Article
Agriculture, Dairy & Animal Science
I. J. Lean, H. M. Golder, S. J. LeBlanc, T. Duffield, J. E. P. Santos
Summary: In this retrospective meta-analysis, individual cow data was used to assess the associations between parity, level of production, and pasture-based or intensively fed systems with fertility. The study found that parity and milk production measures had significant effects on reproductive outcomes. Differences in production systems also influenced reproductive measures.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Suchitra Mohanty, Poonam Yadav, Harini Lakshminarayanan, Priyanshu Sharma, Aravindhan Vivekanandhan, Devarajan Karunagaran
Summary: The study found that RETRA selectively induces necroptosis in cervical cancer cells without cytotoxic effects on normal cells. The induction of cell death by RETRA is associated with mitochondrial hyperpolarization and increased ROS production, emphasizing its importance in the treatment of cervical cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marthe-Susanna Wegner, Nina Schomel, Ellen M. Olzomer, Sandra Trautmann, Catherine Olesch, Frances L. Byrne, Bernhard Brune, Robert Gurke, Nerea Ferreiros, Andreas Weigert, Gerd Geisslinger, Kyle L. Hoehn
Summary: Hepatocellular carcinoma (HCC) is challenging to treat due to late diagnosis and multidrug resistance, leading to poor outcomes. Increasing UGCG expression in liver cells affects mitochondrial respiration and glycolysis, decreasing tumor markers and proliferation, indicating varied outcomes in different cancer types with increased GlcCer expression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Felipe Casado-Barragan, Geraldine Lazcano-Paez, Paulina E. Larenas, Monserrat Aguirre-Delgadillo, Fernanda Olivares-Aravena, Daniela Witto-Oyarce, Camila Nunez-Allimant, Katherin Silva, Quynh My Nguyen, Pilar Cardenas, Modar Kassan, Alexis A. Gonzalez
Summary: Chronic diabetes mellitus can cause kidney damage through increased reactive oxygen species and tubular damage. This study investigates the expression of fibrotic markers and ROS levels in the kidney medulla of male and female mice with streptozotocin-induced type 1 diabetes. The results suggest that NOX-4 plays a role in the induction of profibrotic factors in collecting duct cells and that the antioxidant mechanisms in the renal medullary tissues are regulated differently between males and females.
Article
Biochemistry & Molecular Biology
Yanhong Xu, Kaijian Zhang, Zhonglian Zhang, Yang Liu, Feifei Lv, Peiwen Sun, Shixi Gao, Qiuling Wang, Cuicui Yu, Jiemei Jiang, Chuangjun Li, Meifang Song, Zhihui Gao, Chun Sui, Haitao Li, Yue Jin, Xinwei Guo, Jianhe Wei
Summary: The study sequenced and assembled the genome of Dracaena cochinchinensis, a long-lived and slowly maturing plant famous for producing dragon's blood. The genome revealed insights into the molecular mechanisms underlying its important traits, such as longevity and the formation of dragon's blood. These findings will contribute to the protection and sustainable utilization of Dracaena resources.
PLANT COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Zhiquan Li, Jiangbo Song, Guihua Jiang, Yunzhu Shang, Yu Jiang, Jianfei Zhang, Li Xiao, Min Chen, Dongmei Tang, Xiaoling Tong, Fangyin Dai
Summary: Juvenile hormone (JH) plays a crucial role in insect metamorphosis, reproduction, and longevity, but its molecular mechanism in affecting longevity is unclear. This study showed that JH III and its analog shortened the survival days in male silkworm, while allatostatin, which inhibits JH secretion, extended survival days. The FoxO-TO axis was identified as a potential mechanism of JH in aging research and pest control.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Plant Sciences
Gregorio Barba-Espin, Christian Martinez-Jimenez, Alberto Izquierdo-Martinez, Jose R. Acosta-Motos, Jose A. Hernandez, Pedro Diaz-Vivancos
Summary: Hairy roots grown in vitro, particularly from black carrot, were used in this study for their ability to accumulate anthocyanin. By modulating growth medium composition and H2O2 elicitation, anthocyanin accumulation and biomass production were enhanced. Elicitation with H2O2 led to increased superoxide dismutase activity and anthocyanin accumulation in the hairy roots.
