Article
Food Science & Technology
Chia-Chien Hsieh, Yen-Fang Wang, Pin-Yu Lin, Shih-Han Peng, Mei-Jia Chou
Summary: The study revealed that lunasin can reduce inflammation levels in obese mice, decrease macrophage infiltration in adipose tissue, and regulate spleen size and cell numbers. Additionally, lunasin promotes the production of interferon gamma and interleukin-2 in splenocytes, thus modulating immune responses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Nutrition & Dietetics
Tengteng Ji, Bing Fang, Fang Wu, Yaqiong Liu, Le Cheng, Yixuan Li, Ran Wang, Longjiao Zhu
Summary: The number of obese people is increasing worldwide due to high-fat diets causing excess energy intake. A 12-week dietary intervention study on high-fat diet-induced obese mice showed that changing the diet significantly reduced weight gain and subcutaneous adipose tissue weight. Diet change also affected lipolysis, lipogenesis, and the proportion of adipocyte stem cells in different fat tissues.
Article
Biochemistry & Molecular Biology
Rongrong Tan, Jiayang Li, Lu Liu, Qian Wu, Lei Fan, Ningning Ma, Chuwei Yu, Henglei Lu, Xuemei Zhang, Jing Chen, Likun Gong, Jin Ren
Summary: This study discovered that cysteine sulfinic acid decarboxylase (CSAD) expression significantly decreased in non-alcoholic fatty liver disease (NAFLD) patients, which was confirmed in multiple NAFLD mouse models. The overexpression of CSAD in the liver of high-fat diet-fed mice alleviated NAFLD-associated pathologies and increased the expression of fatty acid beta-oxidation genes. CSAD was also found to improve mitochondrial injury. These findings suggest that CSAD has the potential to become a new therapeutic target for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Wei Song, Chen Song, Li Li, Tianyi Wang, Jinhong Hu, Lina Zhu, Tianli Yue
Summary: The study found that three Lactobacillus strains have inhibitory effects on obesity induced by high-fat diet, reducing weight gain and adipose accumulation, while also improving hepatic steatosis. These probiotics also regulated serum lipid levels and adipocytokines, and altered the diversity of gut microbiota.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rownock Afruza, Nikhil V. Dhurandhar, Vijay Hegde
Summary: This study investigated the effects of E4orf1 expression induced by doxycycline in adipose tissue and dietary fat restriction on hepatic steatosis and its progression in mice. The results showed that E4 expression prevented the development of fatty liver, while diet reversal maintained liver health but did not improve molecular changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Xu Yan, Yuanyuan Zhai, Wenling Zhou, Yuan Qiao, Lingling Guan, Hao Liu, Jizhi Jiang, Liang Peng
Summary: Rutin supplementation can alleviate obesity and metabolic disorders induced by high-fat diet through modulating the composition of intestinal flora. Rutin supplementation reduces body-weight gain, improves insulin resistance, and acts favorably on intestinal barrier, reducing endotoxemia and systemic inflammation. Antibiotic treatment and fecal microbiota transplantation demonstrate the importance of intestinal flora in the beneficial effects of rutin on obesity control.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yaoli Liu, Xiazhou Fu, Zhiyong Chen, Tingting Luo, Chunxia Zhu, Yaoting Ji, Zhuan Bian
Summary: Sulforaphane (SFN) shows potential as a nutritional factor in combating obesity by promoting the browning of white fat, which decreases fat mass, improves glucose metabolism, and enhances insulin sensitivity. This suggests that SFN could serve as a potential medicine in anti-obesity and related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Shijie Fu, Yanting Dang, Huilin Xu, Aimin Li, Xiaoman Zhou, Xiaodong Gao, Zijie Li
Summary: Aloe vera-fermented beverages (AFB) have been found to prevent diet-induced obesity and associated complications. They reduce lipid droplets in cells, inhibit weight gain and fat accumulation, and lower the levels of total cholesterol, alanine aminotransferase, and interleukin 10. Additionally, AFB alters the composition of gut microbiota.
