Article
Anesthesiology
Jesus D. Lorente, Javier Cuitavi, Yolanda Campos-Jurado, Raquel Monton-Molina, Jose L. Gonzalez-Romero, Lucia Hipolito
Summary: Pain-induced negative affect reduces the life quality of patients by increasing psychiatric comorbidities, including alcohol use disorders. Female rats are more likely than male rats to increase alcohol consumption during the reintroduction period, accompanied by enhanced anxiety-like behavior and increased KOR expression in the nucleus accumbens shell.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Chemistry, Analytical
Xavier Duart, Eduardo Quiles, Ferran Suay, Nayibe Chio, Emilio Garcia, Francisco Morant
Summary: The study compared white, red, and green flashing stimuli at three frequencies (5, 12, and 30 Hz) to find that the middle frequency generated the best SNR. White showed as good an SNR as red at 12 Hz, and green at 5 Hz. There was a correlation between attention and SNR at low frequency.
Article
Cardiac & Cardiovascular Systems
Emily Shih, J. Michael DiMaio, John J. Squiers, James Wheeless, William J. Hoffman, Jasjit K. Banwait, Mohanad Hamandi, Ronald Baxter, Katherine B. Harrington
Summary: Preincisional sternal blockade with liposomal bupivacaine did not reduce the amount of opioid medication administered to patients in the first 72 hours after sternotomy.
ANNALS OF THORACIC SURGERY
(2022)
Review
Food Science & Technology
Ricardo A. Wu, Hyun-Gyun Yuk, Donghong Liu, Tian Ding
Summary: This article discusses the cross-protection response and possible molecular mechanisms of foodborne pathogens under acid stress, as well as the threat to food safety. Exposure to acid conditions may induce cross-protection against heat, cold, osmotic, antibiotic, disinfectant, and non-thermal technology stress. Understanding the cross-protection mechanisms in different bacterial species, stress conditions, and food matrixes can help reduce potential food safety risks.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Mathematics, Applied
Karthikeyan Rajagopal, Iqtadar Hussain, Zahra Rostami, Chunbiao Li, Viet-Thanh Pham, Sajad Jafari
Summary: The combination of chemical, physical, electrical, and structural properties of neurons creates highly complex dynamical units. Studying neural spatiotemporal patterns, specifically the spiral pattern, is crucial in understanding cortical activities and potential neurological disorders. External forces like amplitude and frequency play a significant role in controlling the dynamics of spiral waves in neural networks.
APPLIED MATHEMATICS AND COMPUTATION
(2021)
Article
Behavioral Sciences
Luke A. Jelen, James M. Stone, Allan H. Young, Mitul A. Mehta
Summary: This article reviews the dysregulation of the opioid system in depression and the potential of pharmacological modulators of mu, delta, and kappa opioid receptors for the treatment of depression. The review presents evidence from animal and clinical studies supporting the dysregulation of the opioid system in depression, the modulation of behavioral processes and brain regions associated with depression by opioids, and the modulation of antidepressant responses by opioids. The review also evaluates clinical trials examining the safety and efficacy of opioidergic agents in depression and explores the involvement of the opioid system in the effects of other treatments, such as ketamine, that exert antidepressant effects through non-opioid actions. Furthermore, the review explores the neurochemical and molecular mechanisms underlying the therapeutic effects of opioid system engagement, providing a rationale for further investigation into this relevant target in depression treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Kristina Tchalova, Sophie Beland, Mona Lisa Chanda, Daniel J. Levitin, Jennifer A. Bartz
Summary: This study suggests that endogenous opioids may serve as the biological correlate of social belongingness. Participants reported lower self-esteem levels and exhibited heightened attentional bias towards accepting faces after naltrexone administration, indicating an increased social need under opioid receptor blockade.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Jakob Kaiser, Antje Gentsch, Daniela Rodriguez-Manrique, Simone Schuetz-Bosbach
Summary: Motor conflicts arise when we need to quickly overwrite prepotent behavior. Previous studies have come to inconsistent conclusions regarding the neural impact of affective information on conflict processing. Our study indicates that neural conflict processing is primarily driven by the functional relevance of action-related stimuli, not their inherent affective meaning. Furthermore, it sheds light on the role of interconnectivity between ACC and AI for the implementation of flexible behavioral change.
