Article
Chemistry, Applied
Hemalatha Kanniyappan, Manigandan Venkatesan, Jay Panji, Megala Ramasamy, Vignesh Muthuvijayan
Summary: Mesoporous Silica Nanoparticles (MSNs) possess an orderly mesoporous structure, large surface area, and pore volume, showing great potential for drug delivery and tissue engineering. Through a series of experiments, the synthesized pure MSNs have been demonstrated to exhibit biocompatibility, osteogenic, and proangiogenic activities in bone tissue engineering applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Cell Biology
Yan Gong, Ziqi Li, Shitian Zou, Daizhao Deng, Pinglin Lai, Hongling Hu, Yongzhou Yao, Le Hu, Sheng Zhang, Kai Li, Tiantian Wei, Xiaoyang Zhao, Guozhi Xiao, Zifeng Chen, Yu Jiang, Xiaochun Bai, Zhipeng Zou
Summary: Lysosomes control mesenchymal stem cell (MSC) differentiation by proteomic reprogramming. The activity of the chaperone-mediated autophagy (CMA) lysosome subgroup in MSCs is controlled by Van-Gogh-like 2 (Vangl2), which directly binds to lysosome-associated membrane protein 2A (LAMP-2A) and targets it for degradation. The Vangl2:LAMP-2A ratio in MSCs correlates inversely with the capacity of the cells for osteoblastic differentiation in humans and mice.
DEVELOPMENTAL CELL
(2021)
Review
Endocrinology & Metabolism
Fanjin Meng, Yang Yu, Ye Tian, Meng Deng, Kaiyuan Zheng, Xiaolan Guo, Beilei Zeng, Jingjia Li, Airong Qian, Chong Yin
Summary: Long non-coding RNAs (LncRNAs) are important in bone formation and are regulated by various signaling pathways and microRNAs (miRNAs). Current research studies on osteogenic LncRNAs face problems such as sophisticated techniques, high cost for in vivo experiments, and low homology between animal models and humans, hindering translational medicine research. However, new techniques and innovative ideas are being explored to address these problems, and LncRNAs hold promise as therapeutic drugs for osteoporosis in the future.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Mathematics
Maria Jose Cervantes, Lucas O. Basiuk, Ana Gonzalez-Suarez, C. Manuel Carlevaro, Ramiro M. Irastorza
Summary: This study investigated the relationship between the electrical conductivity of trabecular bone and the conductivity of its constituents, including free water content. Computer simulations using microCT images of bovine trabecular samples were conducted to build realistic geometries. The results showed that the conductivity of bone marrow needs to be higher in order to match experimental data, and anisotropy cannot be detected in small trabecular samples. The simulations also demonstrated good fitting of the Bruggeman mixture model, which could be useful for whole-bone electrical simulations.
Article
Materials Science, Multidisciplinary
Hui Zhang, Tianwei Ma
Summary: Adaptive approach overcomes the deficiencies of weak coupling and low energy transduction efficiency in existing energy harvesting methods. Using a piezoelectric device, the adaptive approach can significantly increase the coupling strength and transduction efficiency by blocking energy from flowing back to the vibrating source. It can extract much more power from multi-frequency vibrations compared to the traditional approach.
APPLIED MATERIALS TODAY
(2023)
Article
Environmental Sciences
Raquel Cela-Dablanca, Ana Barreiro, Lucia Rodriguez Lopez, Vanesa Santas-Miguel, Manuel Arias-Estevez, Avelino Nunez-Delgado, Esperanza Alvarez-Rodriguez, Maria J. Fernandez-Sanjurjo
Summary: Sewage sludge as agricultural amendment is a major source of human medicine antibiotics entering soils, posing significant risks to human and ecological health. This study focuses on the retention of the antibiotic amoxicillin onto different bio-adsorbents, including eucalyptus leaf, pine bark, pine needles, wood ash, and mussel shell. The results show that eucalyptus leaf, pine needles, and wood ash have high adsorption capacities for amoxicillin, making them potential bio-adsorbents for reducing the environmental pollution caused by this antibiotic.
ENVIRONMENTAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Feng Li, Jian Li, Xujun Song, Tong Sun, Lian Mi, Jian Liu, Xiaomin Xia, Na Bai, Xue Li
Summary: This study developed and evaluated an appropriate GA-nCeO2 hydrogel scaffold for bone tissue engineering. The results showed that the scaffold had a favorable structure, biocompatibility, and strong osteogenic potential. This research provides a potential new material for the treatment of bone defects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bo Wang, Shuai Yuan, Wei Xin, Yi Chen, Qiwei Fu, Lexiang Li, Yang Jiao
Summary: This study developed a dopamine adhesive chemistry-based silk fibroin hydrogel with nano-hydroxyapatite-graphene oxide hybrid nanofillers and immobilized bone morphogenic protein-2, which effectively promoted in vitro compatibility with rabbit bone marrow derived mesenchymal stem cells and in vivo new bone regrowth. Bone-specific hydrogel scaffolds with upgraded structural features and mechanical properties were achieved, showing promising results for new generation bone regeneration therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Endocrinology & Metabolism
William D. Leslie, Heenam Goel, Neil Binkley, Eugene McCloskey, Didier Hans
Summary: Lumbar spine trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture, but its sensitivity to technical factors and oral antiresorptive therapies is limited. This study analyzed TBS changes over time and in response to osteoporosis treatment, and found that TBS is strongly affected by technical factors and has little effect on monitoring response to antiresorptive treatment. Therefore, the current version of the TBS algorithm has limited usefulness in untreated individuals or routine clinical practice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Georgia-Ioanna Kontogianni, Catarina Coelho, Remy Gauthier, Sonia Fiorilli, Paulo Quadros, Chiara Vitale-Brovarone, Maria Chatzinikolaidou
Summary: Nanohydroxyapatite (nanoHA) is a highly biocompatible and osteoconductive material for bone regeneration. By enriching nanoHA with strontium ions, enhanced mechanical properties and biological activity can be achieved. In this study, nanoHA and nanoHA with different substitution degrees of calcium with strontium ions (Sr-nanoHA_50 and Sr-nanoHA_100) were evaluated for their cytotoxicity and osteogenic potential. All three nanoHA-based materials showed cytocompatibility, needle-shaped nanocrystals, and enhanced osteogenic activity. Gene expression analysis demonstrated significant upregulation of osteocalcin, osteonectin, and osteopontin in all three compositions compared to the control. These findings indicate the great potential of the produced compounds for bone regeneration.
Article
Nutrition & Dietetics
Mariah Kay Jackson, Laura D. Bilek, Nancy L. Waltman, Jihyun Ma, James R. Hebert, Sherry Price, Laura Graeff-Armas, Jill A. Poole, Lynn R. Mack, Didier Hans, Elizabeth R. Lyden, Corrine Hanson
Summary: Little is known about the relationship between diet and inflammation and its impact on bone health. This cross-sectional study examined the association between diet's inflammatory potential and bone-related outcomes in midwestern post-menopausal women. The results showed that there was no significant association between the inflammatory potential of diet and bone density or structure in this cohort.
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Yu Chen, Yanbin Liu, Yangyang Zhang, Jiangming Yu, Liang Tang
Summary: Bone formation depends on osteoblasts derived from BMSCs. Gal-1 plays a crucial role in immunomodulation and has been shown to promote osteogenic differentiation of BMSCs through the activation of Lrp5 expression and Wnt/beta-catenin signaling pathway. Age-related decline in Gal-1 expression in aged mice is associated with attenuated osteogenic differentiation potential of BMSCs.
Review
Biochemistry & Molecular Biology
Banafsheh Safari, Soodabeh Davaran, Ayuob Aghanejad
Summary: Bone tissue engineering aims to create bio-inspired systems with a coordinated combination of cells, scaffolds, and bioactive factors to repair damaged bone tissue. Bioactive factors such as cytokines, growth factors, peptides, and hormonal signals play a significant role in stimulating osteogenic differentiation and proliferation of cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Aerospace
Li-Jin Liu, Yu-Bo Fan, Shou-Hui Wang, Xin-Tong Wu, Xiao Yang, Lian-Wen Sun
Summary: Bone loss induced by microgravity is site-specific, occurring later in cortical bone compared to trabecular bone. This study demonstrates that simulated microgravity can enhance the osteogenic potential of periosteal stem cells, contributing to the maintenance of cortical bone stability.
