Article
Biochemistry & Molecular Biology
Costanza E. Maurici, Robin Colenbier, Britta Wylleman, Luigi Brancato, Eke van Zwol, Johan Van den Bossche, Jean-Pierre Timmermans, Elisa Giovannetti, Marina G. M. C. Mori da Cunha, Johannes Bogers
Summary: The study found that hyperthermia not only directly inhibits the proliferation of PDAC cells, but also enhances the effectiveness of chemotherapy drugs, which has a positive impact on the treatment of PDAC patients.
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Huan Ma, Siyu Jiang, Yinan Yuan, Ji Li, Yizhuo Li, Yanping Lv, Tengjiao Du, Jingqian Guan, Xizi Jiang, Lei Tian, Qianqian Zheng, Lianhe Yang, Qingchang Li
Summary: RUNX1, a member of the RUNX family, is involved in the regulation of non-small cell lung cancer. It promotes cell proliferation and migration via the mTOR pathway and may serve as a potential therapeutic target for NSCLC.
Article
Chemistry, Medicinal
Javier Munoz-Garcia, Mattia Mazza, Cyrille Alliot, Corinne Sinquin, Sylvia Colliec-Jouault, Dominique Heymann, Sandrine Huclier-Markai
Summary: EPS derivatives produced by Alteromonas infernus bacterium exhibit antimetastatic properties on osteosarcoma cells, and when complexed with scandium, show enhanced antiproliferative effects. It is crucial to maintain the biological properties of the vector when complexing with scandium to ensure effectiveness without major structural modifications.
Article
Chemistry, Multidisciplinary
Manali Haniti Mohd-Zahid, Siti Nadiah Zulkifli, Che Azurahanim Che Abdullah, JitKang Lim, Sharida Fakurazi, Kah Keng Wong, Andee Dzulkarnaen Zakaria, Norzila Ismail, Vuk Uskokovic, Rohimah Mohamud, Z. A. Iskandar
Summary: The study demonstrates the specific targeting of 5-FU against colorectal cancer cells by conjugating nanocarriers with anti-CD133 antibodies. Simultaneous functionalisation of PEGylated AuNPs with antibodies and chemotherapeutic drugs is a viable strategy for targeted drug delivery to combat cancer.
Article
Cell Biology
ShiJian Ding, Hao Li, Yu-Hang Zhang, XianChao Zhou, KaiYan Feng, ZhanDong Li, Lei Chen, Tao Huang, Yu-Dong Cai
Summary: Although various types of cancers share common traits such as proliferation and metastasis, they are still very different due to their growth on different organs or tissues. After the Cancer Genome Atlas (TCGA) project, researchers have conducted pan-cancer studies to identify robust gene expression patterns, but face challenges due to large variances in cancer patients. In this study, an alternative approach using cell line data was applied to reduce variance and extract robust pan-cancer biomarkers for personalized cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ammar Said Suliman, Mouhamad Khoder, Ibrahim Tolaymat, Matt Webster, Raid G. Alany, Weiguang Wang, Abdelbary Elhissi, Mohammad Najlah
Summary: In this study, inclusion complexes of DDC-Cu with cyclodextrins were prepared to enhance the solubility of DDC-Cu, showing a significant improvement in solubility and promising anticancer activity against chemoresistant triple negative breast cancer cells.
Article
Biochemistry & Molecular Biology
Rafal Kretowski, Agata Jablonska-Trypuc, Marzanna Cechowska-Pasko
Summary: Breast cancer, the most common cancer in women, requires novel drug approaches due to side effects of traditional therapies. Reduced graphene oxide (rGO) is a potential drug with target selectivity, easy functionalisation, chemisensitisation, and high drug-loading capacity. Studies show rGO induces cytotoxicity and antiproliferative effects in breast cancer cell lines through oxidative stress and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jianhui Yang, Omar Aljitawi, Peter Van Veldhuizen
Summary: This review summarizes the recent research progress on the role of CD133 in prostate cancer stem cells (PCSC), including its selective expression in undifferentiated cells, its correlation to treatment resistance, its gene regulation and functional analysis, and its targeted therapy in vitro, in vivo, and in clinical trials.