Review
Endocrinology & Metabolism
Tarique Hussain, Mahmoud Kandeel, Elsayed Metwally, Ghulam Murtaza, Dildar Hussain Kalhoro, Yulong Yin, Bie Tan, Muhammad Ismail Chughtai, Anjaleena Yaseen, Ali Afzal, Muhammad Saleem Kalhoro
Summary: Male infertility is a global issue with oxidative stress being the main contributing factor, affecting sperm quality and quantity. Dysfunction of mitochondria and inflammation also play important roles in compromised fertility. The interaction between oxidative stress and seminal plasma proteomes further influences male infertility. Understanding these factors can help improve strategies to prevent male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ecology
Cora E. Anderson, Morad C. Malek, Rachael A. Jonas-Closs, Yongmin Cho, Leonid Peshkin, Marc W. Kirschner, Lev Y. Yampolsky
Summary: The effects of maternal age on offspring life history vary and have specific mechanisms. In this study, the specific impact of maternal age on offspring longevity and the propensity to produce male offspring was observed. These effects can be explained by maternal lipid provisioning during embryonic development.
AMERICAN NATURALIST
(2022)
Article
Agriculture, Dairy & Animal Science
Radica Djedovic, Natascha Vukasinovic, Dragan Stanojevic, Vladan Bogdanovic, Hasan Ismael, Dobrila Jankovic, Nikolija Gligovic, Muhamed Brka, Ljuba Strbac
Summary: The quantitative characteristics of animals are influenced by multiple genes with small individual effects and non-genetic factors. Evaluating the genetic parameters of these traits is crucial for breeders. This study focused on the genetic parameters of longevity, milk yield, and type traits in Holstein cows in Serbia. Heritability values and genetic correlations were estimated using the animal model and restricted maximum likelihood approach.
Article
Plant Sciences
Xinyong Li, Wei Sheng, Qianzhen Dong, Rui Huang, Rongshu Dong, Guodao Liu, Xipeng Ding, Jingwen Zhang
Summary: Pigeon pea, a perennial leguminous plant, has high potential as a forage and pharmaceutical plant in subtropical and tropical areas. This study found that fertile tiller number is crucial for increasing the seed yield of pigeon pea. The number of vascular bundle cells and bundle area are significant factors affecting seed shattering, and cellulase and polygalacturonase are involved in the dehiscence process. This research provides a foundation for further molecular studies to enhance pigeon pea seed yield.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Genshen Zhong, Ying Guo, Xue Gong, Meiqi Xu, Qi Wang, Minna Wu, Xiaoying Zhang, Yinming Liang, Weidong Zhao, Hui Wang, Jianping Ye
Summary: The inactivation of ATPIF1 enhances the bactericidal activity of neutrophils, possibly through increasing the levels of ROS and LA. RNA-seq analysis also reveals the downregulation of several genes involved in glutathione metabolism, pyruvate oxidation, and heme synthesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Summary: Metformin exhibits anti-inflammatory effects by inhibiting the differentiation of human monocytes into proinflammatory macrophages and by limiting ROS production by macrophages via the activation of AMPK.
Article
Biochemistry & Molecular Biology
Yuntian Hong, Baoxiang Chen, Chun Wang, Rui Gui, Xiang Zhai, Qun Qian, Xianghai Ren, Xiaoyu Xie, Congqing Jiang
Summary: This study identified a novel circRNA, circPPP2R4, that is upregulated in colorectal cancer (CRC) and is associated with advanced clinical stage and lymph node metastasis. Functional experiments showed that circPPP2R4 overexpression promotes CRC cell proliferation, migration, and invasion, while circPPP2R4 knockdown attenuates these malignant behaviors. Mechanistic studies revealed the circPPP2R4/miR-646/FOXK1 axis in CRC, providing a potential diagnostic biomarker and therapeutic strategy for CRC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biophysics
Clarinda Costa, Zehua Liu, Sandra Simoes, Alexandra Correia, Antti Rahikkala, Jani Seitsonen, Janne Ruokolainen, Ana Aguiar-Ricardo, Helder A. Santos, M. Luisa Corvo
Summary: The study successfully encapsulated Cu,Zn-Superoxide dismutase (SOD) into liposomes using a glass-capillary microfluidic technique, demonstrating significant therapeutic effects in mouse experiments. SOD@Liposomes exhibit high encapsulation efficiency and enzyme activity, and can effectively inhibit edema through intravenous administration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Jean A. Boutin, Frederic Bouillaud, Elzbieta Janda, Istvan Gacsalyi, Gerald Guillaumet, Etienne C. Hirsch, Daniel A. Kane, Francoise Nepveu, Karine Reybier, Philippe Dupuis, Marc Bertrand, Monivan Chhour, Thierry Le Diguarher, Mathias Antoine, Karen Brebner, Herve Da Costa, Pierre Ducrot, Adeline Giganti, Vishalgiri Goswami, Hala Guedouari, Patrick P. Michel, Aakash Patel, Jerome Paysant, Johann Stojko, Marie-Claude Viaud-Massuard, Gilles Ferry