Review
Cell & Tissue Engineering
Oznur Baskan, Ozge Karadas, Gulistan Mese, Engin Ozcivici
CURRENT STEM CELL RESEARCH & THERAPY
(2020)
Article
Biochemistry & Molecular Biology
Asli Adak, Yagmur Ceren Unal, Simge Yucel, Zehra Vural, Fatma Basak Turan, Ozden Yalcin-Ozuysal, Engin Ozcivici, Gulistan Mese
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Oyku Sarigil, Muge Anil-Inevi, Burcu Firatligil-Yildirir, Yagmur Ceren Unal, Ozden Yalcin-Ozuysal, Gulistan Mese, H. Cumhur Tekin, Engin Ozcivici
Summary: The study used magnetic levitation to create 3D scaffold-free adipocyte structures for cell culture and tissue repair. Results showed potential for drug testing and cell therapy applications in soft tissue damage.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Matthew Goelzer, Amel Dudakovic, Melis Olcum, Buer Sen, Engin Ozcivici, Janet Rubin, Andre J. van Wijnen, Gunes Uzer
Summary: Mesenchymal stem cells (MSCs) maintain musculoskeletal system by differentiating into osteoblasts and adipocytes. Mechanical signals like strain and low-intensity vibration regulate MSC differentiation via cell structure control. Lamin A/C protein is crucial for nuclear architecture, and its depletion affects adipogenesis markers and cellular stiffness. The study suggests mechanoregulation of adipogenesis and mechanical activation of focal adhesions happen independently from lamin A/C.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yagmur Ceren Unal, Busra Yavuz, Engin Ozcivici, Gulistan Mese
Summary: Breast cancer is the leading cause of cancer-related deaths in women globally, with early breast cancer having a potential cure, while metastatic breast cancer lacks effective therapies; connexins play critical roles in breast tumorigenesis with various functions and effects, showing similar stage- and context-dependent effects as in other cancers.
Article
Biotechnology & Applied Microbiology
Muge Anil-Inevi, Kerem Delikoyun, Gulistan Mese, H. Cumhur Tekin, Engin Ozcivici
Summary: The study introduces a magnetic levitation system based on a single ring magnet, eliminating physical limitations for biofabrication by utilizing sample culture volume for construct size manipulation and long-term maintenance.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biophysics
Oznur Baskan, Engin Ozcivici
Summary: The study found that the applied frequency and fate induction were important determinants of cell viability, while daily exposure time had no effect.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2022)
Article
Cell Biology
Oznur Baskan, Oyku Sarigil, Gulistan Mese, Engin Ozcivici
Summary: Accumulation of adipocytes in the bone marrow leads to bone defects and reduced regenerative capacity. Applying external mechanical signals, specifically low-intensity vibratory (LIV) signals at 75 Hz, during adipogenesis can significantly suppress adipogenesis and potentially optimize mechanical-based interventions.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Review
Materials Science, Multidisciplinary
E. Alperay Tarim, Betul Karakuzu, Cemre Oksuz, Oyku Sarigil, Melike Kizilkaya, Mahmoud Khatib A. A. Al-Ruweidi, Huseyin Cagatay Yalcin, Engin Ozcivici, H. Cumhur Tekin
Summary: The recent outbreak of SARS-CoV-2 has highlighted the importance of rapid and direct detection of respiratory viruses. Conventional methods for virus detection, relying on cell culture and nucleic acids, require trained personnel and expensive equipment, while microfluidic technologies offer an accurate and specific alternative. Microfluidic-based detection technologies enable affordable, portable, and rapid analysis of intact virus or virus genetic material, essential for controlling outbreaks during pandemics and epidemics.
EMERGENT MATERIALS
(2021)
Article
Engineering, Biomedical
Ozge Karadas, Gulistan Mese, Engin Ozcivici
BIOMEDICAL ENGINEERING LETTERS
(2020)
Proceedings Paper
Engineering, Aerospace
Oyku Sarigil, Muge Anil-Inevi, Esra Yilmaz, Melike Cagan, Gulistan Mese, H. Cumhur Tekin, Engin Ozcivici
2019 9TH INTERNATIONAL CONFERENCE ON RECENT ADVANCES IN SPACE TECHNOLOGIES (RAST)
(2019)
Proceedings Paper
Engineering, Aerospace
Kerem Delikoyun, Ersin Cine, Muge Anil-Inevi, Mustafa Ozuysal, Engin Ozcivici, H. Cumhur Tekin
2019 9TH INTERNATIONAL CONFERENCE ON RECENT ADVANCES IN SPACE TECHNOLOGIES (RAST)
(2019)
Proceedings Paper
Engineering, Aerospace
Muge Anil-Incvi, Oyku Sarigil, Sena Yaman, Ozden Yalcin-Ozuysal, Gulistan Mcsc, H. Cumhur Tekin, Engin Ozcivici
2019 9TH INTERNATIONAL CONFERENCE ON RECENT ADVANCES IN SPACE TECHNOLOGIES (RAST)
(2019)
Article
Chemistry, Analytical
Oyku Sarigil, Muge Anil-Inevi, Esra Yilmaz, Gulistan Mese, H. Cumhur Tekin, Engin Ozcivici
Article
Engineering, Biomedical
Atike Ince Yardimci, Hande Aypek, Ozgur Ozturk, Selahattin Yilmaz, Engin Ozcivici, Gulistan Mese, Yusuf Selamet
JOURNAL OF BIOMIMETICS BIOMATERIALS AND BIOMEDICAL ENGINEERING
(2019)