Article
Multidisciplinary Sciences
Nathan P. Achilly, Wei Wang, Huda Y. Zoghbi
Summary: Research using a mouse model of Rett syndrome shows that intensive training before symptom onset can significantly improve specific motor and memory tasks, delaying the onset of symptoms. The study indicates that task-specific neurons activated during training develop more dendritic arbors and have better neurophysiological responses, enhancing their functionality and delaying symptom onset.
Article
Multidisciplinary Sciences
John R. Sinnamon, Michael E. Jacobson, John F. Yung, Jenna R. Fisk, Sophia Jeng, Shannon K. McWeeney, Lindsay K. Parmelee, Chi Ngai Chan, Siu-Pok Yee, Gail Mandel
Summary: This study provides evidence that a targeted RNA-editing approach can alleviate a hallmark symptom in a mouse model of Rett syndrome. Injection of a Mecp2-targeting virus effectively restores MeCP2 expression and function in the brainstem of mice, alleviating abnormal respiratory patterns and prolonging survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Florian Rosier, Nicolas Fernandez Nunez, Magali Torres, Beatrice Loriod, Pascal Rihet, Lydie C. Pradel
Summary: In this study, the transcriptional response of mice injected with LPS was compared to human cells stimulated with LPS in vitro and the blood cells of septic patients. The results showed a significant overlap in gene regulation and disease processes between mouse and human sepsis, supporting the hypothesis of common molecular and cellular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ipek Akol, Annalisa Izzo, Fabian Gather, Stefanie Strack, Stefanie Heidrich, Darren O. Hailin, Alejandro Villarreal, Christine Hacker, Tudor Rauleac, Chiara Bella, Andre Fischer, Thomas Manke, Tanja Vogel
Summary: Forkhead box G1 (FOXG1) plays important roles in neuronal differentiation and maintaining excitatory/inhibitory balance in the network. In this study, the authors investigated how FOXG1 impacts neuronal maturation at the chromatin level in the mouse hippocampus. They found that FOXG1 regulates transcription, binds to enhancer regions, and alters the epigenetic landscape. FOXG1 and NEUROD1 act cooperatively to control neuronal maturation, and the chromatin alterations affect synaptogenesis and axonogenesis. This study provides insights into the multimodality of FOXG1 functions and suggests epigenetic drugs as potential therapeutic options for neuronal dysfunction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Jialin Sun, Sivan Osenberg, Austin Irwin, Li-Hu Ma, Nigel Lee, Yangfei Xiang, Feng Li, Ying-Wooi Wan, In-Hyun Park, Mirjana Maletic-Savatic, Nurit Ballas
Summary: This study shows that mutations in the MECP2 gene can interfere with the developmental maturation of human astrocytes, thus affecting their ability to support neurons. These mutations, primarily causing Rett syndrome, greatly impact astrocytes' role in brain bioenergetics, mediated by dysfunctional mitochondria. While MECP2 mutations cause intrinsic aberrations in astrocyte transcriptional landscape, they surprisingly do not affect the neuron-induced astrocyte gene expression. However, the mutations prevent astrocytes from developing complex mature morphology due to cell-intrinsic and non-cell-autonomous aberrations.
Article
Biochemistry & Molecular Biology
Catarina Miranda-Lourenco, Jessica Rosa, Nadia Rei, Rita F. Belo, Ana Luisa Lopes, Diogo Silva, Catia Vieira, Teresa Magalhaes-Cardoso, Ricardo Viais, Paulo Correia-de-Sa, Ana M. Sebastiao, Maria J. Diogenes
Summary: This study reveals significant changes in the BDNF and adenosine signaling pathways in a milder phenotype model of Rett Syndrome, suggesting that enhancing adenosinergic activity may be an effective therapeutic strategy for RTT patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Valentina Gigliucci, Jasper Teutsch, Marc Woodbury-Smith, Mirko Luoni, Marta Busnelli, Bice Chini, Abhishek Banerjee
Summary: The study found that Rett syndrome (RTT) is associated with deficits in KCC2 function and E/I balance. Treatment with recombinant human insulin-like growth factor-1 (rhIGF-1) and oxytocin (OXT) may restore KCC2 expression and normalize E/I balance. These findings provide new therapeutic strategies for RTT.
Article
Neurosciences
Marta Lorena Speck, Ana Luiza Azevedo Gomes, Camila Schafer Rojas, Julia Biz Willig, Ana Paula Herrmann, Diogo Andre Pilger, Stela Maris Kuze Rates
Summary: Environmental enrichment has an impact on the behavior and drug responses of mice, with effects varying depending on the developmental stage of exposure and the specific drug used.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Sheryl Anne D. Vermudez, Aditi Buch, Kelly Weiss, Rocco M. Gogliotti, Colleen M. Niswender
Summary: Rett syndrome and MECP2 Duplication syndrome have opposite molecular origins, but share some clinical and preclinical phenotypes. Modulating mGlu2 and mGlu3 receptors may be a potential treatment option for both disorders.
