Article
Multidisciplinary Sciences
Zainab M. Almutairi
Summary: This study characterized the B12Dg gene in pearl millet and investigated its expression in response to abiotic stress and plant hormone treatment during germination. The results showed that PgB12Dg was upregulated in roots and downregulated in seeds, with significant expression changes under drought and cold stress. Additionally, plant hormone treatment revealed upregulation by gibberellic acid and downregulation by abscisic acid in germinated seeds.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Junjie Zhu, Peng Chen, Jiaojiao Liang, Zhaohang Wu, Haiqun Jin, Tianpeng Xu, Yeyi Zheng, Hongfang Ma, Weitao Cong, Xu Wang, Xueqiang Guan
Summary: Diabetes is characterized by perturbed glucose and lipid metabolism, leading to high blood glucose levels, which can cause various complications due to endothelial dysfunction. This study found that the protein level of casein kinase 2a (CK2a) was increased in the endothelium of mice with type I diabetes (T1D). Inhibition of CK2a was found to accelerate skin wound healing in T1D mice by promoting endothelial cell proliferation via the Hedgehog signaling pathway.
Article
Biochemistry & Molecular Biology
Randa Belgacemi, Soula Danopoulos, Gail Deutsch, Ian Glass, Valerian Dormoy, Saverio Bellusci, Denise Al Alam
Summary: The Hedgehog signaling pathway is essential for mouse lung development, and this study found similar expression patterns in human lung development. Inhibiting the Hedgehog signaling pathway in human lung development resulted in reduced branching and dysregulated epithelial-mesenchymal markers and related signaling pathways. These findings are important for exploring therapeutic targets for childhood pulmonary diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lan Zhang, Hongliang Zeng, Ling Jiang, Chuhan Fu, Yushan Zhang, Yibo Hu, Xiaolin Zhang, Lu Zhu, Fan Zhang, Jinhua Huang, Jing Chen, Qinghai Zeng
Summary: Global warming and rising temperature lead to increased heat stress, which affects inflammation, aging, and skin melanogenesis. Heat stress promotes melanogenesis in pigment cells by increasing the paracrine effects of keratinocytes, which is mediated by the activation of the Hedgehog (Hh) signaling pathway. TRPV3 agonists activate the Hh signaling in keratinocytes and enhance its paracrine effect on melanogenesis. The heat-induced activation of the Hh signaling is dependent on TRPV3-mediated Ca2+ influx. These findings provide insights into the mechanisms of heat-induced skin pigmentation.
Article
Multidisciplinary Sciences
Megan Lo, Amnon Sharir, Michael D. Paul, Hayarpi Torosyan, Christopher Agnew, Amy Li, Cynthia Neben, Pauline Marangoni, Libin Xu, David R. Raleigh, Natalia Jura, Ophir D. Klein
Summary: The protein Canopy4 has been found to regulate the level of membrane sterol lipids, and its absence in mouse embryos leads to developmental defects related to Hedgehog (Hh) signaling, particularly changes in digit number. This study reveals a previously unknown aspect of Hh pathway regulation through control of membrane composition.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Shun Ying Quah, Charng Choon Wong, Hui Chyn Wong, Kok Lian Ho, Nizar Abdul Manan, Pran Kishore Deb, Sreenivasa Rao Sagineedu, Johnson Stanslas
Summary: The study revealed that acquired chemoresistance to SRJ09 and SRJ23 in colon and prostate cancer cells may be attributed to alterations in the expression of genes related to the PI3K and autophagy pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Alice Correa Silva-Sousa, Guido Artemio Maranon-Vasquez, Maria Bernadete Sasso Stuani, Peter Proff, Kesly Mary Ribeiro Andrades, Flares Baratto-Filho, Mirian Aiko Nakane Matsumoto, Eva Paddenberg, Erika Calvano Kuechler, Christian Kirschneck
Summary: This study found that genetic variants in the BMP pathway are associated with variations in the palatal rugae pattern in humans. Specific genetic variants were linked to the quantity, length, shape, unification, and predominant shape of the palatal rugae.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Marine Beck, Mathilde Baranger, Ahlam Moufok-Sadoun, Emilie Bersuder, Isabelle Hinkel, Georg Mellitzer, Elisabeth Martin, Laetitia Marisa, Isabelle Duluc, Aurelien de Reynies, Christian Gaiddon, Jean-Noel Freund, Isabelle Gross
Summary: This study focused on the atypical cadherin MUCDHL, which is down-regulated in colorectal tumors, especially in tumors with worse prognosis. Loss of MUCDHL enhanced tumor incidence and burden in intestinal tumor-prone mice, and targeted key oncogenic signaling pathways through its extracellular domain. The study illustrates how the loss of a gene critical for the morphological and functional features of mature cells contributes to tumorigenesis by dysregulating oncogenic pathways.
