Article
Biochemistry & Molecular Biology
Pol Picon-Pages, Monica Bosch-Morato, Laia Subirana, Francisca Rubio-Moscardo, Biuse Guivernau, Hugo Fanlo-Ucar, Melisa Ece Zeylan, Simge Senyuz, Victor Herrera-Fernandez, Ruben Vicente, Jose M. Fernandez-Fernandez, Jordi Garcia-Ojalvo, Attila Gursoy, Ozlem Keskin, Baldomero Oliva, Francesc Posas, Eulalia de Nadal, Francisco J. Munoz
Summary: Alzheimer's disease is caused by misfolded amyloid beta-peptide (Aβ) forming beta-sheets, but there are currently no treatments available to prevent it. Through a genome-wide screen in Saccharomyces cerevisiae, we identified 81 mammalian orthologue genes that enhance Aβ(1-42) toxicity and 157 that provide protection. Further studies revealed that calcium regulation, protein translation, and mitochondrial activity were the main cellular functions affected by Aβ oligomers (oAβ). We focused on SURF4, a protein that regulates the store-operated calcium channel (SOCE), and found that it contributes to oAβ(1-42) neurotoxicity by decreasing SOCE activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Chenglong Yu, Andrew Bakshi, Gerald F. Watts, Alan E. Renton, Brian Fulton-Howard, Alison M. Goate, Pradeep Natarajan, Daniel I. Chasman, Liubov Robman, Robyn L. Woods, Robyn Guymer, Rory Wolfe, Le Thi Phuong Thao, John J. Mcneil, Andrew M. Tonkin, Stephen J. Nicholls, Paul Lacaze
Summary: The study identified genetic variants in the CETP gene region associated with cardiovascular resilience during aging, individuals carrying these variants had better lipid profiles and reduced risk of ASCVD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Cicely Anne Dye, Erica Engelstein, Sean Swearingen, Jeanine Murphy, Timothy Larsen, Annabelle Santos Volgman
Summary: Arrhythmias and sudden cardiac death with sexual activity are rare, but recent studies suggest that these events are occurring in younger individuals, with a higher proportion of female decedents than previously described. Open dialogue between the cardiovascular team and the cardiac patient is necessary to provide education and reassurance for safe sexual activity participation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Enrico Mingardo, Glenda Beaman, Philip Grote, Agneta Nordenskjold, William Newman, Adrian S. Woolf, Markus Eckstein, Alina C. Hilger, Gabriel C. Dworschak, Wolfgang Roesch, Anne-Karolin Ebert, Raimund Stein, Alfredo Brusco, Massimo Di Grazia, Ali Tamer, Federico M. Torres, Jose L. Hernandez, Philipp Erben, Carlo Maj, Jose M. Olmos, Jose A. Riancho, Carmen Valero, Isabel C. Hostettler, Henry Houlden, David J. Werring, Johannes Schumacher, Jan Gehlen, Ann-Sophie Giel, Benedikt C. Buerfent, Samara Arkani, Elisabeth Akesson, Emilia Rotstein, Michael Ludwig, Gundela Holmdahl, Elisa Giorgio, Alfredo Berettini, David Keene, Raimondo M. Cervellione, Nina Younsi, Melissa Ortlieb, Josef Oswald, Bernhard Haid, Martin Promm, Claudia Neissner, Karin Hirsch, Maximilian Stehr, Frank-Mattias Schafer, Eberhard Schmiedeke, Thomas M. Boemers, Iris A. L. M. van Rooij, Wouter F. J. Feitz, Carlo L. M. Marcelis, Martin Lacher, Jana Nelson, Benno Ure, Caroline Fortmann, Daniel P. Gale, Melanie M. Y. Chan, Kerstin U. Ludwig, Markus M. Noethen, Stefanie Heilmann, Nadine Zwink, Ekkehart Jenetzky, Benjamin Odermatt, Michael Knapp, Heiko Reutter
Summary: A genome-wide association study of classic bladder exstrophy reveals eight significant loci, most of which contain genes expressed in embryonic developmental bladder stages. Some genes display rare protein altering variants in classic bladder exstrophy. Additionally, nine coding genes in these important loci show differential expression in bladder cancer.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte, Rudiger Pfeifer, Volkhard Kurowski, Reimer Riessen, Anne Daubmann, Stephan Braune, Gerold Soffker, Eric Bibiza-Freiwald, Karl Wegscheider, Heribert Schunkert, Holger Thiele, Stefan Kluge
Summary: This study found that hypothermic temperature control after IHCA did not improve survival nor functional outcome. The study may have been underpowered to detect clinically important differences between hypothermic temperature control and normothermia.
