Article
Pharmacology & Pharmacy
Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Yu
Summary: Autophagy plays a crucial role in regulating the ageing process and neurodegeneration. Dysfunction of autophagy is implicated in Alzheimer's disease pathogenesis. The activation of TRPV1 using capsaicin induces autophagy, which could potentially be a therapeutic target for Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Shiqi Zhang, Lanlan Tang, Fanshu Xu, Yonghai Hui, Hongjia Lu, Xiong Liu
Summary: Capsaicin exhibits significant hypoglycemic effects by activating the TRPV1 channel, which is lost when the channel is blocked. The hypoglycemic effect of capsaicin is partially attributed to the combined up-regulation of TRPV1 receptors and PDX-1.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Mingliang Chen, Xunhu Dong, Haoyue Deng, Feng Ye, Yuanpeng Zhao, Jin Cheng, Guorong Dan, Jiqing Zhao, Yan Sai, Xiuwu Bian, Zhongmin Zou
Summary: Nitrogen mustard causes severe vesicating skin injury, partially through over-activating autophagy, and partly by activating the TRPV1-Ca2+-CaMKK beta-AMPK-ULK1 signaling pathway. These results suggest that blocking TRPV1-dependent autophagy could be a potential treatment strategy for nitrogen mustard-caused cutaneous injury.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lei Liu, Yuhua Tian
Summary: The presence of TRPV1 ion channels in brain regions other than the hypothalamus has been debated. By injecting capsaicin directly into the lateral ventricle of rats and recording EEGs, we found that capsaicin perturbed brain electrical activity during sleep, suggesting TRPV1 expression in specific brain regions dominant during this stage.
Article
Biochemistry & Molecular Biology
Kyuhyun Choi, Jee Hyun Yi, Changwoo Lee, Kyungjoon Park, Shin Jung Kang, Ki Soon Shin
Summary: This study reveals the significant role of presynaptic HCN channels in high-frequency stimulation-induced presynaptic long-term potentiation and modulation of synaptic transmission. It is important for further understanding the neural mechanisms underlying fear memory.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kyuhyun Choi, Kyungjoon Park, Soonje Lee, Jee Hyun Yi, Changsu Woo, Shin Jung Kang, Ki Soon Shin
Summary: The lateral amygdala (LA) is a main sensory input site from the cortical and thalamic regions, which strongly projects to the basal amygdala (BA). Our study found that high-frequency stimulation ex vivo resulted in long-term potentiation (LTP) and enhanced neurotransmitter release at LA-BA synapses. Auditory fear conditioning also led to presynaptic facilitation at LA-BA synapses, with no changes in the AMPA/NMDA current ratio, suggesting the involvement of presynaptic mechanisms in fear conditioning.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Plant Sciences
Si-Lu Zhu, Mei-Ling Wang, Yue-Teng He, Shu-Wen Guo, Ting-Ting Li, Wei-Jie Peng, Dan Luo
Summary: Capsaicin elevates SIRT1 levels through TRPV1 pathway and suppresses IHG-induced endothelial cell senescence.
Article
Multidisciplinary Sciences
Nicole N. Scheff, Ian M. Wall, Sam Nicholson, Hannah Williams, Elyssa Chen, Nguyen H. Tu, John C. Dolan, Cheng Z. Liu, Malvin N. Janal, Nigel W. Bunnett, Brian L. Schmidt
Summary: Oral cancer patients experience sensitivity to spicy foods and liquids, but the mechanism behind this sensitivity is not yet understood. In a mouse model of oral cancer, researchers found increased expression of TRPV1 in trigeminal ganglion neurons, indicating an anatomical basis for chemosensitivity. They also discovered that PAR(2) plays a role in mediating the sensitivity induced by TRPV1 in tongue afferents in the oral cancer mouse model.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sreepadaarchana Munjuluri, Dru A. Wilkerson, Gagandeep Sooch, Xingjuan Chen, Fletcher A. White, Alexander G. Obukhov
Summary: This review discusses the effects of capsaicin on vascular function, indicating that excessive consumption of capsaicin may lead to vasoconstriction and myocardial infarction, while emphasizing the role of inflammation in sensitizing the vascular channels to capsaicin activation.
