Review
Gastroenterology & Hepatology
Evariste Tshibangu-Kabamba, Yoshio Yamaoka
Summary: Helicobacter pylori is a major human pathogen with increasing antibiotic resistance posing a serious threat to human health. The resistance mechanisms include single drug resistance, multidrug resistance, and heteroresistance, primarily related to mutational changes and target-mediated mechanisms. Further research is needed to explore additional biological attributes driving drug resistance in H. pylori for better treatment outcomes.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
Hilda A. Valdez-Salazar, Miguel A. Ares, Francisco J. Fernandez, J. Antonio Ibarra, Javier Torres, Victor H. Bustamante, Miguel A. De la Cruz
Summary: Infection with Helicobacter pylori is a significant risk factor for developing gastric cancer, with the cag pathogenicity island encoding the T4SS as the main virulence factor. Long-chain fatty acids have been shown to affect the transcription of virulence and regulatory genes of H. pylori, with palmitic and oleic acids up-regulating the transcription of most virulence genes tested.
Article
Genetics & Heredity
Kathleen M. Chen, Aaron K. Wong, Olga G. Troyanskaya, Jian Zhou
Summary: Sei is a new framework for integrating human genetics data with a sequence-based mapping of predicted regulatory activities to elucidate mechanisms contributing to complex traits and diseases.
Article
Microbiology
Anthony Mannion, JoAnn Dzink-Fox, Zeli Shen, M. Blanca Piazuelo, Keith T. Wilson, Pelayo Correa, Richard M. Peek, M. Constanza Camargo, James G. Fox
Summary: Colombia in South America has a high burden of Helicobacter pylori infection and gastric cancer. Multidrug antibiotic regimens can effectively eradicate H. pylori, but treatment efficacy is threatened by the emergence of antibiotic-resistant strains. This study found that H. pylori isolates from Colombia exhibit multidrug antibiotic resistance.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ivica Samanic, Blanka Dadic, Zeljka Sanader Marsic, Mia Dzelalija, Ana Maravic, Hrvoje Kalinic, Pavle Vrebalov Cindro, Zeljko Sundov, Marija Tonkic, Ante Tonkic, Jonatan Vukovic
Summary: This study investigated the molecular genetic mechanisms of clarithromycin and levofloxacin resistance in Helicobacter pylori infections in patients from Croatia. Point mutations in the 23S rRNA, gyrA, and gyrB genes were found to alter target sites or protein structure, leading to reduced efficacy of standard antibiotics. Molecular docking analysis revealed that resistance-related mutations resulted in decreased susceptibility to clarithromycin and levofloxacin due to significant differences in non-covalent interactions, ultimately resulting in antibiotic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Amelia R. Wilhelm, Nicole A. Parsons, Benjamin J. Samelson-Jones, Robert J. Davidson, Charles T. Esmon, Rodney M. Camire, Lindsey A. George
Summary: This study compared an APC-resistant FVIII variant with wild-type FVIII, and found that APC plays an important role in the in vivo regulation of FVIIIa, which could be exploited for developing novel treatments for hemophilia A.
Article
Multidisciplinary Sciences
Sebastien Bastide, Elad Chomsky, Baptiste Saudemont, Yann Loe-Mie, Sandrine Schmutz, Sophie Novault, Heather Marlow, Amos Tanay, Francois Spitz
Summary: We developed a spatially resolved single-cell transcriptomics method to explore the genetic programs underlying the emergence of specialized cell types during mouse limb development. Our study revealed two parallel regulatory systems and demonstrated the complex multiscale reorganization of the embryonic limb upon perturbation of its spatial organizing centers.
Article
Infectious Diseases
Shumaiza Anis, Shakeel R. Farooqi, Saad K. Niaz
Summary: The study aimed to characterize clarithromycin resistance and associated mutations in clinical isolates of H. pylori in Pakistan. Results showed extensive diversity of domain V mutations in H. pylori, with multiple mutations potentially conferring endurance against clarithromycin. Further investigation into the molecular mechanisms of antibiotic resistance in H. pylori is deemed crucial at this stage.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biochemistry & Molecular Biology
Mahdieh Labani, Amin Beheshti, Ahmadreza Argha, Hamid Alinejad-Rokny
Summary: Prostate cancer is highly prevalent and genomic alterations play a key role in its development and progression. In this study, an integrative analysis pipeline was used to identify 646 putative regulatory variants in prostate cancer, of which 30 significantly affected the expression of protein-coding genes. These variants could potentially impact 131 coding and non-coding genes, many of which are involved in disease-related pathways with targeted treatment options already available. Additionally, non-coding RNAs were identified as potential enhancer elements for certain protein-coding genes. Overall, this study provides a comprehensive map of genomic variants in prostate cancer and their potential contribution to the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tu Cam Nguyen, Giao Kim Ngoc Le, Dao Thi Hong Pham, Bao Van Pham, Loan Thi Hong Nguyen, Thai Hoang Che, Hiep Thanh Nguyen, Dinh Quang Truong, Annie Robert, Patrick Bontems, Phuong Ngoc Van Nguyen
Summary: This study assessed the antibiotic resistance patterns and trends of Helicobacter pylori in Vietnamese children. The results showed an alarming high level of antibiotic resistance, especially for clarithromycin, with the emergence of multi- and hetero-resistant strains, posing a major treatment challenge.
