Article
Medical Laboratory Technology
Varinder Singh, Rupinder Kaur, Pratima Kumari, Chirag Pasricha, Ravinder Singh
Summary: Leukocyte migration is vital for lymphocyte recirculation and immune response. ICAM-1 and VCAM-1 play a crucial role in leukocyte adherence to endothelial cells in various diseases. They contribute to inflammation, leukocyte migration, and have implications in multiple pathological states. Understanding their immunoregulatory role and pathophysiological effects helps in disease management.
CLINICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Weixuan Wang, Shuang Li, Xi Wang, Jianbo Wang, Yanshu Zhang
Summary: This study investigated the effect of nano-PbO exposure on lymphocyte cells infiltration and adhesion protein expression in the choroid plexus, as well as the role of reactive oxygen species (ROS) in the process. Results showed that nano-PbO exposure increased lymphocyte cell percentage and upregulated ICAM-1 and VCAM-1 expression. Additionally, nano-PbO treatment led to increased ROS production and decreased antioxidant activity. Inhibition of ROS significantly decreased ICAM-1 and VCAM-1 expression. In conclusion, nano-PbO exposure increases ICAM-1 and VCAM-1 expression through oxidative stress, facilitating lymphocyte infiltration into the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biology
Sandra Marinovic Kulisic, Marta Takahashi, Marta Himelreich Peric, Vedrana Muzic Radovic, Ruzica Jurakic Toncic
Summary: This study evaluated the expression of E-selectin, ICAM-1, and VCAM-1 in skin biopsy specimens of patients with AD using a computer program. The results showed that the number of ICAM-1 and VCAM-1 positive cells decreased, while the E-selectin positive epidermal surface area increased in AD patients. The endothelial area positive for E-selectin and ICAM1 was significantly larger in AD-affected skin. In addition, strong signals of E-selectin were detected in skin macrophages and ICAM-1 in dermal vessel endothelium. VCAM-1 signal could not be found in the endothelial cells of AD-affected skin. The expression of E-selectin, ICAM-1, and VCAM-1 shows significant changes in AD-affected skin compared to control skin.
Article
Chemistry, Multidisciplinary
Yan-rou Bei, Shun-chi Zhang, Yu Song, Mao-lin Tang, Ke-lan Zhang, Min Jiang, Run-chao He, Shao-guo Wu, Xue-hui Liu, Li-mei Wu, Xiao-yan Dai, Yan-wei Hu
Summary: Atherosclerosis is a chronic inflammatory disease in which monocyte adhesion to endothelial cells plays a crucial role. This study shows that the novel gene EPSTI1 is significantly upregulated in atherosclerotic plaques and promotes monocyte adhesion to endothelial cells by increasing the expression of VCAM-1 and ICAM-1. The expression of EPSTI1 is regulated by LPS and is dependent on p65 nuclear translocation. These findings suggest that EPSTI1 may play a potential role in the development of atherosclerosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Ching-Kai Shen, Bor-Ren Huang, Wei-Lan Yeh, Chao-Wei Chen, Yu-Shu Liu, Sheng-Wei Lai, Wen-Pei Tseng, Dah-Yuu Lu, Cheng-Fang Tsai
Summary: This study showed that IL-1 beta induces the expression of ICAM-1 and VCAM-1 in GBM cells, leading to increased adhesive interaction between monocytes and GBM cells. Additionally, IL-1 beta also triggers the production of soluble ICAM-1 and VCAM-1 in GBM, which plays a crucial role in regulating tumor-associated monocyte/macrophage polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai, Fuhou Chang
Summary: The study investigated the regulatory role of LPC on endothelial cell adhesion marker expression, suggesting that the LPC-G2A-ICAM-1/VCAM-1 pathway may contribute to atherogenic activity of oxLDL, with NF-kappa B antagonists potentially serving as effective therapeutic tools for cardiovascular diseases.
Article
Medicine, General & Internal
Sophie Meixensberger, Hanna Kuzior, Bernd L. Fiebich, Patrick Suess, Kimon Runge, Benjamin Berger, Kathrin Nickel, Dominik Denzel, Miriam A. Schiele, Maike Michel, Simon Maier, Karl Bechter, Katharina Domschke, Ludger Tebartz van Elst, Dominique Endres
Summary: The levels of sICAM-1 and sVCAM-1 in the CSF were higher in patients with schizophrenia spectrum disorder compared to those with depression, indicating endothelial dysfunction underlying BBB/BCSFB impairment. Additionally, a significant correlation of sVCAM-1 with CSF protein and AQ levels was observed in patients with schizophrenia spectrum disorders.
