Review
Biochemistry & Molecular Biology
Su Young Ki, Yong Taek Jeong
Summary: Taste receptors are not only found in taste receptor cells, but also in non-gustatory organs, and they have been found to have physiological functions beyond taste. Tuft cells, a type of specialized epithelial cells, are considered to be related to type II taste receptor cells, and the ectopic expression of taste receptors can be categorized into taste receptors in TRC-like cells outside taste buds and taste receptors expressed in completely different cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Makoto Ohmoto, Satsuki Kitamoto, Junji Hirota
Summary: Taste substances are detected by taste receptor cells in the oral epithelium, which are continuously replaced by new ones generated from local epithelial stem cells. Pou2f3 is a key transcription factor that regulates the generation and differentiation of sweet, umami, and bitter cells. Through RNA-sequence data analysis, Eya1 was identified as the only transcription factor gene showing higher expression in bitter cells than in sweet cells, suggesting it plays a role in regulating the generation and differentiation of bitter cells.
CELL AND TISSUE RESEARCH
(2021)
Article
Behavioral Sciences
Quan T. Nguyen, Grace E. Beck Coburn, Amber Valentino, Bekir Karabucak, Marco Tizzano
Summary: A newly discovered chemosensory structure in the rear of the mandibular mucosa in mice may play a role in taste sensation and serve as a potential novel pharmacological target for taste disorders. This structure contains unorganized taste buds associated with the ducts of a minor salivary gland and expresses various taste receptors and signaling molecules, similar to other lingual and palate taste buds.
Article
Immunology
Zhizhongbin Wu, Yilin Huang, Weiqing Hu, Liyin Ren, Peihua Jiang, Robert F. Margolskee, Hong Wang, Shan Feng
Summary: This study found that a subset of taste bud cells and taste neurons express iNOS proteins after inflammation stimulation, and isolated mouse taste epithelium can release NO in vitro. Furthermore, NO may play an important role in inflammation-associated taste disturbances.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Agriculture, Dairy & Animal Science
Yuta Yoshida, Fuminori Kawabata, Shoji Tabata, Samuel E. Aggrey, Romdhane Rekaya, Hong-Xiang Liu
Summary: Recent studies have shown that modern high-yielding broilers exhibit higher sensitivity to bitter taste stimuli compared to traditional meat-type chicken strains. This evolution of taste sensitivities may be associated with alterations in the upper level of the taste system.
Article
Immunology
Daichi Kobayashi, Tomoya Watarai, Madoka Ozawa, Yasuhiro Kanda, Fumihiro Saika, Norikazu Kiguchi, Arata Takeuchi, Masahito Ikawa, Shinsuke Matsuzaki, Tomoya Katakai
Summary: This study found that Tas2R126, Tas2R135, and Tas2R143 are expressed in mouse neutrophils but not in other immune cells. Stimulation of these receptors enhanced the migration of neutrophils in response to CXCL2. This enhancement was dependent on ROCK-MLC2 signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Songhui Hu, Yurong Wang, Xu Han, Min Dai, Yongxing Zhang, Yuanyuan Ma, Shijun Weng, Lei Xiao
Summary: The study identified the expression of oxytocin receptors in the mouse retina, mainly in GABAergic amacrine cells, especially dopaminergic cells. Exogenous oxytocin application activated retinal dopaminergic neurons and decreased bipolar cell activity through oxytocin and dopamine receptors, suggesting a modulation of visual information processing by oxytocin signaling in the retina from the hypothalamus.
Article
Biology
Kengo Inada, Kazoku Tsujimoto, Masahide Yoshida, Katsuhiko Nishimori, Kazunari Miyamichi
Summary: Studies have shown that oxytocin signaling in the arcuate nucleus suppresses excessive food intake, playing an important role in body weight homeostasis and appetite regulation.
Article
Agriculture, Dairy & Animal Science
Claudia Gatta, Valentina Schiano, Chiara Attanasio, Carla Lucini, Antonio Palladino
Summary: In this study, the presence of neurotrophic factors in the taste bud cells of zebrafish is demonstrated. These neurotrophins play an important role in taste bud function and share similarities with those found in mammals. This study further confirms the significance of the zebrafish model in translational research.
Article
Nutrition & Dietetics
Kellie M. Hyde, Ginger D. Blonde, A. Valentina Nisi, Alan C. Spector
Summary: Roux-en-Y gastric bypass (RYGB) in rats decreases preference and intake of sugar solutions. High-fat diet (HFD) also alters behavioral responsiveness to sucrose in rats. However, this study found that these changes are not related to alterations in taste sensitivity.
