Article
Immunology
Lin Qi, Ruiling Xu, Xiaolei Ren, Wenchao Zhang, Zhimin Yang, Chao Tu, Zhihong Li
Summary: This study identified necroptosis-related genes (NRGs) in soft tissue sarcomas (STSs) and found their potential role in prognosis. The results showed that the risk score based on the necroptosis-related gene signature could serve as an independent prognostic factor and could also predict immune infiltration. Furthermore, the necroptosis-related gene signature was validated in other malignancies, indicating its potential as a prognostic indicator in different types of cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Catherine Sarre-Lazcano, Sinziana Dumitra, Marco Fiore
Summary: Pelvic soft tissue sarcomas (PSTS) are a rare and heterogeneous group of tumors that differ from retroperitoneal sarcomas (RPS). Adequate imaging and preoperative biopsy are crucial for differential diagnosis and treatment planning. Surgical approach and multidisciplinary teamwork are essential due to anatomic constraints and potential complications. Early referral to specialized centers is recommended for optimal resection and improved survival. International consensus on PSTS treatment is needed, similar to recent efforts for RPS.
Article
Oncology
Dorian Yarih Garcia-Ortega, Alethia Alvarez-Cano, Miguel Angel Clara-Altamirano, Claudia Caro-Sanchez, Cuauhtemoc De la Cruz Ruvalcaba-Gonzalez, Carlo Cesar Cortes-Gonzalez, Kuauhyama Luna-Ortiz
Summary: This study analyzed the incidence and clinical impact of histologically proven bone invasion in individuals with soft tissue sarcomas. Results showed that bone invasion was associated with lower overall survival (OS) and disease-free survival (DFS), while high histological grade was also related to worse OS.
SURGICAL ONCOLOGY-OXFORD
(2022)
Article
Cell Biology
Zihua Li, Zhengwei Duan, Keyao Jia, Yiwen Yao, Kaiyuan Liu, Yue Qiao, Qiuming Gao, Yunfeng Yang, Guodong Li, Anquan Shang
Summary: This study investigated the role of cuproptosis-related genes (CRGs) in soft tissue sarcoma (STS) and found that different CRG expression patterns were associated with prognosis in sarcoma patients. The study also revealed that these genes may affect immune cell infiltration and prognosis of sarcoma by regulating mitochondrial bioprocesses.
Review
Oncology
Arthur Lebas, Clara Le Fevre, Waisse Waissi, Isabelle Chambrelant, David Brinkert, Georges Noel
Summary: This article provides a systematic review of studies on soft tissue sarcomas of the extremities treated with radiotherapy. The analysis reveals the great heterogeneity among these studies and the difficulty in identifying significant prognostic factors for the benefit of radiotherapy. The review provides valuable insights for optimizing radiotherapy treatment for patients with soft tissue sarcomas of the extremities.
Article
Oncology
Mohamed Kelany, Thomas F. E. Barth, Dina Salem, Marwa M. Shekweer
Summary: PD-L1 expression ranged from 19% to 92% in different cancer subtypes. Positive PD-L1 expression was observed in 24% of soft tissue sarcomas, with rhabdomyosarcoma and desmoid tumors showing the highest prevalence. Patients with positive PD-L1 expression tended to have worse survival outcomes, but the results did not reach statistical significance. Larger clinical trials are needed to validate PD-L1 as a poor prognostic biomarker.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Review
Oncology
Eve Merry, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Soft tissue sarcomas are rare and heterogeneous tumors with limited treatment options, but the development of gene expression profiling has provided new opportunities in sarcoma applications. Transcriptomic analysis has improved understanding of the cancer biology of these rare cancers and identified potential novel therapeutic targets. The current transcriptomic signatures in sarcomas require prospective validation for clinical application.
NPJ PRECISION ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
William G. J. Kerrison, Alexander T. J. Lee, Khin Thway, Robin L. Jones, Paul H. Huang
Summary: Immunotherapy in soft tissue sarcoma has become a popular and promising therapeutic strategy, with immune checkpoint inhibitors showing effectiveness in certain subtypes. Combination therapies have also shown enhanced response rates.
