Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Article
Medicine, General & Internal
Ulvi Kahraman Gursoy, Mervi Gursoy, Anna Liukkonen, Anna Liisa Suominen, Eija Kononen
Summary: The aim of this study was to examine the levels of human beta-defensin 1-3 and human neutrophil peptide 1 (HNP-1) in the saliva of elderly individuals, in order to establish the extent of periodontal disease and tooth loss. The results showed that salivary HNP-1 levels were significantly higher in individuals with periodontal disease. The association between salivary HNP-1 levels and the number of pocket teeth remained significant after adjusting for various factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Nutrition & Dietetics
Julie Rempel, Kanika Grover, Wael El-Matary
Summary: Children and adolescents with inflammatory bowel disease (IBD) are at risk of developing anemia and various micronutrient deficiencies at diagnosis and one year follow-up. Factors such as age and albumin levels may play a role in predicting anemia in these patients.
Article
Biochemistry & Molecular Biology
Paulina Krawiec, Elzbieta Pac-Kozuchowska
Summary: This study aimed to evaluate the level of serum elafin in children with inflammatory bowel disease (IBD) and its relationship with disease activity. The results showed that serum elafin levels were significantly elevated in children with IBD, especially during active phases. ROC analysis suggested that serum elafin could be a potential biomarker for ulcerative colitis.
Article
Genetics & Heredity
Jan K. Nowak, Cyntia J. Szymanska, Aleksandra Glapa-Nowak, Remi Duclaux-Loras, Emilia Dybska, Jerzy Ostrowski, Jaroslaw Walkowiak, Alex T. Adams
Summary: Machine learning using lasso regression was applied to analyze transcriptomic data from IBD patients and controls, leading to the identification of potentially overlooked genes associated with IBD. The results highlighted the role of cell cycle, glycosylation, immunoglobulin binding, TGF-beta pathway, and NK cells in IBD.
Review
Pediatrics
Asha Jois, George Alex
Summary: Inflammatory bowel disease is a common cause of chronic diarrhea in children and has been increasing worldwide. It includes different subtypes, such as Crohn's disease and ulcerative colitis. Diagnosis requires various investigations including imaging and endoscopy. Treatment depends on the severity and subtype, involving immunosuppressive therapies. Poorly controlled disease can lead to psychosocial impacts, growth impairment, and long-term risks. A multidisciplinary team is recommended for managing the disease. This review focuses on the latest clinical practices for diagnosis and management of inflammatory bowel disease in children.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Robin J. Dart, Iva Zlatareva, Pierre Vantourout, Efstathios Theodoridis, Ariella Amar, Shichina Kannambath, Philip East, Timothy Recaldin, John C. Mansfield, Christopher A. Lamb, Miles Parkes, Peter M. Irving, Natalie J. Prescott, Adrian C. Hayday
Summary: This study investigates the presence of tissue-protective gamma delta T cells in the human colon and their association with inflammatory bowel disease. The researchers identified a specific subset of these cells that were diminished and dysregulated in patients with the disease. Additionally, they found that restoration of these cells was associated with remission of the disease. Furthermore, they discovered that individuals with a genetic mutation associated with these cells had an increased risk of developing a severe form of Crohn's disease. These findings highlight the importance of these unique cells in limiting the progression of tissue-damaging diseases.
Article
Medicine, General & Internal
Urszula Daniluk, Kamila Kwiatek-Sredzinska, Piotr Jakimiec, Jaroslaw Daniluk, Aleksandra Czajkowska, Dariusz Marek Lebensztejn
Summary: The study revealed that a significant proportion of children with IBD have liver pathology, with the majority of cases being detected after the diagnosis of IBD. Patients with a specified diagnosis of liver pathology were typically younger and had higher ALT activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Mariusz Olczyk, Elzbieta Czkwianianc, Anna Socha-Banasiak
Summary: In recent years, there has been an increase in the incidence of inflammatory bowel diseases in the pediatric population. However, there is a lack of research in this area, especially regarding metabolic disorders in patients with IBD.
