Review
Oncology
Fatema Tuz Zahra, Md. Sanaullah Sajib, Constantinos M. Mikelis
Summary: Anti-angiogenic therapies targeting VEGF signaling have shown temporary benefits in cancer treatment, with resistance often developing due to the upregulation of other growth factors like bFGF. Recent efforts have focused on developing multi-target anti-angiogenic drugs to overcome resistance mechanisms and improve outcomes in clinical practice.
Article
Biochemistry & Molecular Biology
Xudong Cheng, Fei Wang, Yu Qiao, Ting Chen, Ling Fan, Xikun Shen, Dongwei Yu, Yuyu Huang, Minggang Wei
Summary: The goal of this study is to investigate how lignin analogs, specifically honokiol (HNK), block angiogenesis induced by the inflammatory milieu of lung cancer. The findings showed that HNK drastically decreased the cell viability of lung cancer cells and reduced the production of vascular endothelial growth factor (VEGF), the most important marker of tumor angiogenesis. HNK inhibited the NF-KB signaling pathway, resulting in the downregulation of VEGF and reducing the viability and angiogenesis of lung cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Integrative & Complementary Medicine
Ju-Ah Son, Sun Kyoung Lee, Junhee Park, Min Ju Jung, So-Eun An, Hye Ji Yang, Seung Hwa Son, Ki Rim Kim, Kwang-Kyun Park, Won-Yoon Chung
Summary: Platycodin D inhibits VEGF and IL-8-induced angiogenesis by blocking MAPKs activation, and shows potential for the prevention and treatment of tumor angiogenesis and angiogenesis-related human diseases.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biology
Klaudia Petrova, Miriam Backorova, Zuzana Demcisakova, Eva Petrovova, Michal Goga, Maria Vilkova, Richard Frenak, Martin Backor, Jan Mojzis, Martin Kello
Summary: In this study, the anti-angiogenic activities of usnic acid, a secondary metabolite isolated from Usena antarctica, were evaluated. The results showed that usnic acid inhibited the proliferation, migration, and tube formation of VEGF- and bFGF-stimulated HUVECs in vitro. The ex ovo CAM assay confirmed the inhibitory effects of usnic acid on vessel formation induced by VEGF and bFGF.
Article
Biochemistry & Molecular Biology
Zhibao Wang, Bo Cao, Peng Ji, Fan Yao
Summary: Propofol inhibits tubular structure formation and various biological functions of tumor-associated endothelial cells, including migration, adhesion, proliferation, and survival, by suppressing the expression and secretion of multiple pro-angiogenic factors and specific signaling pathways. These findings provide preclinical evidence for the anti-cancer properties of propofol and its potential mechanisms in inhibiting tumor growth and metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Ali Abdalla, Chandraprabha Murali, Amr Amin
Summary: This study reveals for the first time the antiangiogenic potential of safranal and proposes its possible underlying mechanism in the treatment of hepatocellular carcinoma (HCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Xue Dong, Yi Lei, Zeyang Yu, Tian Wang, Yi Liu, Gang Han, Xiaodan Zhang, Yiming Li, Yinting Song, Heping Xu, Mei Du, Haifang Yin, Xiaohong Wang, Hua Yan
Summary: The study utilized exosomes (EXOs) as carriers for delivering the anti-angiogenic peptide KV11 via retro-orbital injection, showing enhanced suppression of neovascularization and vascular leakage in the retina. This system has the potential to treat proliferative retinopathy in a less invasive manner compared to intravitreal injection.
