Article
Immunology
David Hongo, Pingping Zheng, Suparna Dutt, Rahul D. Pawar, Everett Meyer, Edgar G. Engleman, Samuel Strober
Summary: Classical dendritic cells (cDCs) in mice can be divided into DC1 and DC2 subsets based on the expression of nuclear transcription factors, with DC1 further divided into DC1a and DC1b subsets. DC1b and DC2 cells pulsed with OVA protein are more effective in reducing melanoma growth compared to DC1a cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Felix Pfister, Jan Doerrie, Niels Schaft, Vera Buchele, Harald Unterweger, Lucas R. Carnell, Patrick Schreier, Rene Stein, Marketa Kubankova, Jochen Guck, Holger Hackstein, Christoph Alexiou, Christina Janko
Summary: The influence of superparamagnetic iron oxide nanoparticles (SPIONs) on primary human T cells and their potential for magnetically targeted adoptive T cell therapy were investigated in this study. Results showed that SPION-loading did not affect the mechanics and functionality of T cells, indicating its potential for magnetically enriching T cells in solid tumors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sarah Doetsch, Mortimer Svec, Kilian Schober, Monika Hammel, Andreas Wanisch, Fuesun Goekmen, Sebastian Jarosch, Linda Warmuth, Jack Barton, Luka Cicin-Sain, Elvira D'Ippolito, Dirk H. Busch
Summary: Engagement of PD-1 as a key regulatory pathway in T cells leads to dysfunctional states. Selective ablation of PD-1 through genetic knockout is being explored as an alternative therapeutic approach. This study showed that genetic ablation of PD-1 did not impair the functionality and longevity of adoptively transferred T cells, making it a potential target in T cell-based immunotherapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Fei Sun, Tian-Tian Yue, Chun-Liang Yang, Fa-Xi Wang, Jia-Hui Luo, Shan-Jie Rong, Meng Zhang, Yanchao Guo, Fei Xiong, Cong-Yi Wang
Summary: The functional state of T cells is diverse and under dynamic control, with reversible protein phosphorylation playing a crucial role. Dual specific phosphatases (DUSPs) have emerged as versatile regulators in T cell biology, impacting effector T cell activity, T cell development, and other processes. DUSP proteins could potentially become a druggable target for various diseases, offering an alternative to current therapies focused on protein kinase activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jyoti Rana, Daniel J. Perry, Sandeep R. P. Kumar, Maite Munoz-Melero, Rania Saboungi, Todd M. Brusko, Moanaro Biswas
Summary: Regulatory T cells (Tregs) play a crucial role in modulating immune responses, and redirecting polyclonal Tregs can induce tolerance. In a hemophilia A model, high-affinity chimeric antigen receptor (CAR) Treg cells were able to suppress antibody formation.
Article
Chemistry, Multidisciplinary
Asbjorn Christophersen, Shiva Dahal-Koirala, Marketa Chlubnova, Jorgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid
Summary: This article tests the feasibility of isolating gluten-reactive T cells in celiac disease by sorting T cells based on their distinct phenotypes. The results show that a high percentage of T cells sorted based on the distinct phenotype exhibit gluten reactivity. The study also reveals clonal expansion and sequence sharing, indicating antigen-driven responses. This finding highlights the potential of using phenotypic markers to characterize disease-driving CD4(+) T cells in autoimmune conditions.
Article
Microbiology
Sarah E. Jackson, George X. Sedikides, Veronika Romashova, Georgina Okecha, Ester B. M. Remmerswaal, Frederike J. Bemelman, John H. Sinclair, Mark R. Wills
Summary: In this study, the HCMV-specific IL-10 CD8(+) T-cell responses were described for the first time, demonstrating their broad specificity and the potential immune modulatory role in HCMV latent carriage and periodic reactivation.
Article
Allergy
Shu-Hung Wang, Ulrich M. Zissler, Maren Buettner, Sonja Heine, Alexander Heldner, Sebastian Kotz, Lisa Pechtold, Josephine Kau, Mirjam Plaschke, Julia T. Ullmann, Ferdinand Guerth, Madlen Oelsner, Francesca Alessandrini, Simon Blank, Adam M. Chaker, Carsten B. Schmidt-Weber, Constanze A. Jakwerth
Summary: This study demonstrates that allergen exposure induces the expression of CTLA-4 and PD-1 on T(H)2 cells, and the changes in exhausted T(H)2 cell frequencies show different patterns during the up-dosing and maintenance phases of AIT.
