Review
Materials Science, Biomaterials
Song Xue, Guangfeng Ruan, Jia Li, Henning Madry, Chao Zhang, Changhai Ding
Summary: Osteoarthritis (OA) is a common joint disease characterized by cartilage degradation, bone remodeling, synovitis, meniscal degeneration, and osteophyte formation. Loss of articular cartilage is the most common manifestation of OA. Early detection and treatment of cartilage lesions are crucial due to the lack of self-repair capability.
BIOMATERIALS SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Xiaomeng Wang, Ying-Hwey Nai, Julian Gan, Cheryl Pei Ling Lian, Fraser Kirwan Ryan, Forest Su Lim Tan, Dexter Yak Seng Chan, Jun Jie Ng, Zhiwen Joseph Lo, Tze Tec Chong, Derek John Hausenloy
Summary: Peripheral artery disease (PAD) is a common and debilitating condition characterized by the narrowing of limb arteries. Non-invasive imaging techniques such as CT, MRI, and nuclear imaging have proven valuable in assessing PAD plaques and vessel walls. This review explores the advantages, limitations, and recent advancements of these imaging techniques, as well as the importance of molecular markers in PAD pathophysiology. Integrating molecular and imaging markers holds potential for improving our understanding of PAD, but technical constraints and the need for new molecular markers pose challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Federico Fortuni, Kensuke Hirasawa, Jeroen J. Bax, Victoria Delgado, Nina Ajmone Marsan
Summary: Severe tricuspid regurgitation has a significant negative impact on morbidity and mortality, but there are now various treatment options available, including transcatheter procedures for high surgical risk patients. Accurate assessment of the tricuspid valve and its surrounding structures is crucial for the management of TR patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Weichen Zhang, Dong Xu, Jing Zhang, Wanli Ouyang
Summary: The proposed Progressive Modality Cooperation (PMC) framework effectively transfers knowledge between source and target domains by utilizing multiple modality clues under MMDA and MMDA-PI settings. Through effective collaboration among multiple modalities, reliable pseudo-labeled target samples are selected, capturing modality-specific and modality-integrated information.
IEEE TRANSACTIONS ON IMAGE PROCESSING
(2021)
Article
Chemistry, Multidisciplinary
Ashwin Roy, Mohamed Mansour, David Oxborough, Tarekegn Geberhiwot, Richard Steeds
Summary: Fabry disease is a rare lysosomal storage disorder that affects multiple organs including the heart. Advanced cardiovascular imaging techniques, such as transthoracic echocardiography and cardiac magnetic resonance imaging, can help stage and prognosticate the disease. Early diagnosis using these imaging modalities allows for early initiation of enzyme replacement therapy, reducing the high mortality associated with Fabry cardiomyopathy.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Harley H. L. Chan, Stephan K. Haerle, Michael J. Daly, Jinzi Zheng, Lauren Philp, Marco Ferrari, Catriona M. Douglas, Jonathan C. Irish
Summary: The integrated augmented reality surgical navigation system enhances intra-operative visualization of concealed anatomical structures. Real-time tracking technology combined with a laser pico-projector accurately depicts virtual images on the animal body, highlighting the location of tumors and anatomical structures. Clinical applicability and high precision of the system were demonstrated in pre-clinical studies, with an accuracy noted to be <1mm.
Article
Chemistry, Multidisciplinary
Dana Cohen, Reut Mashiach, Lothar Houben, Andrea Galisova, Yoseph Addadi, David Kain, Alisa Lubart, Pablo Blinder, Hyla Allouche-Arnon, Amnon Bar-Shir
Summary: The study introduces small-sized glycomimetics for sensitive noninvasive in vivo imaging of inflammation, achieved through the involvement of the glycomimetics in inflammation. By doping the nanofluorides with paramagnetic elements, a significant enhancement in MRI sensitivity was achieved, indicating potential applications in multi-target imaging scenarios.