Article
Cardiac & Cardiovascular Systems
Archana Ramireddy, Sumeet S. Chugh
Summary: Sudden cardiac arrest, a sudden and dynamic cardiovascular disease process, has traditionally been believed to have a circadian pattern, but recent studies are challenging this view. This paradigm shift has major implications for the presentation and mechanisms of sudden cardiac arrest.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jean-Philippe Empana, Ivan Lerner, Eugenie Valentin, Fredrik Folke, Bernd Boettiger, Gunnar Gislason, Martin Jonsson, Mattias Ringh, Frankie Beganton, Wulfran Bougouin, Eloi Marijon, Marieke Blom, Hanno Tan, Xavier Jouven
Summary: This study aimed to determine the incidence of sudden cardiac death and out-of-hospital cardiac arrest in the European Union by utilizing data from four large population-based registries with at least 5 years of data collection.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Aye Moa, Timothy Tan, Jenny Wei, Danielle Hutchinson, C. Raina MacIntyre
Summary: This study aimed to determine the rate of hospitalizations for sudden cardiac arrest (SCA) attributable to influenza in Australian adults. The findings showed a significant association between influenza and SCA, particularly in adults aged 65 and over.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Minna Koivunen, Juho Tynkkynen, Niku Oksala, Markku Eskola, Jussi Hernesniemi
Summary: This study aimed to provide comprehensive information on the epidemiology of sudden cardiac arrests (SCA) and sudden cardiac deaths (SCD) after acute coronary syndrome. Through a retrospective study of 10,316 patients with acute coronary syndrome, it was found that the incidence of SCA and SCD was relatively high, accounting for nearly one-third of deaths due to cardiovascular causes. Patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction had a higher incidence of SCA.
AMERICAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
G. Riva, J. Hollenberg
Summary: Out-of-hospital cardiac arrest is a major cause of death in the Western world. Initiating CPR is key to improving survival rates, with early CPR and prompt defibrillation being important factors that influence survival rates.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Medicine, General & Internal
Luigi Pannone, Giulio Falasconi, Lorenzo Cianfanelli, Luca Baldetti, Francesco Moroni, Roberto Spoladore, Pasquale Vergara
Summary: Sudden cardiac death is a major cause of mortality in patients with certain heart diseases, with ongoing research focused on improving risk stratification to identify patients who would benefit from ICD implantation. Despite high levels of available data, there are currently no clear recommendations to reduce the risk of sudden cardiac death in these patient populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Monique Anderson Starks, Larry R. Jackson, Anne Hellkamp, Sana M. Al-Khatib, Daniel B. Mark, Kevin L. Thomas, Graham Nichol, Kerry L. Lee, Linda Davidson-Ray, Jeanne Poole, Jill Anderson, George Johnson, Gust H. Bardy
Summary: Patients with MI-SCA were found to have similar adjusted risks of all-cause mortality and sudden cardiac death compared to those with MI-no SCA. However, after ICD implantation, MI-SCA patients had higher mortality risks.
Article
Biochemistry & Molecular Biology
Shu-Yi Liao, Sean Jacobson, Nabeel Y. Hamzeh, Daniel A. Culver, Briana Q. Barkes, Margerate Mroz, Kristyn Macphail, Karin Pacheco, Divya C. Patel, S. Yasmine Wasfi, Laura L. Koth, Carl D. Langefeld, Sonia Leach, Elizebeth White, Courtney Montgomery, Lisa A. Maier, E. Tasha Fingerlin
Summary: This study aimed to identify novel alleles associated with sarcoidosis susceptibility, evaluate HLA alleles and sarcoidosis susceptibility, and integrate genetic and transcription data to identify risk loci impacting disease pathogenesis. A genome-wide association study was conducted in European descent (EA) and African-American (AA) populations, identifying significant SNPs and HLA alleles associated with sarcoidosis susceptibility. The study confirms the role of HLA class II genes in antigen recognition and/or presentation in sarcoidosis pathogenesis.