Article
Clinical Neurology
Qianwen Lv, Haili Sun, Zhiyong Du, Xiaolu Jiao, Huahui Yu, Qiuju Sun, Fan Li, Yu Wang, Linyi Li, Chaowei Hu, Yanwen Qin
Summary: The study revealed a significant association between circulating VCAM-1 levels and the presence of CAD in Chinese adults with moderate to severe OSA, suggesting VCAM-1 as a potential novel biomarker for monitoring the development and progression of CAD in this population.
Article
Clinical Neurology
Michael Auer, Angelika Bauer, Antonia Oftring, Dagmar Rudzki, Harald Hegen, Gabriel Bsteh, Franziska Di Pauli, Klaus Berek, Anne Zinganell, Thomas Berger, Markus Reindl, Florian Deisenhammer
Summary: Soluble vascular cell adhesion molecule 1 is a suitable pharmacodynamic marker during treatment with NTZ, which is significantly reduced already after the first dose, remains stable in individual patients even on extended interval dosing, and strongly correlates with NTZ SC. However, absolute levels of sVCAM-1 and NTZ SC are difficult to introduce as treatment monitoring biomarkers to predict disease activity in single patients.
Article
Virology
Agnieszka Lembas, Katarzyna Zawartko, Mariusz Sapula, Tomasz Mikula, Joanna Kozlowska, Alicja Wiercniska-Drapalo
Summary: This study found that long-term antiretroviral therapy was associated with lower VCAM-1 levels in HIV-infected patients, suggesting reduced endothelial activation and decreased risk of cardiovascular disease development. However, VCAM-1 alone may not be sufficient to assess this, as there are also many well-known cardiovascular adverse effects of antiretroviral therapy.
Article
Cell Biology
Haitham L. Abdulhadi, Banan R. Dabdoub, Loay H. Ali, Azza Othman, Maggie E. Amer, Mohamed A. El-Missiry
Summary: Punicalagin has protective effects against pancreatic inflammation and oxidative damage in T1DM, reducing inflammatory and adhesion molecule levels, enhancing antioxidant capacity, and improving pancreatic histopathology and immune response in diabetic rats.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Mean Ghim, Kuin T. Pang, Sean A. Burnap, Ferheen Baig, Xiaoke Yin, Mehwish Arshad, Manuel Mayr, Peter D. Weinberg
Summary: The study found that endothelial cells cultured under swirling conditions at the edge of the well secreted a mediator that significantly reduced transendothelial transport and inhibited activation and translocation of NF-icB, adhesion molecule expression, and monocyte adhesion. This mediator was identified as follistatin-like 1 (FSTL1), which reduced transport of LDL-sized particles and inhibited endothelial activation. Additionally, bone morphogenetic protein 4 (BMP4) increased transport of the LDL-sized particles and adhesion molecule expression, but this effect was abolished by FSTL1.
Article
Behavioral Sciences
Walter Royal, Joseph Bryant, Harry Davis, Ming Guo
Summary: Female and Tg rats exposed to nicotine-free CS showed higher total distances. Female rats in the control group and nicotine-free CS-exposed group exhibited higher total distances and center field measures.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell & Tissue Engineering
Ye Ran, Yankai Dong, Yuejiao Li, Jundong Xie, Shubin Zeng, Chuanlei Liang, Wei Dai, Wenjing Tang, Yaojiong Wu, Shengyuan Yu
Summary: Aggregation of 2D cultured MSCs mediated by the interaction of integrin alpha 4 and VCAM-1 poses a potential risk of cerebrospinal fluid obstruction after intrathecal transplantation. Blockade of VCAM-1 can reduce aggregation and alleviate ventricular dilation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Agriculture, Multidisciplinary
Ji Xiao-hao, Wang Bao-liang, Wang Xiao-di, Wang Xiao-long, Liu Feng-zhi, Wang Hai-bo
Summary: This study compared the aroma compositions and concentrations of Kyoho and 87-1 grapes during berry development using SPME and GC-MS, revealing differences in esters and terpenes between the two varieties. Gene expression analysis suggested potential reasons for the differences, offering insights for improving grape aromatic quality.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Chemistry, Medicinal
Marius Mueller, Vladimir Shalgunov, Lars Hvass, Jesper T. Jorgensen, Vasko Kramer, Markus Staudt, Umberto Maria Battisti, Andreas Kjaer, Matthias M. Herth
