Article
Medicine, Research & Experimental
Joseph Heitman
Summary: This Viewpoint is associated with the 25th anniversary of the American Society for Clinical Investigation's Stanley J. Korsmeyer Award, which recognizes scientific excellence, meritorious research, intellectual integrity, and mentoring of future researchers. The 2018 award honored Joseph Heitman for his contributions to understanding microbial pathogen evolution, disease causation, drug resistance, and discovery of immunosuppressive drug targets. Dr. Heitman has mentored numerous students, fellows, and researchers who have pursued successful careers in medicine and biomedical research.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Microbiology
Dipak Kathayat, Dhanashree Lokesh, Sochina Ranjit, Gireesh Rajashekara
Summary: APEC is a pathogen that causes colibacillosis in avian species, potentially posing a foodborne zoonotic risk. In addition to known virulence factors, other factors contribute to APEC pathogenesis. APEC shows resistance to multiple classes of antibiotics, highlighting the need for effective vaccines and alternative therapies.
Review
Microbiology
Mohd W. Azam, Raffaele Zarrilli, Asad U. Khan
Summary: The Enterobacterales order is a large group of Gram-negative bacteria that includes both pathogenic and nonpathogenic members, including beneficial gut microbiota. Pathogenic members produce virulence factors and display antimicrobial resistance. This review focuses on the virulence factors, pathogenicity, and infections caused by multidrug-resistant Enterobacterales, particularly E. coli and similar bacterial species. The review also discusses different approaches for combating these infections. Understanding the virulence factors of pathogenic bacteria can aid in the development of novel strategies to treat infections caused by them.
Editorial Material
Oncology
Naing Lin Shan, Adriana Kahn, Lajos Pusztai
Summary: Recent technological advances have revealed complex biological processes and heterogeneity within tumors, with important clinical implications. These insights have led to the discovery of new biomarkers for immunotherapies, justified the use of serial tumor biopsies for therapeutic target profiling, inspired the development of new treatment strategies, and may ultimately lead to novel therapeutics targeting clonal interdependence.
BRITISH JOURNAL OF CANCER
(2023)
Article
Infectious Diseases
Benjin Xu, Zhuru Hou, Ling Liu, Rongrong Yan, Jinjing Zhang, Jianhong Wei, Miao Du, Yan Xuan, Lei Fan, Zhuoxi Li
Summary: This study comprehensively analyzed the drug resistance and virulence characteristics of Salmonella Enteritidis strain 27A using genomic and proteomic approaches, revealing its drug resistance and virulence mechanisms. It provides important information for food safety, public health monitoring, and research on drug resistance and pathogenicity of Salmonella Enteritidis.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Immunology
Carina Danchik, Arturo Casadevall
Summary: Cell surface hydrophobicity (CSH) is a crucial cellular biophysical parameter that influences cell-cell and cell-surface interactions. Variations in CSH can impact the pathogenicity of fungi and the efficacy of antifungal therapies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Andrea Colautti, Martina Arnoldi, Giuseppe Comi, Lucilla Iacumin
Summary: Lactobacilli are widely used bacteria with various applications in the food and medical sectors, despite being classified as safe microorganisms. Some studies suggest potential health risks for certain individuals, highlighting the importance of proper assessment before use.
Article
Microbiology
Axel B. Janssen, Dennis J. Doorduijn, Grant Mills, Malbert R. C. Rogers, Marc J. M. Bonten, Suzan H. M. Rooijakkers, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik
Summary: Colistin resistance in Klebsiella pneumoniae can rapidly develop through diverse evolutionary trajectories, shortening the lifespan of this last-resort antibiotic for treating infections with multidrug-resistant strains.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Maan T. Khayat, Tarek S. Ibrahim, Khaled M. Darwish, Ahdab N. Khayyat, Majed Alharbi, El-Sayed Khafagy, Mohamed A. M. Ali, Wael A. H. Hegazy, Hisham A. Abbas
Summary: Bacteria communicate through quorum sensing, and Pseudomonas aeruginosa is a clinically important pathogen with high antibiotic resistance and controlled virulence factors through quorum sensing. This study evaluates the anti-quorum sensing and anti-virulence activities of linagliptin against P. aeruginosa, and finds that it effectively inhibits virulence factor production and reduces pathogenesis.
