Review
Chemistry, Multidisciplinary
Chuankai Dai, Xiaoming Liu, Rongyu Tang, Jiping He, Tatsuo Arai
Summary: In recent years, microfluidics has been crucial to the advancement of nerve regeneration research. Microfluidic devices accurately simulate the in vivo microenvironment for various research purposes such as analyzing growth inhibitory factors, screening drugs, evaluating nerve growth factors, and investigating neural injury and regeneration mechanisms. The platform enables precise control of cell behavior, such as neuron isolation, single-cell manipulation, neural patterning, and axon guidance, providing technical support for nerve regeneration.
APPLIED SCIENCES-BASEL
(2022)
Article
Neurosciences
Madhavi Gorla, Karina Chaudhari, Maya Hale, Chloe Potter, Greg J. Bashaw
Summary: This study investigates the role of Nedd4 E3 ubiquitin ligases in axon guidance and their interaction with Ndfip and Robo1. The results show that Nedd4-1 and Nedd4-2 specifically regulate Robo1 and spinal commissural axon guidance. The study also reveals the importance of the interactions between Robo1, Ndfip, and Nedd4 for endosomal sorting, ubiquitylation, and degradation of Robo1.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Valeria Kaltezioti, Iosifina P. Foskolou, Matthieu D. Lavigne, Elpinickie Ninou, Matina Tsampoula, Maria Fousteri, Marigoula Margarity, Panagiotis K. Politis
Summary: Prox1 is identified as a key gene regulatory factor that inhibits neurite elongation, allowing nascent neurons to find the correct position before initiating neurites and axon elongation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Neurosciences
Hong-Jun Cao, Li Huang, Meng-Ru Zheng, Tao Zhang, Ling-Chi Xu
Summary: This study comprehensively investigates the expression of circular RNAs in rat DRGs following injuries to the central and peripheral axon branches and identifies a total of 33 differentially expressed circular RNAs after central branch injury and 55 differentially expressed circular RNAs after peripheral branch injury. The functional enrichment analysis of host genes of differentially expressed circular RNAs reveals the involvement of the Hippo signaling pathway and Notch signaling pathway after both central and peripheral axon injuries.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Sharif Alhajlah, Adam M. Thompson, Zubair Ahmed
Summary: The study shows that RTN3 may play a critical role in promoting axon regeneration in the central nervous system, especially after spinal cord and optic nerve injuries. Overexpression of RTN3 can enhance neurite outgrowth in cell culture and promote survival and axon regeneration in vivo.
Article
Biochemistry & Molecular Biology
Xiaonan Liu, Sara M. Blazejewski, Sarah A. Bennison, Kazuhito Toyo-Oka
Summary: This study reveals the important role of GSTP proteins in initiating neurite formation during cortical development, regulating neurite initiation through the JNK signaling pathway.
HUMAN MOLECULAR GENETICS
(2021)
Article
Anatomy & Morphology
Mevan L. Siriwardane, Kathleen Derosa, George Collins, Bryan J. Pfister
Summary: Biomaterial-based scaffolds used in nerve conduits have shown improvements in nerve repair models, but have not yet matched the effectiveness of autologous nerve grafts. Axons in a 3D hydrogel culture preferentially attach, turn, and follow fibers, indicating that both physical and biochemical presentation of fibers are crucial for enhancing axon guidance and growth.
CELLS TISSUES ORGANS
(2021)
Review
Biochemistry & Molecular Biology
Supraja G. Varadarajan, John L. Hunyara, Natalie R. Hamilton, Alex L. Kolodkin, Andrew D. Huberman
Summary: This article summarizes the research progress on neuronal regeneration and degeneration, compares the regenerative process in the central and peripheral nervous systems, and highlights the primary targets for restoring functional neural circuits.