Article
Biochemistry & Molecular Biology
Kyungjoo Cho, Hyuk Moon, Sang Hyun Seo, Simon Weonsang Ro, Beom Kyung Kim
Summary: The study showed that the sonic hedgehog signaling pathway is up-regulated in cholangiocarcinoma (CCC), and that the sonic hedgehog inhibitor vismodegib has a significant inhibitory effect on CCC cells. In vivo experiments using a murine model of CCC confirmed the anti-cancer efficacy of vismodegib, suggesting that pharmacological inhibition of sonic hedgehog signaling could be an effective molecular target therapy for CCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Yazhen Su, Hao Xing, Jie Kang, Linkun Bai, Liyun Zhang
Summary: The Hedgehog (Hh) signaling pathway plays a crucial role in rheumatic diseases and has the potential to be a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jian Yi Chai, Vaisnevee Sugumar, Mohammed Abdullah Alshawsh, Won Fen Wong, Aditya Arya, Pei Pei Chong, Chung Yeng Looi
Summary: The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is highly conserved in mammals and plays crucial roles in cancer initiation and progression. GLI transcription factors are regulated by both SMO-dependent and SMO-independent mechanisms, with dysregulation leading to tumorigenesis in various cancers. Understanding the complex interplay between GLI and signaling elements could inspire new therapeutic breakthroughs for Hh-GLI-dependent cancers.
Article
Medicine, Research & Experimental
Pingping Yu, Li Wang, Fanren Tang, Shuang Guo, Hongyan Liao, Cengceng Fan, Qin Yang
Summary: Resveratrol pretreatment promotes neurorestoration of ischemic cerebral injury through mediation of the Sonic Hedgehog signaling pathway, enhancing proliferation of neural stem cells.
Article
Plant Sciences
Ping Qiu, Jingqun Liu, Lisha Zhao, Pinghu Zhang, Weike Wang, Dan Shou, Jinjun Ji, Changyu Li, Kequn Chai, Yu Dong
Summary: Inoscavin A, derived from the Sanghuangporus vaninii extract, exhibits anti-tumor activity in an HT-29 colon cancer cell xenograft mouse model. Its anti-tumor effects are related to the hedgehog (Hh) signaling pathway, with Smo being the core receptor and critical for inducing apoptosis.
Article
Biochemistry & Molecular Biology
Dongsheng Gu, Arvin H. H. Soepriatna, Wenjun Zhang, Jun Li, Jenny Zhao, Xiaoli Zhang, Xianhong Shu, Yongshi Wang, Benjamin J. J. Landis, Craig J. J. Goergen, Jingwu Xie
Summary: This study provides direct evidence that activation of hedgehog signaling through expression of activated smoothened can induce fibrosis in the vasculature and aortic valves, leading to abnormal function of aortic valves and heart. The relevance of this mouse model to human health is reflected in the findings that elevated GLI expression is detected in fibrotic aortic valves from patients.