Article
Infectious Diseases
Pablo Rovira
Summary: Antimicrobial resistance (AMR) is a global public health concern. This study investigated the effects of oxytetracycline (OTC) on the microbiome, antibiotic resistance genes (ARGs), and virulence factor genes (VFGs) in grazing beef cattle. OTC significantly affected the diversity of the fecal microbiome and led to an increase in the abundance of certain ARGs. However, OTC had no significant effect on VFGs.
Article
Multidisciplinary Sciences
Shymaa Enany, Samira Zakeer, Aya A. Diab, Usama Bakry, Ahmed A. Sayed
Summary: In this study, the whole genome sequencing of Klebsiella pneumoniae ST627 was conducted, revealing the presence of antimicrobial resistance and virulence genes. Plasmids, phage regions, and CRISPR arrays were also identified and analyzed. The results highlight the critical role of mobile genetic elements in the dissemination of antibiotic resistance in ST 627.
Article
Immunology
Hidetada Hirakawa, Kazutomo Suzue, Haruyoshi Tomita
Summary: The Tol/Pal system is a set of protein complexes produced by Gram-negative bacteria, playing essential roles in colicin uptake, pathogenesis, and cell growth. It is proposed as a potential target for antimicrobial chemotherapy and vaccine development due to its immunogenicity and ability to stimulate immune responses.
Article
Multidisciplinary Sciences
Paul Bowyer, Andrew Currin, Daniela Delneri, Marcin G. Fraczek
Summary: This study utilized multiple sequencing technologies to de novo assemble and polish two laboratory reference strains of Aspergillus fumigatus. The high-quality reference genomes generated will serve as fundamental resources for studying the biology, pathogenicity, and virulence of A. fumigatus and for discovering more effective treatments against diseases caused by this fungus.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Mony Thakur, Yatin Khushboo, Yatin Kumar, Vinod Yadav, Avijit Pramanik, Kashyap Kumar Dubey
Summary: Pseudomonas aeruginosa has various virulence factors that contribute to host infection and persistence. These factors allow the bacteria to cause severe infections in immunocompromised individuals. P. aeruginosa is a nosocomial pathogen that is typically resistant to available antibiotics. Biofilm formation by P. aeruginosa is a major concern in hospitals and can lead to chronic infection and increased mortality risk. Therefore, it is crucial to develop new strategies to disrupt biofilm formation and improve antibiotic efficacy for the treatment of P. aeruginosa infections. Inhibition of quorum sensing and biofilm formation through pharmacological approaches, such as phytochemicals and essential oils, has shown promising results in laboratory studies. LasR, a regulatory protein, plays a key role in quorum sensing signaling, and designing an antagonist molecule that mimics the natural autoinducer could be the best approach for LasR inhibition. In this review, we discuss antibiotic resistance mechanisms and alternative approaches to combat the pathogenicity of P. aeruginosa.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Microbiology
Robert A. Cramer, Caitlin H. Kowalski
Summary: The emphasis on extreme survival curve phenotypes in studying fungal infectious diseases may lead to missed opportunities in identifying new fungal and host factors essential for disease progression. New approaches are needed to define infection site biology beyond survival curve analyses, with the potential introduction of terms like disease initiation factor and disease progression factor to aid in discovering new targets.
