Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, Cesar Luna-Rivero, Erika Mariana Hernandez-Montiel, Luis Alejandro Fernandez-Lopez, Maria Fernanda Cabrera-Cornejo, Eduardo Misael Choreno-Parra, Alfredo Cruz-Lagunas, Andrea Dominguez, Eduardo Marquez-Garcia, Carlos Cabello-Gutierrez, Francina Valezka Bolanos-Morales, Lourdes Mena-Hernandez, Diego Delgado-Zaldivar, Daniel Rebolledo-Garcia, Parmenides Guadarrama-Ortiz, Nora E. Regino-Zamarripa, Criselda Mendoza-Milla, Ethel A. Garcia-Latorre, Tatiana Sofia Rodiguez-Reyna, Diana Cervantes-Rosete, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: The study found that serum levels of CXCL17 were increased only in patients with pandemic influenza A(H1N1), and its expression in lung tissue had specific patterns, while no similar observations were made in COVID-19 and TB patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Rachel E. Geyer, Jack Henry Kotnik, Victoria Lyon, Elisabeth Brandstetter, Monica Zigman Suchsland, Peter D. Han, Chelsey Graham, Misja Ilcisin, Ashley E. Kim, Helen Y. Chu, Deborah A. Nickerson, Lea M. Starita, Trevor Bedford, Barry Lutz, Matthew J. Thompson
Summary: This study assessed the accuracy of an influenza rapid diagnostic test (RDT) conducted at home by lay users with acute respiratory illness. The sensitivity and specificity of the self-test were comparable with those of influenza RDTs used in clinical settings, indicating the importance of home testing for the management of influenza and other respiratory infections.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Infectious Diseases
Basilua Andre Muzembo, Kei Kitahara, Anusuya Debnath, Keinosuke Okamoto, Shin-Ichi Miyoshi
Summary: This study systematically evaluated the accuracy of cholera rapid diagnostic tests (RDTs) and found that they have moderate sensitivity and specificity, especially when enriched with alkaline peptone water (APW). Although they are less useful for clinical management, the current generation of RDTs can be valuable for surveillance efforts if used in a principled manner.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Siau Ek Hwee, Norah Htet Htet, Cho Naing, Wong Siew Tung, Joon Wah Mak
Summary: Leptocheck-WB is a diagnostic test for the detection of acute leptospirosis with moderate sensitivity and specificity. The methodological quality and study design may affect the accuracy of the test.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Behavioral Sciences
Daiva Radzisauskiene, Monika Vitkauskaite, Karolina Zvinyte, Ruta Mameniskiene
Summary: The study described a case series of influenza A-associated neurological complications, with a low incidence rate of influenza-associated neurological complications in hospitalized patients in 2019 at 1.9%. The findings suggest that during influenza epidemics, patients with unexplained neurological symptoms resembling aseptic and septic meningitis/encephalitis should be tested for influenza virus.
BRAIN AND BEHAVIOR
(2021)
Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Areti Angeliki Veroniki, Andrea C. Tricco, Jennifer Watt, Sofia Tsokani, Paul A. Khan, Charlene Soobiah, Ahmed Negm, Amanda Doherty-Kirby, Paul Taylor, Carole Lunny, Jessie McGowan, Julian Little, Patrick Mallon, David Moher, Sabrina Wong, Jacqueline Dinnes, Yemisi Takwoingi, Lynora Saxinger, Adrienne Chan, Wanrudee Isaranuwatchai, Bryn Lander, Adrienne Meyers, Guillaume Poliquin, Sharon E. Straus
Summary: This study aimed to determine the most sensitive and specific rapid test for the diagnosis of SARS-CoV-2 through a rapid review and diagnostic test accuracy network meta-analysis. The results showed that rapid molecular tests had high sensitivity and specificity, while rapid antigen tests were mainly associated with high specificity.
