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Youyi Fong, Yunda Huang, David Benkeser, Lindsay N. Carpp, German Anez, Wayne Woo, Alice McGarry, Lisa M. Dunkle, Iksung Cho, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Flora Castellino, Christos J. Petropoulos, Andrew Leith, Deanne Haugaard, Bill Webb, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars W. P. van der Laan, Nima S. Hejazi, April K. Randhawa, Michele P. Andrasik, James G. Kublin, Julia Hutter, Maryam Keshtkar-Jahromi, Tatiana H. Beresnev, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Julie A. Ake, Cynthia L. Gay, Karen L. Kotloff, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Rena D. Astronomo, Maria P. Lemos, Sandeep R. Narpala, Julie Czartoski, Lamar Ballweber Fleming, Kelly E. Seaton, Madhu Prabhakaran, Yunda Huang, Yiwen Lu, Katharine Westerberg, Lily Zhang, Mary K. Gross, John Hural, Hong-Van Tieu, Lindsey R. Baden, Scott Hammer, Ian Frank, Christina Ochsenbauer, Nicole Grunenberg, Julie E. Ledgerwood, Kenneth Mayer, Georgia Tomaras, Adrian B. McDermott, M. Juliana McElrath
Summary: The study showed that VRC01 can distribute into the female genital and male rectal mucosa, effectively inhibiting HIV-1 infection, providing new insights into in vivo protective efficacy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)