Article
Oncology
Stefano Chiaravalli, Luca Bergamaschi, Virginia Livellara, Giovanna Sironi, Nadia Puma, Olga Nigro, Giovanna Gattuso, Roberto Luksch, Monica Terenziani, Filippo Spreafico, Cristina Meazza, Marta Podda, Veronica Biassoni, Elisabetta Schiavello, Carlo Morosi, Maura Massimino, Michela Casanova, Andrea Ferrari
Summary: This study investigated the pattern of relapse, salvage rates, and factors correlating with the final outcome in pediatric non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) patients. The results showed that the outcome of recurrent NRSTS patients is poor. Local and late relapses as well as achieving secondary remission were associated with better survival rates.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Oncology
Changkai Zhou, Xue Chen, Ying Huang, Qi Zhang, Shu Zhu, Wei Fu
Summary: This article discusses the progress made in the use of nanotechnology for the diagnosis and treatment of soft tissue sarcomas (STS) and highlights the future prospects of STS multimodality therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Sean J. Judge, Joshua D. Bloomstein, Cyrus J. Sholevar, Morgan A. Darrow, Kevin M. Stoffel, Logan V. Vick, Cordelia Dunai, Sylvia M. Cruz, Aryana M. Razmara, Arta M. Monjazeb, Robert B. Rebhun, William J. Murphy, Robert J. Canter
Summary: This study analyzed the gene expression profile of T cells, natural killer (NK) cells, and tumor cells in soft tissue sarcomas (STS). The results showed that NK cells had stable gene expression between blood and tumor subsets, while T cells exhibited upregulation of both activating and inhibitory genes in tumor-infiltrating subsets. Tumors with increased immune cell infiltration and higher expression of the pro-inflammatory receptor TLR4 showed improved survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Andrea Sambri, Emilia Caldari, Michele Fiore, Riccardo Zucchini, Claudio Giannini, Maria Giulia Pirini, Paolo Spinnato, Alberta Cappelli, Davide Maria Donati, Massimiliano De Paolis
Summary: There is still lack of standardized description for assessing margin status of soft tissue sarcomas, highlighting the need for uniform classification and standardization.
Article
Biotechnology & Applied Microbiology
Dandan Zou, Yang Wang, Meng Wang, Bo Zhao, Fei Hu, Yanguo Li, Bingming Zhang
Summary: Soft tissue sarcomas (STSs) are rare and heterogeneous mesenchymal neoplasms. In this study, immune scores and stromal scores of STS patients were evaluated using RNA sequencing data from the TCGA database. A ceRNA network was established through bioinformatics analysis and several TME-related biomarkers with prognostic value were identified, showing potential for prognostic prediction and immune therapy in STS patients.
Article
Oncology
Markus Albertsmeier, Annelore Altendorf-Hofmann, Lars H. Lindner, Rolf D. Issels, Eric Kampmann, Hans-Roland Duerr, Martin K. Angele, Frederick Klauschen, Jens Werner, Achim A. Jungbluth, Thomas Knoesel
Summary: This study demonstrates that VISTA is broadly expressed across subtypes of soft tissue sarcoma and is associated with increased tumor-infiltrating lymphocytes, PD-1, PD-L1, and CD3 expression. Patients with VISTA(+) tumors exhibit improved survival.
Article
Oncology
Patrick Groothuis, Nicola Penel, Antoine Italiano, Nuria Kotecki, Fred Dijcks, Wim Dokter
Summary: Soft tissue sarcoma (STS) is a difficult-to-treat malignancy originating from mesenchymal or connective tissues. The molecule 5T4/trophoblast glycoprotein is found to be prominently expressed on the cell surface of many STS subtypes, making it a potential target for targeted therapies. Further investigation is warranted to determine whether this antigen could trigger an anti-tumor immune response or serve as a target for delivering more potent toxins through antibody drug conjugates, as it is expressed in more than 50% of other STS subtypes.