HUMAN MOLECULAR GENETICS
(2023)
Article
Plant Sciences
Caroline Ariyoshi, Gustavo Cesar Sant'ana, Mariane Silva Felicio, Gustavo Hiroshi Sera, Livia Maria Nogueira, Lucas Mateus Rivero Rodrigues, Rafaelle Vecchia Ferreira, Bruna Silvestre Rodrigues da Silva, Mario Lucio Vilela de Resende, Suzete Aparecida Lanza Destefano, Douglas Silva Domingues, Luiz Filipe Protasio Pereira
Summary: Bacteria halo blight, caused by Pseudomonas syringae pv. garcae, is a significant disease in coffee plants, particularly in mountain regions and mild climate areas. This study focused on identifying genetic factors associated with resistance to this disease in Ethiopian accessions of Coffea arabica. The research utilized population structure analysis and genome-wide association study (GWAS) to identify quantitative trait nucleotides (QTNs) linked to resistance. The findings provide valuable insights into the genetic control of resistance to bacteria halo blight in Coffea arabica and contribute to the understanding of the domestication history of this species.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yun Gi Kim, Joo Hee Jeong, Kyung-Do Han, Seung-Young Roh, Kyongjin Min, Hyoung Seok Lee, Yun Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: This study investigated the association between LDL-cholesterol level and sudden cardiac arrest (SCA) risk in patients with diabetes mellitus. The results showed a U-shaped association, with both low and high LDL-cholesterol levels being associated with increased SCA risk in diabetes patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Amit Saha, Kershaw Patel, Colby Ayers, Christie M. Ballantyne, Adolfo Correa, Christopher Defilippi, Michael E. Hall, Robert J. Mentz, Stephen L. Seliger, Wondwosen Yimer, Javed Butler, Jarett D. Berry, James A. De Lemos, Ambarish Pandey
Summary: Among Black adults, persistent or worsening levels of cardiac troponin I (hs-cTnI) are associated with an increased risk of heart failure (HF). Participants with incident, stable or improved, or worsened hs-cTnI elevation had higher HF risk compared to those without elevated hs-cTnI.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Miller, Deepak L. Bhatt, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Lixia Jiao, Jean-Claude Tardif, Christie M. Ballantyne, Matthew Budoff, R. Preston Mason
Summary: The study found that the use of IPE can reduce the risk of cardiovascular disease in smokers to the level observed in non-smokers.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Ernst J. Schaefer, Hiroaki Ikezaki, Margaret R. Diffenderfer, Elise Lim, Ching -Ti Liu, Ron C. Hoogeveen, Weihua Guan, Michael Y. Tsai, Christie M. Ballantyne
Summary: The study aimed to determine whether direct and calculated sdLDL-C were significant independent ASCVD risk factors in sex and race subgroups. The results showed that both direct and calculated sdLDL-C were significantly associated with ASCVD, but the association was stronger for direct sdLDL-C and not significant for calculated values once direct values were included in the model. Direct sdLDL-C had a significant independent association with incident ASCVD in all subgroups except African Americans.
Article
Cardiac & Cardiovascular Systems
Jarett D. Berry, Haiying Chen, Vijay Nambi, Walter T. Ambrosius, Simon B. Ascher, Michael G. Shlipak, Joachim H. Ix, Rajesh Gupta, Anthony Killeen, Robert D. Toto, Dalane W. Kitzman, Christie M. Ballantyne, James A. de Lemos
Summary: This study aimed to investigate the effects of intensive systolic blood pressure lowering on hs-cTnT and NT-proBNP levels. The results showed that intensive SBP lowering increased hs-cTnT levels, mediated by the effect on reduced kidney filtration, while NT-proBNP levels decreased, explained by the decrease in SBP. These findings highlight the importance of noncardiac factors influencing cardiac biomarker variation and raise questions about the potential role of hs-cTnT as a surrogate marker for heart failure or death in SBP-lowering studies.
Article
Medical Laboratory Technology
Mary R. Rooney, Jingsha Chen, Christie M. Ballantyne, Ron C. Hoogeveen, Olive Tang, Morgan E. Grams, Adrienne Tin, Chiadi E. Ndumele, Faiez Zannad, David J. Couper, Weihong Tang, Elizabeth Selvin, Josef Coresh
Summary: Comparisons of highly multiplexed aptamer-based and proximity-extension immunoassays revealed variations in protein measurements. Furthermore, comparisons between SomaScan and targeted immunoassays showed varying degrees of correlation for different proteins. These findings highlight the importance of considering measurement techniques in protein quantification studies.
CLINICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Olga A. Gimnich, Tatiana Belousova, Christina M. Short, Addison A. Taylor, Vijay Nambi, Joel D. Morrisett, Christie M. Ballantyne, Jean Bismuth, Dipan J. Shah, Gerd Brunner
Summary: Researchers developed a computational microvascular model to study peripheral artery disease (PAD) using contrast-enhanced magnetic resonance imaging signal intensities. They found significant associations between the model parameters and known markers of PAD patients, as well as significant differences between PAD patients and matched controls.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoming Jia, Mahmoud Al Rifai, Chiadi E. Ndumele, Salim S. Virani, James A. de Lemos, Emmanuel Lee, Amil M. Shah, Justin B. Echouffo-Tcheugui, Biykem Bozkurt, Ron Hoogeveen, Elizabeth Selvin, Christie M. Ballantyne, Vijay Nambi
Summary: This study evaluated the impact of incorporating cardiac biomarkers in reclassifying heart failure (HF) and assessed the prognosis of HF using these biomarkers. The results showed that approximately 1 in 5 older adults without prevalent HF were reclassified as Stage B HF, and the measurement of cardiac biomarkers can help identify individuals at higher HF risk.