Article
Cell Biology
Xiaohuan Zhao, Min Gao, Jian Liang, Yuhong Chen, Yimin Wang, Yuwei Wang, Yushu Xiao, Zhenzhen Zhao, Xiaoling Wan, Mei Jiang, Xueting Luo, Feng Wang, Xiaodong Sun
Summary: In this study, we found that SLC7A11 plays a crucial role in protecting RPE cells from ferroptosis in the laser-induced CNV model, providing a new therapeutic target for neovascular AMD patients. The expression of SLC7A11 in RPE cells is associated with the development of CNV and VEGF expression levels. Furthermore, manipulation of SLC7A11 expression affects cellular lipid peroxidation and cell viability in vitro.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ying Chen, Lina Zhang, Xiaoyan Zang, Xuxing Shen, Jianyong Li, Lijuan Chen
Summary: This study reveals for the first time that Baohuoside I (BI) inhibits angiogenesis in multiple myeloma (MM) through the PPARγ-VEGF signaling axis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ravichandran Jayasuriya, Kunka Mohanram Ramkumar
Summary: This study found that mangiferin can regulate angiogenesis in human endothelial cells under a hyperglycemic environment by activating the Nrf2 signaling pathway. Mangiferin can reduce the generation of ROS induced by high glucose and promote angiogenesis-related gene expression, as well as increase cell migration and tube network formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chengjun Hu, Zifang Wu, Zihao Huang, Xiangyu Hao, Shuqi Wang, Jinping Deng, Yulong Yin, Chengquan Tan
Summary: The study reveals that Nox2 deficiency facilitates angiogenesis by inhibiting the VEGF-A and STAT3 pathway, and reducing VEGF-A expression through inducing ROS production in pigs' vascular endothelial cells. The findings suggest that Nox2 could be a potential therapeutic target for increasing VEGF-A expression to promote angiogenesis, and also serve as a prognostic indicator for fetus with IUGR.
Article
Biochemistry & Molecular Biology
Tanyaporn Keratibumrungpong, Warunee Srisuthtayanont, Orawan Wanachewin, Jeerawan Klangjorhor, Thanyaluck Phitak, Peraphan Pothacharoen, Thuzar Hla Shwe, Prachya Kongtawelert
Summary: This study investigates the effect of sesame seed phytochemical sesamin on physiological and pathological angiogenesis. Sesamin significantly inhibits VEGFA-induced pathological angiogenesis and reduces vascular branching, endothelial cell proliferation, and migration. It also inhibits the activation of Src and FAK signaling proteins and reduces the expression of angiogenesis-related genes, suggesting its potential use in the prevention or treatment of diseases with excessive angiogenesis.
Article
Plant Sciences
Guo-Xia Guo, Ke-Yue Wu, Xiao-Yong Zhang, Fu-Xiang Lai, Karl Wah-Keung Tsim, Qi-Wei Qin, Wei-Hui Hu
Summary: This study investigated the effects of Curcumae Longae Rhizoma (CLR) extract on angiogenesis and found that it significantly suppressed angiogenic responses such as proliferation, migration, invasion, and tube formation of endothelial cells. It also reduced subintestinal vessel formation in a zebrafish embryo model. Mechanistically, CLR extract inhibited the VEGF-triggered signaling pathway, decreased phosphorylated VEGFR2 levels, and inhibited downstream regulators. It also reduced the production of NO and ROS. Additionally, CLR extract suppressed cell migration and NF-Kappa B translocation in cancer cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Yufang Liu, Jiao Li, Jiasheng Zhou, Xue Liu, Huibing Li, Yao Lu, Bingcheng Lin, Xiaojie Li, Tingjiao Liu
Summary: Angiogenesis was assessed using a microfluidic chip, showing VEGF as a key determinant for vascular sprouting initiation. Different isoforms of VEGF displayed varying effects on sprout length and number, vessel perfusion, and connectivity, with VEGF(165) demonstrating the highest capacity to induce vascular sprouting and functional vessel formation.
Article
Oncology
Fatma A. Abouelnazar, Xiaoxin Zhang, Jiahui Zhang, Maoye Wang, Dan Yu, Xueyan Zang, Jiayin Zhang, Yixin Li, Jing Xu, Qiurong Yang, Yue Zhou, Haozhou Tang, Yanzheng Wang, Jianmei Gu, Xu Zhang
Summary: This study reveals that SALL4 is overexpressed in stomach adenocarcinoma and is associated with tumor progression and poor prognosis. SALL4 regulates VEGF expression at the transcriptional level, thus promoting angiogenesis. Co-delivery of si-SALL4-B and thalidomide using engineered exosomes shows potential in inhibiting cancer angiogenesis.