Article
Neurosciences
Cristina Contini, Alessandra Olianas, Simone Serrao, Carla Deriu, Federica Iavarone, Mozhgan Boroumand, Alessandra Bizzarro, Alessandra Lauria, Gavino Faa, Massimo Castagnola, Irene Messana, Barbara Manconi, Carlo Masullo, Tiziana Cabras
Summary: Alzheimer's disease (AD) is characterized by misfolded proteins, inflammation, and oxidative damage in the brain, leading to neuronal cell death. The study found that the salivary protein profile of AD patients contained significantly higher levels of multifaceted proteins and peptides, suggesting that patients established defensive mechanisms at the oral level in response to injury conditions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Zaneta Zajaczkowska, Katarzyna Akutko, Martin Kvac, Bohumil Sak, Magdalena Szydlowicz, Andrzej B. Hendrich, Barbara Iwanczak, Marta Kicia
Summary: IBD patients are at risk of opportunistic infections in the gastrointestinal tract due to defective mucosal immunity and immunosuppressive treatment. The prevalence of Enterocytozoon bieneusi infection was significantly higher in IBD children compared to healthy controls, especially in those receiving immunosuppressive treatment.
FRONTIERS IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Mengyi Liu, Yanjun Zhang, Ziliang Ye, Sisi Yang, Chun Zhou, Panpan He, Yuanyuan Zhang, Fan Fan Hou, Xianhui Qin
Summary: This study found an association between inflammatory bowel disease and higher risks of chronic kidney disease and acute kidney injury. The association was stronger in younger participants.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Nutrition & Dietetics
Martyna Jasielska, Urszula Grzybowska-Chlebowczyk
Summary: The study found that the incidence of hypocalcemia and vitamin D deficiency is higher in children with inflammatory bowel diseases and lactose intolerance. However, the use of a low-lactose diet did not have a significant impact on these conditions.
Article
Medicine, General & Internal
Claudia Veltkamp, Shuai Lan, Eleni Korompoki, Karl-Heinz Weiss, Hartmut Schmidt, Helmut K. Seitz
Summary: IBD patients often develop liver problems such as hepatic steatosis and fibrosis. Factors associated with hepatic steatosis include age, BMI, disease duration, and specific serum activities. Hepatic fibrosis is more common in CD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Eva Goncalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Mohammad Karaminejadranjbar, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson, Marlen Zurek, Caterina Strisciuglio, Mamoun Elawad, Bernice Lo, Carolina Arancibia-Carcamo, Adam Bailey, Ellie Barnes, Elizabeth Louise Bird-Lieberman, Oliver Brain, Barbara Braden, Jane Collier, James East, Lucy Howarth, Satish Keshav, Paul Klenerman, Simon Leedham, Rebecca Palmer, Fiona Powrie, Alison Simmons, Matthew Walker, Zoe Tolkien, Stephen Kaptoge, David Allen, Susan Mehenny, Jonathan Mant, Emanuele Di Angelantonio, Simon G. Thompson, Bahtiyar Yilmaz, Pascal Juillerat, Markus Geuking, Reiner Wiest, Andrew J. Macpherson, Francisco Damian Bravo, Lukas Brugger, Ove Carstens, Ulrike Graf Bigler, Benjamin Heimgartner, Monica Rusticeanu, Sybille Schmid (-Uebelhart), Bruno Strebel, Aurora Tatu, Radu Tutuian, Reiner Wiest, Ove Oyas, Charlotte Ramon, Jorg Stelling, Yannick Franc, Nicolas Fournier, Valerie E. H. Pittet, Bernard