Article
Gastroenterology & Hepatology
Christopher G. Fenton, Hagar Taman, Jon Florholmen, Sveinung W. Sorbye, Ruth H. Paulssen
Summary: This study used RNA-Seq technology to compare remission, active UC, and healthy control patients, identifying specific transcriptional signatures for UC in remission with changes in gene expression levels. The results showed partial restoration and improvement of homeostasis in the epithelial mucus layer and revival of immunological functions in UC remission patients. The composition of bacterial gut flora may play a key role in UC remission.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Oncology
Mehrdad Rakaee, Thomas K. Kilvaer, Simin Jamaly, Thomas Berg, Erna-Elise Paulsen, Marte Berglund, Elin Richardsen, Sigve Andersen, Samer Al-Saad, Mette Poehl, Francesco Pezzella, David J. Kwiatkowski, Roy M. Bremnes, Lill-Tove Rasmussen Busund, Tom Donnem
Summary: The study found that TLS score can be used to predict survival rates in NSCLC patients, with different scoring models and measurement methods having a significant impact on prognosis.
BRITISH JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Hallgeir Selven, Lill-Tove Rasmussen Busund, Sigve Andersen, Roy M. Bremnes, Thomas Karsten Kilvaer
Summary: High expression of miR-126 is associated with increased disease-specific survival in colon cancer patients, and it is an independent predictor of improved disease-specific survival in tumor tissue. This finding of miR-126 as a positive prognostic factor may help identify patients who could benefit from adjuvant chemotherapy.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Oddmund Nestegard, Behrouz Moayeri, Fred-Arne Halvorsen, Tor Tonnesen, Sveinung Wergeland Sorbye, Eyvind Paulssen, Kay-Martin Johnsen, Rasmus Goll, Jon Ragnar Florholmen, Kjetil K. Melby
Summary: This study characterized the antimicrobial resistance pattern of H. pylori before and after treatment, and found that clarithromycin resistance was more frequent in the treatment-resistant group. No resistance was observed for amoxicillin and levofloxacin.
Article
Multidisciplinary Sciences
Hallgeir Selven, Sigve Andersen, Mona Pedersen, Ana Paola Giometti Lombardi, Lill-Tove Rasmussen Busund, Thomas Karsten Kilvaer
Summary: This study investigated the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. The results showed that high expression of both miR-17-5p and miR-20a-5p is associated with a favorable prognosis and inhibits cell migration.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jan-Magnus Kvamme, Sveinung Sorbye, Jon Florholmen, Trond S. Halstensen
Summary: This study found a high prevalence of adult celiac disease (CD) in the population of Tromso, Norway, with the majority of patients being previously undiagnosed. A gluten-free diet (GFD) resulted in significant improvements in gastrointestinal symptoms and health-related quality of life for these patients. Therefore, a GFD may be important for the treatment and management of CD patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Nikita Shvetsov, Morten Gronnesby, Edvard Pedersen, Kajsa Mollersen, Lill-Tove Rasmussen Busund, Ruth Schwienbacher, Lars Ailo Bongo, Thomas Karsten Kilvaer
Summary: Tumor tissues from patients contain valuable prognostic and predictive information. Our approach utilizes AI pipelines and training data to identify tissue-infiltrating lymphocytes (TILs) in lung cancer tissue and provide prognostic information. This method has the potential to pave the way for large-scale deployment of digital pathology.
Article
Gastroenterology & Hepatology
Kay-Martin Johnsen, Jon Florholmen, Oystein K. Moe, Mona Gundersen, Julia Beilfuss, Hege Kileng, Sveinung W. Sorbye, Rasmus Goll
Summary: This study aims to describe the long-term outcomes of UC patients following discontinuation of anti-TNF therapy and explore potential biomarkers for predicting outcome.