Article
Nanoscience & Nanotechnology
Shiyang Shen, Xiao Xu, Shiqi Lin, Ying Zhang, Huayu Liu, Can Zhang, Ran Mo
Summary: This study presents a nanoparticle-based strategy for killing CSCs in tumors by inducing CSC differentiation with all-trans retinoic acid release under hypoxic conditions and triggering cell death with camptothecin release in response to increasing reactive oxygen species levels in differentiating CSCs.
NATURE NANOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Kira L. F. Hilton, Chandni Manwani, Jessica E. Boles, Lisa J. White, Sena Ozturk, Michelle D. Garrett, Jennifer R. Hiscock
Summary: The article highlights the potential future health threats of cancer and antimicrobial resistant bacterial infections, emphasizing the importance of developing novel therapeutic strategies. It also summarizes research findings on key differences in the membrane composition of bacterial and cancer cells, as well as the methods used for analogous research between the two fields.
Article
Polymer Science
Rakshita Grover, Sahil Drall, Neelam Poonia, Gaurav Kumar Jain, Geeta Aggarwal, Viney Lather, Prashant Kesharwani, Deepti Pandita, Ramesh K. Goyal
Summary: Cancer stem cells (CSCs) contribute to tumor onset, progression, chemotherapy resistance, and relapse. CD44 and CD133 are commonly expressed markers used to identify aggressive CSCs. Targeting these markers with aptamers conjugated nanocarriers can overcome the limitations of antibodies and has proven to be beneficial in targeting CSCs. This article reviews the recent advancements in aptamers and their conjugation with nanocarriers for specific targeting of CSCs and improved cancer therapy efficacy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Environmental Sciences
Vijayakumar Gunasekaran, Rathinam Yuvakkumar, Ravi Ganesan, Surya Cholayil Palapetta, Harichandran Gurusamy
Summary: In this study, NBA and ABA were synthesized and evaluated for their cell multiplication inhibition activity against MCF-7 and HeLa cancer cell lines. The results showed that both NBA and ABA exhibited antiproliferative action against these cancer cell lines.
ENVIRONMENTAL RESEARCH
(2023)
Article
Plant Sciences
Chung-Pu Wu, Yan-Qing Li, Tai-Ho Hung, Yu-Tzu Chang, Yang-Hui Huang, Yu-Shan Wu
Summary: SFG, a compound derived from plants, has the potential to reverse ABCG2-mediated multidrug resistance in NSCLC cells, suggesting a possible therapeutic effect.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Oncology
Francois Fabi, Pascal Adam, Sophie Parent, Laurence Tardif, Monique Cadrin, Eric Asselin
Summary: The study highlights that NVP-BEZ235 and AZD5363 sensitize cancer cells to cisplatin and doxorubicin, with differences in reducing phosphorylation of proteins. AZD5363 induces apoptosis in cells and reduces cell replicative ability, showing a potential cooperative effect of the compounds.
MOLECULAR ONCOLOGY
(2021)
Article
Veterinary Sciences
Dario Costanza, Pierpaolo Coluccia, Erica Castiello, Adelaide Greco, Leonardo Meomartino
Summary: This study describes the design, implementation, and author experiences of a low-cost PACS system based on network-attached storage. The system is easily installed, resiliently stores redundant copies of data, and excellently balances data recovery, system speed, security, and available memory for storage. It also allows off-site data review and backup in the cloud for future use.
