Article
Multidisciplinary Sciences
Tanvi Tavarna, Bryce Wolfe, Xiao-jun Wu, Leticia Reyes
Summary: This study found that impaired spiral artery remodeling caused by Porphyromonas gingivalis infection was associated with disturbances in uterine natural killer cells and placental bed decidual stroma.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Chow-Seng Kong, Alexandra Almansa Ordonez, Sarah Turner, Tina Tremaine, Joanne Muter, Emma S. Lucas, Emma Salisbury, Rita Vassena, Gustavo Tiscornia, Ali A. Fouladi-Nashta, Geraldine Hartshorne, Jan J. Brosens, Paul J. Brighton
Summary: The study found that uterine natural killer cells play a crucial role in embryo biosensing and implantation process, highlighting their importance in selectively eliminating senescent decidual cells.
Review
Pharmacology & Pharmacy
Rajeev K. Singla, Sahar Behzad, Johra Khan, Christos Tsagkaris, Rupesh K. Gautam, Rajat Goyal, Hitesh Chopra, Bairong Shen
Summary: Endometrial cancer is a common type of cancer among women, and kinases play a significant role in its development. Cyclin-dependent kinases are believed to be involved in the pathogenesis of endometrial cancer. Natural compounds containing certain substances have shown potential as anticancer agents for the treatment of endometrial cancer. Clinical trials have demonstrated the efficacy of two natural compounds as second-line treatments for this type of cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Benedikt Strunz, Jonna Bister, Hanna Jonsson, Iva Filipovic, Ylva Crona-Guterstam, Egle Kvedaraite, Natalie Sleiers, Bogdan Dumitrescu, Mats Brannstrom, Antonio Lentini, Bjorn Reinius, Martin Cornillet, Tim Willinger, Sebastian Gidlof, Russell S. Hamilton, Martin A. Ivarsson, Niklas K. Bjorkstrom
Summary: The study reveals a continuous differentiation pathway of human uterine natural killer cells coupled with profound functional changes in response to local tissue regeneration and pregnancy.
SCIENCE IMMUNOLOGY
(2021)
Article
Oncology
Michelle K. Becker-Hapak, Niraj Shrestha, Ethan McClain, Michael J. Dee, Pallavi Chaturvedi, Gilles M. Leclerc, Lynne I. Marsala, Mark Foster, Timothy Schappe, Jennifer Tran, Sweta Desai, Carly C. Neal, Patrick Pence, Pamela Wong, Julia A. Wagner, David A. Russler-Germain, Xiaoyun Zhu, Catherine M. Spanoudis, Victor L. Gallo, Christian A. Echeverri, Laritza L. Ramirez, Lijing You, Jack O. Egan, Peter R. Rhode, Jin-an Jiao, Gabriela J. Muniz, Emily K. Jeng, Caitlin A. Prendes, Ryan P. Sullivan, Melissa M. Berrien-Elliott, Hing C. Wong, Todd A. Fehniger
Summary: NK cells show promise as a cellular therapy for cancer, but challenges in production of required reagents exist. A novel HFPC platform was developed to activate NK cells against cancer, showing potential for advancement in clinical GMP-grade memory-like NK cell production.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Jaya Lakshmi Thangaraj, Minh-Trang Thi Phan, SoonHo Kweon, Jinho Kim, Jong-Min Lee, Ilwoong Hwang, Jeehun Park, Junsang Doh, Seung-Hwan Lee, Manh-Cuong Vo, Tan-Huy Chu, Ga-Young Song, Seo-Yeon Ahn, Sung-Hoon Jung, Hyeoung-Joon Kim, Duck Cho, Je-Jung Lee
Summary: Genetically engineered K562 cells expressing OX40L, mbIL-18, and mbIL-21 have been shown to improve the expansion of NK cells, increase activation signals, and enhance their cytotoxic activity towards multiple myeloma cells.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Medicine, General & Internal
Laurentiu Craciunas, Nikolaos Zdoukopoulos, Suganthi Vinayagam, Lamiya Mohiyiddeen
Summary: This study investigates the effectiveness and safety of different hormonal regimens on uterine and endometrial development in women with POI. Three studies were included, but due to small sample sizes, meta-analysis was not feasible, resulting in very low-certainty evidence.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Multidisciplinary Sciences
