Article
Nutrition & Dietetics
Anna Markowska, Pawel Kurzawa, Wieslawa Bednarek, Anna Grybos, Marcin Mardas, Monika Krzyzaniak, Jan Majewski, Janina Markowska, Marian Grybos, Jakub Zurawski
Summary: Vitamin D deficiency is involved in the development of uterine fibroids. Supplementing with vitamin D can reduce the size of fibroids. Lower expression of VDR in fibroid tissue may indicate the potential for new fibroids.
Article
Biochemistry & Molecular Biology
Jiezhong Deng, Yusheng Yang, Jinyue He, Zhao Xie, Fei Luo, Jianzhong Xu, Zehua Zhang
Summary: This study demonstrates that activation of VDR by VD administration inhibits M. tuberculosis-induced bone destruction, suggesting that VD and VDR are potential therapeutic targets for this condition.
Review
Biochemistry & Molecular Biology
Alessandra Mirarchi, Elisabetta Albi, Tommaso Beccari, Cataldo Arcuri
Summary: Microglia, accounting for 5-20% of glial cells in the adult brain, have multiple functions in maintaining neural environment, responding to injury, and regulating immune response. They are involved in various neurological disorders and neurodegenerative diseases. Vitamin D3 (VD3) plays a role in the brain's pathophysiology, influencing neurotrophic and neuroprotective actions, neurotransmission, and synaptic plasticity. Studies have focused on the involvement of VD3 and microglia in neurodegeneration and aging-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Antonella Al Refaie, Leonardo Baldassini, Michela De Vita, Stefano Gonnelli, Carla Caffarelli
Summary: Vitamin D plays an important role not only in phospho-calcium metabolism and skeletal disorders, but also in carcinogenesis, inflammation, autoimmunity, and endocrinopathies. There is evidence suggesting possible correlations between vitamin D and adrenal diseases, with common genetic pathways.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Yi-Fan Wang, Lei Li, Xue-Qing Deng, Yu-Jing Fang, Cai-Xia Zhang
Summary: This study found that the cumulative methylation levels of significant CpG sites in VDR and CYP24A1, as well as all CpG sites in CYP2R1, were inversely associated with colorectal cancer risk. However, no significant association was found between cumulative methylation levels of significant CpG sites in CYP2R1 and CYP27B1 and colorectal cancer risk.
CLINICAL EPIGENETICS
(2023)
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Biochemistry & Molecular Biology
Shuang Guo, Wei Zhao, Tingting Zhang, Shuai Li, Jianqiang Guo, Lan Liu
Summary: In this study, a prognostic signature containing 39 Ferroptosis-related genes was identified to effectively predict the prognosis of colorectal cancer patients. Furthermore, it was discovered that vitamin D can promote Ferroptosis in colorectal cancer cells and affect the expression of related genes.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biology
Jose Manuel Garcia-Martinez, Ana Chocarro-Calvo, Javier Martinez-Useros, Maria Jesus Fernandez-Acenero, M. Carmen Fiuza, Jose Caceres-Rentero, Antonio De la Vieja, Antonio Barbachano, Alberto Munoz, Maria Jesus Larriba, Custodia Garcia Jimenez
Summary: Posttranslational modifications of epigenetic modifiers provide a mechanism for rapid adaptations in cancer cells. The study shows that 1,25(OH)(2)D-3 activates SIRT1 by auto-deacetylation in colon cancer cells, inhibiting cell proliferation.
Review
Nutrition & Dietetics
Carsten Carlberg
Summary: The vitamin D metabolite 1 alpha,25-dihydroxyvitamin D-3 acts as a ligand for the transcription factor vitamin D receptor (VDR), and regulates the expression of target genes through chromatin changes. VDR binds to genomic DNA and interacts with partner proteins.
Article
Oncology
Carmen Perez-Duran, Noelia Marquez-Pete, Jose Maria Galvez-Navas, Yasmin Cura, Susana Rojo-Tolosa, Laura Elena Pineda-Lancheros, Mcarmen Ramirez-Tortosa, Carlos Garcia-Collado, Maria del Mar Maldonado-Montoro, Jesus Maria Villar-del-Moral, Cristina Perez-Ramirez, Alberto Jimenez-Morales
Summary: Recent studies have suggested that vitamin D might influence the development and prognosis of colorectal cancer, and its activity might be influenced by single nucleotide polymorphisms in the genes involved in its metabolism. This study evaluated the influence of 13 SNPs in the vitamin D metabolic pathway on colorectal cancer survival. The results showed that variants in VDR, CYP24A1, and GC genes are associated with a lower survival rate.
Article
Biochemistry & Molecular Biology
Salah Gariballa, Ghada S. M. Al-Bluwi, Javed Yasin
Summary: A study on 277 healthy individuals in the United Arab Emirates found an association between vitamin D receptor gene polymorphisms and vitamin D levels. However, this association became non-significant after adjusting for clinical parameters that influence vitamin D levels. Additionally, no association was found between obesity and related pathologies and the vitamin D receptor gene polymorphisms.
Review
Immunology
Laura Tamasauskiene, Ieva Golubickaite, Rasa Ugenskiene, Nikolajs Sjakste, Natalia Paramonova, Lawrence Shih-Hsin Wu, Lawrence Shih-Jiu-Yao Wang, Brigita Sitkauskiene
Summary: The role of vitamin D levels and vitamin D receptor gene polymorphisms in atopy is a topic of interest, but there is still no conclusive data and results from studies are inconsistent. Despite the controversy, more evidence shows a positive impact of vitamin D on the risk and outcomes of allergic diseases.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Medicine, General & Internal
Jonas Seiler, Regina Ebert, Maximilian Rudert, Marietta Herrmann, Ellen Leich, Manuela Weissenberger, Konstantin Horas
Summary: Active vitamin D has direct anti-cancer actions on bone metastases, and vitamin D deficiency is common in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Dirk Lemke, Rainer Johannes Klement, Felix Schweiger, Beatrix Schweiger, Jorg Spitz
Summary: Vitamin D-3 plays an important role in treating autoimmune diseases, and high-dose vitamin D-3 therapy can improve treatment outcomes. Acquired vitamin D resistance may be a plausible pathomechanism for the development of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Aleksandra Szymczak-Tomczak, Alicja Ewa Ratajczak, Marta Kaczmarek-Rys, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Slomski, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Vitamin D plays various roles in patients with inflammatory bowel disease (IBD), including regulating bone mineral metabolism, modulating the immune system, and contributing to the pathogenesis of IBD. Vitamin D affects Th1 and Th2 lymphocytes, cytokine release, and the wnt/beta-catenin pathway. IBD is associated with dysbiosis of microbiota, abnormal inflammatory response, and vitamin D deficiency. Therefore, understanding the metabolic pathways, genetic determinants, and environmental factors of vitamin D is crucial for studying vitamin D supplementation in IBD patients, not only for osteoporosis prevention and therapy, but also for modulating the course and pharmacotherapy of IBD.
JOURNAL OF CLINICAL MEDICINE
(2022)