VETERINARY RADIOLOGY & ULTRASOUND
(2022)
Article
Cardiac & Cardiovascular Systems
Olufunmilayo H. Obisesan, Minghao Kou, Frances M. Wang, Ellen Boakye, Yasuyuki Honda, S. M. Iftekhar Uddin, Omar Dzaye, Albert D. Osei, Olusola A. Orimoloye, Candace M. Howard-Claudio, Josef Coresh, Roger S. Blumenthal, Ron C. Hoogeveen, Matthew J. Budoff, Kunihiro Matsushita, Christie M. Ballantyne, Michael J. Blaha
Summary: This study used ARIC data to evaluate the relationship between lipoprotein(a) (Lp(a)) in middle age and vascular and valvular calcification in older age. The results showed that elevated Lp(a) in middle age is significantly associated with vascular and valvular calcification in older age. The findings suggest the importance of assessing Lp(a) levels and conducting comprehensive vascular and valvular assessments in individuals with increased cardiovascular disease risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Veterinary Sciences
Dario Costanza, Adelaide Greco, Diego Piantedosi, Dario Bruzzese, Maria Pia Pasolini, Pierpaolo Coluccia, Erica Castiello, Claudia Sofia Baptista, Leonardo Meomartino
Summary: This study aimed to evaluate the agreement between heart-to-single vertebra ratio (HSVR) and vertebral heart size (VHS) and to assess the intra- and inter-observer agreement for HSVR. The results showed a strong correlation between VHS and HSVR, and HSVR demonstrated good intra- and inter-observer agreement.
VETERINARY RADIOLOGY & ULTRASOUND
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Adelaide Greco, Leonardo Meomartino, Giacomo Gnudi, Arturo Brunetti, Mauro Di Giancamillo
Summary: Radiography and ultrasonography are commonly used techniques in veterinary practice, but in recent decades, CT, MRI, and MN have become increasingly popular. This article describes the use of CT, MRI, and MN in veterinary medicine.
EUROPEAN JOURNAL OF RADIOLOGY OPEN
(2023)
Letter
Cardiac & Cardiovascular Systems
Yejin Mok, Yasuyuki Honda, Frances M. Wang, Candace M. Howard, Aaron R. Folsom, Josef Coresh, Matthew Budoff, Michael J. Blaha, Kunihiro Matsushita
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Shivendra Singh, Flavia De Carlo, Mohamed A. Ibrahim, Patrice Penfornis, Alan J. Mouton, Siddharth K. Tripathi, Ameeta K. Agarwal, Linda Eastham, David S. Pasco, Premalatha Balachandran, Pier Paolo Claudio
Summary: Our study identified a novel glycolysis inhibitor, gnetin H (GH), which can reduce metabolic activity and lactic acid synthesis and exhibit a strong cytostatic effect in melanoma and glioblastoma cells. Compared to other glycolysis inhibitors, GH combined with the mitochondrial inhibitor phenformin (Phen) more effectively inhibited cell growth. RNA-Seq analysis revealed that GH treatment significantly reduced the expression of thioredoxin interacting protein (TXNIP), a key gene involved in cellular glucose homeostasis. Furthermore, GH in combination with phenformin increased the levels of p-AMPK, indicating metabolic catastrophe. These findings suggest that GH combined with a mitochondrial inhibitor could be a powerful tool for inducing metabolic catastrophe and reducing the growth of cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Dario Costanza, Pierpaolo Coluccia, Luigi Auletta, Erica Castiello, Luigi Navas, Adelaide Greco, Leonardo Meomartino
Summary: This study aimed to determine the normal pituitary size and pituitary-to-brain ratio in domestic short-haired cats using computed tomography. The study found that the normal range for pituitary dimensions is wider than previously reported and there is a low correlation between body weight, age, and pituitary dimensions. The reference values obtained from this study could help in better evaluating suspected pituitary neoplastic lesions in domestic short-haired cats.
Article
Veterinary Sciences
Dario Costanza, Leonardo Meomartino, Barbara Lamagna, Erica Castiello, Pierpaolo Coluccia, Giuseppe Piegari, Ilaria D'Aquino, Francesco Lamagna, Adelaide Greco
Summary: This study aimed to assess the feasibility and standardize the modality of retrobulbar fat injection for the treatment of enophthalmos in dogs. The injection of adipose tissue-like solutions within the retrobulbar space was performed in dog cadavers using an ultrasound-guided approach. Eyeball displacement was evaluated using computed tomography (CT), and necropsy and histopathological examination were conducted to assess retrobulbar structure damage. The study concluded that retrobulbar fat injection may represent a viable treatment option for enophthalmos in dogs.