Article
Engineering, Biomedical
Weiyan Ren, Liqiang Xu, Xuan Zheng, Fang Pu, Deyu Li, Yubo Fan
Summary: The study found that both heating methods - warm bath and infrared radiation - effectively increased contralateral skin temperature and skin blood flow in the foot. However, warm bath had a stronger residual thermal effect compared to infrared radiation.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Pharmacology & Pharmacy
Vadim Yakhnitsa, Guangchen Ji, Matthew Hein, Peyton Presto, Zack Griffin, Olga Ponomareva, Edita Navratilova, Frank Porreca, Volker Neugebauer
Summary: Functional pain syndromes occur without tissue injury or noxious events. Stress is a common trigger for pain attacks in these syndromes. Recent research suggests that kappa opioid receptors in the central nucleus of amygdala contribute to functional pain syndromes, but the underlying mechanisms are still unclear. Blocking these receptors may represent a new therapeutic strategy for stress-induced functional pain syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Gabriela Lorena Salazar-Orbea, Rocio Garcia-Villalba, Francisco A. Tomas-Barberan, Luis Manuel Sanchez-Siles
Summary: Polyphenols are important bioactive compounds in agro-food products, and their stability is influenced by processing, fruit type, polyphenol family, and storage conditions. Manufacturers aiming to preserve the natural content of polyphenols need to find a balance between polyphenol stability and product shelf-life, as residual enzyme activity from processing methods like high-pressure processing can impact polyphenols negatively.
Article
Neurosciences
Justin Hudak, Edward M. Bernat, Spencer T. Fix, Kort C. Prince, Brett Froeliger, Eric L. Garland
Summary: This study found that opioid misuse may lead to top-down deficits in emotional regulation starting as early as 400 ms after the presentation of negative stimuli. This deficit is associated with severe opioid craving. Therefore, interventions focused on reappraisal may be an important approach for treating opioid misuse.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Chemistry, Applied
Henrique Coutinho de Barcelos Costa, Erica Sayuri Siguemoto, Tiago Augusto Bulhoes Bezerra Cavalcante, Danylo de Oliveira Silva, Luiz Gustavo Martins Vieira, Jorge Andrey Wilhelms Gut
Summary: Microwave heating is a promising technology for continuous flow thermal processing of fluid foods due to better quality retention. Inactivation kinetics of POD and PPO in acai-berry pulp varied under different heating technologies, with microwave showing specific effects on protein structure. Additionally, dielectric properties of acai-berry pulp changed with temperature at different frequencies.
Review
Chemistry, Multidisciplinary
Iwona Wojtasik-Kalinowska, Arkadiusz Szpicer, Weronika Binkowska, Monika Hanula, Monika Marcinkowska-Lesiak, Andrzej Poltorak
Summary: Meat is a rich source of volatile compounds that contribute to its flavor and aroma. The formation of these compounds is influenced by both the raw material and processing methods, including thermal and non-thermal processes. Advanced techniques such as ultrasound and cold plasma have been explored to enhance the generation of volatile compounds. Additionally, determining the VOC markers generated during heat treatment is an important area of research.
APPLIED SCIENCES-BASEL
(2023)
Article
Neurosciences
Jan Haaker, Mareike M. Menz, Tahmine Fadai, Falk Eippert, Christian Buechel
HUMAN BRAIN MAPPING
(2016)
Article
Neurosciences
Ming-Tsung Tseng, Yazhuo Kong, Falk Eippert, Irene Tracey
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Falk Eippert, Yazhuo Kong, Anderson M. Winkler, Jesper L. Andersson, Juergen Finsterbusch, Christian Buechel, Jonathan C. W. Brooks, Irene Tracey
Article
Neurosciences
Falk Eippert, Yazhuo Kong, Mark Jenkinson, Irene Tracey, Jonathan C. W. Brooks
Article
Biology
Stephan Geuter, Sabrina Boll, Falk Eippert, Christian Buechel
Review
Neurosciences
Christian Buechel, Stephan Geuter, Christian Sprenger, Falk Eippert
Article
Clinical Neurology
Matthias Zunhammer, Ulrike Bingel, Tor D. Wager
Article
Multidisciplinary Sciences
Matthias Zunhammer, Tamas Spisak, Tor D. Wager, Ulrike Bingel
Summary: Placebo analgesia influences pain-related activity in multiple brain areas, with activity increases mainly in frontoparietal regions, and reductions in regions belonging to ventral attention and somatomotor networks. The findings suggest that the neural mechanisms of placebo analgesia are complex and involve multiple cerebral mechanisms that differ across studies.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buechel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Juergen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Yuichi Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri Van De Ville, Marios C. Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Summary: The study introduces a harmonized quantitative MRI protocol called the spine generic protocol to address challenges in quantitative spinal cord imaging. The protocol provides guidance for assessing spinal cord structure and has been validated in 260 healthy subjects.