Article
Medicine, Research & Experimental
Ying-Yiu Lam, Sheng-Feng Tsai, Pei-Chun Chen, Yu-Min Kuo, Yun-Wen Chen
Summary: Pioglitazone may be a potential therapeutic agent for metabolic disorders and associated depression, as it alleviated glucose metabolic dysfunctions and depressive phenotypes in mice.
The treatment of pioglitazone reduced depression-like behaviors and astrocytic activation induced by a high-fat diet.
Pioglitazone treatment had no effect on anxiety-like behaviors or hippocampus-related learning and memory in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zixuan Chen, Yiwen E, Jun Xiong, Weike Li, Xuemei Chen, Na Li, Jing Long, Chao Tong, Junlin He, Fangfang Li, Cuihua Zhang, Yingxiong Wang, Rufei Gao
Summary: Pregnancy complications are more likely to occur in obese women due to defective decidualization. Obesity-induced endometrial glycolysis modifications and key glycolytic enzyme downregulation during early pregnancy might cause abnormal decidualization, leading to an unsustainable pregnancy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Immunology
Nahdia S. Jones, Katarina Q. Watson, G. William Rebeck
Summary: The study found that APOE genotype and obesity interact to affect important processes related to inflammation and neuronal plasticity in the central nervous system (CNS). The APOE3 genotype modulates a response to high-fat diet, while the APOE4 genotype does not.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Jae-Kwon Jo, Seung-Ho Seo, Seong-Eun Park, Hyun-Woo Kim, Eun-Ju Kim, Jeong-Sang Kim, Ju-Yeon Pyo, Kwang-Moon Cho, Sun-Jae Kwon, Dae-Hun Park, Hong-Seok Son
Summary: This study aimed to identify gut microbiota-metabolomic signatures altered by a high-fat diet, revealing a significant increase in specific Firmicutes in the HFD group correlated with certain metabolites levels, impacting various metabolic pathways.
Article
Biochemistry & Molecular Biology
You-Suk Lee, Eun-Jung Park, Sung-Min Kim, Jong-Yeon Kim, Hae-Jeung Lee
Summary: Honeysuckle berry extract showed beneficial effects on high-fat diet-induced mice with sarcopenic obesity, including reducing obesity, increasing muscle strength and mass, and decreasing markers of muscle atrophy.
Article
Biology
Georges Raad, Fabrizio Serra, Luc Martin, Marie-Alix Derieppe, Jerome Gilleron, Vera L. Costa, Didier F. Pisani, Ez-Zoubir Amri, Michele Trabucchi, Valerie Grandjean
Summary: Research shows that maintaining a paternal Western diet feeding for five consecutive generations in mice leads to an increase in fat mass and related metabolic diseases over generations, but progenies from these multigenerational Western-diet-fed males develop a healthy overweight phenotype characterized by normal glucose metabolism and without fatty liver, which persists for four subsequent generations. Sperm RNA is suggested to be sufficient for the establishment but not for long-term maintenance of epigenetic inheritance of metabolic pathologies.
Article
Chemistry, Medicinal
Thalita Vieira Nascimento Ximenes, Raquel Carvalho, Iluska Senna Bonfa, Vanessa Samudio Santos, Luciane Candeloro, Flavio Macedo Alves, Denise Brentan Silva, Carlos Alexandre Carollo, Karine de Cassia Freitas Gielow, Saulo Euclides Silva-Filho, Monica Cristina Toffoli-Kadri
Summary: This study evaluated the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders and macrophages activation. The results showed that B. trimera prevented the development of obesity and associated comorbidities, as well as the activation of macrophages. This study validates the popular use of this plant tea.