CANCER CELL INTERNATIONAL
(2023)
Article
Physics, Multidisciplinary
Eun Ha Choi, Nagendra Kumar Kaushik, Young June Hong, Jun Sup Lim, Jin Sung Choi, Ihn Han
Summary: This review explores different types of nonthermal biocompatible plasma sources and their characteristics. It introduces the electron temperatures and plasma densities produced by dielectric barrier discharged electrode systems. Additionally, the review presents a schematic view of plasma ultraviolet photolysis of water molecules for the generation of reactive oxygen and nitrogen species inside biological cells or tissues, highlighting their synergistic propagation. The hydroxyl radical and hydrogen peroxide species play a significant role in apoptotic cell death in plasma bioscience and medicine, making nonthermal biocompatible plasma and plasma activated water potential treatments for diseased biological proteins, cancer, and mutated cells, creating a new paradigm for plasma medicine.
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Sang Hye Ji, Mahmuda Akter, Eun Young Ko, Eun Ha Choi, Young Soo Keum, Ihn Han
Summary: This study demonstrates the regenerative effects of plasma-treated extracts of stem cells derived from rice-seed embryos on aging-treated human fibroblasts. The plasma treatment enhances antioxidant activity and skin regeneration, making it a potential anti-aging agent in cosmeceutical formulations.
APPLIED SCIENCES-BASEL
(2022)
Review
Oncology
Sumit Kumar Baral, Partha Biswas, Md. Abu Kaium, Md. Aminul Islam, Dipta Dey, Md Al Saber, Tanjim Ishraq Rahaman, A. M, Talha Bin Emran, Md. Nazmul Hasan, Mi-Kyung Jeong, Ihn Han, Md. Ataur Rahman, Bonglee Kim
Summary: Vaginal cancer is a rare disease that is increasing in younger women due to high-risk HPV infections. It is frequently found along with cervical cancer, and the causes are uncertain. Risk factors such as ring pessaries, chronic vaginitis, and sexual behavior are associated with the disease.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sohail Mumtaz, Juie Nahushkumar Rana, Eun Ha Choi, Ihn Han
Summary: Modern humans are exposed to various radiations daily, and the brain is the most sensitive organ to electromagnetic radiation (EMR) exposure. However, there are still many unknown factors in related studies, including the effects of different parameters and irradiation time. This review analyzes and interprets recent studies on the effects of microwave radiation on learning and memory capabilities in the brain, as well as the mechanisms of brain dysfunction caused by exposure, providing prospective views for future research in developing preventive and therapeutic strategies for brain degeneration caused by microwave radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tabrez Faruqui, Mohd Sajid Khan, Yusuf Akhter, Salman Khan, Zeeshan Rafi, Mohd Saeed, Ihn Han, Eun-Ha Choi, Dharmendra Kumar Yadav
Summary: The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin family that is overexpressed in several cancers. RAGE serves as an important node for the initiation and stimulation of cell stress and growth signaling mechanisms that promote carcinogenesis, tumor propagation, and metastatic potential. Inhibiting the interaction of RAGE with its ligands could provide an effective strategy for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ihn Han, Chulwoo Rhee, Doyoung Kim
Summary: This study explores the effects of calcium magnesium carbonate nanoparticles on plants, bacteria, and cancer cells, finding that they have stimulating effects on plant growth and inhibitory effects on bacteria and cancer cells.
Review
Virology
Ihn Han, Sohail Mumtaz, Eun Ha Choi
Summary: This article outlines recent advances in nonthermal biocompatible plasma (NBP) technology for antiviral applications, highlighting its potential as a new, effective, and safe strategy for viral inactivation.
Article
Engineering, Biomedical
Ihn Han, In-Seok Song, Seung Ah Choi, Taebok Lee, Maksudbek Yusupov, Priyanka Shaw, Annemie Bogaerts, Eun Ha Choi, Jae Jun Ryu
Summary: This study proposes the use of low-dose nonthermal biocompatible dielectric barrier discharge plasma (DBD-NBP) on human gingival fibroblasts (HGFs) to enhance wound healing. The treatment inhibits colony formation but not cell death and induces cell migration through ECM degradation and MMP expression. The study also explores the effect of oxidation on the stability and conformation of FAK's catalytic kinase domain (KD).