Article
Neurosciences
Hannah Hochgerner, Shelly Singh, Muhammad Tibi, Zhige Lin, Niv Skarbianskis, Inbal Admati, Osnat Ophir, Nuphar Reinhardt, Shai Netser, Shlomo Wagner, Amit Zeisel
Summary: The amygdala is a brain region associated with emotional response. Through genetic markers and single-cell transcriptomics, the authors identified 130 neuronal cell types in the adult mouse amygdala and validated their response to fear learning and memory.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Changuk Chung, Wangyong Shin, Eunjoon Kim
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and repetitive symptoms. Studies in mouse models have shown early pathophysiological mechanisms that can be corrected to prevent phenotypic defects in adulthood. Additionally, gene restorations have demonstrated the rescue of ASD-related phenotypes even after the brain has fully matured.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Parker K. Stevenson, Devin M. Casenhiser, Billy Y. B. Lau, Keerthi Krishnan
Summary: The study reveals atypical behavioral patterns in a female mouse model for Rett syndrome during pup retrieval, such as abnormal pup approach and grooming interactions. Individual animals across different genotypes and strains show dynamic changes in goal-related movements during the study.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Environmental Sciences
Olivier Laroche, Sonnich Meier, Svein A. Mjos, Nigel Keeley
Summary: This study examined the impact of salmon farming on several epibenthic suspension-feeders and identified potential molecular indicators of this impact. The results showed species-specific effects and differences in fatty acid profiles and host microbiome communities.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Environmental Sciences
Yawen Han, Hongmei Duan, Xin Du, Li Jiang
Summary: The study reveals that the environmental footprints of the wealthiest households are significantly larger than those of the poorest households; changes in consumption structure can help reduce environmental footprints; awareness of environmental issues can impact household footprints to some extent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agriculture, Dairy & Animal Science
Elda Dervishi, Xuechun Bai, Jian Cheng, Frederic Fortin, Mike K. Dyck, John C. S. Harding, Yolande M. Seddon, Jack C. M. Dekkers, PigGen Canada, Graham Plastow
Summary: This study identifies L-alpha-aminobutyric acid as a potential genetic marker for lymphocyte response after pathogen exposure. It also contributes to understanding the impact of environmental enrichment on plasma metabolite concentration.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Developmental Biology
Mariana Rios, Daniela V. Carreno, Carolina Oses, Nelson Barrera, Bredford Kerr, Manuel Villalon
REPRODUCTION FERTILITY AND DEVELOPMENT
(2016)
Article
Cell Biology
Gabriela Martinez, Rene L. Vidal, Pablo Mardones, Felipe G. Serrano, Alvaro O. Ardiles, Craig Wirth, Pamela Valdes, Peter Thielen, Bernard L. Schneider, Bredford Kerr, Jose L. Valdes, Adrian G. Palacios, Nibaldo C. Inestrosa, Laurie H. Glimcher, Claudio Hetz
Article
Neurosciences
Rodrigo F. Torres, Cecilia Hidalgo, Bredford Kerr
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Review
Endocrinology & Metabolism
Y. Avalos, B. Kerr, M. Maliqueo, M. Dorfman
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Article
Developmental Biology
Bredford Kerr, Andrea Leiva, Marcelo Farias, Susana Contreras-Duarte, Fernando Toledo, Francisca Stolzenbach, Luis Silva, Luis Sobrevia
Article
Developmental Biology
Bredford Kerr, Mariana Rios, Karla Droguett, Manuel Villalon
REPRODUCTION FERTILITY AND DEVELOPMENT
(2018)
Article
Multidisciplinary Sciences
Alejandra Droguett, Paola Krall, M. Eugenia Burgos, Graciela Valderrama, Daniel Carpio, Leopoldo Ardiles, Raquel Rodriguez-Diez, Bredford Kerr, Katherina Walz, Marta Ruiz-Ortega, Jesus Egido, Sergio Mezzano
Article
Multidisciplinary Sciences
Valentina Castillo, Maritza Onate, Ute Woehlbier, Pablo Rozas, Catherine Andreu, Danilo Medinas, Pamela Valdes, Fabiola Osorio, Gabriela Mercado, Rene L. Vidal, Bredford Kerr, Felipe A. Court, Claudio Hetz
Article
Multidisciplinary Sciences
Maritza Onate, Alejandra Catenaccio, Gabriela Martinez, Donna Armentano, Geoffrey Parsons, Bredford Kerr, Claudio Hetz, Felipe A. Court
SCIENTIFIC REPORTS
(2016)
Review
Cell Biology
Jose Luis Morgado-Pascual, Vanessa Marchant, Raul Rodrigues-Diez, Nuria Dolade, Beatriz Suarez-Alvarez, Bredford Kerr, Jose M. Valdivielso, Marta Ruiz-Ortega, Sandra Rayego-Mateos
MEDIATORS OF INFLAMMATION
(2018)
Review
Biochemistry & Molecular Biology
Francisca Stolzenbach, Sharin Valdivia, Patricia Ojeda-Provoste, Fernando Toledo, Luis Sobrevia, Bredford Kerr
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Review
Neurosciences
Rodrigo F. Torres, Ricardo Kouro, Bredford Kerr
Article
Cell Biology
Hianara A. Bustamante, Karina Cereceda, Alexis E. Gonzalez, Guillermo E. Valenzuela, Yorka Cheuquemilla, Sergio Hernandez, Eloisa Arias-Munoz, Cristobal Cerda-Troncoso, Susanne Bandau, Andrea Soza, Gudrun Kausel, Bredford Kerr, Gonzalo A. Mardones, Jorge Cancino, Ronald T. Hay, Alejandro Rojas-Fernandez, Patricia Burgos
Article
Neurosciences
Rodrigo F. Torres, Bredford Kerr
Summary: Research on intracellular calcium stores in neuronal function has shown that Ryr3 plays a role in processes like hippocampal long-term potentiation. Stimuli that increase neuronal activity can upregulate Ryr3 transcriptional activity and DNA methylation. Spatial learning in mice increases hippocampal Ryr3 levels, while training without spatial association reduces expression. Specific DNA modifications accompany these transcriptional changes, with spatial training leading to increased DNA methylation and visible platform training resulting in increased DNA hydroxymethylation.
Article
Physiology
Vanessa Marchant, Alejandra Droguett, Graciela Valderrama, M. Eugenia Burgos, Daniel Carpio, Bredford Kerr, Marta Ruiz-Ortega, Jesus Egido, Sergio Mezzano
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2015)