JACC-HEART FAILURE
(2023)
Article
Pharmacology & Pharmacy
Paul M. Ridker, Lei Lei, Kausik K. Ray, Christie M. Ballantyne, Gary Bradwin, Nader Rifai
Summary: Bempedoic acid (BA) reduces hsCRP and LDL-C levels in patients with atherosclerotic disease and/or familial hypercholesterolemia. It also shows potential anti-inflammatory effects and has similar lipid-lowering and inflammation-inhibiting properties to statin therapy.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Christie M. Ballantyne, Mini Grace Varughese, Layla A. Abushamat
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christie M. Ballantyne, Puja Banka, Gustavo Mendez, Raymundo Garcia, Julio Rosenstock, Anthony Rodgers, Geraldine Mendizabal, Yale Mitchel, Alberico L. Catapano
Summary: MK-0616, an oral PCSK9 inhibitor, effectively reduces LDL-C levels and is well tolerated in the treatment of hypercholesterolemia according to a Phase 2b clinical trial.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Correction
Biochemistry & Molecular Biology
Michael R. Duggan, Lauren Butler, Zhongsheng Peng, Gulzar N. Daya, Abhay Moghekar, Yang An, Stephen R. Rapp, Kathleen M. Hayden, Aladdin H. Shadyab, Ginny Natale, Longjian Liu, Linda Snetselaar, Ruin Moaddel, Casey M. Rebholz, Kevin Sullivan, Christie M. Ballantyne, Susan M. Resnick, Luigi Ferrucci, Keenan A. Walker
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Robert S. Rosenson, Daniel Gaudet, Christie M. Ballantyne, Seth J. Baum, Jean Bergeron, Erin E. Kershaw, Patrick M. Moriarty, Paolo Rubba, David C. Whitcomb, Poulabi Banerjee, Andrew Gewitz, Claudia Gonzaga-Jauregui, Jennifer McGinniss, Manish P. Ponda, Robert Pordy, Jian Zhao, Daniel J. Rader
Summary: Severe hypertriglyceridemia (sHTG) is a known risk factor for acute pancreatitis. Current therapies for sHTG are often insufficient, and this phase 2 trial evaluated the use of evinacumab in patients with sHTG. Although evinacumab showed some effectiveness in reducing triglyceride levels, it did not meet the primary endpoint. However, the safety profile and lipid changes observed support further evaluation in larger trials.
Article
Cardiac & Cardiovascular Systems
Xiaoming Jia, Mahmoud Al Rifai, Ron Hoogeveen, Justin B. Echouffo-Tcheugui, Amil M. M. Shah, Chiadi E. Ndumele, Salim S. Virani, Biykem Bozkurt, Elizabeth Selvin, Christie M. Ballantyne, Vijay Nambi
Summary: This study assessed the association between change in NT-proBNP and the risk for incident heart failure and death. The results showed that change in NT-proBNP was positively correlated with the risk of heart failure and death. Additionally, changes in blood pressure, cholesterol, triglyceride levels, body mass index, and estimated glomerular filtration rate were associated with change in NT-proBNP.
Article
Cardiac & Cardiovascular Systems
Austin Deets, Parag H. Joshi, Alvin Chandra, Kavisha Singh, Amit Khera, Salim S. Virani, Christie M. Ballantyne, James D. Otvos, Robin P. F. Dullaart, Eke G. Gruppen, Margery A. Connelly, Colby Ayers, Ann Marie Navar, Ambarish Pandey, John T. Wilkins, Anand Rohatgi
Summary: This study aimed to assess the association between levels of specific size-based HDL subspecies and atherosclerotic cardiovascular disease, and investigate their role in risk prediction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Salim S. Virani, Karen Aspry, Dave L. Dixon, Keith C. Ferdinand, Paul A. Heidenreich, Elizabeth J. Jackson, Terry A. Jacobson, Janice L. McAlister, David R. Neff, Martha Gulati, Christie M. Ballantyne
Summary: Despite the established role of LDL-C as a major risk factor for CVD, national quality assurance metrics no longer include LDL-C measurement as a required performance metric. This article reviews the history of LDL-C as a quality and performance metric and presents rationales for re-establishing LDL-C measurement to improve cholesterol control and reduce CVD morbidity and mortality, healthcare disparities, and costs.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)