Article
Multidisciplinary Sciences
Mark-Phillip Pebworth, Jayden Ross, Madeline Andrews, Aparna Bhaduri, Arnold R. Kriegstein
Summary: Research on the spatiotemporal, transcriptomic, and morphological variations of neural intermediate progenitor cells (nIPCs) in the developing human brain has provided insights for future studies. The study identifies changes in spatial distribution of nIPCs around gestational week 19/20, along with five transcriptomic subtypes, one of which emerges at this transition. Additionally, a diversity of nIPC morphologies were observed, which do not correspond with specific transcriptomic subtypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Junbao Wang, Andi Wang, Kuan Tian, Xiaojiao Hua, Bo Zhang, Yue Zheng, Xiangfei Kong, Wei Li, Lichao Xu, Juan Wang, Zhiqiang Li, Ying Liu, Yan Zhou
Summary: This study identified the neCtnnb1 element, which plays a regulatory role in the development of the neocortex. neCtnnb1 drives the transcription of the Ctnnb1 gene and is predominantly active in the subventricular zone of the developing neocortex. Knocking out neCtnnb1 leads to reduced production and amplification of intermediate progenitors, resulting in fewer upper-layer neocortex projection neurons. Understanding the transcriptional regulation of Ctnnb1 contributes to our knowledge of the mechanisms underlying neocortex expansion during development.
Article
Neurosciences
Melanie Piller, Inge L. Werkman, Evan A. Brown, Andrew J. Latimer, Sarah Kucenas
Summary: The study found that the ionotropic glutamate receptor subunit GluR4A plays a crucial role in OPC migration and myelination, disruption of which leads to abnormal migration and distribution of OPCs in the spinal cord. Through genetic and pharmacological experiments, it was discovered that voltage-gated calcium channels are downstream of glutamate receptor signaling in OPCs and can rescue migration and myelination defects caused by disrupted glutamate signaling.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Immunology
Rodrigo A. Morales, Soraya Rabahi, Oscar E. Diaz, Yazan Salloum, Bianca C. Kern, Mikaela Westling, Xinxin Luo, Sara M. Parigi, Gustavo Monasterio, Srustidhar Das, Pedro P. Hernandez, Eduardo J. Villablanca
Summary: This study reveals the previously underappreciated IL-10-Notch axis that regulates goblet cell homeostasis in the developing zebrafish intestine. It also suggests conservation across species and may help explain the disease severity of IL-10 deficiency in mammalian intestines.
MUCOSAL IMMUNOLOGY
(2022)
Article
Cell Biology
Qilin Li, Ding Xia, Zhihua Wang, Bo Liu, Jing Zhang, Ping Peng, Qiujun Tang, Jie Dong, Juan Guo, Dong Kuang, Weimin Chen, Jing Mao, Qiuhui Li, Xin Chen
Summary: The study identified that circadian rhythm gene PER3 acts as a negative regulator in prostate cancer stem cells (PCSCs), controlling their stemness through the WNT/beta-catenin signaling pathway in the tumor microenvironment. PER3 downregulation is associated with enhanced tumor-initiating abilities, while PER3 overexpression suppresses tumorigenicity and colony-forming capacities in PCa cells, suggesting a potential novel therapeutic strategy for PCa patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Eunice Cho, Hua Jane Lou, Leena Kuruvilla, David A. Calderwood, Benjamin E. Turk
Summary: This study identifies PPP6C as a crucial phosphatase for MEK in the ERK pathway, which is frequently mutated or downregulated in melanoma. Loss of PPP6C leads to hyperphosphorylation of MEK, enhancing signaling through the pathway and reducing sensitivity to MEK inhibitors. Its recurrent mutations in melanoma cause MEK hyperphosphorylation, suggesting their role in promoting the disease by activating the core oncogenic pathway.
Article
Neurosciences
Xiangbin Ruan, Gaoao Liu, Jiafeng Zhou, Pan Chen, Changjie Sun, Wei Liu, Chao Wu, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng
Summary: The study revealed the important role of Zbed3 in regulating neuronal layer fates during brain development. Overexpression of Zbed3 increased the generation of deep-layer neurons, while its knockdown shifted neuronal fates from deep layers to upper layers.
Article
Cell & Tissue Engineering
Chanyi Lu, Xiaoli Lin, Jumpei Yamashita, Ranhui Xi, Minliang Zhou, Yali Zhang, Hong Wang, Robert E. Margolskee, Bon-Kyoung Koo, Hans Clevers, Ichiro Matsumoto, Peihua Jiang
Summary: The study reveals the important roles of RNF43/ZNRF3 in regulating taste and lingual epithelial tissue homeostasis. R-spondin interacts with RNF43/ZNRF3 to enhance WNT signaling, thereby controlling taste cell regeneration and lingual epithelial tissue homeostasis.