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Alfredo Cruz-Lagunas, Tatiana Sofia Rodriguez-Reyna, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Diana Lizzeth Hernandez-Garcia, Eduardo M. Choreno-Parra, Yalbi I. Balderas-Martinez, Mariana Esther Martinez-Sanchez, Eduardo Marquez-Garcia, Edda Sciutto, Jose Moreno-Rodriguez, Jose Omar Barreto-Rodriguez, Hazel Vazquez-Rojas, Gustavo Ivan Centeno-Saenz, Nestor Alvarado-Pena, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, David Galeana-Cadena, Gabriela Hernandez, Criselda Mendoza-Milla, Andrea Dominguez, Julio Granados, Lula Mena-Hernandez, Luis Angel Perez-Buenfil, Guillermo Dominguez-Cheritt, Carlos Cabello-Gutierrez, Cesar Luna-Rivero, Jorge Salas-Hernandez, Patricio Santillan-Doherty, Justino Regalado, Angelica Hernandez-Martinez, Lorena Orozco, Federico Avila-Moreno, Ethel A. Garcia-Latorre, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: By comparing patients with COVID-19 and pandemic influenza A(H1N1), it was found that influenza patients had more severe respiratory symptoms, while COVID-19 patients more often experienced dry cough and gastrointestinal symptoms. The immune responses also differed between the two diseases, with pandemic influenza A(H1N1) characterized by higher levels of certain cytokines and COVID-19 displaying a distinct immune profile with increased Th1 and Th2 cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jianyong Li, Rui Lin, Yi Yang, Rongtao Zhao, Shiping Song, Yi Zhou, Jiye Shi, Lihua Wang, Hongbin Song, Rongzhang Hao
Summary: The development of a multichannel electrochemical immunoassay platform for on-site detection of SARS-CoV-2 and A(H1N1) offers great potential for timely diagnosis and prevention of the spread of infectious diseases in communities or resource-limited regions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Medicine, General & Internal
Maniya Arshadi, Fatemeh Fardsanei, Behnaz Deihim, Zahra Farshadzadeh, Farhad Nikkhahi, Farima Khalili, Giovanni Sotgiu, Amir Hashem Shahidi Bonjar, Rosella Centis, Giovanni Battista Migliori, Mohammad Javad Nasiri, Mehdi Mirsaeidi
Summary: This study evaluated the accuracy of rapid antigen tests (RATs) in diagnosing COVID-19. The results showed that RATs had high sensitivity and specificity compared to the reference test (real-time PCR), making them suitable for early detection and resource-limited countries.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hien Thi Tuong, Ju Hwan Jeong, Young Ki Choi, Hyun Park, Yun Hee Baek, Seon-Ju Yeo
Summary: Novel monoclonal antibodies (McAbs) against influenza A H9 viruses were developed for the rapid diagnostic detection of H9N2 virus in feces samples, with linear epitope McAbs showing superior performance in animal studies with 100% relative sensitivity in fecal samples at 6 days post-infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Infectious Diseases
Hidehiro Someko, Yuji Okazaki, Yasushi Tsujimoto, Masahiro Ishikane, Kenji Kubo, Tomoki Kakehashi
Summary: This study aimed to investigate the usefulness of rapid antigen tests in cerebrospinal fluid (CSF) for triaging pneumococcal meningitis. The meta-analysis of 44 studies found that the sensitivity of rapid antigen tests in CSF was 99.5% and the specificity was 98.2%. The results suggest that this testing method can be utilized for triaging pneumococcal meningitis, but further research is needed to validate its clinical benefits.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Hannah E. Maier, Raffael Nachbagauer, Guillermina Kuan, Sophia Ng, Roger Lopez, Nery Sanchez, Daniel Stadlbauer, Lionel Gresh, Amy Schiller, Arvind Rajabhathor, Sergio Ojeda, Andrea F. Guglia, Fatima Amanat, Angel Balmaseda, Florian Krammer, Aubree Gordon
