Article
Agriculture, Dairy & Animal Science
Fuqing Huang, Kunling Teng, Yayong Liu, Tianwei Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Nisin Z has potential anti-inflammatory effects on mastitis by inhibiting the activation of the ERK1/2 and p38 MAPK signaling pathway and promoting the blood-milk barrier.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Plant Sciences
Hong Gao, Liangyu Jiang, Banghan Du, Bin Ning, Xiaodong Ding, Chuanzhong Zhang, Bo Song, Shanshan Liu, Ming Zhao, Yuxin Zhao, Tianyu Rong, Dongxue Liu, Junjiang Wu, Pengfei Xu, Shuzhen Zhang
Summary: This study reveals that the GmMKK4-GmMPK6-GmERF113 cascade triggers resistance to P. sojae in soybean, enhancing the soybean's ability to resist diseases. GmMKK4 activates GmMPK6, which then phosphorylates GmERF113, increasing its stability and transcriptional activity.
Article
Biochemistry & Molecular Biology
Bethany K. K. Patton, Surabhi Madadi, Shawn M. M. Briley, Avery A. A. Ahmed, Stephanie A. A. Pangas
Summary: SOHLH1 and NOBOX are important oocyte-expressed transcription factors in ovary development and fertility. Sumoylation, a posttranslational modification, regulates their function and may play a crucial role in oogenesis and reprogramming to generate germ cells.
Article
Plant Sciences
Ye Chen, Lin Chen, Xiaomeng Sun, Shuang Kou, Tiantian Liu, Jianke Dong, Wei Tu, Yiling Zhang, Botao Song
Summary: The study identified key genes in the MAPK pathway of both S. acaule and S. tuberosum through comparative genomics analysis, showing increased expression of SaMKK2 and SaMAPK16 in cold-tolerant S. acaule. The interaction between SaMKK2 and SaMAPK4/7 may positively promote cold resistance in potato.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Cell Biology
Maria Josefina Quezada, Pablo Lopez-Bergami
Summary: ROR1 is a receptor for WNT5A and related Wnt proteins, which regulates cell migration, cell polarity, neural patterning, and organogenesis during embryonic development. It transduces signals from Wnt glycoproteins to intracellular Wnt/PCP and Wnt/Ca++ pathways. In addition, it activates multiple signaling pathways in cancer cells, such as PI3K/AKT, MAPK, NF-Kappa B, STAT3, and Hippo pathways. Aberrant expression of ROR1 in cancer is associated with tumor progression and poor survival, making it a potential therapeutic target.
CELLULAR SIGNALLING
(2023)
Article
Food Science & Technology
Yu-Hsiang Yu, Yi-Han Lai, Felix Shih-Hsiang Hsiao, Yeong-Hsiang Cheng
Summary: The study reveals that DON induces inflammation in porcine intestinal epithelial cells (IPEC-J2) through phosphorylation of MAPK signaling pathways. However, co-treatment with DON and lipopolysaccharide (LPS) does not further enhance the expression of inflammation and tight junction-associated genes. Mycotoxin adsorbent agents can attenuate DON-induced inflammatory responses in IPEC-J2 cells by modulating the phosphorylation of p38, ERK, and JNK.
Article
Biochemistry & Molecular Biology
Woonghee Lee, Gwonhwa Song, Hyocheol Bae
Summary: Recent studies have identified obesity as one of the world's most serious chronic disorders. The regulation of adipogenesis through inhibiting adipogenic differentiation and reactive oxygen species (ROS) production has been selected as a strategy to treat obesity. Fraxetin, a major component extracted from the stem barks of Fraxinus rhynchophylla, has many bioactivities. The effects of fraxetin on adipogenesis and ROS production involve mitogen-activated protein kinase (MAPK) signaling pathways.
Article
Veterinary Sciences
Rongduo Wen, Hideharu Ochiai, Jumpei Uchiyama, Nanako Osawa, Mami Oba, Yukie Katayama, Kaixin Li, Tsutomu Omatsu, Kenichi Tamukai, Kaoru Suzuki, Hiroo Madarame, Shinji Makino, Tetsuya Mizutani
Summary: The study revealed that African hedgehog adenovirus uses the p38 pathway for replication in infected cells and induces cytopathic effects. Inhibitors of the p38 pathway were effective in suppressing viral replication, but did not inhibit virus-induced cytopathic effects.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaojie Tian, Mingliang He, Enyang Mei, Baowen Zhang, Jiaqi Tang, Min Xu, Jiali Liu, Xiufeng Li, Zhenyu Wang, Wenqiang Tang, Qingjie Guan, Qingyun Bu
Summary: The study reveals the crosstalk between WRKY53, BR signaling, and the MAPK pathway in regulating plant architecture and seed size. GSK2 plays a crucial role in this interplay by phosphorylating WRKY53 and MAPKK4. The findings highlight the complex regulatory mechanisms involved in controlling rice yield.
