Article
Biotechnology & Applied Microbiology
Qingbo Zheng, Na Ye, Pengjia Bao, Xiaolan Zhang, Fubin Wang, Lanhua Ma, Min Chu, Xian Guo, Chunnian Liang, Heping Pan, Ping Yan
Summary: By conducting single-cell RNA sequencing and analysis, this study revealed the gene expression characteristics and differentiation trajectories of different cell types in yak hair follicles during anagen and catagen, providing important insights for understanding the hair follicle cycle and promoting the development and utilization of yak villi.
Article
Dermatology
Wen-Yen Huang, Jin-Bon Hong, Michael Chang, Shih-Yi Wang, Shih-Fan Lai, Hsiung-Fei Chien, Sung-Jan Lin
Summary: The effects of cyclophosphamide on anagen hair follicles depend on dosage, with low dosages leading to dystrophy that can be self-repaired, while high dosages prematurely induce other growth stages. Analysis of cell dynamics revealed that apoptosis of central cells in hair bulbs is repairable, bulge stem cells remain unaffected, and basal cup cells can quickly replenish damaged cells and reconstruct structures.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Carla M. Abreu, Mariana T. Cerqueira, Rogerio P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
Summary: The conditioned medium from interfollicular keratinocytes (KCs-CM) has been shown to improve the hair inductive ability of DP cells, with significant effects on DP cell growth and restoration of activity. Additionally, DP cells cultured with KCs-CM in spheroids demonstrated superior activity and supported the formation of hair follicle- and sebaceous gland-like structures in mice when co-grafted with human keratinocytes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Rajiv L. Tiwari, Pratibha Mishra, Nicola Martin, Nikhil Oommen George, Vadim Sakk, Karin Soller, Kodandaramireddy Nalapareddy, Kalpana Nattamai, Karin Scharffetter-Kochanek, Maria Carolina Florian, Hartmut Geiger
Summary: As aging progresses, hair regeneration is impaired due to changes in the signaling pathways of HFSCs, such as a shift from canonical to non-canonical Wnt signaling. However, treatment with a specific pharmacological inhibitor can restore the functional deficits in aged HFSCs.
Article
Cell Biology
Yao Jiang, Quan Zou, Bo Liu, Shujuan Li, Yi Wang, Tianlong Liu, Xiangdong Ding
Summary: The study found similarities between pig and human follicle morphogenesis, providing a useful model for human hair research and complex hair diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Peipei Zhang, Masaki Ishikawa, Andrew Doyle, Takashi Nakamura, Bing He, Yoshihiko Yamada
Summary: Panx3 regulates skin development by modulating the transcription factor Epfn. Panx3(-/-) mice show impaired skin development and delayed hair follicle regeneration, while Panx3 overexpression promotes HaCaT cell differentiation.
SCIENTIFIC REPORTS
(2021)
Review
Dermatology
Takahiro Suzuki, Taisuke Ito, Amos Gilhar, Yoshiki Tokura, Kristian Reich, Ralf Paus
Summary: The article systematically explores the connection between psoriasis and growing scalp hair follicles, revealing that certain drugs and stressors that trigger/aggravate psoriasis can inhibit hair growth, while skin/HF trauma can favor the development of psoriatic lesions. The proposal of the bidirectional hair follicle-psoriasis axis suggests shared molecular mechanisms and potential therapeutic targets for the management of both conditions.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Biology
Marie-Claire Mechin, Michel Simon
Summary: This article discusses the role of peptidylarginine deiminases (PADs) in physiological processes and their involvement in human diseases. PAD1 and PAD3 are important for keratinocyte differentiation and epidermal barrier function, while mutations in the PADI3 gene are associated with hair disorders and alopecia. The study highlights the significance of PADs in skin health and disease.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Fatuma Jumapili Ramadhani, Dong-Ho Bak, Seong Hee Kang, Chul-hong Park, Sang Hwa Park, Byung Yeoup Chung, Hyoung-woo Bai
Summary: This study investigates the effects of CGE on hair growth and explores the mechanism behind the acceleration of anagen induction. Results demonstrate that CGE promotes cell proliferation, increases gene expression related to hair growth, and activates specific signaling pathways. These findings suggest that CGE could be a potential therapeutic reagent for promoting hair growth.