Article
Cardiac & Cardiovascular Systems
Dayan Yang, Tangna Wu, Lini Gao, Lili Liu, Fujin Liu, Xiangxiang Jing
Summary: This study reported a case of a 79-year-old female patient with cardiac lymphoma, diagnosed using myocardial contrast echocardiography and multi-modal imaging. Multi-modal imaging is of great value in determining the etiology, location, and blood supply of cardiac masses, and it complements conventional echocardiography, providing a basis for clinical treatment and decision-making.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Alessia Gimelli, Sabine Ernst, Riccardo Liga
Summary: Noninvasive cardiac imaging is essential for characterizing patients undergoing cardiac ablations, providing anatomical and functional information for better risk assessment. Imaging-guided electrophysiological procedures lead to improved outcomes and lower recurrence rates compared to traditional ablation procedures.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xin Tang, Jiawei Zhang, Yichun He, Xinhe Zhang, Zuwan Lin, Sebastian Partarrieu, Emma Bou Hanna, Zhaolin Ren, Hao Shen, Yuhong Yang, Xiao Wang, Na Li, Jie Ding, Jia Liu
Summary: Currently, biotechnologies allow the measurement of multiple high-dimensional modalities from the same cells. The authors developed UnitedNet, an explainable deep neural network, to analyze single-cell multi-modality biological data and quantify the relationship between gene expression and other modalities with cell-type specificity. UnitedNet demonstrated high accuracy in integrating multi-modal data and has the potential to facilitate the discovery of cell-type-specific regulation kinetics.
NATURE COMMUNICATIONS
(2023)
Article
Optics
Zhan Pang, Yike Wang, Yongchao Wang, Zezou Sun, Weizhi Qi, Lei Xi
Summary: Multimodal imaging combines various imaging modalities to observe vascular networks and morphological changes in deep tissues more comprehensively. The use of a commercial ultrasound platform demonstrates the potential of the method for future clinical translation.
Review
Cardiac & Cardiovascular Systems
Malgorzata Wamil, Marcos Goncalves, Alexander Rutherford, Alessandra Borlotti, Patricia Ann Pellikka
Summary: Diabetic heart disease is a significant healthcare problem, with diabetes patients having a twice as high cardiovascular death rate as the general population. Multimodality cardiac imaging plays a crucial role in diagnosing and managing diabetic heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hisanori Kosuge, Maki Nakamura, Ayako Oyane, Kazuko Tajiri, Nobuyuki Murakoshi, Satoshi Sakai, Akira Sato, Atsushi Taninaka, Taishiro Chikamori, Hidemi Shigekawa, Kazutaka Aonuma
Summary: This study evaluated the viability of macrophages with GNPs after NIR laser exposure and assessed the utility of intravenously injected GNPs for in vivo imaging of vascular inflammation in mice. The results showed that GNPs reduced macrophage viability upon NIR laser exposure and accumulated at sites of vascular inflammation, enabling detection of carotid atherosclerosis and AAAs in CT imaging. Therefore, GNPs have potential as multifunctional biologically compatible particles for the detection and therapy of vascular inflammation.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Review
Oncology
Mohamed Elshikh, Ahmed W. Moawad, Usama Salem, Sergio P. Klimkowski, Talaat Hassan, Brinda Rao Korivi, Corey T. Jensen, Sanaz Javadi, Khaled M. Elsayes
Summary: The lymphatic system is a complex vascular network responsible for interstitial fluid homeostasis, transport of large particles and cells, immunity, and lipid absorption in the gastrointestinal tract. Many malignancies induce lymphangiogenesis, increasing the likelihood of lymphatic spread. Radiologic evaluation is crucial for oncologic patient treatment and management, with multiple imaging modalities available for disease staging.
