Article
Veterinary Sciences
Manyu Li, Yan Wang, Kejian Li, Haiyun Lan, Cheng Zhou
Summary: In this study, key genes in the chronic infection of Hepatitis E virus (HEV) in rabbits were investigated using bioinformatics and experimental analysis. MX1, OAS2, and IFI44 were found to be significantly upregulated in rabbits with chronic HEV infection, suggesting their potential involvement in the pathogenesis of HEV chronicity.
BMC VETERINARY RESEARCH
(2022)
Article
Infectious Diseases
Wenjing Zhang, Yasushi Ami, Yuriko Suzaki, Yen Hai Doan, Suljid Jirintai, Masaharu Takahashi, Hiroaki Okamoto, Naokazu Takeda, Masamichi Muramatsu, Tian-Cheng Li
Summary: Rabbit hepatitis E virus (HEV) generated by a reverse genetics system is infectious and could be a valuable tool for studying HEV replication mechanisms and the pathogenesis of viral hepatitis. Ribavirin efficiently inhibits rabbit HEV replication, making it a potential therapeutic option.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Microbiology
Milagros Virhuez Mendoza, Kenzo Yonemitsu, Keita Ishijima, Shohei Minami, Supriyono, Ngo T. B. Tran, Yudai Kuroda, Kango Tatemoto, Yusuke Inoue, Ai Okada, Hiroshi Shimoda, Ryusei Kuwata, Ai Takano, Shintaro Abe, Kayo Okabe, Yasushi Ami, Wenjing Zhang, Tian-Cheng Li, Ken Maeda
Summary: This study found HEV infection among feral rabbits, with HEV RNA detected in some rabbits and confirmed experimental infection in a naïve rabbit. A novel rabbit HEV strain circulating in Japan was identified through phylogenetic analysis.
VETERINARY MICROBIOLOGY
(2021)
Article
Environmental Sciences
Maria Casares-Jimenez, Transito Garcia-Garcia, Jose M. Suarez-Cardenas, Ana B. Perez-Jimenez, Maria A. Martin, Javier Caballero-Gomez, Carmen Michan, Diana Corona-Mata, Maria A. Risalde, Ignacio Perez-Valero, Rafael Guerra, Ignacio Garcia-Bocanegra, Antonio Rivero, Antonio Rivero-Juarez, Juan J. Garrido
Summary: Our study longitudinally monitored the presence of HEV and RHEV in wastewater samples and evaluated their possible correlation with human cases in Cordoba, Spain. The results showed that only one sample (0.9%) tested positive for HEV, while almost all samples (94.3%) tested positive for RHEV.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Review
Microbiology
Rayana Maryse Toye, Carmen Luisa Loureiro, Rossana Celeste Jaspe, Fabien Zoulim, Flor Helene Pujol, Isabelle Chemin
Summary: HBV genotypes E to J are understudied and have specific distributions across different regions. Genotype F is the most divergent and has further subgenotypes. There is a lack of data from sub-Saharan Africa and Latin America due to under-representation in clinical and research cohorts.
