Review
Cell Biology
Alyson Sujkowski, Luke Hong, R. J. Wessells, Sokol Todi
Summary: Endurance exercise is an accessible and cost-effective intervention that has a variety of benefits for multiple organ systems. It improves physical performance, reduces the risk of various pathologies, and has protective effects on neurodegenerative diseases. These effects may be mediated by mechanisms such as neuronal survival and plasticity, neurogenesis, and angiogenesis.
AGEING RESEARCH REVIEWS
(2022)
Review
Cell Biology
Anita Pras, Ellen A. A. Nollen
Summary: Proteome damage is closely associated with aging and age-related neurodegenerative diseases, as molecular quality control mechanisms that prevent protein misfolding and aggregation decline with age, leading to the accumulation of harmful proteins in cells. Various model organisms have been used to study the mechanisms of protein toxicity acceleration or prevention, and understanding these mechanisms can help develop interventions that delay aging and age-related diseases by optimizing protein homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Nayomi Camilus, Carlos Quintero Arias, Sanela Martic
Summary: TDP-43 plays a role in cellular function, but its nucleus-cytoplasm shuttling is disrupted in diseases like ALS. The variability of TDP-43 structures is influenced by environmental factors that contribute to protein pathogenesis. Identifying triggers that affect TDP-43 biochemistry could lead to new therapies. This review discusses recent findings on the diversity of TDP-43 structures and the triggers that lead to their formation.
Review
Pharmacology & Pharmacy
Girija Pawge, Gopal L. Khatik
Summary: The review discusses the role of p53 in the formation of DNA-SCARS, various upstream target proteins, and pathways involved in p53 regulation. Senolytic therapies that modulate p53 upstream targets could be a promising approach for preventing age-related disorders.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Ophthalmology
Xingjun Fan, Vincent M. Monnier
Summary: Crystallins, the predominant lens proteins, remain unchanged throughout the entire human lifespan, but are susceptible to post-synthetic modifications such as oxidation and glycation. As individuals age, significant changes occur in the lens, including decreased antioxidative defense capacity and protein glycation.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Run Jin, Aidan Kai Yeung Chan, Jingsong Wu, Tatia Mei Chun Lee
Summary: The review discusses the potential mechanisms and strategies for ameliorating age-related neurocognitive changes associated with inflammation, providing important insights for understanding the pathophysiological mechanisms of neurocognitive disorders and developing preventative measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Valentina Vapore, Corrado Mazzaglia, Diego Sibilia, Mara Del Vecchio, Gernot Fruhmann, Marta Valenti, Elena Miranda, Teresa Rinaldi, Joris Winderickx, Cristina Mazzoni
Summary: The study found that expression of human wild-type NS and the polymerogenic variant G392E NS in yeast led to the formation of protein aggregates mainly localized within the endoplasmic reticulum (ER). NS inclusions delayed the exit from the lag phase, causing cellular stress, and showed higher resistance following mild oxidative stress treatments.
Review
Cell Biology
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Annalisa Barbieri, Lorenzo Rossi, Giovanni Ricevuti, Ciro Esposito, Salvatore Chirumbolo, Nicoletta Marchesi, Alessia Pascale
Summary: Aging is a major risk factor for various diseases. Understanding the molecular mechanisms and discovering new therapies for aging-related diseases are crucial, as the population continues to age exponentially.
AGEING RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Mercedes M. Perez-Jimenez, Jose M. Monje-Moreno, Ana Maria Brokate-Llanos, Monica Venegas-Caleron, Alicia Sanchez-Garcia, Paula Sansigre, Amador Valladares, Sara Esteban-Garcia, Irene Suarez-Pereira, Javier Vitorica, Jose Julian Rios, Marta Artal-Sanz, Angel M. Carrion, Manuel J. Munoz
Summary: The study demonstrates that loss of function of the steroid sulfatase sul-2 in Caenorhabditis elegans increases lifespan and ameliorates protein aggregation diseases, through mechanisms involving factors related to germline-mediated longevity. Sul-2 is predominantly expressed in sensory neurons, suggesting regulation by environmental cues.
