Article
Food Science & Technology
Shengli Gao, Yingying He, Liping Zhang, Lina Liu, Changfeng Qu, Zhou Zheng, Jinlai Miao
Summary: CLA potentially contributes to ameliorating hepatic steatosis in obese mice by modulating liver inflammation, intestinal permeability, and gut microbiota.
FOOD & NUTRITION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh
Summary: This study found that in leptin-deficient obesity, lipocalin-2 (LCN2) mediates the activation of hepatic stellate cells (HSCs) via α-SMA/MMP9/STAT3 signaling, thereby exacerbating the progression of non-alcoholic steatohepatitis (NASH).
Article
Food Science & Technology
Mohammed Said Moose Al-Bulish, Wanxiu Cao, Ruili Yang, Yuming Wang, Changhu Xue, Qingjuan Tang
Summary: The study found that DHA-rich fish oil can improve hepatic lipid metabolism by inhibiting liver lipid deposition, which may be related to the promotion of short chain fatty acid production and the modulation of gut microbiome.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhicong Li, Zhichao Zheng, Janak L. Pathak, Hongtao Li, Gang Wu, Shaofen Xu, Tianqi Wang, Haoyu Cheng, Zhengguo Piao, Richard T. T. Jaspers, Lihong Wu
Summary: This study analyzed the periodontal status, alveolar bone phenotype, and oral microbiome status in leptin-deficient obese mice. The results showed that leptin-deficient obese mice exhibited epithelial hyperplasia in gingiva, disordered periodontal ligaments, increased alveolar bone loss, lower abundance of beneficial bacteria, and higher abundance of inflammatory bacteria in the oral cavity, suggesting a potential risk factor for periodontitis development.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Immunology
Ling-Cui Meng, Jia-Yi Zheng, Yu-Hui Qiu, Li Zheng, Jue-Yan Zheng, Yu-Qing Liu, Xiao-Lu Miao, Xin-Yi Lu
Summary: In this study, the protective effects of Salvianolic acid B (SalB) on non-alcoholic fatty liver disease (NAFLD) were investigated. The results showed that SalB significantly reduced body and liver weights, improved plasma markers of liver damage, and reduced hepatic lipid accumulation in a mouse model of NAFLD. SalB also inhibited inflammation and the activation of NLRP3 inflammasome. These findings suggest that SalB has potential as a hepatoprotective agent against NAFLD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Naseer A. Kutchy, Amelia Palermo, Rong Ma, Zhong Li, Alexandria Ulanov, Shannon Callen, Gary Siuzdak, Sabita Roy, Shilpa Buch, Guoku Hu
Summary: Morphine administration causes distinct metabolic changes, with acute and chronic use leading to different plasma metabolite concentrations. The alterations in metabolites are linked to the development of tolerance to morphine's analgesic effects. The study also identified metabolites that were differentially affected by acute versus chronic morphine use, suggesting that metabolic changes may be mitigated by prolonged exposure to the drug.
Article
Biochemistry & Molecular Biology
Seohyun Park, Jae-Joon Lee, Jisu Lee, Jennifer K. Lee, Jaemin Byun, Inyong Kim, Jung-Heun Ha
Summary: Obesity is closely associated with chronic inflammation and dyslipidemia, and the consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) may regulate obesity-related disorders. This study aimed to investigate the importance of n-3 PUFA consumption, including the ratio of n-6/n-3 PUFAs and the amount of n-3 PUFAs. The results suggest that a dietary intervention with a lower n-6/n-3 PUFA ratio can significantly alleviate metabolic dysfunction in LPS-induced ob/ob mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Toxicology
Sybille van den Brule, Margaux Rappe, Jerome Ambroise, Caroline Bouzin, Chantal Dessy, Adrien Paquot, Giulio G. Muccioli, Dominique Lison
Summary: Oral exposure to DEP at doses relevant for human health can alter the composition and function of the gut microbiota, but these changes do not translate into ultimate atherosclerotic or metabolic outcomes.