Review
Biochemistry & Molecular Biology
Mengmeng Zhang, Shuqun Zhang
Summary: This review provides a historic and recent understanding of the role of mitogen-activated protein kinase (MAPK) cascades in plant immunity, response to environmental stresses, and normal growth and development. The signaling specificity of MAPKs in plants is an interesting topic of research and is influenced by factors such as activation kinetics, spatial and temporal expression patterns, and functional characterization of MAPK substrates.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xinwei Liu, Jing Hao, Peng Wei, Xiaohong Zhao, Qiuyan Lan, Lu Ni, Yongzhen Chen, Xue Bai, Ling Ni, Chen Dong
Summary: In this study, the researchers found that SMAD4 plays a critical role in promoting CD8(+) T cell function in both tumor and infection models. SMAD4-mediated transcriptional regulation enhances CD8(+) T cell activation and cytotoxicity through the T cell receptor (TCR) signaling pathway. Furthermore, SMAD4 is directly phosphorylated by ERK following TCR activation.
Article
Plant Sciences
Minchae Kim, Soongon Jeong, Chae Woo Lim, Sung Chul Lee
Summary: Protein phosphorylation by kinase is crucial for adapting to drought stress conditions, and CaDIMK1 has been identified as a positive modulator of drought tolerance and ABA signal transduction in pepper plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Marjan Moallem, Akhi Akhter, Giovanni L. Burke, John Babu, Benjamin G. Bergey, J. Bryan McNeil, Mohammad S. Baig, Emanuel Rosonina
Summary: Numerous proteins are sumoylated in normally growing yeast and SUMO conjugation levels rise upon exposure to several stress conditions. Reduced sumoylation is well-tolerated under nonstress conditions, but strains with reduced activity of Ubc9, the sole SUMO conjugase, are temperature-sensitive, implicating sumoylation in the heat stress response. Increased sumoylation is triggered by mild heat shock which requires functional levels of Ubc9 and decreased desumoylation. A ubc9 mutant strain with low sumoylation levels shows a growth defect, abnormal distribution of RNA polymerase II, and expanded redistribution of RNAPII after heat shock.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuanzhi Chen, Yingying He, Shubai Liu
Summary: Ovarian cancer is a leading cause of gynecological death worldwide, and RUNX1 plays an important role in its occurrence, development, and response to therapy. Decreased expression of RUNX1 improves chemotherapy sensitivity and provides support for diagnosis and treatment of ovarian cancer. However, the role of RUNX1 in ovarian cancer needs further investigation.
Article
Biochemistry & Molecular Biology
Xin Jin, Samuel Starke, Yang Li, Sheetal Sethupathi, George Kung, Paarth Dodhiawala, Yuqi Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Neurosciences
Virginia M. Dickison, Angela M. Richmond, Ameair Abu Irqeba, Joshua G. Martak, Sean C. E. Hoge, Matthew J. Brooks, Mohammed I. Othman, Ritu Khanna, Alan J. Mears, Adnan Y. Chowdhury, Anand Swaroop, Judith Mosinger Ogilvie
Article
Biochemistry & Molecular Biology
Ming Zhu, Matthew P. Torres, Joshua B. Kelley, Henrik G. Dohlman, Yuqi Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Yang Li, Yuqi Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Ameair Abu Irqeba, Yang Li, Mahmoud Panahi, Ming Zhu, Yuqi Wang
Article
Biochemistry & Molecular Biology
Shan Huang, Alex Benben, Robert Green, Nina Cheranda, Grace Lee, Benita Joseph, Shannon Keaveney, Yuqi Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Ameair Abu Irqeba, Judith Mosinger Ogilvie
Article
Biochemistry & Molecular Biology
Shan Huang, David Zhang, Fangli Weng, Yuqi Wang
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Biology
Ameair Abu Irqeba, Mosinger Ogilvie
BMC RESEARCH NOTES
(2019)
Article
Biochemistry & Molecular Biology
Yuqi Wang, Ming Zhu, Mihretu Ayalew, Jack A. Ruff
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Review
Cardiac & Cardiovascular Systems
Yuqi Wang, Henrik G. Dohlman
CIRCULATION RESEARCH
(2006)
Article
Microbiology
R. Keith Esch, Yuqi Wang, Beverly Errede
Article
Biochemistry & Molecular Biology
YQ Wang, HG Dohlman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2006)