Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus

Interpretation of Association Signals and Identification of Causal Variants from Genome-wide Association Studies

(2010) Kai Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pharmacological Characterization of 30 Human Melanocortin-4 Receptor Polymorphisms with the Endogenous Proopiomelanocortin-Derived Agonists, Synthetic Agonists, and the Endogenous Agouti-Related Protein Antagonist,‡

(2010) Zhimin Xiang et al.   BIOCHEMISTRY

From monogenic to polygenic obesity: recent advances

(2010) Anke Hinney et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients

(2009) Zhen-Chuan Fan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

Association of the MC4R V103I Polymorphism With Obesity: A Chinese Case–control Study and Meta-analysis in 55,195 Individuals

(2009) Du Wang et al.   Obesity

Three at One Swoop!

(2009) Anke Hinney et al.   Obesity Facts

Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

(2008) Bingshan Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic association analysis with FAMHAP: a major program update

(2008) Christine Herold et al.   BIOINFORMATICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS