Article
Oncology
Natascia Marino, Rana German, Ram Podicheti, Douglas B. Rusch, Pam Rockey, Jie Huang, George E. Sandusky, Constance J. Temm, Sandra Althouse, Kenneth P. Nephew, Harikrishna Nakshatri, Jun Liu, Ashley Vode, Sha Cao, Anna Maria Storniolo
Summary: This study found molecular aberrations in normal breast tissue of women at high risk for breast cancer, which may contribute to breast cancer susceptibility. This is also the first study to molecularly characterize true normal breast tissue.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Viviane A. Lin, Robin Lohse, Michael T. Madsen, Tina Fransgaard, Feza H. Remzi, Ismail Goegenur
Summary: This study found no significant differences in long-term outcomes between patients with ulcerative colitis-associated colorectal cancer and those with sporadic colorectal cancer. However, the results are limited by potential residual confounding and heterogeneity in confounding adjustment during the meta-analysis.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Cell Biology
Tayyebeh Ghasemi, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Parviz Asadi
Summary: The deregulation of lncRNAs in colorectal cancer is crucial for its carcinogenesis. This study analyzed lncRNA expression in CRC and its correlation with clinicopathological variables. SNHG6, MIR4435-2HG, and TRPM2-AS1 were identified as upregulated lncRNAs in CRC, with SNHG6 and TRPM2-AS1 potentially serving as diagnostic biomarkers for CRC development.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Yanhui Ma, Lin Deng, Yuchan Huangfu, Yunlan Zhou, Ping Wang, Lisong Shen
Summary: This study aims to evaluate the association between serum vitamin D level and the risk of non-hereditary colorectal cancer (CRC). The results showed that an adequate level of vitamin D was associated with a reduced risk of CRC, especially in the elderly. The use of statins may affect the protective effect of vitamin D and could be an important confounding factor for the inverse association between serum 25(OH)D and colorectal cancer.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Yan Zhang, Shunxia Hu, Jun Li, Duo Shi, Bing Luo
Summary: This study found that hypermethylation of the TMEM130 gene may affect the migration ability of GC cells and is associated with EBV infection. TMEM130 shows promise as a potential biomarker for the diagnosis of GC.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Oncology
Anchao Zhu, Yingying Liu, Zongmin Li, Ying He, Lijing Bai, Youtian Wu, Yuying Zhang, Ying Huang, Ping Jiang
Summary: This study assessed the microbial composition and diversity of SCRC tumors with varying MLH1 status, and investigated the effects of functional genes on bacterial markers and clinical diagnostic prediction. The results identified Lachnoclostridium and Coprococcus as key species that may serve as crucial biomarkers for non-invasive diagnostic prediction of DM in patients with SCRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ling Lv, Jianzhong Ma, Lina Wu, Chao Zhang, Yueping Wang, Guang Wang
Summary: This study found that the transcriptional inactivation of the FBN1 gene may start from normal colonic epithelium, and the FBN1 gene methylation catalyzed by DNMT gradually generates powerful force, accelerates expansion, and eventually leads to colorectal cancer (CRC). FBN1 methylation is a promising biomarker, and the FBN1 methylation risk size in feces reflects the non-invasive detection results in tissue.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhenwei Zhang, Eric Ganguly, Krunal Patel, Sonja Dawsey, Jacob Bledsoe, Michelle Yang
Summary: Patients with sporadic hyperplastic polyps (HPs) have an increased risk of developing metachronous colorectal cancer (CRC). Historical HPs were reclassified into sessile serrated adenomas (SSAs) or true HPs based on the 2010 and 2019 WHO criteria. The risk of developing metachronous CRC was significantly higher in patients with SSAs and HPs compared to the control group.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Hui Zhang, Chenxin Xu, Chen Shi, Junying Zhang, Ting Qian, Zhuo Wang, Rong Ma, Jianzhong Wu, Feng Jiang, Jifeng Feng
Summary: In this study, HPSE2 was identified as a novel tumor suppressor gene frequently inactivated through promoter methylation in CRC, with its hypermethylation-low expression associated with poor patient prognosis. HPSE2 exerts its tumor suppressive function by activating the p53/p21 signaling cascade to inhibit tumor growth. Promoter hypermethylation of HPSE2 represents a potential therapeutic target in patients with CRC, especially those with late-stage disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Claudia Gebhard, Roger Mulet-Lazaro, Dagmar Glatz, Lucia Schwarzfischer-Pfeilschifter, Peter Schirmacher, Jochen Gaedcke, Wilko Weichert, Edith Reuschel, Wolfgang Dietmaier, Michael Rehli
Summary: A specific subtype of colorectal carcinoma, known as the CpG island methylator phenotype (CIMP), has been identified with a high incidence of DNA methylation and a distinct group of CGIs. This subtype is associated with colon localization, KRAS or BRAF mutations, and minimal chromosomal losses. The study provides a basis for defining new marker panels for a more reliable classification of CIMP in all CRCs.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Humberto Parada, Leili Sahrai, Mary S. Wolff, Regina M. Santella, Jia Chen, Alfred Neugut, Susan L. Teitelbaum
Summary: This study examined the interactions between parabens, global DNA methylation, and breast cancer risk. It found that exposure to parabens may increase the risk of breast cancer among women with hypomethylated global DNA methylation and tumors with gene-specific hypomethylated promoter regions.
MOLECULAR CARCINOGENESIS
(2022)
Article
Multidisciplinary Sciences
Yi Zhang, Yunfei Xu, Yuzhi Wang
Summary: This study highlights the role of abnormal alternative polyadenylation (APA) events in colorectal cancer (CRC) and establishes an APA event signature that can effectively predict the prognosis of CRC patients. The signature can serve as a potential predictor for survival and treatment in CRC patients.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Fatima Khan, Preeti Agarwal, Sameer Gupta, Malti Kumari Maurya, Pooja Singh, Apoorva Agarwal, Kulranjan Singh, Abhinav Arun Sonkar, Madhu Mati Goel
Summary: This study aimed to assess the methylation status of BRCA1 in breast cancer patients and investigate its association with hormone profile and prognostic parameters. The results showed a significant correlation between BRCA1 promoter methylation and loss of BRCA1 protein, hormone profile, tumor grade, lymph vascular invasion, as well as nodal metastasis. These findings suggest that BRCA1 loss in sporadic breast cancer could potentially be a biomarker for targeted therapy.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Oncology
Wen-Wei Liang, Rita Jui-Hsien Lu, Reyka G. Jayasinghe, Steven M. Foltz, Eduard Porta-Pardo, Yifat Geffen, Michael C. Wendl, Rossana Lazcano, Iga Kolodziejczak, Yizhe Song, Akshay Govindan, Elizabeth G. Demicco, Xiang Li, Yize Li, Sunantha Sethuraman, Samuel H. Payne, David Fenyo, Henry Rodriguez, Maciej Wiznerowicz, Hui Shen, D. R. Mani, Karin D. Rodland, Alexander J. Lazar, Ana I. Robles, Li Ding
Summary: DNA methylation is critical for maintaining cellular identity, but is often dysregulated in tumors. This study identified aberrant methylation in different cancer types and its association with changes in RNA and protein abundance. Lineage-specific epigenetic drivers and the role of methylation subtypes in tumor heterogeneity and phenotypes were also revealed.
Article
Gastroenterology & Hepatology
Diego Casas-Deza, Luis Javier Lamuela-Calvo, Fernando Gomollon, Jose Miguel Arbones-Mainar, Berta Caballol, Javier P. Gisbert, Montserrat Rivero, Eugenia Sanchez-Rodriguez, Lara Arias Garcia, Ana Gutierrez Casbas, Olga Merino, Lucia Marquez, Viviana Laredo, Maria Dolores Martin-Arranz, Pilar Lopez Serrano, Sabino Riestra Menendez, Carlos Gonzalez-Munoza, Luisa de Castro Parga, Marta Calvo Moya, Esteban Fuentes-Valenzuela, Maria Esteve, Marisa Iborra, Miguel Dura Gil, Manuel Barreiro-De Acosta, Rufo Humberto Lorente-Poyatos, Noemi Mancenido, Margalida Calafat, Iago Rodriguez-Lago, Jordi Guardiola Capo, Maria Antonia Payeras, Victor Jair Morales Alvarado, Carlos Tardillo, Luis Bujanda, Jose Fernando Munoz-Nunez, Yolanda Ber Nieto, Fernando Bermejo, Pedro Almela, Merce Navarro-Llavat, Pilar Martinez Montiel, Cristina Rodriguez Gutierrez, Manuel Van Domselaar, Eva Sese, Teresa Martinez Perez, Elena Ricart, Maria Chaparro, Maria Jose Garcia, Antonio Lopez-Sanroman, Beatriz Sicilia, Beatriz Orts, Alicia Lopez-Garcia, Eduardo Martin-Larraz, Jose Lazaro Perez-Calle, Ruth de Francisco, Esther Garcia-Planella, Eugeni Domenech, Santiago Garcia-Loper
Summary: Ustekinumab shows similar effectiveness in elderly patients with CD as it does in non-elderly patients. The safety profile is also similar, except for a higher rate of de novo neoplasms in elderly patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Jean-Francois Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamas Molnar, Mark Lowenberg, Jonas Halfvarson, Edyta Zagorowicz, Helene Rousseau, Cedric Baumann, Filip Baert, Laurent Beaugerie
Summary: The I-CARE study aims to evaluate the benefit-risk ratio of current therapies in IBD patients. It collected data from 10,206 patients and observed the treatment risks of anti-tumor necrosis factor and other biologic therapies, particularly the risks of cancer/lymphoma and serious infections. The results showed that different treatment regimens had varying effects on patients, and further research is needed to assess specific risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Frederik Emil Juul, Kjetil Garborg, Eugen Nesbakken, Magnus Loberg, Paulina Wieszczy, Joaquin Cubiella, Mette Kalager, Michael F. Kaminski, Rune Erichsen, Hans-Olov Adami, Monika Ferlitsch, Siv K. B. Furholm, Ann G. Zauber, Enrique Quintero, Marek Bugajski, Oyvind Holme, Evelien Dekker, Rodrigo Jover, Michael Bretthauer
Summary: There is significant practice variation in the number of colonoscopies performed to achieve complete polyp removal, indicating the need for targeted quality improvement to reduce patient burden.
Article
Genetics & Heredity
Yasmin Soares de Lima, Coral Arnau-Collell, Jenifer Munoz, Cristina Herrera-Pariente, Leticia Moreira, Teresa Ocana, Marcos Diaz-Gay, Sebastia Franch-Exposito, Miriam Cuatrecasas, Sabela Carballal, Anael Lopez-Novo, Lorena Moreno, Guerau Fernandez, Aranzazu Diaz de Bustamante, Sophia Peters, Anna K. Sommer, Isabel Spier, Iris B. A. W. te Paske, Yasmijn J. van Herwaarden, Antoni Castells, Luis Bujanda, Gabriel Capella, Verena Steinke-Lange, Khalid Mahmood, JiHoon Eric Joo, Julie Arnold, Susan Parry, Finlay A. Macrae, Ingrid M. Winship, Christophe Rosty, Joaquin Cubiella, Daniel Rodriguez-Alcalde, Elke Holinski-Feder, Richarda de Voer, Daniel D. Buchanan, Stefan Aretz, Clara Ruiz-Ponte, Laura Valle, Francesc Balaguer, Laia Bonjoch, Sergi Castellvi-Bel
Summary: Rare germline variants in the WNK2 gene were identified through functional evaluation of a candidate gene and replication in additional SPS cohorts. These variants may affect protein function in the MAPK pathway, thereby increasing the risk for SPS.
JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Biochemistry & Molecular Biology
Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, Joan Maurel, Ajay Goel
Article
Oncology
Olfat Khannous-Lleiffe, Jesse R. Willis, Ester Saus, Victor Moreno, Sergi Castellvi-Bel, Toni Gabaldon
Summary: Colorectal cancer (CRC) is a global healthcare challenge influenced by genetic and environmental factors. This study used 16S rRNA sequencing to analyze FIT samples and found that the gut microbiome has predictive potential and undergoes changes during the progression from healthy tissue to carcinoma. These findings have implications for understanding the role of microbes in adenoma to carcinoma progression and improving CRC screening programs.
Article
Gastroenterology & Hepatology
Francisco J. Caballero-Camino, Pedro M. Rodrigues, Fredrik Wangsell, Alona Agirre-Lizaso, Paula Olaizola, Laura Izquierdo-Sanchez, Maria J. Perugorria, Luis Bujanda, Bo Angelin, Sara Straniero, Anna Walleback, Ingemar Starke, Per-Goran Gillberg, Ellen Strangberg, Britta Bonn, Jan P. Mattsson, Martin R. Madsen, Henrik H. Hansen, Erik Lindstrom, Peter Akerblad, Jesus M. Banales
Summary: The ASBT inhibitor A3907 improves cholestatic liver diseases by clearing circulating bile acids and protecting liver function. A3907 targets ASBT in the intestine, liver, and kidney, leading to improved bilirubin and liver injury markers. A3907 is well tolerated in healthy individuals, supporting further clinical development.
Article
Biochemistry & Molecular Biology
Miriam Gene, Miriam Cuatrecasas, Irene Amat, Jesus Alberto Veiga, Maria Jesus Fernandez Acenero, Victoria Fuste Chimisana, Jordi Tarragona, Ismael Jurado, Rebeca Fernandez-Victoria, Carolina Martinez Ciarpaglini, Cristina Alenda Gonzalez, Carlos Zac, Pilar Ortega de la Obra, Maria Teresa Fernandez-Figueras, Manel Esteller, Eva Musulen
Summary: Colitis-associated colorectal carcinoma (CAC) in inflammatory bowel disease (IBD) is caused by p53 alterations and follows a chronic inflammation-dysplasia-cancer carcinogenesis pathway. Gastric metaplasia (GM) is described as the initial event of serrated colorectal cancer (CRC) in the colon mucosa under chronic stress. This study analyzed p53 alterations and microsatellite instability (MSI) to characterize CAC and investigate its relationship with GM. Results showed that p53 mutation pattern was present in more than half of the CAC cases, with stable (MSS) tumors being the most common and MUC5AC negative. Only six unstable (MSI-H) tumors had wild-type p53 pattern (p=0.010) and were MUC5AC positive (p=0.005). MUC5AC staining was more frequently observed in intestinal mucosa with inflammation or chronic changes than in CAC, particularly in those with wild-type p53 pattern and MSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Joel Flores-Arriaga, Maria C. Aso, Arantzazu Izagirre, Ami D. Sperber, Olafur S. Palsson, Shrikant I. Bangdiwala, Angel Lanas, Luis Bujanda, Beatriz Lobo, Carmen Alonso-Cotoner, Alex Sanchez-Pla, Javier Santos
Summary: The study used data from the Rome Foundation Global Epidemiology Study to assess the prevalence and burden of gut-brain disorders in Spain. The survey, completed by 2072 participants, revealed that 43.6% of respondents met diagnostic criteria for at least one disorder, with functional constipation being the most prevalent. The study highlights the need for specialized training and future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
Carolina Mangas-Sanjuan, Luisa de-Castro, Joaquin Cubiella, Pilar Diez-Redondo, Adolfo Suarez, Maria Pellise, Nereida Fernandez, Sara Zarraquinos, Henar Nunez-Rodriguez, Veronica Alvarez-Garcia, Oswaldo Ortiz, Noelia Sala-Miquel, Pedro Zapater, Rodrigo Jover, CADILLAC Study Investigators
Summary: Computer-aided detection did not improve the identification of advanced colorectal neoplasias during colonoscopy.
