Article
Immunology
Dylan T. Bergstedt, Wyatt J. Tarter, Ryan A. Peterson, Marie L. Feser, Mark C. Parish, Christopher C. Striebich, M. Kristen Demoruelle, LauraKay Moss, Elizabeth A. Bemis, Jill M. Norris, V. Michael Holers, Jess D. Edison, Geoffrey M. Thiele, Ted R. Mikuls, Kevin D. Deane
Summary: In rheumatoid arthritis (RA), ACPA and RF are predictive markers for future RA. This study found that changes in RF isotypes were associated with an increased risk for developing RA, and SE was associated with an increased risk of RA. These findings are important for counseling individuals at-risk for RA and designing clinical trials for RA prevention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Wataru Hirose, Masayoshi Harigai, Koichi Amano, Toshihiko Hidaka, Kenji Itoh, Kazutoshi Aoki, Masahiro Nakashima, Hayato Nagasawa, Yukiko Komano, Toshihiro Nanki
Summary: The study compares the clinical effectiveness of tofacitinib and abatacept in patients with RA, with tofacitinib showing superiority in changes from baseline in DAS28-ESR and remission achievement at week 4. SE positivity is associated with DAS28-ESR remission by week 24 in patients receiving abatacept, but not in those receiving tofacitinib.
ARTHRITIS RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Caroline Carle, Yannick Degboe, Adeline Ruyssen-Witrand, Marina I. Arleevskaya, Cyril Clavel, Yves Renaudineau
Summary: T cells play a crucial role in the development of rheumatoid arthritis (RA). A comprehensive review based on the analysis of the Immune Epitope Database (IEDB) was conducted to better understand the contribution of T cells to RA. It was found that an immune CD8+ T cell senescence response is present in RA and inflammatory diseases, driven by viral antigens and self-apoptotic peptides. Additionally, pro-inflammatory CD4+ T cells in RA are selected by MHC class II and immunodominant peptides derived from molecular chaperones, host peptides, and bacterial cross-reactive peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Joe Zhuo, Qian Xia, Niyati Sharma, Sheng Gao, Sonie Lama, Jing Cui, Vivi Feathers, Nancy Shadick, Michael E. Weinblatt
Summary: Patients with rheumatoid arthritis (RA) who have the genetic risk factor shared epitope (SE) often have more severe and harder-to-treat disease, and this is associated with being positive for anti-citrullinated protein antibodies (ACPAs).
RHEUMATOLOGY AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Merel A. A. Opdam, Sophie Benoy, Lise M. Verhoef, Sandra Van Bijnen, Femke Lamers-Karnebeek, Rene A. M. Traksel, Petra Vos, Alfons A. den Broeder, Jasper Broen
Summary: Patients with inflammatory rheumatic diseases do not have an increased risk for COVID-19 compared to the general population. Older age and obesity are major risk factors for hospitalization for COVID-19 in patients with IRD, while the use of methotrexate may have a protective effect in reducing the risk of hospitalization.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Geriatrics & Gerontology
Jie Xiao, Chaoyi Liang, Lizeai Zhang, Jinling Li, Sijia Liu
Summary: This article reviews the immune mechanisms and pathological interactions between COVID-19 and RA, highlighting the similarities in immune inflammation. The potential mechanisms leading to cardiovascular complications and challenges in treating RA patients with COVID-19 are also discussed. Additionally, the use of antirheumatic drugs as potential treatment options for COVID-19 is explored, given the similar proinflammatory cytokines induced in both diseases.
Article
Immunology
Yunjuan Zhao, Vilma Urbonaviciute, Bingze Xu, Weiwei Cai, Zeynep Sener, Changrong Ge, Rikard Holmdahl
Summary: A new model for rheumatoid arthritis has been established in C57BL/6 mice by immunization with human cartilage oligomeric matrix protein (COMP). This model is dependent on a COMP specific peptide binding A(b) and induces severe arthritis with high incidence in C57BL/6NJ (B6N) mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Yoshiya Tanaka, Ayako Yamaguchi, Toshiaki Miyamoto, Kazuhide Tanimura, Hideyuki Iwai, Yuko Kaneko, Tsutomu Takeuchi, Koichi Amano, Naoki Iwamoto, Atsushi Kawakami, Miho Murakami, Norihiro Nishimoto, Tatsuya Atsumi, Takayuki Sumida, Koichiro Ohmura, Tsuneyo Mimori, Hisashi Yamanaka, Keishi Fujio, Yoshihisa Fujino, Kazuyoshi Saito, Kazuhisa Nakano, Shintaro Hirata, Shingo Nakayamada
Summary: In patients with rheumatoid arthritis who achieved sustained remission, continuing treatment, dose reduction, or discontinuation of methotrexate and dose reduction of biologic disease-modifying antirheumatic drugs (bDMARDs) achieved comparable disease control after one year. Subsequent de-escalation of methotrexate had no impact on disease control but decreased adverse events in year two.