Article
Multidisciplinary Sciences
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buchel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Jurgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen H. Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Y. Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri van de Ville, Marios C. Yiannakas, Kenneth A. . Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Summary: The paper introduces a spine generic quantitative MRI protocol and presents normative values and statistics generated from datasets across multiple centers, demonstrating high reproducibility of the protocol. This will support the development of accessible and reproducible quantitative MRI in the spinal cord.
Article
Clinical Neurology
Katja Wiech, Falk Eippert, Joachim Vandekerckhove, Jonas Zaman, Katerina Placek, Francis Tuerlinckx, Johan W. S. Vlaeyen, Irene Tracey
Summary: This study investigated the neural basis of how prior expectations can bias pain perception. The results showed that changes in perceptual decision-making and altered information processing contribute to the expectancy effect on pain. The dorsolateral prefrontal cortex, amygdala, and periaqueductal gray were found to be involved in these processes.
Article
Multidisciplinary Sciences
Moritz M. Nickel, Laura Tiemann, Vanessa D. Hohn, Elisabeth S. May, Cristina Gil Avila, Falk Eippert, Markus Ploner
Summary: The perception of pain is influenced by both somatosensory information and expectations, but the brain mechanisms involved in conveying these influences differ.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Merve Kaptan, S. Johanna Vannesjo, Toralf Mildner, Ulrike Horn, Ronald Hartley-Davies, Valeria Oliva, Jonathan C. W. Brooks, Nikolaus Weiskopf, Juergen Finsterbusch, Falk Eippert
Summary: Functional magnetic resonance imaging (fMRI) of the human spinal cord faces challenges due to signal loss caused by local magnetic field inhomogeneities. This study proposes a slice-specific z-shimming technique to address this issue. The effects of z-shimming on various aspects of spinal fMRI are evaluated, and two automated procedures are developed to improve upon the time-consuming and subjective manual selection of z-shims. The results demonstrate the beneficial effects of z-shimming across different echo times and for both the dorsal and ventral horn. The automated approaches are faster than the manual one, leading to significant improvements in gray matter tSNR compared to no z-shimming. While the field-map-based approach performed slightly worse than the manual one, the EPI-based approach performed as well as the manual one and was validated on an external dataset. Overall, automated z-shimming may enhance data quality and reproducibility in future spinal fMRI studies.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
T. Stephani, B. Nierula, A. Villringer, F. Eippert, V. V. Nikulin
Summary: Identical sensory stimuli can lead to different neural responses depending on the instantaneous brain state. Our study reveals spatially distinct excitability dynamics within the primary somatosensory cortex, with different frequencies showing different spatial specificity.
Article
Neurosciences
Merve Kaptan, Ulrike Horn, S. Johanna Vannesjo, Toralf Mildner, Nikolaus Weiskopf, Juergen Finsterbusch, Jonathan C. W. Brooks, Falk Eippert
Summary: The investigation of spontaneous fluctuations of BOLD signal in the spinal cord has attracted clinical interest. Resting-state fMRI studies have shown functional connectivity in dorsal and ventral horns of the spinal cord. This study evaluated the reliability of resting-state signals in the cervical spinal cord, finding fair to good reliability for dorsal-dorsal and ventral-ventral connectivity, but poor reliability for within-and between-hemicord dorsal-ventral connectivity. The impact of noise sources on connectivity was also investigated, showing that removal of physiological noise reduces connectivity strength and reliability, while removal of thermal noise increases detectability of connectivity without clear influence on reliability.