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Immunology
Tim K. Tsang, Kyu Han Lee, Betsy Foxman, Angel Balmaseda, Lionel Gresh, Nery Sanchez, Sergio Ojeda, Roger Lopez, Yang Yang, Guillermina Kuan, Aubree Gordon
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Medicine, Research & Experimental
Jennifer Nayak, Gregory Hoy, Aubree Gordon
Summary: Influenza imposes a significant disease burden on children worldwide, with unique aspects to how children present with infection. Children also play a significant role in viral transmission within communities. Early influenza infection can uniquely establish lasting immunologic memory in children, making an understanding of viral immunity development critical for better protection and vaccine development.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Xin Wang, You Li, Katherine L. O'Brien, Shabir A. Madhi, Marc-Alain Widdowson, Peter Byass, Saad B. Omer, Qalab Abbas, Asad Ali, Alberta Amu, Eduardo Azziz-Baumgartner, Quique Bassat, W. Abdullah Brooks, Sandra S. Chaves, Alexandria Chung, Cheryl Cohen, Marcela Echavarria, Rodrigo A. Fasce, Angela Gentile, Aubree Gordon, Michelle Groome, Terho Heikkinen, Siddhivinayak Hirve, Jorge H. Jara, Mark A. Katz, Najwa Khuri-Bulos, Anand Krishnan, Oscar de Leon, Marilla G. Lucero, John P. McCracken, Ainara Mira-Iglesias, Jennifer C. Moisi, Patrick K. Munywoki, Millogo Ourohire, Fernando P. Polack, Manveer Rahi, Zeba A. Rasmussen, Barbara A. Rath, Samir K. Saha, Eric A. F. Simoes, Viviana Sotomayor, Somsak Thamthitiwat, Florette K. Treurnicht, Marylene Wamukoya, Lay-Myint Yoshida, Heather J. Zar, Harry Campbell, Harish Nair
LANCET GLOBAL HEALTH
(2020)
Article
Immunology
John Kubale, Guillermina Kuan, Lionel Gresh, Sergio Ojeda, Amy Schiller, Nery Sanchez, Roger Lopez, Eduardo Azziz-Baumgartner, Steph Wraith, Eva Harris, Angel Balmaseda, Jon Zelner, Aubree Gordon
Summary: The study indicates that influenza is an important driver of both primary and secondary pneumonia among children, with distinct periods of elevated pneumonia risk in the 30 days following influenza.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Alexandria D. Tricoche, Abram L. Wagner, Angel Balmaseda, Nery Sanchez, Mayuri Patel, Roger Lopez, Amy Schiller, Sergio Ojeda, Aaron M. Frutos, Guillermina Kuan, Aubree Gordon
Summary: This study showed that symptomatic influenza cases are more likely to have a strong antibody response compared to asymptomatic cases. Therefore, asymptomatic infections may be underestimated in influenza virus studies relying on serological assays.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Abram L. Wagner, Lionel Gresh, Nery Sanchez, Guillermina Kuan, John Kubale, Roger Lopez, Sergio Ojeda, Eduardo Azziz-Baumgartner, Angel Balmaseda, Aubree Gordon
Summary: The study found that a large proportion of children under 2 years old in Nicaragua contract influenza, with partially vaccinated children experiencing milder symptoms. However, the vaccination rate is low, with few children being fully vaccinated. Future studies should focus on the effectiveness of a two-dose vaccination schedule.
Article
Immunology
Zion Congrave-Wilson, Wesley A. Cheng, Yesun Lee, Stephanie Perez, Lauren Turner, Carolyn Jennifer Marentes Ruiz, Shirley Mendieta, Adam Skura, Jaycee Jumarang, Jennifer Del Valle, John Kubale, Emma Kaitlynn Allen, Paul G. Thomas, Aubree Gordon, Pia S. Pannaraj
Summary: This study compared the serological responses following natural infection and vaccination, finding that responses after natural infection were more variable while antibody levels after vaccination remained durable for up to 12 months. Individuals with both infection and vaccination had more robust and slower declining SARS-CoV-2-specific antibody levels.