CELL AND BIOSCIENCE
(2023)
Review
Oncology
Ryan C. Augustin, Robert D. Leone, Aung Naing, Lawrence Fong, Riyue Bao, Jason J. Luke
Summary: Evidence supports targeting the adenosine pathway in immuno-oncology, with clinical programs focusing on adenosine receptors and related factors. Intervening in the adenosine pathway can restore immune cell function and inhibit tumor growth.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Letter
Gastroenterology & Hepatology
Mohammad Azhar Aziz, Haafiz Allah-Bakhsh
SAUDI JOURNAL OF GASTROENTEROLOGY
(2018)
Review
Oncology
Abdulrahman Alhumaid, Zeyad AlYousef, Haafiz A. Bakhsh, Saleh AlGhamdi, Mohammad Azhar Aziz
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2018)
Article
Multidisciplinary Sciences
Abderrezak Bouchama, Mohammad Azhar Aziz, Saeed Al Mahri, Musa Nur Gabere, Meshan Al Dlamy, Sameer Mohammad, Mashael Al Abbad, Mohamed Hussein
SCIENTIFIC REPORTS
(2017)
Article
Medicine, Research & Experimental
Mamoon Rashid, Ramesh K. Vishwakarma, Ahmad M. Deeb, Mohamed A. Hussein, Mohammad A. Aziz
EXPERIMENTAL BIOLOGY AND MEDICINE
(2019)
Article
Oncology
Cheng Zhang, Mohammed Aldrees, Muhammad Arif, Xiangyu Li, Adil Mardinoglu, Mohammad Azhar Aziz
FRONTIERS IN ONCOLOGY
(2019)
Review
Medicine, General & Internal
Mesnad Alyabsi, Abdulrahman Alhumaid, Haafiz Allah-Bakhsh, Mohammed Alkelya, Mohammad Azhar Aziz
Article
Oncology
Saeed Al Mahri, Amal Al Ghamdi, Maaged Akiel, Monira Al Aujan, Sameer Mohammad, Mohammad Azhar Aziz
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Suliman A. Alsagaby, Rajendran Vijayakumar, Mariappan Premanathan, Suresh Mickymaray, Wael Alturaiki, Raid S. Al-Baradie, Saleh AlGhamdi, Mohammad A. Aziz, Fahad A. Alhumaydhi, Faisal A. Alzahrani, Ameen S. Alwashmi, Waleed Al Abdulmonem, Naif Khalaf Alharbi, Chris Pepper
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Multidisciplinary Sciences
Aisha M. Basudan, Mohammad Azhar Aziz, Yanqi Yang
Summary: Through a combination of laser-capture microdissection and microarray analysis, this study identified differential gene expression profiling and altered pathways in different zones of mandibular condylar cartilage (MCC) in 5-week-old rats. The study found that MCC cells exhibit distinguishable phenotypes from articular chondrocytes and identified potential markers for each zone. Pathway analysis revealed activated signaling pathways in MCC compared to femoral condylar cartilage, providing new insights for future therapeutic strategies.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Bader Almuzzaini, Jahad Alghamdi, Alhanouf Alomani, Saleh AlGhamdi, Abdullah A. Alsharm, Saeed Alshieban, Ahood Sayed, Abdulmohsen G. Alhejaily, Feda S. Aljaser, Manal Abudawood, Faisal Almajed, Abdulhadi Samman, Mohammed A. Al Balwi, Mohammad Azhar Aziz
Summary: The study conducted a comprehensive cancer sequencing analysis using archived samples from Saudi Arabia, identifying 466 novel variants, including 174 pathogenic somatic variants first identified in the colon. Certain gene mutations showed significant correlations with specific colorectal cancer variants, laying the groundwork for biomarker discovery in the local population.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Saleh Althenayyan, Mohammed H. H. AlMuhanna, Abdulkareem AlAbdulrahman, Bandar Alghanem, Suliman A. A. Alsagaby, Abdulaziz Alfahed, Glowi Alasiri, Mohammad Azhar Aziz
Summary: There is a need for prognostic biomarkers in colorectal cancer metastasis for personalized medicine. Alternative splicing analysis identified ADAM12 and MUC4 as strong biomarker candidates. Their isoform expression was characterized in colorectal cancer cell lines and validated in patient cohorts. The study also demonstrated the potential of isoforms as predictive biomarkers in response to treatment. This comprehensive study highlights the importance of studying alternative splicing isoforms for cancer prognosis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Oncology
Amal AlGhamdi, Saeed AlMahri, Maaged AlAkiel, Sameer Mohammad, Mohammad Aziz
Letter
Gastroenterology & Hepatology
Mohammad Azhar Aziz
SAUDI JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Medicine, General & Internal
Ahmad M. Deeb, Zeyad Yousef, Mishal Al-Johani, Mohammad Azhar Aziz
INTERNATIONAL JOURNAL OF HEALTH SCIENCES-IJHS
(2018)
Review
Oncology
Mohammad Azhar Aziz, Zeyad Yousef, Ayman M. Saleh, Sameer Mohammad, Bandar Al Knawy
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2017)