Article
Biochemistry & Molecular Biology
Edouard Charlebois, Yupeng Li, Victoria Wagner, Kostas Pantopoulos, Martin Olivier
Summary: The survival, growth, and virulence of Leishmania parasites depend on proper access and regulation of iron. Macrophages, Leishmania's host cell, can control iron levels by reducing uptake or increasing efflux via ferroportin. In response, the parasite inhibits ferroportin synthesis and induces its degradation. The role of iron in leishmaniasis was studied using Hjv(-/-) mice, a model of hemochromatosis. These mice showed delayed growth of Leishmania major and increased inflammatory response when infected. However, genetic iron overload did not affect the development of visceral leishmaniasis caused by Leishmania infantum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Wes Brown, Anirban Bardhan, Kristie Darrah, Michael Tsang, Alexander Deiters
Summary: The study reveals that light-activated circular morpholino oligonucleotides can be used to conditionally control microRNA function and study their role in zebrafish embryo development. Precise spatial and temporal control over microRNA function was achieved through irradiation, providing insights into the cell populations and developmental timepoints involved in each process.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Max D. Knickmeyer, Juan L. Mateo, Stephan Heermann
Summary: The study demonstrates that BMP plays a significant role in optic chiasm formation and RGC axon pathfinding in zebrafish, potentially through an interaction with midline guidance cues and optic stalk morphogenesis. Induction of BMP4 at different time points results in distinct neurodevelopmental abnormalities, severely affecting RGC axon projections in different ways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hung-Yu Shih, Chia-Wei Chang, Yi-Chieh Chen, Yi-Chuan Cheng
Summary: Bone morphogenetic protein (BMP) signaling plays a crucial role in the regulation of neural induction, neuronal specification, and neuronal differentiation. However, its role in neural progenitors is still not well understood. By manipulating BMP signaling in zebrafish embryos, researchers discovered that inhibiting BMP signaling during gastrulation can increase the proliferation of neural progenitors and decrease the number of neuronal precursors. This study also revealed that there is a fine balance between BMP and Notch signaling in regulating the proliferation of neural progenitor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Angeliki Katsarou, Konstantinos Gkouvatsos, Carine Fillebeen, Kostas Pantopoulos
Summary: Our study reveals that dietary iron has differential effects on ferroportin expression in mouse tissues, suggesting the existence of hepcidin-dependent and -independent mechanisms for ferroportin regulation.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Yu-Fen Lu, Da-Wei Liu, I-Chen Li, Jamie Lin, Chien-Ming Wang, Kuo-Chang Chu, Hsiao-Hui Kuo, Che-Yi Lin, Ling-Huei Yih, Yun-Jin Jiang, Sheng-Ping L. Hwang
Summary: Research has shown that in zebrafish embryos, Delta/Jagged-mediated activation of Notch signaling induces the differentiation of agr2-positive EMCs, which are maintained by proliferation.
Article
Dermatology
Kristin Knoke, Robert R. Rongisch, Katarzyna M. Grzes, Roman Schwarz, Beate Lorenz, Nir Yogev, Erika L. Pearce, Edward J. Pearce, David M. Kofler, Mario Fabri
Summary: This study investigates the effects of Jak inhibitors, specifically tofacitinib, on the host defense responses in toll-like receptor 4-activated macrophages. The findings suggest that tofacitinib blocks macrophage responses to IL-10 and regulates iron metabolism. The study also identifies the toll-like receptor 4-IL-10-signal transducer and activator of transcription 3-HAMP axis as a potential therapeutic target to counteract immune evasion.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Environmental Sciences
Rong Xu, Yong Huang, Chen Lu, Weiming Lv, Shihua Hong, Shuqin Zeng, Wenyan Xia, Li Guo, Huiqiang Lu, Yijian Chen
Summary: Exposure to Ticlopidine leads to developmental and cardiac toxicity in zebrafish embryos, possibly by increasing oxidative stress. The study highlights the importance of further research on the potential harms of Ticlopidine in humans.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Jaeho Yoon, Vijay Kumar, Ravi Shankar Goutam, Sung-Chan Kim, Soochul Park, Unjoo Lee, Jaebong Kim
Summary: Gastrulation is a critical step in development, with cell movements regulated by noncanonical Wnt and Bmp signaling gradients.