Burnand, Mara Egger, Yannick Franc, Delphine Golay, Astrid Marot, Leilla Musso, Valerie Pittet, Jean-Benoit Rossel, Vivianne Seematter, Joachim Sommer, Rachel Vulliamy, Pierre Michetti, Michel H. Maillard, Celine Keller, Michel H. Maillard, Andreas Nydegger, Alain Schoepfe, Eva Archanioti, Jessica Ezri, Montserrat Fraga, Alain Schoepfer, Christoph Mueller, Gerhard Rogler, Luc Biedermann, Mirjam Blattmann, Sabine Burk, Barbara Dora, Michael Fried, Benjamin Misselwitz, Beat Mullhaupt, Nicole Obialo, Daniel Pohl, Nadia Raschle, Gerhard Rogler, Michael Scharl, Stephan Vavricka, Roland Von Kanel, Jonas Zeitz, Karim Abdelrahman, Gentiana Ademi, Jan Borovicka, Stephan Brand, Remus Frei, Johannes Haarer, Christina Knellwolf -Grieger, Claudia Krieger (-Grubel), Patrizia Kunzler, Christa Meyenberger, Pamela Meyer, Nina Rohrich, Mikael Sawatzki, Martin Schelling, Gian-Marco Semadeni, Michael Sulz, Dorothee Zimmermann, Patrick Aepli, Dominique H. Criblez, Cyrill Hess, Jean-Pierre Richterich, Johannes Spalinger, Dominic Staudenmann, Andreas Stulz, Stefanie Wohrle, Amman Thomas, Claudia Anderegg, Henrik Kohler, Rachel Kusche, Anca-Teodora Antonino, Eviano Arrigoni, Jose M. Bengoa, Sophie Cunningham, Philippe de Saussure, Laurent Girard, Diana Bakker de Jong, Polat Basturk, Simon Brunner, Lukas Degen, Petr Hruz, Carolina Khalid-de Bakker, Jan Niess, Bruno Balsiger, Janine Haldemann, Gaby Saner, Frank Seibold, Peter Bauerfeind, Andrea Becocci, Dominique Belli, Janek Binek, Peter Hengstler, Stephan Boehm, Tujana Boldanov, Patrick Buhr, Rebekka Koller, Vanessa Rueger, Arne Senning, Emanuel Burri, Sophie Buyse, Dahlia-Thao Cao, Fabrizia D'Angelo, Joakim Delarive, Christopher Doerig, Roxane Hessler, Claudia Preissler, Ronald Rentsch, Branislav Risti, Marc Alain Ritz, Michael Steuerwald, Jurg Vogtlin, Markus Sagmeister, Bernhard Sauter, Susanne Schibli, Christiane Sokollik, Johannes Spalinger, Hugo Schlauri, Jean-Francois Schnegg, Mariam Seirafi, Holger Spangenberger, Philippe Stadler, Peter Staub, Volker Stenz, Michela Tempia-Caliera, Joel Thorens, Kaspar Truninger, Patrick Urfer, Francesco Viani, Dominique Vouillamoz, Silvan Zander, Tina Wyli, L. Jostins, N. A. Kennedy, T. Ahmad, C. A. Lamb, C. Edwards, A. Hart, C. Hawkey, J. C. Mansfield, C. Mowat, W. G. Newman, A. Simmons, M. Tremelling, J. C. Lee, N. J. Prescott, C. G. Mathew, C. W. Lees, D. P. B. McGovern, S. R. Targan, G. Botwin, E. Mengesha, P. Fleshner, C. Landers, D. Li, J. D. Rioux, A. Bitton, J. Cote-Daigneault, M. J. Daly, R. Xavier, K. Morris, G. Boucher, J. H. Cho, C. Abraham, M. Merad, B. Sands, I. Peter, K. Hao, Y. Itan, R. H. Duerr, L. Konnikova, M. B. Schwartz, S. Proksell, E. Johnston, V. Miladinova, W. Chen, S. R. Brant, L. Datta, M. S. Silverberg, L. P. Schumm, S. Birch, M. Giri, K. Gettler, Y. Sharma, C. Stevens, M. Lazarev, T. Haritunians
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Joep Beumer, Jens Puschhof, Julia Bauza-Martinez, Adriana Martinez-Silgado, Rasa Elmentaite, Kylie R. James, Alexander Ross, Delilah Hendriks, Benedetta Artegiani, Georg A. Busslinger, Bas Ponsioen, Amanda Andersson-Rolf, Aurelia Saftien, Charelle Boot, Kai Kretzschmar, Maarten H. Geurts, Yotam E. Bar-Ephraim, Cayetano Pleguezuelos-Manzano, Yorick Post, Harry Begthel, Franka van der Linden, Carmen Lopez-Iglesias, Willine J. van de Wetering, Reinier van der Linden, Peter J. Peters, Albert J. R. Heck, Joachim Goedhart, Hugo Snippert, Matthias Zilbauer, Sarah A. Teichmann, Wei Wu, Hans Clevers