Article
Biochemistry & Molecular Biology
Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Yu
Summary: Microglia energy metabolism is suppressed during chronic A beta-tolerant processes, but pharmacological activation of TRPV1 can rescue microglial dysfunction and restore immune responses, leading to reduced amyloid pathology and reversed memory deficits in AD mice. This study suggests that TRPV1 is an important target for regulating metabolic reprogramming in microglial functions for AD treatment.
Article
Cell Biology
Ya-Kai Xie, Hao Luo, Shan-Xin Zhang, Xiao-Ying Chen, Ran Guo, Xiao-Yun Qiu, Shuai Liu, Hui Wu, Wen-Bo Chen, Xing-Hua Zhen, Qiang Ma, Jin-Lan Tian, Shun Li, Xinzhong Chen, Qingjian Han, Shumin Duan, Chengyong Shen, Fan Yang, Zhen-Zhong Xu
Summary: This study reveals the mechanisms underlying the development of DNP in patients with diabetes and identifies a potential therapeutic target. The researchers found that GPR177 in A-fiber neurons mediates the secretion of WNT5a, which in turn activates the TRPV1 ion channel and causes pain. These findings contribute to the search for therapies to relieve neuropathic pain.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Vipin Arora, James N. Campbell, Man-Kyo Chung
Summary: Capsaicin, the pungent ingredient in chili peppers, can cause intense burning pain in humans, but it has also been used as an analgesic for chronic pain conditions. The analgesic effects of capsaicin depend on concentration, with low concentrations inducing short-term defunctionalization and high concentrations leading to long-term defunctionalization.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Jennifer Radwitz, Torben J. Hausrat, Frank F. Heisler, Philipp C. Janiesch, Yvonne Pechmann, Michael Rubhausen, Matthias Kneussel
Summary: In this study, it was found that neuronal activity can affect microtubule growth and Tubb3 expression, with downregulation of Tubb3 accelerating microtubule growth specifically in axons and dendrites. This downregulation also led to an upregulation of the Tubb4 gene expression and reduced tubulin polyglutamylation, while increasing KIF5C motility and boosting the transport of synaptic cargo N-Cadherin. This suggests a feedback mechanism where neuronal activity regulates tubulin expression to influence microtubule dynamics and the delivery of synaptic cargoes.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Shi-Yu Deng, Xue-Chun Tang, Yue-Chen Chang, Zhen-Zhen Xu, Qin-Yi Chen, Nan Cao, Liang-Jing-Yuan Kong, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si
Summary: This study showed that activation of TRPV1 by capsaicin increases the expression and function of NKCC1 protein in DRG, possibly mediated by the PKC/p-ERK signaling pathway. These findings suggest that DRG NKCC1 may participate in the inflammatory pain induced by TRPV1.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Kylie A. Huckleberry, Roberto Calitri, Anna J. Li, Mackenna Mejdell, Ashna Singh, Vasvi Bhutani, Mikaela A. Laine, Andrei S. Nastase, Maria Morena, Matthew N. Hill, Rebecca M. Shansky
Summary: Increasing evidence suggests that there may be differences in the neurobiological processes underlying learning and memory in males and females, but the specific mechanisms are not fully understood. This study explored the potential sex differences in the modulation of fear conditioning and extinction by endocannabinoids (eCBs). The results showed that females classified as "Darters" responded differently to the administration of eCB receptor drugs compared to those classified as "Non-darters". These findings suggest that there may be a sex-specific dependence on CB1Rs for context processing in females that is sensitive to disruption by TRPV1.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bjoern H. Schott, Golo Kronenberg, Ulrike Schmidt, Henning P. Duesedau, Stefanie Ehrentraut, Olga Geisel, Oliver von Bohlen Und Halbach, Peter Gass, Ildiko Rita Dunay, Rainer Hellweg
Summary: Our study reveals that p75NTR signaling plays a role in regulating hippocampal BDNF levels, particularly under stress conditions. Furthermore, the p75NTR signaling modulates baseline Il6 expression in mice but has a lesser effect on stress-induced Il6 increase.
PHARMACOPSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Marcus W. Meinhardt, Simone Pfarr, Gregory Fouquet, Cathrin Rohleder, Manuela L. Meinhardt, Janet Barroso-Flores, Rebecca Hoffmann, Jerome Jeanblanc, Elisabeth Paul, Konstantin Wagner, Anita C. Hansson, Georg Koehr, Nils Meier, Oliver von Bohlen und Halbach, Richard L. Bell, Heike Endepols, Bernd Neumaier, Kai Schoenig, Dusan Bartsch, Mickael Naassila, Rainer Spanagel, Wolfgang H. Sommer
Summary: The study identified a common molecular pathological mechanism for both executive dysfunction and alcohol craving in alcohol-dependent patients, and proposed a personalized mGluR2 mechanism-based intervention strategy for medication development.
Article
Multidisciplinary Sciences
Javad Hami, Viola von Bohlen Und Halbach, Anja Tetzner, Thomas Walther, Oliver von Bohlen und Halbach
Summary: Numerous studies have shown evidence of a local renin-angiotensin system (RAS) in the central nervous system (CNS), with the identification of a novel receptor known as Mas-related G-protein coupled receptor D (MrgD). The distribution pattern of MrgD receptors in the adult mouse brain reveals its presence in specific areas related to reward and limbic functions, suggesting a potential role in processes such as pain perception/modulation, synaptic plasticity, learning, memory, and cognition.
Article
Biology
Viola von Bohlen Und Halbach, Simone Venz, Simon Nwakor, Christian Hentschker, Elke Hammer, Heike Junker, Andreas W. Kuss, Oliver von Bohlen Und Halbach, Lars R. Jensen
Summary: The study found that FTSJ1 deficiency in mice resulted in altered neuronal plasticity in the hippocampal area, both morphologically and physiologically. These changes may contribute to impaired learning and memory functions.
Editorial Material
Neurosciences
Oliver von Bohlen, Halbach
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Simone Venz, Viola von Bohlen Und Halbach, Christian Hentschker, Heike Junker, Andreas Walter Kuss, Thomas Sura, Elke Krueger, Uwe Voelker, Oliver von Bohlen Und Halbach, Lars Riff Jensen, Elke Hammer
Summary: A workflow for tandem mass spectrometry-based protein profiling of immunohistochemistry specimens was established and applied to tissue sections. The CA1 region of the hippocampus was investigated using protein extraction and digestion methods followed by mass spectrometry measurement and data analysis. Literature searches and Gene Ontology annotation verified the applicability of this method for global protein profiling using formalin-fixed and embedded material and previously used immunohistochemistry slides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Julia Sophie Ehlers, Katharina Bracke, Viola von Bohlen Und Halbach, Florian Siegerist, Nicole Endlich, Olivervon Bohlen Und Halbach
Summary: The SLC35F1 gene mutation in humans is associated with neurodevelopmental disorders. However, Slc35f1-deficient mice do not exhibit obvious deficits in learning and memory, and neuroanatomical parameters of neuronal plasticity are also unaffected. Therefore, they do not display a neurodevelopmental phenotype.
BRAIN STRUCTURE & FUNCTION
(2023)
Review
Cell Biology
Oliver von Bohlen und Halbach
Summary: The brain has its own intrinsic renin-angiotensin system (RAS) and ACE2 system, which play important roles in processes such as neuronal plasticity and learning and memory. Malfunctions in the brain ACE2 system are associated with disturbances in neuronal plasticity, and it is possible that Neuro-Covid may depend on a disturbed balance in the ACE2 system due to the high affinity of SARS-CoV-2 towards ACE2.
HISTOLOGY AND HISTOPATHOLOGY
(2021)