Review
Food Science & Technology
Guadalupe Di Cola, Anabella C. Fantilli, Maria Belen Pisano, Viviana E. Re
Summary: Foodborne viruses, such as HAV and HEV, pose a serious threat to the food industry and public health, leading to outbreaks worldwide. HAV outbreaks have been mainly reported since 1956 in the USA, with increasing numbers in Europe, while HEV transmission is mainly through consumption of undercooked meat, with isolated cases mostly in industrialized countries. Detection of these viruses in food matrices requires specialized processing, with real-time PCR being the standard method for HAV detection but lacking a consensus assay for HEV. More research is needed to understand the prevalence, contamination sources, and maintenance of these foodborne viruses, especially in developing countries.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Food Science & Technology
Catherine Hennechart-Collette, Oceane Dehan, Michel Laurentie, Audrey Fraisse, Sandra Martin-Latil, Sylvie Perelle
Summary: The research characterized a method derived from ISO standard to detect HAV, HEV and norovirus in artificially-contaminated multicomponent foodstuffs. Results showed no significant difference in recovery rates among settings and extraction yields varied for different viruses. LOD95 and LOQ values were determined for different types of viruses.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Nadia Marascio, Salvatore Rotundo, Angela Quirino, Giovanni Matera, Maria Carla Liberto, Chiara Costa, Alessandro Russo, Enrico Maria Trecarichi, Carlo Torti
Summary: Despite significant differences in virology and clinical presentation, HEV and HCV share many similarities in terms of transmission, pathogenesis, and treatment response. The study of coinfection and its consequences remains largely unexplored, which is important for research and clinical practice.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Microbiology
Bingzhe Li, Han Wu, Ziping Miao, Linjie Hu, Lu Zhou, Yihan Lu
Summary: This study characterized the codon usage bias of different genotypes of Hepatitis E virus (HEV), revealing significant differences in codon usage between human, zoonotic, and animal HEV genotypes. The study also found that HEV is influenced by translation selection, leading to a unique dinucleotide usage pattern. Natural selection was identified as the main driver of codon usage bias in HEV, although mutation pressure also played a role in certain genotypes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Shuangshuang Li, Manyu Li, Qiyu He, Zhaochao Liang, Jingyi Shu, Lin Wang, Ling Wang
Summary: This study investigated the characteristics and outcomes of natural infection of Rabbit hepatitis E virus (HEV3-ra) in 70 farmed rabbits in Beijing, China. It was found that infected rabbits could shed high viral load through feces for up to 22 weeks, increasing the risk of transmission among rabbits and to humans.
JOURNAL OF VIRAL HEPATITIS
(2021)
Article
Agriculture, Dairy & Animal Science
Kuihao Liu, Fanliang Meng, Jun Zhao, Yiran Zhao, Ningwei Geng, Siqi Wang, Liya Zhu, Yufei Lou, Mengda Liu, Ning Li
Summary: This study investigated the prevalence of avian hepatitis E virus (HEV) in chicken farms in Tai'an City, Shandong Province, China and found evidence of potential novel genotypes. The study also provided reliable evidence of possible vertical transmission of avian HEV.
Article
Virology
Fengmei Yang, Yanyan Li, Yongjie Li, Weihua Jin, Suqin Duan, Hongjie Xu, Yuan Zhao, Zhanlong He, Yasushi Ami, Yuriko Suzaki, Yen Hai Doan, Naokazu Takeda, Wenjing Zhang, Masamichi Muramatsu, Tian-Cheng Li
Summary: Through experimental studies, it was found that cynomolgus and rhesus monkeys are susceptible to rat hepatitis E virus (rat HEV) and may cause zoonotic infections. These findings provide an animal model for the development of vaccines.
Editorial Material
Biology
Altaira D. Dearborn, Ashish Kumar, Joseph Marcotrigiano
Summary: A domain in the ORF1 polyprotein of the hepatitis E virus, previously believed to be a protease, is actually a zinc-binding domain.
Article
Microbiology
Wenjing Zhang, Yasushi Ami, Yuriko Suzaki, Michiyo Kataoka, Naokazu Takeda, Masamichi Muramatsu, Tiancheng Li
Summary: Novel genotypes of HEV have been identified in wild animals, with HEV-8 able to cross species and infect rabbits, while HEV-5 and HEV-7 cannot infect rabbits.
Article
Virology
Chunnan Liang, Chenyan Zhao, Tianlong Liu, Bo Liu, Zhiguo Liu, Huili Huang, Wei Liu, Minghai Zhao, Nan Xu, Qiong Lu, Jianhui Nie, Li Zhang, Weijin Huang, Ruiping She, Youchun Wang
Summary: We characterized the course of chronic HEV infection in immunocompetent rabbits and found that 47.5% of the rabbits developed chronic infection with persistent viral shedding for more than 6 months.