Article
Chemistry, Medicinal
Hakmin Mun, Helen Elizabeth Townley
Summary: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in pediatric patients, with low survival rates for relapsed or refractory cases. This study found that helenalin promotes RMS cell death in vitro through mechanisms such as increasing oxidative stress levels and decreasing mitochondrial membrane potential.
Review
Medicine, Research & Experimental
Ghader Babaei, Shiva Gholizadeh-Ghaleh Aziz, Masoumeh Rajabi Bazl, Mohammad Hassan Khadem Ansari
Summary: Cancer is a major challenge for human societies, with natural products like Alantolactone (ALT) being studied for their anti-cancer properties by inhibiting signaling pathways and generating free radicals. These studies aim to introduce the latest molecular mechanisms of ALT proposed by researchers in recent years.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Integrative & Complementary Medicine
Di-Wen Shou, Yi-Rong Li, Xiu-Juan Xu, Mu-Hua Dai, Wei Zhang, Xue Yang, Yue-Xing Tu
Summary: This study investigates the effects of parthenolide (PTL) on sepsis-associated acute kidney injury (AKI). The results show that PTL can suppress inflammation and alleviate kidney damage. Through experiments and animal models, the researchers have demonstrated the potential value of PTL in the treatment of sepsis-associated AKI.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tahir Mehmood, Chatchai Muanprasat
Summary: This review discusses the anti-cancer activities of deoxyelephantopin and isodeoxyelephantopin, major compounds found in Elephantopus scaber and Elephantopus carolinianus. These compounds target multiple signaling pathways deregulated in cancers, disrupting several processes involved in cancer progression. The future research directions for these compounds in anti-cancer drug development are also discussed.
Article
Oncology
Katherine L. Morel, Anis A. Hamid, John G. Clohessy, Nicole Pandell, Leigh Ellis, Christopher J. Sweeney
Summary: NF-kappa B activation is linked to prostate cancer progression and resistance to androgen-deprivation therapy, suggesting the potential of NF-kappa B inhibitors to prevent resistance. Dimethylaminoparthenolide (DMAPT) shows promise as an oral NF-kappa B inhibitor, reducing NF-kappa B levels and enhancing AR inhibition in prostate cancer cells.
MOLECULAR CANCER RESEARCH
(2021)
Article
Toxicology
Michaela Sadibolova, Risto O. Juvonen, Seppo Auriola, Iva Bousova
Summary: This study investigates the metabolism of helenalin, a sesquiterpene lactone used in European and Chinese folk medicine, revealing differences in metabolic pathways between rats and humans. In humans, hepatic enzymes CYP2B6, CYP3A4, CYP3A5, and CYP3A7, as well as extrahepatic CYP2A13, play significant roles in metabolizing helenalin. The study also shows that helenalin acts as an inhibitor of CYP3A4, CYP3A5, and a mechanism-based inhibitor of CYP2A13.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Matthew A. Caporizzo, Benjamin L. Prosser
Summary: The microtubule network of cardiac muscle cells plays a crucial role in cardiac mechanics and heart diseases. Understanding the contribution and remodeling of microtubules can provide insights into potential therapies for acquired heart diseases.
NATURE REVIEWS CARDIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Colin Brownlee
Summary: A new study has identified the major components that enable the Venus flytrap to fire action potentials, revealing the recruitment of different ion channels and transporters that give rise to this unique plant behavioral response.
Article
Agriculture, Multidisciplinary
Cecile Chenot, Eloi Thibault de Chanvalon, Philippe Janssens, Sonia Collin
Summary: The study investigated the effects of temperature, wort density, maturation time, and yeast strain on the efficiency of free thiol release by Saccharomyces cerevisiae yeast. It was found that maturation is a crucial step for the excretion of free thiols from yeast cells. Different yeast strains release sulfanylalkyl alcohols at varying levels, with SafAle K-97 releasing the highest amount.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Physics, Multidisciplinary
F. Javier Garcia de Abajo, Andrea Konecna
Summary: By exploiting free-space interactions between electron beams and tailored light fields, on-demand phase profiles can be imprinted on electron wave functions, enabling controllable optical manipulation of electron beams.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Takayuki Kaneko, Yuichiro Mita, Kanako Nozawa-Kumada, Masana Yazaki, Mieko Arisawa, Etsuo Niki, Noriko Noguchi, Yoshiro Saito
Summary: This study reveals the role of hydrogen sulfide, hydropersulfides, and hydropolysulfides in cell signaling and protection against oxidative stress. The mechanism of action involves both two-electron and one-electron redox reactions, with the former receiving more attention. The study also highlights the antioxidant effects of these compounds in inhibiting lipid peroxidation.