Article
Oncology
Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Summary: The study demonstrates that adding IL-21 during in vitro T cell culture can generate tumor-specific T cells with a less-differentiated phenotype, potentially enhancing their anti-tumor effects.
Article
Immunology
Kingsley Gideon Kumashie, Marcin Cebula, Claudia Hagedorn, Florian Kreppel, Marina C. Pils, Friedrich Koch-Nolte, Bjorn Rissiek, Dagmar Wirth
Summary: Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the liver, limiting the control of viruses. A study found a subpopulation of intrahepatic CXCR5+ Ova-specific CD8+ T cells with cytotoxic abilities and memory recall, which could be tissue resident cells dependent on OXPHOS and glycolysis. Treatment with CpG oligonucleotide reinvigorated exhausted T cells and supported the formation of resident memory T cells, specifically targeting CXCR5+ CD8+ T cells for expansion to combat chronic liver infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Evan W. Weber, Kevin R. Parker, Elena Sotillo, Rachel C. Lynn, Hima Anbunathan, John Lattin, Zinaida Good, Julia A. Belk, Bence Daniel, Dorota Klysz, Meena Malipatlolla, Peng Xu, Malek Bashti, Sabine Heitzeneder, Louai Labanieh, Panayiotis Vandris, Robbie G. Majzner, Yanyan Qi, Katalin Sandor, Ling-Chun Chen, Snehit Prabhu, Andrew J. Gentles, Thomas J. Wandless, Ansuman T. Satpathy, Howard Y. Chang, Crystal L. Mackall
Summary: This study showed that transient cessation of chimeric antigen receptor (CAR) signaling can enhance the efficacy of CAR-T cells, reactivating their anti-tumor functions, and challenging the notion that exhaustion is an epigenetically fixed state.
Editorial Material
Oncology
James Reading, Kane Foster, Kroopa Joshi, Benny Chain
Summary: This article discusses two papers published in Cancer Cell (Zheng et al., 2022 and Veatch et al., 2022) that demonstrate the application of single-cell sequencing in defining a molecular phenotype to identify tumor-specific T cells.
Article
Biology
Hanako Koguchi-Yoshioka, Elena Hoffer, Stanley Cheuk, Yutaka Matsumura, Sa Vo, Petra Kjellman, Lucian Grema, Yosuke Ishitsuka, Yoshiyuki Nakamura, Naoko Okiyama, Yasuhiro Fujisawa, Manabu Fujimoto, Liv Eidsmo, Rachael A. Clark, Rei Watanabe
Summary: Research indicates that skin T cells in elderly individuals maintain their density, diversity, and protective cytokine production, contrasting with a decline in T-cell diversity and function in the blood. The study demonstrates the importance of skin resident T cells as a long-term, highly protective immunity reservoir in elderly individuals, regardless of ethnicity.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xin Yang, Qiuxia Yu, Hao Xu, Jianfeng Zhou
Summary: Treatment failure or relapse in CART therapy due to reduction in target antigen expression is a challenge. Epigenetic drug Chidamide can enhance CD22 expression on B-cell tumor cells, improving the efficacy of CD22 CART therapy by affecting protein distribution.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Niklas Kuhl, Andreas Linder, Nora Philipp, Daniel Nixdorf, Hannah Fischer, Simon Veth, Gunnar Kuut, Teng Teng Xu, Sebastian Theurich, Thomas Carell, Marion Subklewe, Veit Hornung
Summary: The cGAS-STING signaling pathway is functional in human T cells and can contribute to antiviral immunity, but its activation negatively affects T cell function.