Article
Biochemical Research Methods
Shimon M. Rosenthal, Tvisha Misra, Hala Abdouni, Tess C. Branon, Alice Y. Ting, Ian C. Scott, Anne-Claude Gingras
Summary: Researchers adapted proximity labeling for protein discovery in zebrafish, developing in vivo TurbolD and mini-Turbo labeling techniques. By providing biotin directly in the egg water, they demonstrated successful biotinylation of prey proteins after 12 hours, enabling time-resolved analysis of development.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Tiago L. Duarte, Nick P. Talbot, Hal Drakesmith
Summary: This review discusses the roles of oxygen-sensing pathways in iron homeostasis regulation, highlighting the significance of NRF2 in macrophages and the interaction between low iron/hypoxia and HIF2a in renal and intestinal tissues. The close crosstalk between oxygen-sensing pathways and iron regulatory mechanisms ensures prompt detection and restoration of systemic iron levels. Future therapeutic approaches may target redox-sensitive transcription factors to regulate iron levels systemically.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Hematology
Michela Asperti, Elisa Brilli, Andrea Denardo, Magdalena Gryzik, Francesca Pagani, Fabiana Busti, Germano Tarantino, Paolo Arosio, Domenico Girelli, Maura Poli
Summary: Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder caused by mutations on the TMPRSS6 gene, leading to excessive hepcidin production and resistance to oral iron supplementation. In a study using a mouse model, researchers compared different iron status parameters in homozygous and heterozygous mice, finding that Sucrosomial iron may be a promising option for oral iron supplementation in IRIDA patients.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Hematology
Christopher B. Mahony, Pietro Cacialli, Corentin Pasche, Rui Monteiro, Savvas N. Savvides, Julien Y. Bertrand
Summary: The study found that the ECM component haplalb in zebrafish embryos plays a crucial role in the specification of HSPCs, and the gene kitigb related to the ECM also plays a key role in determining HSPCs.
Article
Toxicology
Dou Yang, Juhua Xiao, Mengqi Wan, Jieping Liu, Ling Huang, Xue Li, Li Zhang, Fasheng Liu, Desheng Liang, Yongliang Zheng, Baogang Xie, Xinjun Liao, Guanghua Xiong, Huiqiang Lu, Zigang Cao, Shouhua Zhang
Summary: This study investigated the effects of roxadustat on early embryonic development using zebrafish. The results showed that roxadustat exposure caused abnormal embryonic development and liver metabolic imbalance in zebrafish embryos. Additionally, roxadustat down-regulated Notch signaling, which contributed to hepatotoxicity. This research provides valuable insights for the clinical use of roxadustat.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luis Felix, Carolina Lobato-Freitas, Sandra M. Monteiro, Carlos Venancio
Summary: The study found that 24-epibrassinolide (24-EPI) can mitigate the teratogenic effects of caffeine during early zebrafish development, particularly reducing tail curvature. However, caffeine exposure resulted in locomotor deficits and disrupted anxiety responses. Coexposure to caffeine and the highest 24-EPI concentrations showed less pronounced behavioral deficits.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ahmed A. Alkhateeb, Peter D. Buckett, Andrew M. Gardeck, Jonghan Kim, Shaina L. Byrne, Paula G. Fraenkel, Marianne Wessling-Resnick