ANNALS OF INTERNAL MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Laia Bonjoch, Sergi Castellvi-bel, Clara Ruiz-ponte
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, Stiliano Maimaris, Suneil A. Raju, Olivia L. Green, Giulia Mantica, Amelie Therrien, David Flores-Marin, Justin Linden, Fernando Fernandez-Banares, Maria Esteve, Daniel Leffler, Federico Biagi, David S. Sanders
Summary: Objective Persistent villous atrophy (pVA), a condition where the intestinal lining remains damaged despite a gluten-free diet, has unclear significance in coeliac disease (CD). This study aimed to investigate the relationship between pVA and long-term outcomes and develop a scoring system to identify patients at risk of pVA. The results showed that patients with pVA had increased risk of complications and mortality. A 5-point score was developed to classify patients into low, intermediate, and high risk categories. Age at diagnosis, classic pattern of CD, lack of clinical response to GFD, and poor GFD adherence were identified as predictors for pVA.
Article
Oncology
Joan Llach, Inmaculada Salces, Ana Guerra, Beatriz Penas, Daniel Rodriguez-Alcalde, Pilar Diez Redondo, Joaquin Cubiella, Oscar Murcia, Maite Escalante, Jordi Gratacos-Gines, Anna Pocurull, Maria Daca-Alvarez, Irina Luzko, Ariadna Sanchez, Cristina Herrera-Pariente, Teresa Ocana, Sabela Carballal, Ignasi Elizalde, Sergi Castellvi-Bel, Gloria Fernandez-Esparrach, Antoni Castells, Francesc Balaguer, Leticia Moreira
Summary: While clinical practice guidelines exist for hereditary diffuse gastric cancer, there is no consensus on how to approach familial intestinal gastric cancer. A multicenter observational study was conducted in nine Spanish hospitals to investigate the yield of gastric cancer surveillance, as well as identify risk factors for development of gastric cancer and precursor lesions in these families. The study found that Helicobacter pylori infection was independently associated with an increased risk of developing precursor lesions or gastric cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Natalia Gonzalez-Lopez, Enrique Quintero, Antonio Z. Gimeno-Garcia, Luis Bujanda, Jesus Banales, Joaquin Cubiella, Maria Salve-Bouzo, Jesus Miguel Herrero-Rivas, Estela Cid-Delgado, Victoria Alvarez-Sanchez, Alejandro Ledo-Rodriguez, Maria Luisa de-Castro-Parga, Romina Fernandez-Poceiro, Luciano Sanroman-Alvarez, Jose Santiago-Garcia, Alberto Herreros-de-Tejada, Teresa Ocana-Bombardo, Francesc Balaguer, Maria Rodriguez-Soler, Rodrigo Jover, Marta Ponce, Cristina Alvarez-Urturi, Xavier Bessa, Maria-Pilar Roncales, Federico Sopena, Angel Lanas, David Nicolas-Perez, Zaida Adrian-de-Ganzo, Marta Carrillo-Palau, Enrique Gonzalez-Davila
Summary: In this study, the uptake of FIT screening was compared to colonoscopy screening in high-risk individuals for CRC. The results showed that FIT screening did not improve the screening uptake and detected fewer advanced colorectal neoplasia compared to colonoscopy. Further studies are needed to improve the screening uptake in this high-risk group, including inclusion in population-based screening programs.
Article
Oncology
Joaquin Cubiella, Beatriz Calderon-Cruz, Raquel Almazan, Angel Gomez-Amorin
Summary: The interruption of population-based organized colorectal cancer screening programs due to the COVID pandemic increased delays but did not reduce participation, adherence to colonoscopy, or the diagnostic yield of colonoscopy.