Article
Biology
Atsushi Yamauchi, Minus van Baalen, Yutaka Kobayashi, Junji Takabayashi, Kaori Shiojiri, Maurice W. Sabelis
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2015)
Article
Biology
William Lee, Minus van Baalen, Vincent A. A. Jansen
JOURNAL OF THEORETICAL BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Sebastien Boyer, Dipanwita Biswas, Ananda Kumar Soshee, Natale Scaramozzino, Clement Nizak, Olivier Rivoire
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Microbiology
Mounira Smati, Giuseppe Magistro, Sandrine Adiba, Andreas Wieser, Bertrand Picard, Soeren Schubert, Erick Denamur
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Klaus Eyer, Raphael C. L. Doineau, Carlos E. Castrillon, Luis Briseno-Roa, Vera Menrath, Guillaume Mottet, Patrick England, Alexei Godina, Elodie Brient-Litzler, Clement Nizak, Allan Jensen, Andrew D. Griffiths, Jerome Bibette, Pierre Bruhns, Jean Baudry
NATURE BIOTECHNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Anandakumar Soshee, Stefan Zuercher, Nicholas D. Spencer, Avraham Halperin, Clement Nizak
Article
Evolutionary Biology
Miguel Navascues, Delphine Legrand, Cecile Campagne, Marie-Louise Cariou, Frantz Depaulis
BMC EVOLUTIONARY BIOLOGY
(2014)
Article
Chemistry, Multidisciplinary
Souvik Modi, Saheli Halder, Clement Nizak, Yamuna Krishnan
Article
Multidisciplinary Sciences
Antoine Chaillon, Tanawan Samleerat, Faustine Zoveda, Sebastien Ballesteros, Alain Moreau, Nicole Ngo-Giang-Huong, Gonzague Jourdain, Sara Gianella, Marc Lallemant, Frantz Depaulis, Francis Barin
Article
Microbiology
Guillaume Geslain, Andre Birgy, Sandrine Adiba, Melanie Magnan, Celine Courroux, Corinne Levy, Robert Cohen, Philippe Bidet, Stephane Bonacorsi
Article
Biotechnology & Applied Microbiology
Annabelle Gerard, Adam Woolfe, Guillaume Mottet, Marcel Reichen, Carlos Castrillon, Vera Menrath, Sami Ellouze, Adeline Poitou, Raphael Doineau, Luis Briseno-Roa, Pablo Canales-Herrerias, Pascaline Mary, Gregory Rose, Charina Ortega, Matthieu Delince, Sosthene Essono, Bin Jia, Bruno Iannascoli, Odile Richard-Le Goff, Roshan Kumar, Samantha N. Stewart, Yannick Pousse, Bingqing Shen, Kevin Grosselin, Baptiste Saudemont, Antoine Sautel-Caille, Alexei Godina, Scott McNamara, Klaus Eyer, Gael A. Millot, Jean Baudry, Patrick England, Clement Nizak, Allan Jensen, Andrew D. Griffiths, Pierre Bruhns, Colin Brenan
NATURE BIOTECHNOLOGY
(2020)
Correction
Biotechnology & Applied Microbiology
Annabelle Gerard, Adam Woolfe, Guillaume Mottet, Marcel Reichen, Carlos Castrillon, Vera Menrath, Sami Ellouze, Adeline Poitou, Raphael Doineau, Luis Briseno-Roa, Pablo Canales-Herrerias, Pascaline Mary, Gregory Rose, Charina Ortega, Matthieu Delince, Sosthene Essono, Bin Jia, Bruno Iannascoli, Odile Richard-Le Goff, Roshan Kumar, Samantha N. Stewart, Yannick Pousse, Bingqing Shen, Kevin Grosselin, Baptiste Saudemont, Antoine Sautel-Caille, Alexei Godina, Scott McNamara, Klaus Eyer, Gael A. Millot, Jean Baudry, Patrick England, Clement Nizak, Allan Jensen, Andrew D. Griffiths, Pierre Bruhns, Colin Brenan
NATURE BIOTECHNOLOGY
(2020)
Article
Biochemical Research Methods
Steven Schulz, Sebastien Boyer, Matteo Smerlak, Simona Cocco, Remi Monasson, Clement Nizak, Olivier Rivoire
Summary: This study investigates the selective potential of antibody scaffolds by analyzing large antibody populations based on different scaffolds selected against various targets. The results suggest that the evolution of the scaffold influences the selective response of antibodies.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Microbiology
Herve Dupont, Pascaline Choinier, David Roche, Sandine Adiba, Megan Sookdeb, Catherine Branger, Erick Denamur, Hedi Mammeri
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Chemistry, Multidisciplinary
Johan Fenneteau, Dany Chauvin, Andrew D. Griffiths, Clement Nizak, Janine Cossy
CHEMICAL COMMUNICATIONS
(2017)