Summary: This article aims to develop the first small molecule HER2 PET imaging probe based on tucatinib that can penetrate the blood-brain barrier. Despite its high affinity, no significant tumor accumulation was observed for [11C]tucatinib, possibly due to its high lipophilicity. Chemical modifications are required to increase the polarity of [11C]tucatinib for tumor imaging.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemical Research Methods
Natasha Bidesi, Vladimir Shalgunov, Umberto Maria Battisti, Lars Hvass, Jesper Tranekjaer Jorgensen, Christian B. M. Poulie, Andreas I. Jensen, Andreas Kjaer, Matthias M. Herth
Summary: Pretargeting imaging has gained attention for its excellent bioorthogonality and improved imaging contrast compared to conventional imaging. A new iodo tetrazine derivative has been synthesized and developed into an iodine-125 analog. Radiolabeling with N-chlorosuccinimide or chloramine-T in MeCN or MeOH resulted in a radiochemical conversion of >80%. Deprotection was successful when the radiolabeled tetrazine was stirred in 6-M HCl(aq.) at 60 degrees C for 2.5 h. This is the first iodine-labeled H-tetrazine. In vivo investigations on its pretargeting ability are currently underway.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Lyngby Lassen, Mads Wissenberg, Christina Byrne, Andreas Kjaer, Philip Hasbak
Summary: This study found that 8 and 16 ECG gates can be used interchangeably for volumetric assessments in Rb-82 myocardial perfusion imaging. However, if filling and emptying rates are of interest, a minimum of 16 ECG gates should be used.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Review
Oncology
Gitte Dam, Henning Gronbaek, Anna Sundlov, Johan Botling, Anders Sundin, Rene Horsleben Petersen, Staffan Welin, Espen-Thiis Evensen, Halfdan Sorbye, Elizaveta Tabaksblat, Anne Kirstine Arveschoug, Jann Mortensen, Andreas Kjaer, Ulrich Knigge, Eva Tiensuu Janson, Seppo W. Langer
Summary: Lung neuroendocrine neoplasms (NEN) are a heterogeneous group of tumors different from common lung cancers in terms of pathology, clinical behavior, and prognosis. Recent advances and new methods in diagnosis and treatment of lung-NEN patients are summarized in these Nordic guidelines. These guidelines are designed to be useful for clinicians in their daily practice and reflect the current state of the art. Small cell lung carcinoma (SCLC) is not covered in these guidelines.
Article
Otorhinolaryngology
Eva Lykke, Anders Christensen, Karina Juhl, Ulla Feldt-Rasmussen, Mette Friberg Hitz, Sannia Mia Svenningsen Sjostedt, Christoffer Holst Hahn, Ditte Maria Kraik Svensson, Karoline Kanstrup Springborg, Mads Georg Stage, Gitte Bjorn Hvilsom, Linda Maria Hilsted, Morten Dahl, Giedrius Lelkaitis, Andreas Kjaer, Preben Homoe, Christian von Buchwald
Summary: The purpose of this study was to investigate whether near-infrared autofluorescence image guidance can reduce the incidence of hypoparathyroidism in total thyroidectomy. The results showed that near-infrared autofluorescence imaging can improve the detection rate of parathyroid glands and reduce the rate of hypoparathyroidism, but the difference was not statistically significant. Further studies are needed to confirm the use of near-infrared autofluorescence imaging as an auxiliary tool for parathyroid gland identification.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Anders Christensen, Irene Wessel, Birgitte Wittenborg Charabi, Karina Juhl, Katalin Kiss, Giedrius Lelkaitis, Jann Mortensen, Andreas Kjaer, Christian von Buchwald, Jesper Filtenborg Tvedskov
Summary: The aim of this study was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. A total of 50 cN0 OSCC patients scheduled for SNB were prospectively studied and injected with the tracer complex Tc99m:ICG:Nacocoll. Optical imaging appeared to be an effective tool for real-time SN identification unaffected by possible interference from the injection.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Cell Biology
Thorbjorn Soren Ronn Jensen, Tina Binderup, Markus Harboe Olsen, Andreas Kjaer, Kare Fugleholm
Summary: Anti-inflammatory treatment reduces the risk of recurrent chronic subdural hematoma (CSDH), but clinical implementation is improper due to side effects. This study aims to investigate the associations between cytokine levels and the risk of recurrence in CSDH patients and identify potential medical targets. The study found elevated levels of interleukin-1 receptor antagonist (IL-1ra) in recurrent CSDH patients, suggesting IL-1ra as a possible target for medical treatment.