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Afza Ahmad, Rohit Kumar Tiwari, Mohd Saeed, Hadba Al-Amrah, Ihn Han, Eun-Ha Choi, Dharmendra K. K. Yadav, Irfan Ahmad Ansari
Summary: In recent times, there has been a significant increase in focusing on the hedgehog (HH)/GLI signaling pathway as a therapeutic target for cervical cancer. The HH pathway is known to play a critical role in the development of cervical cancer and is also associated with recurrence and chemoresistance. Carvacrol (CAR) has previously been shown to inhibit proliferation in prostate cancer cells by targeting the Notch signaling pathway, making it a rational choice to study its antiproliferative effects in cervical cancer cells. This study aimed to investigate the anticancer and apoptotic potential of CAR in C33A cervical cancer cells and explore the underlying mechanisms.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rida Javed, Sohail Mumtaz, Eun Ha Choi, Ihn Han
Summary: Nonthermal biocompatible plasma (NBP) is a promising technology in agriculture for enhancing plant growth. Plasma serves as a source of reactive oxygen and nitrogen species (RONS) that activate signaling molecules in plant metabolism. However, the acidic pH of plasma-treated water (PTW) may be detrimental to pH-sensitive plants. Therefore, innovative techniques to neutralize the pH value of PTW to broaden the application of NBP in agriculture are urgently needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sohail Mumtaz, Juie Nahushkumar Rana, Jun Sup Lim, Rida Javed, Eun Ha Choi, Ihn Han
Summary: This study investigates the effect of plasma on-times on the efficacy of nonthermal atmospheric pressure plasma (NTAPP) for biomedical applications. Different duty ratios were used while keeping the treatment time fixed. The results show that increasing the plasma on-time significantly increases the levels of reactive oxygen and nitrogen species (ROS/RNS), which in turn affects cell viability and ATP levels in U87-MG brain cancer cells. This study highlights the importance of optimizing plasma on-time to enhance the effectiveness of soft plasma jet for biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jun Sup Lim, Daeun Kim, Sehoon Ki, Sohail Mumtaz, Abdul Munnaf Shaik, Ihn Han, Young June Hong, Gyungsoon Park, Eun Ha Choi
Summary: We investigated the characteristics of a rollable dielectric barrier discharge (RDBD) and evaluated its effects on seed germination rate and water uptake. The rotational and vibrational temperatures were measured to be 342 K and 2860 K, respectively. Chemical species analysis showed that O-3 production was dominant and NOx production was restrained at the given temperatures. Treatment of spinach seeds with RDBD for 5 minutes increased water uptake and germination rate by 10% and 15%, respectively, and reduced the standard error of germination by 4% compared to the controls. RDBD enables an important step forward in non-thermal atmospheric-pressure plasma agriculture for omnidirectional seed treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Desh Deepak Singh, Youngsun Kim, Seung Ah Choi, Ihn Han, Dharmendra Kumar Yadav
Summary: Based on recent research, the non-coding genome plays a crucial role in controlling genes and genetic programming during development, as well as in health and cardiovascular diseases. Non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, and circRNAs, have significant regulatory and structural roles in the human genome, making them promising for advanced diagnostics and prognosis evaluation.
Article
Cell Biology
Juie Nahushkumar Rana, Sohail Mumtaz, Eun Ha Choi, Ihn Han
Summary: This study observed the effects of pulsed 3.5 GHz high-power microwave on normal brain astrocytes and cancer cells, and investigated the underlying mechanisms. The results showed that high-power microwave radiation produced reactive oxygen species, affecting cell viability, mitochondrial activity, and cell death rates. 60 pulses were found to be harmful, while 25 pulses showed therapeutic effects on cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Desh Deepak Singh, Ihn Han, Eun-Ha Choi, Dharmendra Kumar Yadav
Summary: SARS-CoV-2 causes severe respiratory distress and organ failure, and supportive treatment options are currently used. Targeting viral proteins and enzymes, as well as developing antibodies and antiviral drugs, are effective approaches for COVID-19 treatment. Clinical studies are exploring various therapy categories. This article provides new insights into drug pathophysiology and development.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)