PARTICLE AND FIBRE TOXICOLOGY
(2021)
Article
Immunology
Zhihua Ren, Samuel Kumi Okyere, Lei Xie, Juan Wen, Jiayi Wang, Zhengli Chen, Xueqin Ni, Junliang Deng, Yanchun Hu
Summary: This study investigated the ameliorative effects of Bacillus toyonensis-SAU-20 (B. toyo SAU-20) on insulin resistance and hepatic steatosis in type 2 diabetic mice. Results showed that B. toyo SAU-20 significantly suppressed the elevation of glucose, lipid profile, lipogenic genes, and pro-inflammatory cytokines in T2DM mice. Additionally, B. toyo SAU-20 improved liver morphology, dyslipidemia, oxidative stress, and inflammation. These findings suggest that B. toyo SAU-20 alleviates insulin resistance and hepatic steatosis by improving lipid profiles, antioxidant status, and downregulating lipogenic genes and pro-inflammatory cytokines expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Correction
Multidisciplinary Sciences
Kalpana D. Acharya, Xing Gao, Elizabeth P. Bless, Jun Chen, Marc J. Tetel
Summary: An updated version of this paper has been published and is accessible through a link at the top of the paper.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Yafang He, Kun Xu, Yunfeng Li, Huan Chang, Xia Liao, Hang Yu, Tian Tian, Chao Li, Yuan Shen, Qian Wu, Xin Liu, Lin Shi
Summary: The study found that CLA can improve body composition, with changes in the metabolome predicting responsiveness to intervention. Post-intervention metabolite alterations were associated with changes in body composition, showing the potential of baseline metabolite profiling in predicting CLA-induced benefits.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Shigeru Murakami, Kohei Funahashi, Natsuki Tamagawa, Ma Ning, Takashi Ito
Summary: Taurine ameliorated diabetes and its complications by improving hepatic glucose metabolism and reducing oxidative stress.
Article
Chemistry, Analytical
Yan Cao, Wei Li, Xingcheng Gong, Xiaoya Niu, Jiao Zheng, Juan Yu, Jun Li, Pengfei Tu, Yuelin Song
Summary: This study used widely quantitative metabolomics to investigate the fluctuation trajectory of bile acid (BA) pool in rats after dosing ursodeoxycholic acid (UDCA) treatment. The results showed that UDCA significantly shaped the sub-metabolome of BAs, increasing the content of downstream BAs and causing significant upgradation for BAs with greater distance from UDCA.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Inge Everaert, Thibaux Van der Stede, Jan Stautemas, Maxime Hanssens, Cleo van Aanhold, Hans Baelde, Lynn Vanhaecke, Wim Derave
Summary: This study investigated the effects of anserine or carnosine supplementation on BTBR ob/ob mice, showing that anserine supplementation can increase circulating and kidney anserine levels in diabetic mice, but is not able to attenuate the development of T2D or diabetic nephropathy.
Article
Immunology
Xuerun Liu, Luoyang Wang, Huiren Zhuang, Zhenghuan Yang, Guoqiang Jiang, Zheng Liu
Summary: Recent research has shown that anthocyanins have prebiotic attributes and can be used to treat microbiota-associated diseases. This study investigates the effects of bilberry anthocyanins on the gut microbiota composition, metabolism, and the intestinal mucosal immune system of mice. The findings suggest that oral administration of anthocyanins can help maintain intestinal homeostasis and may have applications in immunotherapy and related fields.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hye-Yeong Jin, Seung-Yeon Yoo, Ji-Ae Lee, Xianyu Wen, Younghoon Kim, Hye Eun Park, Yoonjin Kwak, Nam-Yun Cho, Jeong Mo Bae, Jung Ho Kim, Hye Seung Lee, Gyeong Hoon Kang
Summary: Tumor stroma and tumor-infiltrating lymphocytes (TILs) have different effects on the prognosis of colorectal cancer (CRC) patients. The combinatory statuses of tumor-stromal percentage (TSP) and TILs can provide powerful prognostic information for CRCs.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pathology
Ji Ae Lee, Mi-Kyoung Seo, Seung-Yeon Yoo, Nam-Yun Cho, Yoonjin Kwak, Kyoungbun Lee, Jung Ho Kim, Gyeong Hoon Kang
Summary: Decreased expression of CDX2, SATB2, and KRT20 in colorectal carcinomas (CRCs) is commonly associated with microsatellite instability-high (MSI-H) and CpG island methylator phenotype-high (CIMP-H), but the specific features associated with the loss of each marker differ in CRCs.
Article
Multidisciplinary Sciences
Xianyu Wen, Hye-Yeong Jin, Meihui Li, Younghoon Kim, Nam-Yun Cho, Yoonjin Kwak, Jeong Mo Bae, Hye Seung Lee, Gyeong Hoon Kang
Summary: Through genome-wide methylation profiling, the methylation markers NCOR2, PARK2, and ZSCAN12 were found to be closely associated with the density of CD3-positive and CD8-positive cells and could serve as biomarkers for predicting the prognosis of patients with gastric carcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Jung Ho Kim, Mi-Kyoung Seo, Ji Ae Lee, Seung-Yeon Yoo, Hyeon Jeong Oh, Hyundeok Kang, Nam-Yun Cho, Jeong Mo Bae, Gyeong Hoon Kang, Sangwoo Kim
Summary: CRCs with MSI-H are immunologically heterogeneous and can be classified into immune-high, immune-intermediate, and immune-low subgroups. Immune-low MSI-H CRCs show similarities to specific subgroups of microsatellite-stable CRCs in terms of immune parameters, but exhibit distinct pathological features, genomic alterations, and activated signaling pathways, further dividing into different gene expression subtypes. These findings provide insights into precise immunotherapeutic strategies for different subtypes of MSI-H tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Genetics & Heredity
Jeong Mo Bae, Ji Young Ahn, Heonyi Lee, Hoon Jang, Hyojun Han, Jaehwan Jeong, Nam-Yun Cho, Kwangsoo Kim, Gyeong Hoon Kang
Summary: DNA methylation profiling is a promising method for predicting the tissue of origin in cancer patients. By extracting genomic DNA from formalin-fixed tissues, a targeted bisulfite sequencing panel based on hybrid capture has been developed and found to be useful in clinical practice.