FREE RADICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Wei-Long Xing, De-Guang Liu, Ming-Chen Fu
Summary: A transition-metal-free decarboxylative thiolation protocol is introduced for the synthesis of a variety of functionalized aryl alkyl sulfides and C-Se bond compounds, which is successfully applied for the modification of pharmaceutical carboxylates.
Article
Biochemistry & Molecular Biology
Siriphorn Chimplee, Sittiruk Roytrakul, Suchada Sukrong, Theera Srisawat, Potchanapond Graidist, Kanyanatt Kanokwiroon
Summary: The study found that 7HF derived from Grangea maderaspatana exhibits strong anti-TNBC activity and low toxicity to normal breast cells. The mechanism of action of 7HF involves regulating signal transduction associated with G2/M phase arrest and apoptosis.
Review
Biochemistry & Molecular Biology
Thomas J. Schmidt, Karl-Heinz Klempnauer
Summary: The transcription factor MYB plays an important role in hematopoietic progenitor cells. It cooperates with CCAAT box/enhancer binding protein (C/EBP) to form a transcriptional module, and is involved in the development of human leukemia, specifically T-ALL and AML. Inhibitors that target the MYB-C/EBP beta-p300 transcriptional module may have potential as anti-tumor drugs. Natural products belonging to different structural classes have been identified as inhibitors, and this review provides an overview of these inhibitors and their mechanisms of action, as well as their potential for further development.
Article
Chemistry, Physical
Yanrong Chen, Xiao Nai, Mingyuan Li, Jing Kong, Shengyu Hao, Hui Yan, Min Liu, Qian Zhang, Jie Liu
Summary: This study comprehensively investigated the interaction mode and properties of LSL and SPI composite systems, revealing different performance optimizations under various mass ratios. The combination of LSL and SPI altered the protein structure, enhancing our understanding of the interaction mechanism between the two components.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Cell & Tissue Engineering
Shanshan Pei, Mohammad Minhajuddin, Biniam Adane, Nabilah Khan, Brett M. Stevens, Stephen C. Mack, Sisi Lai, Jeremy N. Rich, Anagha Inguva, Kevin M. Shannon, Hyunmin Kim, Aik-Choon Tan, Jason R. Myers, John M. Ashton, Tobias Neff, Daniel A. Pollyea, Clayton A. Smith, Craig T. Jordan
Article
Oncology
Haobin Ye, Biniam Adane, Nabilah Khan, Erica Alexeev, Nichole Nusbacher, Mohammad Minhajuddin, Brett M. Stevens, Amanda C. Winters, Xi Lin, John M. Ashton, Enkhtsetseg Purev, Lianping Xing, Daniel A. Pollyea, Catherine A. Lozupone, Natalie J. Serkova, Sean P. Colgan, Craig T. Jordan
Article
Biochemistry & Molecular Biology
Chaitanya A. Kulkarni, Paul S. Brookes
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Review
Hematology
Daniel A. Pollyea, Craig T. Jordan
CURRENT OPINION IN HEMATOLOGY
(2019)
Article
Cell Biology
Biniam Adane, Haobin Ye, Nabilah Khan, Shanshan Pei, Mohammad Minhajuddin, Brett M. Stevens, Courtney L. Jones, Angelo D'Alessandro, Julie A. Reisz, Vadym Zaberezhnyy, Maura Gasparetto, Tzu-Chieh Ho, Kathleen K. Kelly, Jason R. Myers, John M. Ashton, Julie Siegenthaler, Tsutomu Kume, Eric L. Campbell, Daniel A. Pollyea, Michael W. Becker, Craig T. Jordan
Article
Developmental Biology
Yunki Lim, Karinna Rubio-Pena, Peter J. Sobraske, Paola A. Molina, Paul S. Brookes, Vincent Galy, Keith Nehrke
DEVELOPMENTAL BIOLOGY
(2019)
Article
Oncology