VETERINARY SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Antonio Cortese, Francesca Spirito, Pier Paolo Claudio, Lorenzo Lo Muzio, Alessandro Ruggiero, Maurizio Gargiulo
Summary: Virtual surgical planning for CAD/CAM mandibular reconstruction using titanium prosthesis has been recently reported. However, there may be difficulties in TMJ function due to prosthesis contamination from oral mucosa dehiscence. Two cases of mandibular reconstruction after ameloblastoma resection using custom-made CAD/CAM titanium prosthesis were presented, aiming to preserve TMJ function and avoid intraoral incisions. Finite elements analysis was performed to ensure the efficacy of the prosthetic device. Although successful, there are still drawbacks and risks, and limitations and side effects must be considered when using this technique.
Article
Cell Biology
Tulika Ranjan, Soma Sengupta, Michael J. Glantz, Richard M. Green, Alexander Yu, Dawit Aregawi, Rekha Chaudhary, Ricky Chen, Mario Zuccarello, Christine Lu-Emerson, Hugh D. Moulding, Neil Belman, Jon Glass, Aaron Mammoser, Mark Anderson, Jagan Valluri, Nicholas Marko, Jason Schroeder, Steven Jubelirer, Frances Chow, Pier Paolo Claudio, Anthony M. Alberico, Seth T. Lirette, Krista L. Denning, Candace M. Howard
Summary: Therapy-resistant cancer stem cells (CSCs) contribute to poor clinical outcomes in patients with recurrent glioblastoma (rGBM), but the ChemoID assay offers a personalized approach for selecting effective treatments and improves survival in rGBM patients compared to physician-chosen chemotherapy.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Tulika Ranjan, Alexander Yu, Shaed Elhamdani, Candace M. Howard, Seth T. Lirette, Krista L. Denning, Jagan Valluri, Pier Paolo Claudio
Summary: This study demonstrates the use of personalized anticancer therapy based on a chemotherapeutics assay report to improve the survival of GBM patients. Patients in the high-response treatment group had significantly longer overall survival and higher probability of survival at 12 months compared to the low-response treatment group. This approach also has potential to reduce healthcare costs.
NEURO-ONCOLOGY ADVANCES
(2023)
Review
Biochemistry & Molecular Biology
Isaiah A. Edwards, Flavia De Carlo, Juliana Sitta, William Varner, Candace M. Howard, Pier Paolo Claudio
Summary: The response to cancer treatments varies greatly and can cause severe side effects. Researchers aim to develop new treatments that can specifically target and kill tumor cells with minimal drug dosage. Despite advancements in drug formulations and active targeting, the desired clinical outcome has not been achieved. This review discusses the current classification and standard of care for breast cancer, as well as the use of nanomedicine and ultrasound-responsive carriers in preclinical studies for drug and gene delivery to breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Juliana Sitta, Pier Paolo Claudio, Candace M. Howard
Summary: Immunotherapy has shown promising results in certain types of cancer, but the immune suppression mechanisms of tumors limit its efficacy. Oncolytic viruses, as a novel therapeutic approach, can enhance immune response and improve treatment outcomes through genetic engineering. However, developing preclinical models that replicate human immune response remains a challenge.
Article
Dentistry, Oral Surgery & Medicine
Antonio Cortese, Salvatore Catalano, Antonio Alberto Maria Giunta, Antonio Borri, Daniele Panetta, Pier Paolo Claudio
Summary: The study presents a reconstructive method for lip reconstruction using the Goldstein-Robotti technique and buccinator flap, achieving satisfactory functional and aesthetic outcomes.