Article
Medicine, General & Internal
Jing Jing, Peng Xu, Jia-Li Xu, Yu-Xin Ding, Xiao-Shuang Yang, Xiao-Qin Jin, Li-Juan Zhou, Yu-Hong Chen, Xian-Jie Wu, Zhong-Fa Lu
Summary: Sox10 expression varies during hair follicle morphogenesis and cycling, suggesting its involvement in early follicle formation and postnatal cycling.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Byoung Ha Kim, Myong Jin Lee, Won-Yung Lee, Jaesung Pyo, Myoung-Sook Shin, Gwi Seo Hwang, Dongchul Shin, Chang Eop Kim, Eun-Seok Park, Ki Sung Kang
Summary: The study demonstrates that the extract of CMX is effective in promoting proliferation of human hair follicle dermal papilla cells through the activation of Wnt/beta-catenin, ERK, and JNK signaling pathways, leading to increased secretion of growth factors. The satisfactory bioavailability score of CMX compounds suggests its potential as a promising treatment for hair regeneration and minimizing hair loss.
Review
Dermatology
Subin Jeong, Yoojin Na, Hyeon-Min Nam, Gun Yong Sung
Summary: This article mainly introduces the research and treatment progress of hair, emphasizes the limitations of current hair follicle research models, and proposes the necessity to construct an in vitro culture system similar to the in vivo environment. It also discusses the development direction of hair follicle chips.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jiyu Hyun, Jisoo Im, Sung-Won Kim, Han Young Kim, Inwoo Seo, Suk Ho Bhang
Summary: The use of Morus alba root extract promotes hair growth by activating beta-catenin in hair follicle dermal papilla cells, leading to the induction of the anagen phase. Additionally, the extract enhances growth factor secretion and shows no cytotoxic effects on the cells. Overall, Morus alba root extract demonstrates potential in transitioning hair follicles from the telogen phase to the anagen phase.
Article
Biochemistry & Molecular Biology
Anna Geueke, Giada Mantellato, Florian Kuester, Peter Schettina, Melanie Nelles, Jens Michael Seeger, Hamid Kashkar, Catherin Niemann
Summary: This study reveals the impact of Bcl-2 on the function of hair follicle stem cells, maintaining the homeostasis and regeneration of stem cells by controlling the apoptosis response, which may also suppress carcinogenesis.
Review
Oncology
Cristina Casalou, Hugo Moreiras, Jay M. Mayatra, Aurelie Fabre, Desmond J. Tobin
Summary: This article focuses on the early stages of cutaneous melanoma development, examining how melanocyte cells can be influenced by different cellular contexts and micro-environments to determine their tumor fate. It also discusses how unique features of follicular-melanin units can protect melanocytes from melanomagenesis, and explores the potential insights provided by various pigment cell diseases into immune- and non-immune-mediated outcomes for melanocytes in cutaneous melanin units.
FRONTIERS IN ONCOLOGY
(2022)
Article
Peripheral Vascular Disease
Mika Sawane, Yuki Ogura, Ayano Nakamura, Hitomi Otaka, Hiroyasu Kidoya, Katsujiro Sato, Nobuyuki Takakura, Kentaro Kajiya
Summary: The study found that appropriate stiffness induces vascular maturation and upregulated APJ expression, while overexpression of APJ promotes the formation of large vessels, potentially providing a novel mechanism for preventing human skin aging.
Article
Pharmacology & Pharmacy
Tongyu C. Wikramanayake, Jeremy Cheret, Alec Sevilla, Mark Birch-Machin, Ralf Paus
Summary: The analysis of mitochondria in oxidative damage and skin aging is important in dermatological research. Mitochondria produce reactive oxygen species (ROS) that can be cytotoxic and DNA-damaging, leading to (photo-)aging. However, mitochondria also have physiological functions and their dysfunction is involved in skin diseases and cancers. This paper explores the role of mitochondria in skin physiology and evaluates potential lead compounds for therapeutic research. The mitochondrial protein MPZL3 is highlighted as a promising target for future research.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Letter
Dermatology
J. Gherardini, K. E. Rivas, J. Cheret, N. Strbo, R. Paus
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Alec Sevilla, Jeremy Cheret, Wendy Lee, Ralf Paus
Summary: This pilot study aimed to investigate the effects of melatonin on melanin production and melanocytes in intact human epidermis. The results showed that melanin content and melanocyte dendricity increased with melatonin treatment, while tyrosinase activity was inhibited. Higher doses of melatonin increased the number and proliferation of melanocytes and keratinocytes, as well as the expression of the premelanosomal marker gp100. These findings suggest that long-term melatonin therapy may stimulate melanogenesis and increase the activity of epidermal melanocytes.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Elijah J. Horesh, Jennifer Gherardini, Majid Alam, Jose Rodriguez-Feliz, Alan J. Bauman, Jeremy Cheret, Ralf Paus
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Julie Terzic, Mohamed A. Abu el Maaty, Regis Lutzing, Alexandre Vincent, Rana El Bizri, Matthieu Jung, Celine Keime, Daniel Metzger
Summary: Androgen deprivation therapy is a key treatment for prostate cancer, but some cases develop into castration-resistant prostate cancer (CRPC). In this study, it was found that the major luminal cell population in CRPC is castration-resistant, with enhanced expression of inflammation and stemness markers. Additionally, hypoxia-inducible factor 1 (HIF1) signaling, which promotes malignant progression, is further activated. Inhibition of HIF1A enhances the sensitivity of Pten-deficient prostatic tumors to castration and induces apoptotic signaling in human CRPC cell lines.
