Identification of Candidate Small-Molecule Therapeutics to Cancer by Gene-Signature Perturbation in Connectivity Mapping

Does Breast Cancer Start in the Womb?

(2010) Ana M. Soto et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-Induced Regulation of Target Expression

(2010) Murat Iskar et al.   PLoS Computational Biology

The Role of Retinoid Deficiency and Estrogens as Cofactors in Cervical Cancer

(2009) Patricio Gariglio et al.   ARCHIVES OF MEDICAL RESEARCH

Induction of TAp63 by histone deacetylase inhibitors

(2009) Berna S. Sayan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway

(2009) Soo-Jung Park et al.   BIOCHEMICAL PHARMACOLOGY

sscMap: An extensible Java application for connecting small-molecule drugs using gene-expression signatures

(2009) Shu-Dong Zhang et al.   BMC BIOINFORMATICS

GEM-TREND: a web tool for gene expression data mining toward relevant network discovery

(2009) Chunlai Feng et al.   BMC GENOMICS

Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures

(2009) Chiara Braconi et al.   CANCER

Combined cetuximab and genistein treatment shows additive anti-cancer effect on oral squamous cell carcinoma

(2009) Sung-Jin Park et al.   CANCER LETTERS

Resveratrol Suppresses Growth of Human Ovarian Cancer Cells in Culture and in a Murine Xenograft Model: Eukaryotic Elongation Factor 1A2 as a Potential Target

(2009) M.-H. Lee et al.   CANCER RESEARCH

Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronanin vitroand peritoneal metastasisin vivo

(2009) Futoshi Teranishi et al.   CANCER SCIENCE

Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia

(2009) C. Wu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Combination of Proteasome and HDAC Inhibitors for Uterine Cervical Cancer Treatment

(2009) Z. Lin et al.   CLINICAL CANCER RESEARCH

Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds

(2009) K. De Preter et al.   CLINICAL CANCER RESEARCH

Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis

(2009) Mariela Bilotas et al.   FERTILITY AND STERILITY

Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target

(2009) Erik D. Wiklund et al.   INTERNATIONAL JOURNAL OF CANCER

Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines

(2009) D Eads et al.   Journal of Inflammation-London

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

(2009) Lena Wendeburg et al.   Journal of Neuroinflammation

Aromatase inhibitors in breast cancer

(2009) Stephen Hiscox et al.   MATURITAS

Retinoid and thiazolidinedione therapies in melanoma: an analysis of differential response based on nuclear hormone receptor expression

(2009) Joshua P Klopper et al.   Molecular Cancer

Pharmacogenomics in acute myeloid leukemia

(2009) Christophe Roumier et al.   PHARMACOGENOMICS

Application of connectivity mapping in predictive toxicology based on gene-expression similarity

(2009) Joshua L. Smalley et al.   TOXICOLOGY

Antipsychotic Drugs Inhibit the Function of Breast Cancer Resistance Protein

(2008) Jun-Sheng Wang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia

(2008) C. K. Cheng et al.   BLOOD

A simple and robust method for connecting small-molecule drugs using gene-expression signatures

(2008) Shu-Dong Zhang et al.   BMC BIOINFORMATICS

An indicator of cancer: downregulation of Monoamine Oxidase-A in multiple organs and species

(2008) Leszek A Rybaczyk et al.   BMC GENOMICS

Prostacyclin Prevents Murine Lung Cancer Independent of the Membrane Receptor by Activation of Peroxisomal Proliferator-Activated Receptor  

(2008) R. Nemenoff et al.   Cancer Prevention Research

Expanding the Use of Retinoids in Acute Myeloid Leukemia: Spotlight on Bexarotene

(2008) S. McNamara et al.   CLINICAL CANCER RESEARCH

A Phase I Study of Bexarotene, a Retinoic X Receptor Agonist, in Non-M3 Acute Myeloid Leukemia

(2008) D. E. Tsai et al.   CLINICAL CANCER RESEARCH

Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E2

(2008) Myoungseok Han et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression

(2008) Luigi Scotto et al.   GENES CHROMOSOMES & CANCER

Update on novel therapeutic agents for cervical cancer

(2008) Josep Maria del Campo et al.   GYNECOLOGIC ONCOLOGY

In vitro biology of human myeloid leukemia

(2008) Hector Mayani et al.   LEUKEMIA RESEARCH

Molecular Genetic Pathways as Therapeutic Targets in Acute Myeloid Leukemia

(2008) T. Haferlach   Hematology-American Society of Hematology Education Program

Identification of genes with abnormal expression changes in acute myeloid leukemia

(2007) Derek L. Stirewalt et al.   GENES CHROMOSOMES & CANCER