Article
Immunology
Xu He, Juqi Zhang, Mingli Gong, Yanlun Gu, Bingqi Dong, Xiaocong Pang, Chenglong Zhang, Yimin Cui
Summary: This study identified and validated PTGS2, ENO1, and GRN as potential biomarkers related to ferroptosis in RA. ENO1 was found to be highly expressed in RA synovium and its involvement in synovial cell proliferation and regulation of ferroptosis through the ENO1-ACO1 axis was demonstrated. These findings provide potential diagnostic and therapeutic targets for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Melody Kasher, Maxim B. Freidin, Frances Mk Williams, Stacey S. Cherny, Ida Malkin, Gregory Livshits
Summary: This study investigated the genetic association between rheumatoid arthritis (RA) and osteoporosis (OP), and found evidence of pleiotropy. Shared genetic variants associated with both RA and OP were identified.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Geriatrics & Gerontology
Jie Xiao, Chaoyi Liang, Lizeai Zhang, Jinling Li, Sijia Liu
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading worldwide and poses a major health concern with COVID-19. Rheumatoid arthritis (RA) patients may have a higher risk of infection and disease progression due to impaired immune systems, immunosuppressants, and comorbidities. The immune mechanisms and pathological interactions between COVID-19 and RA are reviewed, as the immune inflammation in COVID-19 resembles that of RA. The potential cardiovascular complications and challenges of treating RA patients with COVID-19 are also discussed.
Article
Rheumatology
Nilasha Ghosh, Pankti Reid, Carlos Andres Aude, Jessica Kirschman, Susan Goodman, Vivian P. Bykerk, Amit Lakhanpal, Diviya Rajesh, Karmela K. Chan, William H. Robinson, Anne R. Bass
Summary: In this study, the expansion of ACPA epitopes in CCP+ICI-IA was compared with patients with RA. It was found that patients with ICI-IA had lower ACPA titres and targeted fewer ACPA epitopes compared to longstanding RA patients, and there were no significant differences in the presence of the shared epitope between ICI-IA patients and ICI controls. This suggests that ICI-IA may represent an accelerated model of RA pathogenesis.
Article
Medicine, General & Internal
Marina I. Arleevskaya, Regina V. Larionova, Elena I. Shagimardanova, Natalia E. Gogoleva, Olga A. Kravtsova, Andrej A. Novikov, Gevorg G. Kazarian, Caroline Carle, Yves Renaudineau
Summary: This study investigated factors associated with the conversion from familial rheumatoid arthritis (RA) to RA. The results showed that before the onset of RA, individuals at risk of progressing to RA among those with familial RA relatives were characterized by arthralgia, severe morning symptoms, a lower educational level, and rural location. Additionally, the HLA-DRB1 SE risk factor, symmetrical arthralgia, and passive smoking were associated with the conversion to RA.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Farah Perveen Mughal, Ann Christina Bergmann, Ha Uyen Buu Huynh, Sarah Hyllekvist Jorgensen, Inaam Mansha, Meliha Kesmez, Patrick Mark Schurch, Alexandre Pierre Andre Theocharides, Paul Robert Hansen, Tina Friis, Morten Orebo Holmstrom, Evaldas Ciplys, Rimantas Slibinskas, Peter Hojrup, Gunnar Houen, Nicole Hartwig Trier
Summary: This study generated and characterized eight peptide antibodies targeting the C-terminal of CRTfs, which are important tools for understanding the molecular mechanisms of MPNs and developing new diagnostic assays and therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Fenne Wouters, Marc P. Maurits, Laurette van Boheemen, Marloes Verstappen, Kulveer Mankia, Xanthe M. E. Matthijssen, Annemarie L. Dorjee, Paul Emery, Rachel Knevel, Dirkjan van Schaardenburg, Rene E. M. Toes, Annette H. M. van der Helm-van Mil
Summary: HLA-SE and smoking act at different stages in the development of rheumatoid arthritis: smoking increases the risk of autoantibody and symptom development, while HLA-SE mediates symptom and inflammatory arthritis development. These findings enhance our understanding of the timing of key risk factors in RA development.
ANNALS OF THE RHEUMATIC DISEASES
(2022)