Review
Cardiac & Cardiovascular Systems
Tom Kai Ming Wang, Allan L. Klein
Summary: Advancements in multi-modality cardiac imaging have greatly improved the evaluation and treatment guidance of pericardial diseases, with echocardiography, CT, and MRI playing valuable roles in assessing different aspects of these conditions.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sonia Y. Angell, Michael McConnell, Cheryl A. M. Anderson, Kirsten Bibbins-Domingo, Douglas S. Boyle, Simon Capewell, Majid Ezzati, Sarah de Ferranti, Darrell J. Gaskin, Ron Z. Goetzel, Mark D. Huffman, Marsha Jones, Yosef M. Khan, Sonia Kim, Shiriki K. Kumanyika, Alexa T. McCray, Robert K. Merritt, Bobby Milstein, Dariush Mozaffarian, Tyler Norris, Gregory A. Roth, Ralph L. Sacco, Jorge F. Saucedo, Christina M. Shay, David Siedzik, Somava Saha, John J. Warner
Letter
Cardiac & Cardiovascular Systems
Mirwais Wardak, Gayatri Gowrishankar, Xin Zhao, Yonggang Liu, Edwin Chang, Mohammad Namavari, Tom Haywood, Moustafa T. Gabr, Evgenios Neofytou, Tony Chour, Xulei Qin, Jose G. Vilches-Moure, Jonathan Hardy, Christopher H. Contag, Michael V. McConnell, Joseph C. Wu, Sanjiv Sam Gambhir
Article
Cardiac & Cardiovascular Systems
David Calvin Goff, Sadiya Sana Khan, Donald Lloyd-Jones, Donna K. Arnett, Mercedes R. Carnethon, Darwin R. Labarthe, Matthew Shane Loop, Russell V. Luepker, Michael V. McConnell, George A. Mensah, Mahasin S. Mujahid, Martin Enrique O'Flaherty, Dorairaj Prabhakaran, Veronique Roger, Wayne D. Rosamond, Stephen Sidney, Gina S. Wei, Janet S. Wright
Summary: More than 40 years after the 1978 Bethesda Conference on the Declining Mortality from Coronary Heart Disease provided a blueprint for understanding declining rates of coronary heart disease, recent data suggests that the decline may have ended or even reversed. While mortality rates for overall cardiovascular disease are decelerating, those for heart failure are increasing. The symposium discussed trends in cardiovascular disease, obesity, and diabetes epidemics, as well as opportunities for promoting cardiovascular health and preventing disease.
Article
Chemistry, Multidisciplinary
Mahsa Gifani, Devon J. Eddins, Hisanori Kosuge, Yapei Zhang, Sesha L. A. Paluri, Timothy Larson, Nicholas Leeper, Leonore A. Herzenberg, Sanjiv Sam Gambhir, Michael McConnell, Eliver E. B. Ghosn, Bryan Ronain Smith
Summary: Targeting inflammatory immune cells in atherosclerotic plaques may provide clinically relevant diagnostic information about cardiovascular disease, and a new method combining ultraselective nanoparticle targeting and clinically-viable photoacoustic imaging has shown promise in accurately identifying and diagnosing inflamed plaques.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Health Care Sciences & Services
Dan E. Webster, Meghasyam Tummalacherla, Michael Higgins, David Wing, Euan Ashley, Valerie E. Kelly, Michael McConnell, Evan D. Muse, Jeffrey E. Olgin, Lara M. Mangravite, Job Godino, Michael R. Kellen, Larsson Omberg
Summary: VO2max is an important biometric for cardiovascular health and overall mortality, but the high cost and participant burden limit its widespread measurement in research and clinical settings. A digital VO2max estimation protocol using smartphone sensors was developed and validated in a diverse population, showing high accuracy across different skin tones and phone configurations. This protocol provides a cost-effective and convenient way to measure VO2max remotely.
JMIR MHEALTH AND UHEALTH
(2021)
Review
Cardiac & Cardiovascular Systems
Christophe Leclercq, Henning Witt, Gerhard Hindricks, Rodolphe P. Katra, Dave Albert, Andrea Belliger, Martin R. Cowie, Thomas Deneke, Paul Friedman, Mehdiyar Haschemi, Trudie Lobban, Isabelle Lordereau, Michael V. McConnell, Leonardo Rapallini, Eigil Samset, Mintu P. Turakhia, Jagmeet P. Singh, Emma Svennberg, Manish Wadhwa, Franz Weidinger
Summary: Digital technology has become an essential part of medicine, improving patient care and enabling individuals to better manage their own health. Wearable technologies and artificial intelligence allow for real-time monitoring and analysis of health data. Privacy and security concerns, as well as regulatory and value assessment processes, are important considerations in the development and implementation of digital tools.
Article
Cardiac & Cardiovascular Systems
Steven A. Lubitz, Anthony Z. Faranesh, Caitlin Selvaggi, Steven J. Atlas, David D. McManus, Daniel E. Singer, Sherry Pagoto, Michael V. McConnell, Alexandros Pantelopoulos, Andrea S. Foulkes
Summary: Undiagnosed atrial fibrillation can be detected using a PPG algorithm on wearable devices. The algorithm has a high positive predictive value and can identify individuals at risk for atrial fibrillation.