Article
Biochemistry & Molecular Biology
Yuta Yoshida, Fuminori Kawabata, Shotaro Nishimura, Shoji Tabata
Summary: This study characterizes the peripheral taste-sensing systems in chickens by analyzing the distributions of mammalian types I, II, and III taste cell markers in chicken taste buds. The results demonstrate a unique subset of chicken taste cells expressing multiple taste cell type marker proteins, providing new insights into the taste-sensing mechanisms in vertebrate taste buds.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Rio Ikuta, Kanae Myoenzono, Jun Wasano, Kayoko Hamaguchi-Hamada, Shun Hamada, Mami Kurumata-Shigeto
Summary: The study examined the localization of N-cadherin in mouse taste buds, showing it is important for the formation and maintenance of synapses in type II cells. N-cadherin was detected in nerve fibers and connective tissues, suggesting its role in afferent synapses.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Alizee Vercauteren Drubbel, Benjamin Beck
Summary: Using single-cell RNA sequencing, we discovered taste buds specifically in the cervical segment of the mouse esophagus. These taste buds have similar cellular composition to those in the tongue, but express fewer taste receptor types. Through transcriptional regulatory network analysis, specific transcription factors associated with the differentiation of immature progenitors into different taste bud cell types were identified. Lineage tracing experiments revealed that esophageal taste buds arise from squamous bipotent progenitors, indicating that all esophageal progenitors are not unipotent. Our characterization of the cervical esophagus epithelium at the cellular level will provide a better understanding of esophageal progenitor potency and the development of taste buds.
Article
Biochemistry & Molecular Biology
Marialuisa Aragona, Caterina Porcino, Marilena Briglia, Kamel Mhalhel, Francesco Abbate, Maria Levanti, Giuseppe Montalbano, Rosaria Laura, Eugenia Rita Lauriano, Antonino Germana, Maria Cristina Guerrera
Summary: This study reveals the presence of Vimentin RV202 in taste bud cells of zebrafish for the first time. Vimentin RV202 may play an important role in the maturation and regeneration of taste bud cells. Further research is needed to elucidate its synergistic work with ubiquitin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hsin-Ju Chuang, Chun-Yung Chang, Huai-Ping Ho, Ming-Yi Chou
Summary: The study demonstrates that oxytocin system plays a significant role in stress responses and adaptation in fish. Different environmental stressors can affect the expression of oxytocin receptors in fish, leading to changes in the number and expression of oxytocin neurons. Through the use of transgenic technology, the role of oxytocin neurons in various nuclei regulating anxiety levels and aggressiveness in adult zebrafish under different environmental stresses is revealed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Robin Dando, Elizabeth Pereira, Mani Kurian, Rene Barro-Soria, Nirupa Chaudhari, Stephen D. Roper
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2015)
Review
Physiology
Stephen D. Roper
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2015)
Article
Psychology, Biological
Michael S. Sinclair, Isabel Perea-Martinez, Marianne Abouyared, Steven J. St John, Nirupa Chaudhari
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Multidisciplinary Sciences
An Wu, Gennady Dvoryanchikov, Elizabeth Pereira, Nirupa Chaudhari, Stephen D. Roper
NATURE COMMUNICATIONS
(2015)
Review
Neurosciences
Stephen D. Roper, Nirupa Chaudhari
NATURE REVIEWS NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Gennady Dvoryanchikov, Damian Hernandez, Jennifer K. Roebber, David L. Hill, Stephen D. Roper, Nirupa Chaudhari
NATURE COMMUNICATIONS
(2017)
Article
Oncology
Dongwook Kim, Manu Shivakumar, Seonggyun Han, Michael S. Sinclair, Young-Ji Lee, Yonglan Zheng, Olufunmilayo I. Olopade, Dokyoon Kim, Younghee Lee
MOLECULAR CANCER RESEARCH
(2018)
Article
Behavioral Sciences
Tricia L. Meredith, Alan Corcoran, Stephen D. Roper
Article
Multidisciplinary Sciences
Andrew K. Haack, Chandni Sheth, Andrea L. Schwager, Michael S. Sinclair, Shashank Tandon, Sharif A. Taha
Article
Neurosciences
Sara C. M. Leijon, Amanda F. Neves, Joseph M. Breza, Sidney A. Simon, Nirupa Chaudhari, Stephen D. Roper
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Review
Behavioral Sciences
Kathrin Ohla, Ryusuke Yoshida, Stephen D. Roper, Patricia M. Di Lorenzo, Jonathan D. Victor, John D. Boughter, Max Fletcher, Donald B. Katz, Nirupa Chaudhari
Article
Neurosciences
Jennifer K. Roebber, Stephen D. Roper, Nirupa Chaudhari
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
David W. Sant, Michael Sinclair, Christopher J. Mungall, Stefan Schulz, Daniel Zerbino, Ruth C. Lovering, Colin Logie, Karen Eilbeck
Summary: The Sequence Ontology (SO) is a structured, controlled vocabulary for genomic annotation. The GREEKC initiative aims to curate information on how gene expression is regulated at the molecular level. Recent updates to the SO include more accurate, human-readable terms, new definitions, and relationships related to gene expression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Neurosciences
Yuryanni A. Rodriguez, Jennifer K. Roebber, Gennady Dvoryanchikov, Vivien Makhoul, Stephen D. Roper, Nirupa Chaudhari
Summary: Research showed that Type I cells in mammalian taste buds primarily respond to ATP, not to other chemicals or taste stimuli. The study suggests that Type I cells may sense chemosensory activation and participate in synaptic signaling, similar to glial cells in the CNS.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Physiology
Stephen D. Roper
Summary: Studies have shown that various neurotransmitters, including ATP, serotonin, GABA, acetylcholine, and norepinephrine, are secreted by taste cells and exert paracrine interactions in taste buds. Most research has focused on interactions between Type II and Type III taste cells.
CURRENT OPINION IN PHYSIOLOGY
(2021)