Mengwei Han, Luni Hu, Di Wu, Yime Zhang, Peng Li, Xingyu Zhao, Yanyu Zeng, Guanqun Ren, Zhiyuan Hou, Yanli Pang, Tongbiao Zhao, Chao Zhong
Summary: This study characterizes the differentiation and activation of uterine trNK cells during pregnancy, revealing a mechanism involving IL-21R-STAT3 axis and an apoptotic program to control their functionality and avoid tissue damage.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
David B. Rosen, Anne Mansson Kvarnhammar, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Enping Hong, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zuniga, Kathy Bang, Simran Singh Sabharwal, Karan Uppal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Diana Reich, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M. Singel, Kennett Sprogoe, Juha Punnonen
Summary: Recombinant interleukin-2 (IL-2) is an approved cancer immunotherapy, but it has severe toxicities and suboptimal pharmacokinetics. TransCon IL-2 beta/gamma is a novel prodrug designed to address these issues, showing sustained release of IL-2 and potential antitumor activity in animal models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Min Liu, Yuan Meng, Leisheng Zhang, Zhongchao Han, Xiaoming Feng
Summary: Study found that the combined use of IL-2, IL-15, IL-18 can best promote the ex vivo expansion and proportion of NK cells in peripheral blood mononuclear cells. Meanwhile, the obtained NK cell population expressed high levels of activating molecules (CD16 and NKG2D) and exhibited splendid cytotoxicity against K562 cell line.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tsvetana Petrova, Jiazhen Zhang, Sambit K. Nanda, Clara Figueras-Vadillo, Philip Cohen
Summary: The atypical E3 ligase HOIL-1 plays a role in restricting IL-18 signaling and cytokine production by forming ester-linked ubiquitin bonds, with implications for immune cell activation. Changes in HOIL-1-catalysed ester-linked ubiquitylation can promote or reduce cytokine production depending on the context, potentially due to differences in the ubiquitylation of IRAK2.
Article
Microbiology
Sho Sugawara, Brady Hueber, Griffin Woolley, Karen Terry, Kyle Kroll, Cordelia Manickam, Daniel R. Ram, Lishomwa C. Ndhlovu, Paul Goepfert, Stephanie Jost, R. Keith Reeves
Summary: Natural killer (NK) cells play important roles in defense against HIV-1 and SIV infections, but their functions are often dysregulated. The comprehensive understanding of NK cell signaling is lacking. In this study, we developed a multiplex signaling assay for NK cells and found that CD16 signaling is downregulated in chronic lentiviral infections. We demonstrated that increased ADAM17 expression and elevated plasma IL-18 levels are involved in this downregulation, and perturbing ADAM17 can restore CD16 expression and signaling. This study provides insights into impaired NK cell activities and offers potential for NK cell-based immunotherapeutics for HIV-1 disease.
Article
Oncology
Linda Bilonda Mutala, Cecile Deleine, Matilde Karakachoff, Delphine Dansette, Kathleen Ducoin, Romain Oger, Olivia Rousseau, Juliette Podevin, Emilie Duchalais, Pierre Fourquier, Wassila El Alami Thomas, Pierre-Antoine Gourraud, Jaafar Bennouna, Camille Brochier, Nadine Gervois, Celine Bossard, Anne Jarry
Summary: In colorectal cancer, the interaction between tumor cells and tumor-infiltrating lymphocytes (TILs) plays a crucial role in the disease progression. The study aimed to investigate the potential modulatory role of the caspase-1/IL-18 axis in tumor cells on TILs in CRC. Results indicated that most CRC tumor cells can be considered as innate immune cells with a functional caspase-1/IL-18 axis that can modulate the adaptive Th1/Tc1 anti-tumor response of TILs. Targeting the caspase-1/IL-18 axis may improve the anti-tumor immune response in subgroups of CRC.
