期刊
PLOS ONE
卷 5, 期 9, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0013098
关键词
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资金
- University of Pennsylvania Research Foundation
- Burroughs Wellcome Fund Career Award for Medical Scientists
- NIH [K08AG033101-01]
- AAN-ALS Association
- James S. McDonnell Foundation
- Alfred P. Sloan Foundation
- David and Lucille Packard Foundation
Background: Human brain aging has received special attention in part because of the elevated risks of neurodegenerative disorders such as Alzheimer's disease in seniors. Recent technological advances enable us to investigate whether similar mechanisms underlie aging and neurodegeneration, by quantifying the similarities and differences in their genome-wide gene expression profiles. Principal Findings: We have developed a computational method for assessing an individual's physiological brain age'' by comparing global mRNA expression datasets across a range of normal human brain samples. Application of this method to brains samples from select regions in two diseases - Alzheimer's disease (AD, superior frontal gyrus), frontotemporal lobar degeneration (FTLD, in rostral aspect of frontal cortex, similar to BA10) - showed that while control cohorts exhibited no significant difference between physiological and chronological ages, FTLD and AD exhibited prematurely aged expression profiles. Conclusions: This study establishes a quantitative scale for measuring premature aging in neurodegenerative disease cohorts, and it identifies specific physiological mechanisms common to aging and some forms of neurodegeneration. In addition, accelerated expression profiles associated with AD and FTLD suggest some common mechanisms underlying the risk of developing these diseases.
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