Review
Biochemistry & Molecular Biology
Nhung Thi Nguyen, Tuyet Thi Nguyen, Kyu-Sang Park
Summary: Inorganic phosphate (Pi) is essential but excessive Pi leads to vascular calcification through oxidative stress. The Na+-dependent Pi cotransporter PiT-1/-2 plays a crucial role in Pi uptake by vascular smooth muscle cells, leading to depolarization-activated Ca2+ entry and oxidative stress. Mitochondrial Pi transporters, including phosphate carrier (PiC), also contribute to oxidative stress and intracellular and mitochondrial Pi overload. Increased Ca2+ and Pi accumulation further enhances oxidative stress and osteogenic differentiation.
Article
Biochemistry & Molecular Biology
Yong Sung Cha, Jae Seung Chang, Hyun Kim, Kyu-Sang Park
Summary: Mitochondrial and oxidative stress are involved in the pathogenic mechanisms of carbon monoxide-induced toxicity. This study found that serum levels of specific stress biomarkers can reflect brain injury and act as prognostic markers for the development of neurocognitive sequelae following CO poisoning.
Review
Pathology
Younghoon Kim, Nam Yun Cho, Gyeong Hoon Kang
Summary: The association between F. nucleatum and prognosis or clinicopathological features in colorectal cancer varies among studies and may be influenced by the type of biospecimen.
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park, Gyeong Hoon Kang
Summary: The optimal tumor budding cut-off number for estimating LN metastasis in submucosal CRC was determined and a composite scoring system (CSS) was developed.
Article
Pathology
Minsun Jung, Ji Ae Lee, Seung-Yeon Yoo, Jeong Mo Bae, Gyeong Hoon Kang, Jung Ho Kim
Summary: This study investigates the spatial heterogeneity of tumor-infiltrating lymphocytes (TILs) in colorectal carcinomas (CRCs) and identifies its prognostic and immunologic significance. It demonstrates that TILs density and spatial distribution have a significant impact on prognosis in CRCs. TIL-low CRCs can be divided into two subgroups with distinct prognosis and immunologic characteristics based on the spatial heterogeneity of TILs. These findings suggest that the intratumoral spatial heterogeneity of TILs can be a key element for clinically relevant immunologic subtyping of tumors.
Article
Multidisciplinary Sciences
Dae-yeol Ye, Myung Hyun Noh, Jo Hyun Moon, Alfonsina Milito, Minsun Kim, Jeong Wook Lee, Jae-Seong Yang, Gyoo Yeol Jung
Summary: Unlike eukaryotic systems, bacterial hosts lack a membranous system, which is a limitation for efficient metabolic engineering. In this study, a kinetic compartmentalization strategy was used to increase substrate availability from competitive reactions for the efficient production of itaconate in E. coli.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Chae Won Kang, Hyun Gyu Lim, Jaehyuk Won, Sanghak Cha, Giyoung Shin, Jae-Seong Yang, Jaeyoung Sung, Gyoo Yeol Jung
Summary: In this study, the authors developed a synthetic adaptation strategy to improve the production of a microbial consortium. By introducing a genetic circuit in one of the strains, they were able to control the production of a specific compound and acclimate the consortium for higher production.
NATURE COMMUNICATIONS
(2022)
Review
Plant Sciences
Alfonsina Milito, Moritz Aschern, Josie L. McQuillan, Jae-Seong Yang
Summary: This review focuses on Chlamydomonas reinhardtii, a microalgal species commonly used in bioengineering research, and discusses the key obstacles and potential solutions in synthetic promoter development. Microalgae have great potential as carbon-fixing biofactories to provide safe and sustainable high-value compounds, but optimizing their metabolic outputs and making them competitive with established industrial hosts requires precise control over transgene expression. However, the current repertoire of functional synthetic promoters for microalgae, especially for C. reinhardtii, is limited compared to other commercial chassis. The review highlights the need to expand the microalgal gene expression toolbox and proposes novel approaches and perspectives for synthetic promoter development in microalgae.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Oncology
Younghoon Kim, Gyeong Hoon Kang, Haeryoung Kim
Summary: A systematic review and meta-analysis showed that the presence of heterologous component is associated with worse overall survival in gynecologic carcinosarcoma, but not with recurrence-free survival and disease-free survival.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)