Article
Immunology
Yung-Chang Lin, Cheng-Heng Wu, Pin-Jung Chen, Chien-Hao Huang, Chan-Keng Yang, Avijit Dutta, Ching-Tai Huang, Chun-Yen Lin
Summary: The roles of tumor-infiltrating CD4(+)Foxp3(-) T cells have been further clarified in a mouse model of colon cancer. These cells maintain an effector phenotype, express inflammatory cytokines and cytolytic molecules, and exhibit cytotoxic function against tumor cells. They are distinct from CD4(+) regulatory T cells and are activated through the IL-12/IL-27 pathway. This study highlights the importance of understanding the plasticity and functional diversity within the CD4(+) T cell population in the tumor microenvironment.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Immunology
Mengmeng Shen, Yanfeng Liu, Xiaona Ma, Qingwen Zhu
Summary: In this study, we found that Erbu Zhuyu decoction (EBZY) can promote embryo implantation in mice with embryo implantation dysfunction (EID) by enhancing endometrial angiogenesis through activation of the PI3K/Akt/eNOS pathway. However, there is no evidence to suggest that EBZY can regulate the expression of uterine natural killer (uNK) cells.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Marie Petitbarat, Paolo Durigutto, Paolo Macor, Roberta Bulla, Alessandro Palmioli, Anna Bernardi, Maria-Grazia De Simoni, Nathalie Ledee, Gerard Chaouat, Francesco Tedesco
JOURNAL OF IMMUNOLOGY
(2015)
Review
Immunology
Mona Rahmati, Marie Petitbarat, Sylvie Dubanchet, Armand Bensussan, Gerard Chaouat, Nathalie Ledee
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2015)
Review
Immunology
Nathalie Ledee, Marie Petitbarat, Lucie Chevrier, Dominique Vitoux, Katia Vezmar, Mona Rahmati, Sylvie Dubanchet, Hanne Gahery, Armand Bensussan, Gerard Chaouat
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Immunology
Nathalie Ledee, Laura Prat-Ellenberg, Lucie Chevrier, Richard Balet, Cynthia Simon, larisse Lenoble, Elie El Irani, Dominique Bouret, Guy Cassuto, Dominique Vitoux, Katia Vezmar, Armand Bensussan, Gerard Chaouat, Marie Petitbarat
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2017)
Article
Obstetrics & Gynecology
Alexandre Rouen, Lea Carlier, Solveig Heide, Matthieu Egloff, Pauline Marzin, Flavie Ader, Mathias Schwartz, Eli Rogers, Nicole Joye, Richard Balet, Nathalie Ledee, Laura Prat-Ellenberg, Nino Guy Cassuto, Jean-Pierre Siffroi
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Article
Immunology
Nathalie Ledee, Laura Prat-Ellenberg, Marie Petitbarat, Lucie Chevrier, Cynthia Simon, Elie El Irani, Dominique Vitoux, Armand Bensussan, Gerard Chaouat
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2018)
Article
Obstetrics & Gynecology
N. Ledee, V. Gridelet, S. Ravet, C. Jouan, O. Gaspard, F. Wenders, F. Thonon, N. Hincourt, M. Dubois, J. M. Foidart, C. Munaut, S. Perrier d'Hauterive
HUMAN REPRODUCTION
(2013)
Article
Oncology
Nathalie Ledee, Carine Munaut, Julie Aubert, Valerie Serazin, Mona Rahmati, Gerard Chaouat, Olivier Sandra, Jean Michel Foidart
JOURNAL OF PATHOLOGY
(2011)
Article
Immunology
Nathalie Ledee, Claudine Vasseur, Marie Petitbarat, Lucie Chevrier, Katia Vezmar, Geraldine Dray, Sandra Cheniere, Annina Lobersztajn, Dominique Vitoux, Guy Nino Cassuto, Gerard Chaouat
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Jennifer H. Southcombe, Nathalie Ledee, Sophie Perrier d'Hauterive, Karen Turner, Tim Child, James V. Snider, Christopher W. G. Redman, Ian L. Sargent, Ingrid Granne
Article
Multidisciplinary Sciences
Mona Rahmati, Marie Petitbarat, Sylvie Dubanchet, Armand Bensussan, Gerard Chaouat, Nathalie Ledee
Article
Genetics & Heredity
Lucie Pierron, Alexandra Irrmann, Alienor de Chalus, Adrien Bloch, Solveig Heide, Eli Rogers, Nathalie Ledee, Laura Prat-Ellenberg, Aurelie Coussement, Jean-Michel Dupont, Nino Guy Cassuto, Jean-Pierre Siffroi, Alexandre Rouen
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Endocrinology & Metabolism
Laure Noel, Anne-Francoise Donneau, Caroline Jouan, Sophie Schoenen, Nathalie Ledee, Jean-Michel Foidart, Michelle Nisolle, Carine Munaut
GYNECOLOGICAL ENDOCRINOLOGY
(2020)
Article
Obstetrics & Gynecology
Fabien Krief, Cynthia Simon, Rebecca Goldstein, Laura Prat Ellenberg, Nathalie Ledee
Summary: The study aimed to analyze whether treatment with a combination of pentoxifylline and tocopherol could increase endometrial volume in patients with poor endometrial development. The findings revealed that this combination therapy significantly increased endometrial volume.
Article
Biotechnology & Applied Microbiology
Nino Guy Cassuto, David Piquemal, Florence Boitrelle, Lionel Larue, Nathalie Ledee, Ghada Hatem, Lea Ruoso, Dominique Bouret, Jean-Pierre Siffroi, Alexandre Rouen, Said Assou
Summary: This study demonstrates a strong correlation between sperm morphology and gene expression, providing a biomarker panel for sperm analysis during ART and a new tool to explore male infertility.
BIOMED RESEARCH INTERNATIONAL
(2021)