Article
Fisheries
Can Yang, Juanjuan Shu, Yujia Miao, Xiaoyu Liu, Tianle Zheng, Ruixin Hou, Jun Xiao, Hao Feng
Summary: This study demonstrates that TRIM25 negatively regulates IKK epsilon/IFN signaling by enhancing the ubiquitination of IKK epsilon and inhibiting its phosphorylation. Over-expression of TRIM25 attenuates the activation of IFN signaling and antiviral activity induced by IKK epsilon.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Jing-Ping Huang, Jing Li, Yan-Ping Xiao, Liang-Guo Xu
Summary: Our research reveals that BAG6 is a critical regulator in the RIG-I/VISA-mediated innate immune response. It inhibits the aggregation of VISA and attenuates the recruitment of TRAF2, thereby inhibiting the activation of the RLR signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Oncology
Andrea Marranci, Antonella Prantera, Simona Masotti, Raffaella De Paolo, Caterina Baldanzi, Maurizio S. S. Podda, Serena Mero, Marianna Vitiello, Cinzia Franchin, Mariavittoria Laezza, Laura Comelli, Giorgio Arrigoni, Tiziana Cervelli, Giovanna Del Pozzo, Laura Poliseno
Summary: Our study reveals that PARP1 can down-regulate the translation of BRAF-X1, negatively impacting the MAPK pathway and sensitizing melanoma cells to BRAF and MEK inhibitors, both in vitro and in vivo.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Liping Wu, Bin Tian, Mingshu Wang, Anchun Cheng, Renyong Jia, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Juan Huang, XinXin Zhao, Shun Chen, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Yanling Yu, Ling Zhang, LeiCHang Pan
Summary: In this study, a monocyte/macrophages cell model was used to study the transcriptome associated with Duck plague virus (DPV) infection. Differentially expressed genes analysis showed that a large number of genes were altered in infected cells. Functional enrichment analysis revealed their involvement in metabolic pathways, viral infectious diseases, immune system, and signal transduction. The study also identified the negative regulation of the JNK pathway in modulating antiviral signaling and inflammatory pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Sha Song, Xianjue Ma
Summary: The study identifies a crucial E2 enzyme called Bruce that acts as a bridge between the cell surface signal and the activation of the Hippo pathway in Drosophila. Bruce works in synergy with the E3 ubiquitin ligase POSH to regulate growth and ubiquitination-mediated Ex degradation, thereby affecting Hippo pathway.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Piergiorgio La Rosa, Giulia Bartoli, Stefano Farioli Vecchioli, Eleonora Cesari, Vittoria Pagliarini, Claudio Sette
Summary: This study investigated the role of dihydrotestosterone (DHT) in regulating neural progenitor cell (NPC) stemness and differentiation, revealing that DHT activates androgen receptor (AR) to increase NPC proliferation and reduce neuronal differentiation. The findings suggest that androgens engage an AR-dependent signaling pathway to impact neurogenesis by expanding the NPC pool in the developing mouse cortex.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Fisheries
Qun Wang, Yue Ai, Chanyuan Wang, Yankai Liu, Huijuan Zhong, Weiyi Yan, Yunfan He, Zhuoyi Deng, Jun Zou, Hao Feng
Summary: The study cloned bcPKAC alpha from black carp and investigated its role in the innate immune antiviral signaling pathway. It was found that bcPKAC alpha positively regulates NF-kappa B signaling but negatively regulates TAK1/IRF7 signaling pathway. Knockdown of bcPKAC alpha slightly enhanced antiviral activity against SVCV, indicating its involvement in the antiviral response.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Clinical Neurology
C. A. Mutch, A. Poduri, M. Sahin, B. Barry, C. A. Walsh, A. J. Barkovich
AMERICAN JOURNAL OF NEURORADIOLOGY
(2016)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Christopher A. Mutch, Bhavya Rehani, Lawrence S. W. Lau
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2017)
Article
Cell Biology
Jianing Zhang, Gregory J. Woodhead, Sruthi K. Swaminathan, Stephanie R. Noles, Erin R. McQuinn, Anna J. Pisarek, Adam M. Stocker, Christopher A. Mutch, Nobuo Funatsu, Anjen Chenn
DEVELOPMENTAL CELL
(2010)
Article
Biochemistry & Molecular Biology
Ashley S. Pawlisz, Christopher Mutch, Anthony Wynshaw-Boris, Anjen Chenn, Christopher A. Walsh, Yuanyi Feng
HUMAN MOLECULAR GENETICS
(2008)
Article
Neurosciences
Christopher A. Mutch, Nobuo Funatsu, Edwin S. Monuki, Anjen Chenn
JOURNAL OF NEUROSCIENCE
(2009)
Article
Developmental Biology
Carolyn N. Wrobel, Christopher A. Mutch, Sruthi Swaminathan, Makoto M. Taketo, Anjen Chenn
DEVELOPMENTAL BIOLOGY
(2007)
Article
Neurosciences
Gregory J. Woodhead, Christopher A. Mutch, Eric C. Olson, Anjen Chenn
JOURNAL OF NEUROSCIENCE
(2006)
Article
Biochemistry & Molecular Biology
F Beuschlein, BD Looyenga, SE Bleasdale, C Mutch, DL Bavers, AF Parlow, JH Nilson, GD Hammer
MOLECULAR AND CELLULAR BIOLOGY
(2003)
Article
Endocrinology & Metabolism
F Beuschlein, C Mutch, DL Bavers, YM Ulrich-Lai, WC Engeland, C Keegan, GD Hammer
Article
Endocrinology & Metabolism
F Beuschlein, CE Keegan, DL Bavers, C Mutch, JE Hutz, S Shah, YM Ulrich-Lai, WC Engeland, B Jeffs, JL Jameson, GD Hammer
ENDOCRINE RESEARCH
(2002)