Article
Psychology, Clinical
Ashley M. Snyder, Adelheid U. Brandenberger, Vanina L. Taliercio, Bianca E. Rich, Lisa B. Webber, Abram P. Beshay, Joshua E. Biber, Rachel Hess, Jamie L. W. Rhoads, Aaron M. Secrest
Summary: Chronic inflammatory skin diseases like AD and psoriasis not only impact patients' quality of life but also affect the QOL of their family members. This study reveals that these diseases can affect family members' lifestyle, emotions, and relationships with their loved ones.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Dermatology
Ashley M. Snyder, Suephy C. Chen, Mary-Margaret Chren, Laura K. Ferris, LaVar D. Edwards, Robert A. Swerlick, Nicholas D. Flint, Amy M. Cizik, Rachel Hess, Jacob Kean, Aaron M. Secrest
Summary: With the increasing availability of disease- and symptom-specific measures and the proven usefulness of patient-reported outcome measures (PROMs), the routine use of PROMs in clinical care is now possible. PROMs can enhance healthcare efficiency, improve the clinician-patient relationship, and increase patient satisfaction. However, there are barriers to overcome, such as the cost of implementing the technology, selecting appropriate PROMs for different diseases, and helping patients and clinicians understand the value of PROMs. Recommendations are provided to assist dermatologists in incorporating PROMs into their practices.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Oriol Mitja, Gilmar Reis, David R. Boulware, Adam M. Spivak, Ammar Sarwar, Christine Johnston, Brandon Webb, Michael D. Hill, Davey Smith, Peter Kremsner, Marla Curran, David Carter, Jim Alexander, Marc Corbacho, Todd C. Lee, Katherine Huppler Hullsiek, Emily G. McDonald, Rachel Hess, Michael Hughes, Jared M. Baeten, Ilan Schwartz, Luanne Metz, Lawrence Richer, Kara W. Chew, Eric Daar, David Wohl, Michael Dunne
Summary: This study conducted a pooled analysis of individual participant data from 11 randomized controlled trials to evaluate the efficacy of hydroxychloroquine (HCQ) in outpatients with mild COVID-19. The results suggest that HCQ does not show significant effects on viral clearance and hospitalization rate, and therefore, the use of HCQ in mild COVID-19 outpatients should be discontinued to reduce the risk of disease progression.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Maribel Cedillo, Polina V. V. Kukhareva, Skylar M. M. Larsen, Kathleen M. M. McTigue, Cindy L. L. Bryce, Bethany Barone Gibbs, Rachel Hess, Kimberly Huber, Molly B. B. Conroy
Summary: The study found that coaching interventions delivered through electronic health records (EHR) had a positive effect on weight management. The results also showed that participants who were satisfied with EHR delivery and felt a strong connection to their coach had better weight maintenance. On the other hand, participants whose needs were not met by the intervention, such as in-person support in a group or individual setting, experienced more weight regain.
Article
Cell & Tissue Engineering
Arya Afsahi, Rebecca Burchett, Christopher L. Baker, Allyson E. Moore, Jonathan L. Bramson
Summary: We engineered T cells to express recombinant single-chain IL-27 and a synthetic antigen receptor, and found that IL-27-expressing T cells sustained anti-tumor immunity and cytotoxicity while reducing pro-inflammatory cytokines. IL-27-expressing T cells may provide a potential avenue to avoid treatment-related toxicities commonly associated with engineered T-cell therapy.
Article
Cell & Tissue Engineering
Ksenia Bezverbnaya, Joanne A. Hammill, Derek Cummings, Bojana Bojovic, Bella Groisman, Christopher L. Baker, Craig Aarts, Danielle L. Hayes, Donna Rill, Stacey X. Xu, Andreas G. Bader, Christopher W. Helsen, Jonathan L. Bramson
Summary: B-cell maturation antigen (BCMA) is a clinically validated target for multiple myeloma. The authors have developed a fully humanized BCMA-specific T-cell antigen coupler (TAC) receptor. Optimization of the BCMA-specific TAC receptor was achieved through iterations of the BCMA-TAC design.
Article
Medicine, General & Internal
Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. McComsey, Lisa McCorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, Daniel J. Shinnick, Carolin C. M. Schulte, Rachel Atchley-Challenner, Leora I. Horwitz, Andrea S. Foulkes