Article
Immunology
Abram L. Wagner, Nery Sanchez, John Kubale, Guillermina Kuan, Lionel Gresh, Roger Lopez, Sergio Ojeda, Eduardo Azziz-Baumgartner, Angel Balmaseda, Aubree Gordon
Summary: In a cohort study of young children in Nicaragua, this study found that partial influenza vaccination provided some protection within 3 to 9 months, but this protection waned after 5 months, highlighting the importance of a second dose.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Gregory Hoy, Guillermina Kuan, Roger Lopez, Nery Sanchez, Brenda Lopez, Sergio Ojeda, Hannah Maier, Mayuri Patel, Steph Wraith, Alyssa Meyers, Lora Campredon, Angel Balmaseda, Aubree Gordon
Summary: Asymptomatic influenza infection in children is rare and age-dependent, but viral shedding still occurs. Post-influenza sequelae in children in the community setting are rare, and the risk of sequelae depends on virus strain.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Hannah E. Maier, Miguel Plazaola, Roger Lopez, Nery Sanchez, Saira Saborio, Sergio Ojeda, Carlos Barilla, Guillermina Kuan, Angel Balmaseda, Aubree Gordon
Summary: Prior infection with SARS-CoV-2 is associated with shorter viral shedding and lower viral loads, which may be important in the transition from pandemic to endemicity.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Letter
Medicine, General & Internal
Qian Wang, Anthony Bowen, Riccardo Valdez, Carmen Gherasim, Aubree Gordon, Lihong Liu, David D. D. Ho
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Aaron M. Frutos, Guillermina Kuan, Roger Lopez, Sergio Ojeda, Abigail Shotwell, Nery Sanchez, Saira Saborio, Miguel Plazaola, Carlos Barilla, Eben Kenah, Angel Balmaseda, Aubree Gordon
Summary: Infection-induced immunity is associated with decreased infectivity in adults and adolescents, but not in young children. Prior infection or asymptomatic presentation does not reduce infectivity in young children in a household setting.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Gregory Hoy, Hannah E. Maier, Guillermina Kuan, Nery Sanchez, Roger Lopez, Alyssa Meyers, Miguel Plazaola, Sergio Ojeda, Angel Balmaseda, Aubree Gordon
Summary: The SARS-CoV-2 pandemic and break in influenza circulation have resulted in reduced population immunity to influenza, particularly among children with limited exposure prior to the pandemic. Based on data from a prospective pediatric cohort study conducted in Managua, Nicaragua, we compared the incidence and severity of influenza A/H3N2 and influenza B/Victoria between 2022 and two pre-pandemic seasons. We observed higher incidence of A/H3N2 in older children in 2022 compared to pre-2020, along with a higher proportion of severe influenza cases, primarily among children aged 0-4, suggesting an impact of the SARS-CoV-2 pandemic on influenza incidence and severity in children.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Infectious Diseases
Holly M. Biggs, Eric A. F. Simoes, Ilham Abu Khader, Mark G. Thompson, Aubree Gordon, Danielle R. Hunt, Nicholas P. DeGroote, Rachael M. Porter, Silvia Bino, Basima Marar, Lionel Gresh, Joanne de Jesus-Cornejo, Gayle Langley, Natalie J. Thornburg, Teresa C. T. Peret, Brett Whitaker, Yange Zhang, Lijuan Wang, Mira C. Patel, Meredith McMorrow, William Campbell, Iris Hasibra, Enkeleda Duka, Mahmoud Al-Gazo, John Kubale, Felix Sanchez, Marilla G. Lucero, Veronica L. Tallo, Eduardo Azziz-Baumgartner, Artan Simaku, Susan Gerber, IRIS Network
Summary: This study investigated RSV infection in hospitalized infants <1-year-old in Albania, Jordan, Nicaragua, and the Philippines during respiratory seasons from 2015 to 2017. It found that 31% of hospitalized infants tested positive for RSV, and 52% of RSV-positive infants had severe illness. Age, weight, and mode of delivery were associated with the severity of RSV infection. Implementing RSV prevention strategies targeting young infants could reduce RSV-associated hospitalizations in middle-income countries.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)