Article
Medical Laboratory Technology
Tevhide Ziver-Sarp, Pelin Yuksel-Mayda, Suat Saribas, Suleyman Demiryas, Nesrin Gareayaghi, Sevgi Ergin, Ihsan Tasci, Dogukan Ozbey, Kadir Bal, Yusuf Erzin, Seher Akkus, Hrisi Bahar-Tokman, Mehmet Demirci, Banu Tufan-Kocak, Bekir Kocazeybek
Summary: This study aimed to determine the resistance of H. pylori strains to clarithromycin and levofloxacin, and investigate the mutations responsible for levofloxacin resistance. The findings showed that mutations in the gyrA gene had an enhancing effect on levofloxacin resistance, while dual resistance developed with increased rates of clarithromycin and levofloxacin resistance.
CLINICAL LABORATORY
(2021)
Review
Biochemistry & Molecular Biology
Peter T. Chivers
Article
Chemistry, Inorganic & Nuclear
Carolyn E. Carr, Francesco Musiani, Hsin-Ting Huang, Peter T. Chirvers, Stefano Ciurli, Michael J. Maroney
INORGANIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Hsin-Ting Huang, Cedric E. Bobst, Jeffrey S. Iwig, Peter T. Chivers, Igor A. Kaltashov, Michael J. Maroney
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Correction
Chemistry, Multidisciplinary
Khadine A. Higgins, Peter T. Chivers, Michael J. Maroney
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Correction
Multidisciplinary Sciences
Simon J. Moore, Sven T. Sowa, Christopher Schuchardt, Evelyne Deery, Andrew D. Lawrence, Jose Vazquez Ramos, Susan Billig, Claudia Birkemeyer, Peter T. Chivers, Mark J. Howard, Stephen E. J. Rigby, Gunhild Layer, Martin J. Warren
Article
Multidisciplinary Sciences
Simon J. Moore, Sven T. Sowa, Christopher Schuchardt, Evelyne Deery, Andrew D. Lawrence, Jose Vazquez Ramos, Susan Billig, Claudia Birkemeyer, Peter T. Chivers, Mark J. Howard, Stephen E. J. Rigby, Gunhild Layer, Martin J. Warren
Article
Biochemistry & Molecular Biology
Andrew W. Foster, Rafael Pernil, Carl J. Patterson, Andrew J. P. Scott, Lars-Olof Palsson, Robert Pal, Ian Cummins, Peter T. Chivers, Ehmke Pohl, Nigel J. Robinson
NATURE CHEMICAL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Khadine A. Higgins, Heidi Q. Hu, Peter T. Chivers, Michael J. Maroney
Article
Biochemistry & Molecular Biology
Erin L. Benanti, Peter T. Chivers
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Chemistry, Multidisciplinary
Khadine A. Higgins, Peter T. Chivers, Michael J. Maroney
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Biochemistry & Molecular Biology
Peter T. Chivers, Erin L. Benanti, Vanessa Heil-Chapdelaine, Jeffrey S. Iwig, Jessica L. Rowe
Article
Multidisciplinary Sciences
Katie J. Denby, Jeffrey Iwig, Claudine Bisson, Jodie Westwood, Matthew D. Rolfe, Svetlana E. Sedelnikova, Khadine Higgins, Michael J. Maroney, Patrick J. Baker, Peter T. Chivers, Jeffrey Green
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Deenah Osman, Maria Alessandra Martini, Andrew W. Foster, Junjun Chen, Andrew J. P. Scott, Richard J. Morton, Jonathan W. Steed, Elena Lurie-Luke, Thomas G. Huggins, Andrew D. Lawrence, Evelyne Deery, Martin J. Warren, Peter T. Chivers, Nigel J. Robinson
NATURE CHEMICAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Priyanka Basak, Diane E. Cabelli, Peter T. Chivers, Erik R. Farquhar, Michael J. Maroney
Summary: This study reveals the involvement of L-histidine in the protease-mediated maturation of nickel-dependent superoxide dismutase (NiSOD), and demonstrates that L-histidine can serve as a metallochaperone to facilitate nickel incorporation.