MOLECULAR PHARMACOLOGY
(2019)
Article
Infectious Diseases
Reinier J. M. Bom, Kalja van der Linden, Amy Matser, Nicolas Poulin, Maarten F. Schim van der Loeff, Bouko H. W. Bakker, Theodoor F. van Boven
BMC INFECTIOUS DISEASES
(2019)
Article
Toxicology
Philippe Haouzi, Marissa McCann, Nicole Tubbs, Annick Judenherc-Haouzi, Joseph Cheung, Frederic Bouillaud
TOXICOLOGICAL SCIENCES
(2019)
Article
Microbiology
Arthur Roux, Heloise Leroy, Benedicte De Muylder, Lucie Bracq, Samia Oussous, Isabelle Dusanter-Fourt, Ghina Chougui, Rachida Tacine, Clotilde Randriamampita, Delphine Desjardins, Roger Le Grand, Frederic Bouillaud, Serge Benichou, Florence Margottin-Goguet, Remi Cheynier, Georges Bismuth, Marianne Mangeney
Article
Cell Biology
Esther Aguilar, Pauline Esteves, Tiphaine Sancerni, Veronique Lenoir, Thomas Aparicio, Frederic Bouillaud, Renaud Dentin, Carina Prip-Buus, Daniel Ricquier, Claire Pecqueur, Sandra Guilmeau, Marie-Clotilde Alves-Guerra
Article
Biochemistry & Molecular Biology
Minoo Hamraz, Raymond Abolhassani, Mireille Andriamihaja, Celine Ransy, Veronique Lenoir, Laurent Schwartz, Frederic Bouillaud
Article
Multidisciplinary Sciences
Marta Grauso, Annaig Lan, Mireille Andriamihaja, Frederic Bouillaud, Francois Blachier
SCIENTIFIC REPORTS
(2019)
Article
Behavioral Sciences
Caroline Gerard, Mathilde Valenchon, Nicolas Poulin, Odile Petit
Article
Biochemistry & Molecular Biology
Mathilde S. Piel, Sandrine Masscheleyn, Frederic Bouillaud, Karine Moncoq, Bruno Miroux
Summary: UCP1, found in brown adipocytes, increases proton conductance in the presence of long-chain fatty acids, leading to increased fatty acid oxidation and heat release. The proposed crucial amino acids for LCFA binding and UCP1 activation were found not relevant in a more physiological context. NMR titration experiments in DPC detergent did not accurately reflect UCP1 function.
Article
Biochemistry & Molecular Biology
Celine Ransy, Clement Vaz, Anne Lombes, Frederic Bouillaud
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Nathalie Le Foll, Jean-Christophe Pont, Audrey L'Hostis, Thomas Guilbert, Frederic Bouillaud, Jean-Philippe Wolf, Ahmed Ziyyat
Summary: cFEE improves gamete interaction in humans by enhancing sperm movement parameters and increasing the percentage of hyperactivated sperm. However, it does not significantly impact the analyzed mitochondrial bioenergetic parameters, indicating that it may act through a more efficient use of energy resources.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Frederic Bouillaud, Noureddine Hammad, Laurent Schwartz
Summary: The Warburg effect refers to the phenomenon where cells choose to undergo glycolysis for energy production even in the presence of oxygen, instead of more efficient oxidation. This metabolic bias is likely influenced by hypermetabolic states caused by cancer growth or inflammation. In addition to efficiency issues, factors like biosynthesis, ATP production, oxygen supply, and time-space constraints may also play a role in the enhancement of the Warburg effect.
Editorial Material
Biochemistry & Molecular Biology
Frederic Bouillaud
Summary: This article examines the consequences of sulfide oxidation by mitochondrial sulfide quinone reductase in mammalian cells. The oxidation of sulfide helps to avoid self-poisoning and has a lower ATP/O-2 ratio compared to other mitochondrial substrates. It increases cellular oxygen consumption and impacts the cellular ATP/ADP ratio.
Review
Biochemistry & Molecular Biology
Frederic Bouillaud
Summary: Succinate dehydrogenase (SDH) is a key enzyme in the tricarboxylic acid cycle and mitochondrial respiratory chain. Certain fungicides that target SDH have been shown to inhibit its activity in both humans and non-target organisms. In this document, the focus is on the metabolic consequences of SDH inhibition in mammals, particularly the liver. The solubility of these fungicides in lipids suggests that diet composition may affect their absorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bastiaan S. Star, Elisabeth C. van der Slikke, Celine Ransy, Alain Schmitt, Robert H. Henning, Frederic Bouillaud, Hjalmar R. Bouma
Summary: This study demonstrates that GYY4137 promotes the release of hydrogen sulphide (H2S) within the mitochondria of endothelial cells, increasing oxygen consumption. The presence of sulfide:quinone oxidoreductase (SQOR) regulates this process.