Summary: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, known as postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID. This study developed a definition of PASC based on self-reported symptoms and described the frequencies of PASC across cohorts, vaccination status, and number of infections.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Leora I. Horwitz, Tanayott Thaweethai, Shari B. Brosnahan, Mine S. Cicek, Megan L. Fitzgerald, Jason D. Goldman, Rachel Hess, S. L. Hodder, Vanessa L. Jacoby, Michael R. Jordan, Jerry A. Krishnan, Adeyinka O. Laiyemo, Torri D. Metz, Lauren Nichols, Rachel E. Patzer, Anisha Sekar, Nora G. Singer, Lauren E. Stiles, Barbara S. Taylor, Shifa Ahmed, Heather A. Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V. Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie-Abele C. Bind, Lora J. Black, Andra L. Blomkalns, Hassan Brim, Mario Castro, James Chan, Alexander W. Charney, Benjamin K. Chen, Li Qing Chen, Peter Chen, David Chestek, Lori B. Chibnik, Dominic C. Chow, Helen Y. Chu, Rebecca G. Clifton, Shelby Collins, Maged M. Costantine, Sushma K. Cribbs, Steven G. Deeks, John D. Dickinson, Sarah E. Donohue, Matthew S. Durstenfeld, Ivette F. Emery, Kristine M. Erlandson, Julio C. Facelli, Rachael Farah-Abraham, Aloke V. Finn, Melinda S. Fischer, Valerie J. Flaherman, Judes Fleurimont, Vivian Fonseca, Emily J. Gallagher, Jennifer C. Gander, Maria Laura Gennaro, Kelly S. Gibson, Minjoung Go, Steven N. Goodman, Joey P. Granger, Frank L. Greenway, John W. Hafner, Jenny E. Han, Michelle S. Harkins, Kristine S. P. Hauser, James R. Heath, Carla R. Hernandez, On Ho, Matthew K. Hoffman, Susan E. Hoover, Carol R. Horowitz, Harvey Hsu, Priscilla Y. Hsue, Brenna L. Hughes, Prasanna Jagannathan, Judith A. James, Janice John, Sarah Jolley, S. E. Judd, Joy J. Juskowich, Diane G. Kanjilal, Elizabeth W. Karlson, Stuart D. Katz, J. Daniel Kelly, Sara W. Kelly, Arthur Y. Kim, John P. Kirwan, Kenneth S. Knox, Andre Kumar, Michelle F. Lamendola-Essel, Margaret Lanca, Joyce K. Lee-Iannotti, R. Craig Lefebvre, Bruce D. Levy, Janet Y. Lin, Brian P. Logarbo Jr, Jennifer K. Logue, Michele T. Longo, Carlos A. Luciano, Karen Lutrick, Shahdi K. Malakooti, Gail Mallett, Gabrielle Maranga, Jai G. Marathe, Vincent C. Marconi, Gailen D. Marshall, Christopher F. Martin, Jeffrey N. Martin, Heidi T. May, Grace A. McComsey, Dylan McDonald, Hector Mendez-Figueroa, Lucio Miele, Murray A. Mittleman, Sindhu Mohandas, Christian Mouchati, Janet M. Mullington, Girish N. Nadkarni, Erica R. Nahin, Robert B. Neuman, Lisa T. Newman, Amber Nguyen, Janko Z. Nikolich, Igho Ofotokun, Princess U. Ogbogu, Anna Palatnik, Kristy T. S. Palomares, Tanyalak Parimon, Samuel Parry, Sairam Parthasarathy, Thomas F. Patterson, Ann Pearman, Michael J. Peluso, Priscilla Pemu, Christian M. Pettker, Beth A. Plunkett, Kristen Pogreba-Brown, Athena Poppas, J. Zachary Porterfield, John G. Quigley, Davin K. Quinn, Hengameh Raissy, Candida J. Rebello, Uma M. Reddy, Rebecca Reece, Harrison T. Reeder, Franz P. Rischard, Johana M. Rosas, Clifford J. Rosen, Nadine G. Rouphael, Dwight J. Rouse, Adam M. Ruff, Christina Saint Jean, Grecio J. Sandoval, Jorge L. Santana, Shannon M. Schlater, Frank C. Sciurba, Caitlin Selvaggi, Sudha Seshadri, Howard D. Sesso, Dimpy P. Shah, Eyal Shemesh, Zaki A. Sherif, Daniel J. Shinnick, Hyagriv N. Simhan, Upinder Singh, Amber Sowles, Vignesh Subbian, Jun Sun, Mehul S. Suthar, Larissa J. Teunis, John M. Thorp Jr, Amberly Ticotsky, Alan T. N. Tita, Robin Tragus, Katherine R. Tuttle, Alfredo E. Urdaneta, P. J. Utz, Timothy M. VanWagoner, Andrew Vasey, Suzanne D. Vernon, Crystal Vidal, Tiffany Walker, Honorine D. Ward, David E. Warren, Ryan M. Weeks, Steven J. Weiner, Jordan C. Weyer, Jennifer L. Wheeler, Sidney W. Whiteheart, Zanthia Wiley, Natasha J. Williams, Juan P. Wisnivesky, John C. Wood, Lynn M. Yee, Natalie M. Young, Sokratis N. Zisis, Andrea S. Foulkes
Summary: The RECOVER-Adult study aims to comprehensively study the post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, in US adults. This national cohort study will characterize the prevalence, symptoms, natural history, and risk factors of PASC. The results will inform public health, stimulate clinical trials, and expand treatment options.