Brett Stevens, Amanda Winters, Jonathan A. Gutman, Aaron Fullerton, Gregory Hemenway, Derek Schatz, Nicholas Miltgen, Qi Wei, Taher Abbasi, Shireen Vali, Neeraj K. Singh, Leylah Drusbosky, Christopher R. Cogle, Andrew Hammes, Diana Abbott, Craig T. Jordan, Clayton Smith, Daniel A. Pollyea
Article
Cardiac & Cardiovascular Systems
Yves T. Wang, Yunki Lim, Matthew N. McCall, Kai-Ting Huang, Cole M. Haynes, Keith Nehrke, Paul S. Brookes
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2019)
Editorial Material
Physiology
Andrew M. Dylag, Paul S. Brookes, Michael A. O'Reilly
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Catherine G. Burke, Jason R. Myers, Lisbeth A. Boule, Christina M. Post, Paul S. Brookes, B. Paige Lawrence
SCIENTIFIC REPORTS
(2019)
Article
Biophysics
Daniel A. Pollyea, Amanda Winters, Christine McMahon, Marc Schwartz, Craig T. Jordan, Rachel Rabinovitch, Diana Abbott, Clayton A. Smith, Jonathan A. Gutman
Summary: The combination therapy of venetoclax and azacitidine has shown promising results in treating AML patients over 60 years old, with potential for improved outcomes compared to maintenance therapy. In particular, allogeneic stem cell transplant following ven/aza treatment in newly diagnosed AML patients shows excellent outcomes, suggesting the need for further investigation to refine timing and patient selection for transplant.
BONE MARROW TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Qianze Dong, Yan Xiu, Yang Wang, Christina Hodgson, Nick Borcherding, Craig Jordan, Jane Buchanan, Eric Taylor, Brett Wagner, Mariah Leidinger, Carol Holman, Dennis J. Thiele, Sean O'Brien, Hai-hui Xue, Jinming Zhao, Qingchang Li, Howard Meyerson, Brendan F. Boyce, Chen Zhao
Summary: The transcription factor HSF1 is specifically required for the maintenance of leukemia stem cells in acute myeloid leukemia (AML), and pharmacologically targeting HSF1 may have broad anti-leukemic effects.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Rachel Culp-Hill, Brett M. Stevens, Courtney L. Jones, Shanshan Pei, Monika Dzieciatkowska, Mohammad Minhajuddin, Craig T. Jordan, Angelo D'Alessandro
Summary: Recent advances in targeting leukemic stem cells (LSCs) with venetoclax and azacitidine (ven + aza) have improved outcomes for de novo acute myeloid leukemia (AML) patients. However, relapsed AML patients often develop resistance to venetoclax and have poor clinical outcomes. This study shows that fatty acid desaturation drives relapsed AML survival and inhibiting it could be a promising therapeutic target for relapsed AML, as demonstrated by decreased AML viability when combining fatty acid desaturation inhibition with ven + aza.
Article
Oncology
Zachary J. Walker, Beau M. Idler, Lorraine N. Davis, Brett M. Stevens, Michael J. VanWyngarden, Denis Ohlstrom, Shelby C. Bearrows, Andrew Hammes, Clayton A. Smith, Craig T. Jordan, Tomer M. Mark, Peter A. Forsberg, Daniel W. Sherbenou
Summary: The study found that multiple myeloma cells from patients generally exhibit significantly increased rates of protein translation compared to normal cells, with over 2.5-fold difference, and demonstrated the inhibitory effect of omacetaxine on multiple myeloma cells. Omacetaxine showed synergy with IMiDs in vitro in multiple myeloma cells, while producing a double-hit on the critical IRF4/c-MYC pathway.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Alisa B. Lee-Sherick, Kristen M. Jacobsen, Curtis J. Henry, Madeline G. Huey, Rebecca E. Parker, Lauren S. Page, Amanda A. Hill, Xiaodong Wang, Stephen Frye, H. Shelton Earp, Craig T. Jordan, Deborah DeRyckere, Douglas K. Graham