Article
Multidisciplinary Sciences
Sydney Fearnley, Reesha Raja, Jean-Francois Cloutier
Summary: Differential expression of cell adhesion molecules in neuronal populations plays a crucial role in promoting the formation of neural circuits. Each member of the IgLON family displays distinct expression patterns in different brain regions, indicating their potential contribution to specific neuronal circuitry.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Wei Pi, Ci Li, Meng Zhang, Wei Zhang, Pei-Xun Zhang
Summary: Studies have shown that combined treatment with myelin-associated glycoprotein (MAG) and chitin conduit can effectively inhibit the formation of painful neuroma after sciatic nerve transection and alleviate neuropathic pain. The combined treatment reduces autotomy behaviors, decreases the expression of pain markers, reduces the density of regenerated axons, and alters the ratio of myelinated to unmyelinated axons.
NEURAL REGENERATION RESEARCH
(2022)
Article
Ophthalmology
Sujia Ma, Ke Zhang, Yu Zhu, Xuexia Cao, Lili Wang
Summary: The study demonstrates that papaverine significantly promotes axon outgrowth in primary retinal ganglion cells and restores their growth on chondroitin sulfate proteoglycans. This may have implications for the treatment of optic nerve injuries caused by glaucoma and other diseases.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biology
Oshri Avraham, Rui Feng, Eric Edward Ewan, Justin Rustenhoven, Guoyan Zhao, Valeria Cavalli
Summary: Peripheral nerve injuries lead to the appearance of a distinct subset of satellite glial cells in DRG and activation of the PPAR alpha signaling pathway, promoting axon regeneration. Central axon injuries do not trigger the same response, highlighting the potential for manipulating non-neuronal cells to promote functional recovery after CNS injuries or disease.
Review
Cell & Tissue Engineering
Scott R. Echternacht, Miranda A. Chacon, Jonathan Leckenby
Summary: The process of cranial nerve regeneration remains largely unknown, and future research should continue to focus on elucidating the mechanisms of cranial nerve regeneration, as well as the cellular interactions, molecules, and pathways involved.
REGENERATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Noemie Vilallongue, Julia Schaeffer, Anne-Marie Hesse, Celine Delpech, Beatrice Blot, Antoine Paccard, Elise Plissonnier, Blandine Excoffier, Yohann Coute, Stephane Belin, Homaira Nawabi
Summary: In the injured adult central nervous system, activation of pro-growth molecular pathways in neurons leads to long-distance regeneration, but guidance defects in regenerative fibers prevent reinnervation and functional recovery. The authors use mass spectrometry to analyze the proteomes of major nuclei in the adult visual system and find that guidance-associated molecules are expressed in adult visual targets. They also demonstrate that bilateral optic nerve injury modulates the expression of specific proteins, while the expression of guidance molecules remains steady. The study suggests that modulating axon guidance of regenerative neurons could potentially achieve circuit repair in adults.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Sergei Reverdatto, Aparna Prasad, Jamie L. Belrose, Xiang Zhang, Morgan A. Sammons, Kurt M. Gibbs, Ben G. Szaro
Summary: This study examines the differences in DNA methylation between regenerative and non-regenerative central nervous system (CNS) of the South African claw-toed frog, Xenopus laevis. The findings suggest that increased injury-associated DNA methylation in regenerative CNS may promote successful CNS axon regeneration. The insights gained from this research could lead to novel therapeutic approaches for treating CNS injury in mammals.
