Article
Biology
Nigel A. Morrison, Mark R. Forwood
Summary: In this study, the effects of different cytokines on the expression of chemokines in human CD14(+) cells in culture were investigated. It was found that M-CSF treatment promoted MCP1 expression, while GM-CSF suppressed MCP1 expression. Furthermore, addition of MCP1 significantly increased osteoclast formation and overcame the suppression caused by GM-CSF.
Article
Oncology
Lin Yan, Sneha Sundaram, Bret M. Rust, Matthew J. Picklo, Michael R. Bukowski
Summary: The study revealed that adipose-derived MCP-1 plays a role in the development of male breast cancer. Mice with a deficiency in adipose Mcp-1 had lower tumor incidence and weight, impacting pathways of amino acid and carbohydrate metabolism. Further investigation into the potential role of adipose-derived MCP-1 in cancer metabolism and tumorigenesis is warranted.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Xueyan Xi, Yang Guo, Min Zhu, Yuhui Wei, Gang Li, Boyu Du, Yunfu Wang
Summary: The levels of chemokines, particularly monocyte chemotactic protein 1 (MCP-1), are elevated in mild COVID-19 patients in Shiyan City, China. The high expression of MCP-1 in mild cases may be correlated with inhibition of interferon signaling, providing potential therapeutic targets.
Review
Immunology
Zhuqing Jin, En Zheng, Candice Sareli, Pappachan E. Kolattukudy, Jianli Niu
Summary: Inflammatory response is a protective mechanism of the host, but can also lead to immunopathology and tissue damage. Recent studies on the MCPIP family of chemical molecules, particularly the role of MCPIP-1 in the NF kappa B signaling pathway, have revealed important biological functions in resolving inflammation. Understanding the roles of the MCPIP family members can provide new insights into the treatment of infections and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fangyang Shao, Lei Ci, Jiahao Shi, Fei Fang, Bowen Yan, Xijun Liu, Xiangyu Yao, Mengjie Zhang, Hua Yang, Zhugang Wang, Jian Fei
Summary: In this study, we established a transgenic mouse model to monitor MCP-1 expression by observing the luciferase levels in live mice. The results showed that the luciferase signal is correlated with endogenous MCP-1 expression in mice and the anti-inflammatory drug dexamethasone can inhibit MCP-1 and luciferase gene expression significantly.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Reproductive Biology
Daniela Brunnert, Vijay Kumar, Vibha Kaushik, Jens Ehrhardt, Kirti Raj Chahar, Phulwanti Kumari Sharma, Marek Zygmunt, Pankaj Goyal
Summary: Thrombin was found to enhance MCP-1 secretion in HTR-8/SVneo cells, with the secretion being regulated through the activation of PAR-1 and PKC alpha, beta, and Rho/Rho-kinase-dependent pathways. This modulation of MCP-1 secretion negatively impacted the ability of HTR-8/SVneo cells to mimic tube formation.
REPRODUCTIVE BIOLOGY
(2021)
Article
Psychology, Experimental
Jasinta D. M. Dewi, Jeanne Bagnoud, Catherine Thevenot
Summary: This study examines the application of the instance theory of automatization in alphabet-arithmetic verification tasks and reveals a previously mistaken inference. Through a training experiment, the authors demonstrate that opportunistic stopping is not an observable phenomenon in this task.
Review
Medicine, General & Internal
Zhuo Chen, Chenwei Li, Jian Yu
Summary: The study found that MCP-1 has diagnostic value for adult patients with sepsis, with high sensitivity and specificity, and can be used as a biomarker for clinical application.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Shan Wan, Jinwei Xie, Yan Liang, Xijie Yu
Summary: Type 2 diabetes is associated with an abnormal accumulation of bone marrow adipose tissue (BMAT) and increased secretion of MCP-1. This study found that MCP-1 originating from BMAT inhibits the proliferation and insulin secretion of islet cells, exacerbating glucose metabolism disorder. Inhibiting MCP-1 signaling can partially restore islet cell function and improve glucose homeostasis.
CELL DEATH DISCOVERY
(2023)
Article
Allergy
Hanna Lugowska-Umer, Monika Zablotna, Magdalena Lange, Marek Niedoszytko, Roman Nowicki, Boguslaw Nedoszytko
Summary: The study found that patients with cutaneous mastocytosis are more likely to carry the GG genotype of the MCP-1 gene, while the frequency is lower in systemic mastocytosis patients and controls. Additionally, the MCP-1 serum level is higher in systemic mastocytosis patients compared to cutaneous mastocytosis patients and controls.
POSTEPY DERMATOLOGII I ALERGOLOGII
(2021)
Article
Immunology
Ze Wu, Lanlan Fang, Yuxi Li, Yang Yan, Avinash Thakur, Jung-Chien Cheng, Ying-Pu Sun
Summary: The circulating MCP-1 levels are significantly higher in women with PCOS compared to those without PCOS, indicating an association between elevated MCP-1 levels and the risk of PCOS. However, there was no significant difference in circulating MCP-1 levels between obese and non-obese PCOS patients.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Florian G. Scurt, Jan Menne, Sabine Brandt, Anja Bernhardt, Peter R. Mertens, Hermann Haller, Christos Chatzikyrkou
Summary: The study found that MCP-1 was associated with the development of microalbuminuria in patients with type 2 diabetes, suggesting it may be a marker and potentially a mediator of early diabetic nephropathy.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Kun Ji, Yarning Zhang, Daojing Huang
Summary: This study investigated the use of nano-targeted drugs and angioplasty to treat and prevent vascular restenosis in patients with lower extremity angiopathy. It also analyzed the influence of this treatment on the expression level of monocyte chemotactic protein 1 (MCP-1). The results showed that the nano-targeted drugs and angioplasty effectively increased the expression level of MCP-1, suggesting their potential clinical application in treating lower extremity angiopathy.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Pediatrics
Abeer M. E. Osman, Ayat A. M. Motawie, Amany M. Abd Al-Aziz, Nadia A. A. Mostafa, Nehal S. Hasan, Mohamed S. El-Baz
Summary: This study investigated the relationship between adiponectin, resistin, MCP-1 levels and specific asthma phenotypes in overweight/obese children with asthma. The results showed that overweight/obese asthmatic children had higher levels of adiponectin and lower levels of MCP-1, but no difference in resistin levels. Additionally, overweight/obese asthmatic children had better pulmonary function test results compared to normal weight asthmatic children.
Article
Endocrinology & Metabolism
Anouk I. M. van der Velden, Bernard M. van den Berg, B. J. van den Born, Henrike Galenkamp, Daphne H. T. Ijpelaar, Ton J. Rabelink
Summary: This study aimed to investigate ethnic differences in two urinary inflammatory markers in participants with type 2 diabetes mellitus (T2DM). The results showed that urinary MCP-1 levels were higher in Moroccan participants and lower in African Surinamese and Ghanaian participants compared with Dutch. Ethnic differences were also found in the association between MCP-1 and HPSE-1 levels with albuminuria.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)