Article
Immunology
Arya Afsahi, Christopher M. M. Silvestri, Allyson E. E. Moore, Carly F. F. Graham, Kaylyn Bacchiochi, Martine St-Jean, Christopher L. L. Baker, Robert G. G. Korneluk, Shawn T. T. Beug, Eric C. C. LaCasse, Jonathan L. L. Bramson
Summary: The SMAC mimetic drug LCL161 enhances T cell function by inhibiting IAP proteins and activating the non-canonical NF-kappa B pathway. However, LCL161 does not improve T cell anti-tumor function when interacting with myeloma cells, possibly due to sensitization of T cells to Fas-mediated apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Chelsey R. Schlechter, Thomas J. Reese, Jennifer Wirth, Bryan Gibson, Kensaku Kawamoto, Tracey Siaperas, Alan Pruhs, Courtney Pariera Dinkins, Yue Zhang, Michael Friedrichs, Stephanie George, Cho Y. Lam, Joni H. Pierce, Emerson P. Borsato, Ryan C. Cornia, Leticia Stevens, Anna Martinez, Richard L. Bradshaw, Kimberly A. Kaphingst, Rachel Hess, Guilherme Del Fiol, David W. Wetter
Summary: Racial/ethnic minority, low socioeconomic status, and rural populations are disproportionately affected by COVID-19. Developing and evaluating interventions to address COVID-19 testing and vaccination among these populations are crucial. The rapid-cycle design and adaptation process, which includes assessing context, determining intervention components, and conducting iterative adaptations, can improve the relevance and timeliness of interventions for populations experiencing health inequities. Real-time data on COVID-19 policies, case rates, and healthcare system capacity can inform and guide adaptations to ensure interventions are relevant and timely for patients.
TRANSLATIONAL BEHAVIORAL MEDICINE
(2023)
Article
Microbiology
Adam M. Spivak, Bradley J. Barney, Tom Greene, Richard Holubkov, Cody S. Olsen, Jordan Bridges, Raj Srivastava, Brandon Webb, Frances Sebahar, Ainsley Huffman, Christina F. Pacchia, J. Michael Dean, Rachel Hess
Summary: Early in the COVID-19 pandemic, hydroxychloroquine was considered as a potential early treatment to prevent clinical worsening. However, this study found that hydroxychloroquine did not significantly alter the natural history of early COVID-19 disease.
MICROBIOLOGY SPECTRUM
(2023)
Article
Cardiac & Cardiovascular Systems
Brian Zenger, Haojia Li, T. Jared Bunch, Candice Crawford, James C. Fang, Christopher A. Groh, Rachel Hess, Leenhapong Navaravong, Ravi Ranjan, Jeff Young, Yue Zhang, Benjamin A. Steinberg
Summary: By analyzing a large amount of data, this study found that there is significant variability in the cost of atrial fibrillation (AF) ablation procedures due to different operators. Direct costs and other services (primarily anesthesia) account for the majority of the costs associated with AF ablations. This research is of great significance for reducing the cost of AF ablation procedures and improving cost effectiveness.
Article
Medicine, General & Internal
Tanayott R. Thaweethai, Sarah E. Jolley, Elizabeth Karlson, Emily M. Levitan, Bruce Levy, Grace McComsey, Lisa S. McCorkell, Girish D. Nadkarni, Sairam E. Parthasarathy, Upinder J. Singh, Tiffany Walker, Caitlin W. Selvaggi, Daniel Shinnick, Carolin C. M. P. Schulte, Rachel M. Atchley-Challenner, Leora Horwitz, Andrea Foulkes
Summary: This study aims to develop a definition of postacute sequelae of SARS-CoV-2 infection (PASC) using self-reported symptoms and analyze the frequencies of PASC across different cohorts, vaccination status, and number of infections. The results show that PASC is associated with various symptoms and around 10% of participants were PASC positive at 6 months after infection.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Jessica A. Breznik, Ahmad Rahim, Tara Kajaks, Megan Hagerman, Lucas Bilaver, Karen Colwill, Roaya M. Dayam, Anne -Claude Gingras, Chris P. Verschoor, Janet E. McElhaney, Jonathan L. Bramson, Dawn M. E. Bowdish, Andrew P. Costa
Summary: A longitudinal cohort study in nursing and retirement homes in Ontario, Canada, identified vaccine type, number of doses, and recent infection history as important factors for protection against Omicron variant infection in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Dermatology
Z. H. Hopkins, G. Kuceki, V. L. Taliercio, A. M. Snyder, G. J. Stoddard, K. C. Duffin, R. Hess, A. M. Secrest
Summary: This study evaluated the construct validity of Skindex-16 in patients with psoriasis and found a moderate correlation between Skindex-16 scores and clinician-reported outcome measure of disease severity. Severe discordance was rare and primarily observed in patients with clear skin but poor quality of life.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)