Article
Engineering, Biomedical
Ying-Bao Huang, Jin Mei, Yaling Yu, Yuqiang Ding, Weizhi Xia, Ting Yue, Weijian Chen, Meng-Tao Zhou, Yun-Jun Yang
Article
Biochemistry & Molecular Biology
Tao-Fang Xi, Dan-Ni Li, Yu-Yian Li, Ying Qin, Hai -Hong Wang, Ning-Ning Song, Qiong Zhang, Yu-Qiang Ding, Xuan-Zheng Shi, Dong-Ping Xie
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Neurosciences
Qiong Zhang, Ying Huang, Lei Zhang, Yu-Qiang Ding, Ning-Ning Song
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Ding-Mei Zhang, Tian Zhang, Ming-Ming Wang, Xin-Xin Wang, Yuan-Yuan Qin, Junchao Wu, Rong Han, Rui Sheng, Yan Wang, Zhong Chen, Feng Han, Yuqiang Ding, Mei Li, Zheng-Hong Qin
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Cell Biology
Pengcheng Ma, Ning-Ning Song, Yongxin Li, Qiong Zhang, Lei Zhang, Longlong Zhang, Qinghua Kong, Li Ma, Xiangcai Yang, Biyu Ren, Chaocui Li, Xudong Zhao, Yan Li, Ying Xu, Xiang Gao, Yu-Qiang Ding, Bingyu Mao
Article
Biochemistry & Molecular Biology
Lei Zhang, Ning-Ning Song, Qiong Zhang, Wan-Ying Mei, Chun-Hui He, Pengcheng Ma, Ying Huang, Jia-Yin Chen, Bingyu Mao, Bing Lang, Yu-Qiang Ding
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Cell Biology
Michal Pruski, Ling Hu, Cuiping Yang, Yubing Wang, Jin-Bao Zhang, Lei Zhang, Ying Huang, Ann M. Rajnicek, David St Clair, Colin D. McCaig, Bing Lang, Yu-Qiang Ding
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Article
Developmental Biology
Ning-Ning Song, Pengcheng Ma, Qiong Zhang, Lei Zhang, Huishan Wang, Longlong Zhang, Liang Zhu, Chun-Hui He, Bingyu Mao, Yu-Qiang Ding
Article
Neurosciences
Andrea Forero, Hsing-Ping Ku, Ana Belen Malpartida, Sina Waeldchen, Judit Alhama-Riba, Christina Kulka, Benjamin Aboagye, William H. J. Norton, Andrew M. J. Young, Yu-Qiang Ding, Robert Blum, Markus Sauer, Olga Rivero, Klaus-Peter Lesch
Article
Neurosciences
Tongtong Wang, Xin Ye, Wei Bian, Zhichi Chen, Juanjuan Du, Mengyi Li, Peng Zhou, Huairui Cui, Yu-Qiang Ding, Shuangshuang Qi, Min Liao, Chenyou Sun
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Psychiatry
Xiao-Qing Wang, Lei Zhang, Zhong-Yuan Xia, Jia-Yin Chen, Yiru Fang, Yu-Qiang Ding
Summary: The study reveals that PTEN plays a key role in chronic stress-induced neuronal atrophy and depression-like behaviors, and can be prevented by systemic administration of PTEN inhibitors.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Cell Biology
Qiong Zhang, Lei Zhang, Ying Huang, Pengcheng Ma, Bingyu Mao, Yu-Qiang Ding, Ning-Ning Song
Summary: The transcription factor special AT-rich binding protein 2 (Satb2) is crucial for the development of dopaminergic (DA) neurons in the arcuate nucleus (ARC), with its expression observed in a large proportion of DA neurons. Loss of Satb2 leads to a reduced number of ARC DA neurons, highlighting its critical role in the gene regulatory network for DA neuron development.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Yun-Qing Hu, Ting-Ting Niu, Jian-Ming Xu, Li Peng, Qing-Hua Sun, Ying Huang, Ji Zhou, Yu-Qiang Ding
Summary: The exposure to negative air ions (NAI) has been found to alleviate depressive-like behaviors induced by chronic mild stress (CMS) in mice, possibly by modulating corticosterone levels and rebalancing the function of Th1 and Th2 cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shangyao Qin, Yimin Yuan, Xiao Huang, Zijian Tan, Xin Hu, Hong Liu, Yingyan Pu, Yu-qiang Ding, Zhida Su, Cheng He
Summary: This study reveals the preferential expression of TOP2a in neurogenic niches and its crucial role in the self-renewal and proliferation of adult neural stem cells. The researchers identified Usp37 as a direct target gene of TOP2a through RNA sequencing and chromatin immunoprecipitation sequencing, and found that overexpression of Usp37 can rescue the impaired self-renewal ability of adult neural stem cells caused by Top2a knockout.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Pengcheng Ma, Li Pear Wan, Yuwei Li, Chun-Hui He, Ning-Ning Song, Shiping Zhao, Huishan Wang, Yu-Qiang Ding, Bingyu Mao, Nengyin Sheng
Summary: RNF220 acts as an E3 ubiquitin ligase for AMPARs, playing a significant role in excitatory synaptic transmission and brain function. Lack of RNF220 increases AMPAR protein levels, enhancing basal synaptic activity and impairing synaptic plasticity.