BMC GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Khalid Al-Shibli, Hiba Abdul Latif Mohammed, Ramona Maurseth, Mikkel Fostervold, Sebastian Werner, Sveinung Wergeland Sorbye
Summary: The study aimed to investigate the detection rate of CIN3+ in women aged 25-39 with normal cytology by using a 3-type HPV mRNA test as a targeted quality assurance measure. Results showed that testing women with normal cytology result using a specific 3-type HPV mRNA test can increase the screening program sensitivity without an excessive additional workload. Women with normal cytology and a negative HPV mRNA test have a very low risk of cervical cancer.
Article
Oncology
Amir Rad, Sveinung Wergeland Sorbye, Sweta Tiwari, Maja-Lisa Lochen, Finn Egil Skjeldestad
Summary: Cervical cancer is the fourth most common cancer in women worldwide. Persistent high-risk human papillomavirus (HPV) can cause invasive cervical cancer through a series of precancerous lesions. Screening women with either cytology examinations or a test detecting HPV infection can prevent cervical cancer. HPV tests are substituting cytology examinations in cervical cancer screening, but more knowledge is needed about the screening performance of HPV tests, especially among younger women. Our findings suggest that women with a negative result may extend the screening interval up to 10 years.
Article
Oncology
Hallgeir Selven, Lill-Tove Rasmussen Busund, Sigve Andersen, Mona Irene Pedersen, Ana Paola Giometti Lombardi, Thomas Karsten Kilvaer
Summary: This study investigated the expression of protein biomarkers in stromal and tumor tissue of colon cancer patients. High expression of IRS1 in stromal tissue and RUNX3 and SMAD4 in both stromal and tumor tissue were associated with better prognosis. Particularly, the expression of RUNX3 in stromal tissue was correlated with the density of tumor-infiltrating lymphocytes. This finding has implications for understanding the role of lymphocytes in prognosis and improving immunotherapy effectiveness in colon cancer.
Article
Oncology
Erna-Elise Paulsen, Sigve Andersen, Mehrdad Rakaee, Mona Irene Pedersen, Ana Paola Lombardi, Mette Pohl, Thomas Kilvaer, Lill-Tove Busund, Francesco Pezzella, Tom Donnem
Summary: This study investigates the different microvessel patterns in non-small cell lung carcinomas (NSCLC) and their associations with immune cell infiltration. The non-angiogenic alveolar pattern is found to be prevalent in NSCLC and is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
M. Rakaee, S. Andersen, K. Giannikou, E. -E Paulsen, T. K. Kilvaer, L. -T. R. Busund, T. Berg, E. Richardsen, A. P. Lombardi, E. Adib, M. I. Pedersen, M. Tafavvoghi, S. G. F. Wahl, R. H. Petersen, A. L. Bondgaard, C. W. Yde, C. Baudet, P. Licht, M. Lund-Iversen, B. H. Gronberg, L. Fjellbirkeland, A. Helland, M. Pohl, D. J. Kwiatkowski, T. Donnem
Summary: This study aimed to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer patients. The model, based on machine learning, classified tumors into three categories based on the spatial distribution of CD8+ T cells. The study found significant associations between the immune phenotypes and adaptive immunity gene expression signatures.
ANNALS OF ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Heidi Holmen, Are Martin Holm, Thomas Karsten Kilvaer, Tone Marte Ljosa, Lars-Petter Granan, Christopher Ekholdt, Lotte Sandberg Larsen, Erik Fosse
Summary: This study aims to evaluate the effectiveness of a digital outpatient service intervention, providing personalized follow-up and improving patients' health literacy. The intervention uses a mobile app and online chat platform for self-monitoring and patient-reported outcomes, with a traffic light system to alert healthcare workers to urgent patient reports. This multicenter, non-randomized controlled trial is expected to yield results in December 2023, providing important knowledge about the applicability and effects of digital healthcare services.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Oncology
Sveinung Wergeland Sorbye, Bente Marie Falang, Matthys H. Botha, Leon Cornelius Snyman, Haynes van der Merwe, Cathy Visser, Karin Richter, Greta Dreyer
Summary: This study examined the potential of a test-and-treat strategy using mRNA HPV tests to prevent cervical cancer in a high-prevalence HIV population. The results suggest that testing for mRNA-HPV genotyping can effectively prevent cervical cancer.