Article
Immunology
Michal P. Wandel, Bae-Hoon Kim, Eui-Soon Park, Keith B. Boyle, Komal Nayak, Brice Lagrange, Adrian Herod, Thomas Henry, Matthias Zilbauer, John Rohde, John D. MacMicking, Felix Randow
Correction
Biochemistry & Molecular Biology
Joep Beumer, Jens Puschhof, Julia Bauza-Martinez, Adriana Martinez-Silgado, Rasa Elmentaite, Kylie R. James, Alexander Ross, Delilah Hendriks, Benedetta Artegiani, Georg A. Busslinger, Bas Ponsioen, Amanda Andersson-Rolf, Aurelia Saftien, Charelle Boot, Kai Kretzschmar, Maarten H. Geurts, Yotam E. Bar-Ephraim, Cayetano Pleguezuelos-Manzano, Yorick Post, Harry Begthel, Franka van der Linden, Carmen Lopez-Iglesias, Willine J. van de Wetering, Reinier van der Linden, Peter J. Peters, Albert J. R. Heck, Joachim Goedhart, Hugo Snippert, Matthias Zilbauer, Sarah A. Teichmann, Wei Wu, Hans Clevers
Letter
Gastroenterology & Hepatology
Matthias Zilbauer, Robert Heuschkel
Article
Pediatrics
Malik Aydin, Ella A. Naumova, Soeren Lutz, Almut Meyer-Bahlburg, Wolfgang H. Arnold, Florian Kreppel, Anja Ehrhardt, Jan Postberg, Stefan Wirth
FRONTIERS IN PEDIATRICS
(2020)
Article
Oncology
Caterina Strisciuglio, Felicity Payne, Komal Nayak, Marialuisa Andreozzi, Alessandra Vitale, Erasmo Miele, Matthias Zilbauer
Summary: The study found significant differences in mucosal DNA methylation profiles between children diagnosed with EoE and the control group, highlighting the potential for these epigenetic signatures to be developed into clinically applicable biomarkers.
CLINICAL EPIGENETICS
(2021)
Review
Biochemistry & Molecular Biology
Francesca Perrone, Matthias Zilbauer
Summary: The development of human organoid culture models offers opportunities for generating three-dimensional miniature organs that mimic in vivo conditions, contributing to drug discovery and personalized treatment. However, establishing a living organoid biobank requires greater coordination, resources, and expertise compared to traditional tissue repositories, facing various challenges and complexities.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Microbiology
Anton Pembaur, Erwan Sallard, Patrick Philipp Weil, Jennifer Ortelt, Parviz Ahmad-Nejad, Jan Postberg
Summary: Establishing a global decentralized surveillance system for SARS-CoV-2 is urgent, and nanopore-sequencing could be crucial for this purpose due to its mobility, scalability, and cost-effectiveness. Streamlined protocols using midnight 1200 bp amplicon split primers have been developed to simplify the identification of SARS-CoV-2 variants. Diagnostic CT values can act as key criteria for specimen selection, with lower genome copy numbers potentially leading to incomplete assemblies.
Review
Cell Biology
Carolin Baehren, Eleni Buedding, Aliyah Bellm, Frank Schult, Anton Pembaur, Stefan Wirth, Anja Ehrhardt, Friedrich Paulsen, Jan Postberg, Malik Aydin
Summary: This review discusses the roles of bacteria, fungi, and archaea in the upper respiratory tract microbiome, as well as their relationship with respiratory diseases and atopic disorders. The aim is to summarize the latest contributions in this field published in the past decade and to establish a bridge between basic and clinical science.