Article
Immunology
Jeri A. Lyons, Melissa M. Riter, Alaa M. Almatrook, Michael J. Ramsbottom, Anne H. Cross
JOURNAL OF NEUROIMMUNOLOGY
(2016)
Article
Biology
Peggy R. Biga, Mary N. Latimer, Jacob Michael Froehlich, Jean-Charles Gabillard, Iban Seiliez
Article
Fisheries
Nicholas J. Galt, Jacob Michael Froehlich, Stephen D. McCormick, Peggy R. Biga
Article
Biochemistry & Molecular Biology
M. N. Latimer, R. M. Reid, P. R. Biga, B. M. Cleveland
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2019)
Article
Integrative & Complementary Medicine
Bethany Forseth, Michele Polfuss, Michael Brondino, Michael W. Lawlor, Margaret J. Beatka, Mariah J. Prom, Janis Eells, Jeri-Ann Lyons
Summary: Yoga participants had significantly lower scores in perceived stress and depression compared to non-yoga participants, but no significant differences in inflammatory markers were observed. Further research is needed.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Review
Cell Biology
Anne M. Bronikowski, Richard P. Meisel, Peggy R. Biga, James R. Walters, Judith E. Mank, Erica Larschan, Gerald S. Wilkinson, Nicole Valenzuela, Ashley Mae Conard, Joao Pedro de Magalhaes, Jingyue (Ellie) Duan, Amy E. Elias, Tony Gamble, Rita M. Graze, Kristin E. Gribble, Jill A. Kreiling, Nicole C. Riddle
Summary: Sex differences in aging, including lifespan, age-associated decline, and physiological markers, vary greatly across animal species. The underlying causes of these differences remain mostly unknown, highlighting the need for further research on the role of sex-determination mechanisms and their impact on aging.
Article
Rehabilitation
Bethany Forseth, Michele Polfuss, Michael Brondino, Stacy D. Hunter, Michael W. Lawlor, Margaret J. Beatka, Mariah J. Prom, Janis Eells, Jeri-Ann Lyons
Summary: This study found that participating in an 8-week yoga intervention can significantly reduce stress and symptoms of depression among college students, as well as lower erythrocyte sedimentation rate. Participants who did not meet physical activity recommendations received greater benefits.
JOURNAL OF BODYWORK AND MOVEMENT THERAPIES
(2022)
Review
Geriatrics & Gerontology
Nicole C. Riddle, Peggy R. Biga, Anne M. Bronikowski, James R. Walters, Gerald S. Wilkinson, IISAGE Consortium
Summary: Comparative studies of aging are a promising method to identify general characteristics and processes of aging. While current research has mainly focused on narrow species groups, new methodological innovations allow for studies across evolutionarily distant species. However, conducting comparative aging studies across a wide range of species with distinct life histories presents additional challenges in experimental design.
Article
Surgery
Miguel Tolentino, Chi C. Cho, Jeri-Anne Lyons
Summary: This study found that photobiomodulation (PBM) at 830 nm wavelength can reduce nitrosative stress levels in patients with multiple sclerosis (MS), regardless of disease severity. This finding suggests that PBM may potentially alleviate the negative effects of nitrosative stress at any stage of MS.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2022)
Article
Surgery
Miguel Tolentino, Chi C. Cho, Jeri-Anne Lyons
Summary: Photobiomodulation (PBM) therapy has the potential to modulate cytokine production in patients with multiple sclerosis (MS), and the effect is dose- and wavelength-dependent. Disease severity affects the immune cell response.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2022)
Meeting Abstract
Sport Sciences
Mitra Rouhani, Miguel Tolentino, Erik Queoff, Chris Cho, Jeri-Anne Lyons, Alexander V. Ng
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Meeting Abstract
Immunology
Miguel Tolentino, Chi C. Cho, Jeri-Anne Lyons
JOURNAL OF IMMUNOLOGY
(2020)
Meeting Abstract
Sport Sciences
Mitra Rouhani, Miguel Tolentino, Erik Queoff, Chris Cho, Jeri-Anne Lyons, Alexander V. Ng
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Sport Sciences
Bethany Forseth, Janis Eells, Jeri-Anne Lyons, Stacy Hunter, Michele Polfuss
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Immunology
Miguel Tolentino, Chi C. Cho, Jeri-Anne Lyons
JOURNAL OF IMMUNOLOGY
(2019)