Article
Biochemistry & Molecular Biology
Mads Lawaetz, Anders Christensen, Karina Juhl, Kirstine Karnov, Giedrius Lelkaitis, Anne-Marie Kanstrup Fiehn, Andreas Kjaer, Christian von Buchwald
Summary: There is currently no approved tumor-specific imaging agents for head and neck cancer. This study explored the expression of nine imaging targets in oral squamous cell carcinoma (OSCC) patients to identify potential molecular imaging targets. The urokinase-type plasminogen activator receptor (uPAR), integrin alpha v beta 6, and tissue factor showed high expression rates and are promising imaging targets for OSCC primary tumors, lymph node metastases, and recurrences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Marina Simon, Jesper Tranekjaer Jorgensen, Kamilla Norregaard, Jonas Rosager Henriksen, Gael Clergeaud, Thomas L. Andresen, Anders Elias Hansen, Andreas Kjaer
Summary: Traditional cancer treatments are often insufficient to achieve complete responses, so combination therapies are commonly used. Nanoparticle-based photothermal therapy (PTT) is a promising add-on treatment that uses localized hyperthermia to kill cancer cells. In this study, we evaluated the combination of gold nanoshell-based PTT and liposomal doxorubicin for colorectal cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Constance E. Grandjean, Sune F. Pedersen, Camilla Christensen, Altea Dibenedetto, Thomas Eriksen, Tina Binderup, Andreas Kjaer
Summary: Atherosclerosis is a chronic inflammatory disease that can lead to cardiovascular events. This study evaluated and compared three different PET tracers and their uptake in the arterial vessel wall, as well as compared gene expression alterations.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Rosa Maja Mohring Gynthersen, Mette Frimodt Hansen, Lukas Frans Ocias, Andreas Kjaer, Randi Fons Petersen, Sisse Rye Ostrowski, Lene Harritshoj, Soren Jacobsen, Ulrik Overgaard, Karen Angeliki Krogfelt, Anne-Mette Lebech, Helene Mens
Summary: The presence of N. mikurensis DNA was detected in immunocompromised patients in Denmark, highlighting the potential underdiagnosis of this bacterium in Danish patients.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Endocrinology & Metabolism
Mikkel Jurgens, Morten Schou, Philip Hasbak, Andreas Kjaer, Emil Wolsk, Bo Zerahn, Niels H. Brandt-Jacobsen, Peter Gaede, Peter Rossing, Jens Faber, Silvio E. Inzucchi, Finn Gustafsson, Caroline Kistorp
Summary: Empagliflozin has been found to reduce measured glomerular filtration rate (mGFR), estimated plasma volume (PV), and estimated extracellular volume (ECV) in patients with type 2 diabetes (T2D) and high risk of cardiovascular events. The 13-week randomized controlled trial showed a decrease in mGFR, ECV, and PV with the use of the drug.
DIABETES OBESITY & METABOLISM
(2023)
Article
Immunology
Xueyi Chen, Ferdia Gallagher, Mark A. Sellmyer, Alvaro A. Ordonez, Andreas Kjaer, Michael Ohliger, David M. Wilson, Sanjay K. Jain
Summary: Bacterial infections remain a major global threat even after the discovery of penicillin nearly a century ago. The overuse of antibiotics has led to the selection of multidrug-resistant super-bugs, highlighting the urgent need for new clinical tools. Next-generation molecular imaging offers unique opportunities to identify and monitor bacterial infections in a noninvasive manner, overcoming the limitations of current tools.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mads Lawaetz, Tina Binderup, Anders Christensen, Karina Juhl, Giedrius Lelkaitis, Eva Lykke, Line Knudsen, Christian von Buchwald, Andreas Kjaer
Summary: This study established oral squamous cell carcinoma (OSCC) PDX models and evaluated the effectiveness of [Cu-64]Cu-uPAR-PET/CT for tumor imaging in these models.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Danna Kamstrup Sell, Anders Wilgaard Sinkjaer, Babak Bakhshinejad, Andreas Kjaer
Summary: Mixing multiple peptide libraries with different displayed peptide characteristics can increase the throughput of selection. This study used next-generation sequencing to investigate the amplification capacity of three widely used commercial phage display peptide libraries and found that the length and cyclic conformation of displayed peptides can affect the propagation capacity of the libraries. Additionally, the Ph.D.(TM)-7 library showed higher propagation capacity. These findings provide evidence for considering peptide characteristics when pooling multiple combinatorial libraries for phage display selection.