Review
Gastroenterology & Hepatology
G. Natasha, Matthias Zilbauer
Summary: The global incidence and prevalence of paediatric inflammatory bowel disease is increasing, especially in developing countries with historically low rates. This suggests that environmental and epigenetic factors may play an important role in the pathogenesis and progression of IBD. The identification of cell-type-specific epigenetic mechanisms could lead to personalized treatment approaches for IBD.
FRONTLINE GASTROENTEROLOGY
(2022)
Article
Virology
Jonas Scholz, Patrick Philipp Weil, Daniel Pembaur, Georgia Koukou, Malik Aydin, Dorota Hauert, Jan Postberg, Florian Kreppel, Claudia Hagedorn
Summary: Only two decades after discovering miRNAs, our understanding of their functional effects in disease development, particularly cancer, has greatly expanded. This has led to the development of miRNA-based diagnostic markers and therapeutic strategies. We have established an Ad-based miRNA vector platform that allows efficient delivery and expression of high levels of miRNAs, providing accurate dosing and potential downregulation of target RNAs.
Article
Biochemistry & Molecular Biology
Carolin Baehren, Anton Pembaur, Patrick P. Weil, Nora Wewers, Frank Schult, Stefan Wirth, Jan Postberg, Malik Aydin
Summary: Microbiome analyses often overlook archaea and eukaryotes, focusing primarily on bacteria. However, due to difficulties in culturing these microorganisms, little is known about their relevance to human health and diseases. The use of next generation sequencing techniques has enabled a stronger focus on archaea and eukaryotes, but refinement is needed to achieve a holistic view of the microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Matthias Zilbauer, Kylie James, Mandeep Kaur, Sebastian Pott, Zhixin Li, Albert Burger, Jay L. Thiagarajah, Joseph Burclaff, Frode L. Jahnsen, Francesca Perrone, Alexander D. Ross, Gianluca Matteoli, Nathalie Stakenborg, Tomohisa Sujino, Andreas Moor, Raquel Bartolome-Casado, Espen S. Baekkevold, Ran S. Zhou, Bingqing Xie, Ken T. Lau, Shahida Din, Scott T. Magness, Qiuming Yao, Semir Beyaz, Mark Arends, Alexandre Denadai-Souza, Lori A. Coburn, Jellert T. Gaublomme, Richard Baldock, Irene Papatheodorou, Jose Ordovas-Montanes, Guy Boeckxstaens, Anna Hupalowska, Sarah A. Teichmann, Aviv Regev, Ramnik J. Xavier, Alison Simmons, Michael P. Snyder, Keith T. Wilson
Summary: The number of single-cell profiling studies in the human gastrointestinal tract has significantly increased, presenting an opportunity to generate the first Human Gut Cell Atlas (HGCA). However, there are still major challenges that need to be addressed, including the need for structured and coordinated efforts globally. This Roadmap provides a comprehensive direction and overview of the challenges, as well as recommendations for future studies and the integration of the healthy gut atlas with diseases and gut organoids.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Pediatrics
Patrick Philipp Weil, Jacqueline Hentschel, Frank Schult, Anton Pembaur, Beniam Ghebremedhin, Olivier Mboma, Andreas Heusch, Anna-Christin Reuter, Daniel Mueller, Stefan Wirth, Malik Aydin, Andreas C. W. Jenke, Jan Postberg
Summary: The combination of RT-qPCR with subsequent pyrosequencing allows for a reliable interpretation of results in specimens with low viral loads. This method was successfully tested in a large pediatric cohort in Germany, uncovering previously unidentified cases of pediatric SARS-CoV-2-associated diseases. The protocol also enables the detection of SARS-CoV-2 variants of concern, allowing for pre-selection of specimens for deep sequencing.
MOLECULAR AND CELLULAR PEDIATRICS
(2021)