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2015)
Article
Evolutionary Biology
Frederic G. Brunet, Fiona W. Fraser, Marley J. Binder, Adam D. Smith, Christopher Kintakas, Carolyn M. Dancevic, Alister C. Ward, Daniel R. McCulloch
BMC EVOLUTIONARY BIOLOGY
(2015)
Article
Hematology
Bonnie Patchen, Tiago Koppe, Aaron Cheng, Young Ah Seo, Marianne Wessling-Resnick, Paula G. Fraenkel
BLOOD CELLS MOLECULES AND DISEASES
(2016)
Review
Infectious Diseases
M. Naville, A. Warren, Z. Haftek-Terreau, D. Chalopin, F. Brunet, P. Levin, D. Galiana, J. -N. Volff
CLINICAL MICROBIOLOGY AND INFECTION
(2016)
Article
Evolutionary Biology
Frederic G. Brunet, Jean-Nicolas Volff, Manfred Schartl
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Biophysics
Frederic G. Brunet, Benjamin Audit, Guenola Drillon, Francoise Argoul, Jean-Nicolas Volff, Alain Arneodo
BIOPHYSICAL JOURNAL
(2018)
Article
Genetics & Heredity
Thibault Lorin, Frederic G. Brunet, Vincent Laudet, Jean-Nicolas Volff
G3-GENES GENOMES GENETICS
(2018)
Article
Hematology
Vera Gaun, Bonnie Patchen, Josephine Volovetz, Aileen W. Zhen, Aleksandr Andreev, Michael P. Pollastri, Paula G. Fraenkel
BLOOD CELLS MOLECULES AND DISEASES
(2014)
Article
Biochemistry & Molecular Biology
Marie Tohme, Sophie M. Prud'homme, Abdel Boulahtouf, Eric Samarut, Frederic Brunet, Laure Bernard, William Bourguet, Yann Gibert, Patrick Balaguer, Vincent Laudet
Article
Genetics & Heredity
Jean-Nicolas Volff, Yvonne Selz, Carsten Hoffmann, Alexander Froschauer, Christina Schultheis, Cornelia Schmidt, Qingchun Zhou, Wolfgang Bernhardt, Reinhold Hanel, Astrid Boehne, Frederic Brunet, Beatrice Segurens, Arnaud Couloux, Sylvie Bernard-Samain, Valerie Barbe, Catherine Ozouf-Costaz, Delphine Galiana, Martin J. Lohse, Manfred Schartl
Article
Gastroenterology & Hepatology
Aileen W. Zhen, Nancy H. Nguyen, Yann Gibert, Shmulik Motola, Peter Buckett, Marianne Wessling-Resnick, Ernest Fraenkel, Paula G. Fraenkel
Article
Multidisciplinary Sciences
Emilien Voldoire, Frederic Brunet, Magali Naville, Jean-Nicolas Volff, Delphine Galiana
Article
Multidisciplinary Sciences
Camille Berthelot, Frederic Brunet, Domitille Chalopin, Amelie Juanchich, Maria Bernard, Benjamin Noel, Pascal Bento, Corinne Da Silva, Karine Labadie, Adriana Alberti, Jean-Marc Aury, Alexandra Louis, Patrice Dehais, Philippe Bardou, Jerome Montfort, Christophe Klopp, Cedric Cabau, Christine Gaspin, Gary H. Thorgaard, Mekki Boussaha, Edwige Quillet, Rene Guyomard, Delphine Galiana, Julien Bobe, Jean-Nicolas Volff, Carine Genet, Patrick Wincker, Olivier Jaillon, Hugues Roest Crollius, Yann Guiguen
NATURE COMMUNICATIONS
(2014)
Article
Microbiology
Julien Fouret, Frederic G. Brunet, Martin Binet, Noemie Aurine, Francois Enchery, Severine Croze, Marie Guinier, Abdelghafar Goumaidi, Doris Preininger, Jean-Nicolas Volff, Marc Bailly-Bechet, Joel Lachuer, Branka Horvat, Catherine Legras-Lachuer
FRONTIERS IN MICROBIOLOGY
(2020)
Review
Genetics & Heredity
Jeremy Barbier, Cedric Vaillant, Jean-Nicolas Volff, Frederic G. Brunet, Benjamin Audit
Summary: The nucleosome plays a critical role in regulating DNA accessibility and cell processes. DNA sequence and factors like ATP-dependent remodelers affect nucleosome positioning on genomes and influence accessibility. Sequence-encoded nucleosome positioning has functional impacts on cell processes and can be selected or counter-selected during evolution.