EMBO MOLECULAR MEDICINE
(2023)
Article
Dermatology
Moe Tsutsumi, Saito Sakaguchi, Kazuki Takagaki, Jeremy Cheret, Ralf Paus, Kentaro Kajiya
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
Jeremy Cheret, Tara Samra, Samantha D. Verling, Jennifer Gherardini, Jose Rodriguez-Feliz, Alan J. Bauman, Celina Amaya Sanchez, Tongyu C. Wikramanayake, Xiang-Xi Xu, Ralf Paus
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Dermatology
Sung-Jan Lin, Zhicao Yue, Ralf Paus
Summary: This article describes the clinical manifestation and pathobiology of radiotherapy-induced alopecia (RIA), emphasizing the importance of studying the principles of human organ and stem cell repair, regeneration, and loss. The article discusses the response of different hair follicle and extrafollicular cell populations to radiation, their roles in hair follicle repair and regeneration, and how they contribute to hair follicle miniaturization or even loss in persistent RIA. Finally, the article highlights the potential of targeting various pathways in future RIA management.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Ilaria Piccini, Jeremy Cheret, Moe Tsutsumi, Saito Sakaguchi, Leslie Ponce, Luis Almeida, Wolfgang Funk, Maximilian Kueckelhaus, Kentaro Kajiya, Ralf Paus, Marta Bertolini
Summary: Recent research has found that epidermal Merkel cells (MCs) not only have mechanotransduction function for light-touch sensory stimuli, but also are thermosensitive, suggesting a physiological role beyond mechanosensation. Functional olfactory receptors, specifically OR2AT4, were found to be expressed by epidermal MCs in healthy human skin, similar to neighboring keratinocytes. Stimulation of OR2AT4 by topical application of the synthetic odorant Sandalore significantly increased Piccolo protein expression in MCs, indicating increased vesicle trafficking and recycling, and reduced nerve growth factor (NGF) immunoreactivity within MCs, potentially suggesting increased neurotrophin release upon OR2AT4 activation. Further investigation is needed to explore whether these newly discovered properties of MCs are dysregulated in specific skin disorders and if they can be targeted therapeutically to maintain/promote skin health.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Max van Lessen, Andrei Mardaryev, David Broadley, Marta Bertolini, Janin Edelkamp, Maximilian Kueckelhaus, Wolfgang Funk, Tamas Biro, Ralf Paus
Summary: In this pilot study, scientists reported that healthy human skin of different age groups undergoes extremely accelerated ageing within only 3 days when organ-cultured in a defined serum-free medium. They found significant changes in ageing-associated biomarkers in the ex vivo phenotype and discovered that caffeine and 2,5-dimethylpyrazine have anti-ageing effects.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Yo Tanaka, Misako Sato-Matsubara, Daisuke Tsuruta, Hiroshi Tanaka, Chiho Kadono, Koji Sugawara, Norifumi Kawada, Kazumasa Wakamatsu, Shosuke Ito, Katsutoshi Yoshizato
Summary: CYGB plays a regulatory role in the melanogenic process by maintaining redox homeostasis through controlling intracellular levels of reactive oxygen species and nitric oxide.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anna Y. Belorusova, Daniela Rovito, Yassmine Chebaro, Stefanie Doms, Lieve Verlinden, Annemieke Verstuyf, Daniel Metzger, Natacha Rochel, Gilles Laverny
Summary: This study demonstrates that BXL-62 and Gemini-72, two C-20-modified vitamin D analogs, restore the transcriptional activities of VDR variants unresponsive to the natural ligand. The elucidated mechanisms of action highlight the mutual adaptation between the ligand and the VDR ligand-binding pocket.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)