Review
Cardiac & Cardiovascular Systems
Christian O'Donnell, Pablo Amador Sanchez, Bettia Celestin, Michael V. Mcconnell, Francois Haddad
Summary: The echocardiographic assessment of right heart function has seen advancements in both physiology and methodology, including the emergence of artificial intelligence and point-of-care ultrasound. Recent studies have highlighted the prognostic value of certain metrics such as right ventricular longitudinal strain, right ventricular end-systolic dimensions, and right atrial size and function in pulmonary hypertension and heart failure. Methodological advances such as post-processing 3D software and AI-based quantification are also changing the landscape of right heart imaging. A multi-parametric approach guided by physiology and AI algorithms can help define integrated right heart profiles for improved disease detection and monitoring.
CURRENT CARDIOLOGY REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
W. Gregory Hundley, David A. Bluemke, Jan Bogaert, Scott D. Flamm, Marianna Fontana, Matthias G. Friedrich, Lars Grosse-Wortmann, Theodoros D. Karamitsos, Christopher M. Kramer, Raymond Y. Kwong, Michael McConnell, Eike Nagel, Stefan Neubauer, Robin Nijveldt, Dudley J. Pennell, Steffen E. Petersen, Subha Raman, Albert van Rossum
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Medicine, Research & Experimental
Sean Bae, Silviu Borac, Yunus Emre, Jonathan Wang, Jiang Wu, Mehr Kashyap, Si-Hyuck Kang, Liwen Chen, Melissa Moran, Julie Cannon, Eric S. Teasley, Allen Chai, Liu Yun, Neal Wadhwa, Michael Krainin, Michael Rubinstein, Alejandra Maciel, Michael V. McConnell, Shwetak Patel, Greg S. Corrado, James A. Taylor, Jiening Zhan, Ming Jack Po
Summary: This study validates the accuracy of smartphone camera-based techniques in measuring heart rate and respiratory rate across various pre-defined subgroups.
COMMUNICATIONS MEDICINE
(2022)
Article
Health Care Sciences & Services
Matthew Abueg, Robert Hinch, Neo Wu, Luyang Liu, William Probert, Austin Wu, Paul Eastham, Yusef Shafi, Matt Rosencrantz, Michael Dikovsky, Zhao Cheng, Anel Nurtay, Lucie Abeler-Dorner, David Bonsall, Michael V. McConnell, Shawn O'Banion, Christophe Fraser
Summary: The study shows that combining digital exposure notifications with other measures can effectively reduce COVID-19 infection and mortality rates, complementing traditional contact tracing. This research provides guidance for health authorities, highlighting the importance of digital technologies in fighting the spread of the virus.
NPJ DIGITAL MEDICINE
(2021)
Article
Medical Informatics
Anna Shcherbina, Steven G. Hershman, Laura Lazzeroni, Abby C. King, Jack W. O'Sullivan, Eric Hekler, Yasbanoo Moayedi, Aleksandra Pavlovic, Daryl Waggott, Abhinav Sharma, Alan Yeung, Jeffrey W. Christle, Matthew T. Wheeler, Michael V. McConnell, Robert A. Harrington, Euan A. Ashley
LANCET DIGITAL HEALTH
(2019)
Article
Cardiac & Cardiovascular Systems
Yuko Tada, Atsushi Tachibana, Shahriar Heidary, Phillip C. Yang, Michael McConnell, Rajesh Dash
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2019)
Article
Health Care Sciences & Services
Marcus A. Badgeley, John R. Zech, Luke Oakden-Rayner, Benjamin S. Glicksberg, Manway Liu, William Gale, Michael McConnell, Bethany Percha, Thomas M. Snyder, Joel T. Dudley
NPJ DIGITAL MEDICINE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed M. Ghanem, Jatin Raj Matta, Reham Elgarf, Ahmed Hamimi, Ranganath Muniyappa, Hadjira Ishaq, Colleen Hadigan, Michael McConnell, Ahmed M. Gharib, Khaled Z. Abd-Elmoniem
RADIOLOGY-CARDIOTHORACIC IMAGING
(2019)