NATURE COMMUNICATIONS
(2021)
Review
Neurosciences
Ishfaq Ahmad Ahanger, Sania Bashir, Zahoor Ahmad Parray, Mohamed F. Alajmi, Afzal Hussain, Faizan Ahmad, Md. Imtaiyaz Hassan, Asimul Islam, Anurag Sharma
Summary: The study found that monosodium glutamate (MSG) may induce neurological diseases through its role in protein aggregation, specifically by enhancing the aggregation of BSA. Additionally, MSG was also found to significantly enhance the aggregation of CTAB-BSA.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Alessandra Bigi, Roberta Cascella, Cristina Cecchi
Summary: The misfolding and aggregation of a-synuclein is the key feature of synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies. Soluble oligomeric assemblies formed during the early stages of aggregation are toxic to neurons, while fibrillar conformers contribute to the spreading of the pathology. Recent studies have also shown that a-synuclein fibrils release soluble and highly toxic oligomeric species, leading to immediate dysfunction in recipient neurons. This review discusses the mechanisms of cellular dysfunction caused by a-synuclein oligomers and fibrils in synucleinopathies.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J. Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis
Summary: Expansion of the polyglutamine tract in Ataxin-1's N terminus is the main cause of SCA1, while the phosphorylation event on residue serine 776 in the C-terminal part also plays a crucial role in disease development. 14-3-3 proteins have a direct anti-aggregation effect on Ataxin-1 by interfering with its dimerization, which is particularly important in the context of SCA1 where soluble mutant Ataxin-1 drives pathology.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Meghana Somlapura, Benjamin Gottschalk, Pooja Lahiri, Iris Kufferath, Daniela Pabst, Thomas Ruelicke, Wolfgang F. Graier, Helmut Denk, Kurt Zatloukal
Summary: The study reveals differences in the interaction with keratins 8 and 18 and in the cytoplasmic distribution and aggregation behavior of p62 isoforms p62-H1 and p62-H2, indicating the importance of considering p62 isoforms in protein aggregation disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Sharon Negri, Madison Sanford, Helen Shi, Stefano Tarantini
Summary: TRP channels in the vascular endothelium play a crucial role in regulating membrane potential and intracellular calcium concentration. Aging is a significant risk factor for vascular cognitive impairment (VCI), and no preventative or therapeutic treatments are currently available. This review explores the involvement of endothelial TRP channels in brain physiology and the pathogenesis of age-related VCI, and discusses potential neuroprotective strategies for the future.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Orthopedics
Alan J. Mueller, Mandy J. Peffers, Carole J. Proctor, Peter D. Clegg
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Article
Multidisciplinary Sciences
Louise I. Pease, Peter D. Clegg, Carole J. Proctor, Daryl J. Shanley, Simon J. Cockell, Mandy J. Peffers
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Carole J. Proctor, Katarzyna Goljanek-Whysall
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Ciaran M. Welsh, Nicola Fullard, Carole J. Proctor, Alvaro Martinez-Guimera, Robert J. Isfort, Charles C. Bascom, Ryan Tasseff, Stefan A. Przyborski, Daryl P. Shanley
Article
Cell Biology
Alvaro Martinez Guimera, Ciaran M. Welsh, Carole J. Proctor, Anne McArdle, Daryl P. Shanley
MECHANISMS OF AGEING AND DEVELOPMENT
(2018)
Article
Rheumatology
Wang Hui, David A. Young, Andrew D. Rowan, Xin Xu, Tim E. Cawston, Carole J. Proctor
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Review
Biochemistry & Molecular Biology
Alvaro Martinez Guimera, Daryl P. Shanley, Carole J. Proctor
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Neurosciences
Carole J. Proctor, Douglas A. Gray
MOLECULAR NEURODEGENERATION
(2010)
Article
Neurosciences
Carole J. Proctor, Ilse Sanet Pienaar, Joanna L. Elson, Thomas B. L. Kirkwood
MOLECULAR NEURODEGENERATION
(2012)
Article
Biochemistry & Molecular Biology
Joao F. Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J. Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B. L. Kirkwood, Thomas von Zglinicki
MOLECULAR SYSTEMS BIOLOGY
(2010)
Article
Multidisciplinary Sciences
Carole J. Proctor, Ian A. J. Lorimer
Article
Multidisciplinary Sciences
Carole J. Proctor, Delphine Boche, Douglas A. Gray, James A. R. Nicoll
Article
Multidisciplinary Sciences
Carole J. Proctor, Graham R. Smith
Article
Rheumatology
C. J. Proctor, C. Macdonald, J. M. Milner, A. D. Rowan, T. E. Cawston
ARTHRITIS & RHEUMATOLOGY
(2014)
Review
Biochemistry & Molecular Biology
Mark T. Mc Auley, Alvaro Martinez Guimera, David Hodgson, Neil Mcdonald, Kathleen M. Mooney, Amy E. Morgan, Carole J. Proctor
BIOSCIENCE REPORTS
(2017)