Article
Engineering, Biomedical
Alina Zenych, Charlene Jacqmarcq, Rachida Aid, Louise Fournier, Laura M. Forero Ramirez, Frederic Chaubet, Thomas Bonnard, Denis Vivien, Didier Letourneur, Cedric Chauvierre
Summary: The development of fucoidan-functionalized hydrogel polysaccharide submicroparticles as a nanocarrier for targeted thrombolysis using alteplase has shown promising results in vitro and in vivo, demonstrating improved clot dissolution and reduced post-ischemic cerebral infarct lesions and blood-brain barrier permeability in a murine model of acute thromboembolic ischemic stroke.
Article
Nanoscience & Nanotechnology
Junyan Chen, Wuyan Xu, Tianming Dai, Songsong Jiao, Xiang Xue, Jiayang Jiang, Siming Li, Qingqi Meng
Summary: In this study, HA-based cartilage-targeted nanomicelles were constructed to deliver pioglitazone in a sustained manner for the treatment of osteoarthritis (OA). The results showed that C-HA-DOs effectively inhibited cell death, restored cell function, and delayed the progression of OA by targeting cartilage.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Feiyang Liu, Lingyan Liu, Dongya Liu, Peng Wei, Wei Feng, Tao Yi
Summary: We report an excipient-free nanoformulation for the targeted treatment of hepatocellular carcinoma (HCC) using sugar-coated bullets that can be decomposed quickly by reactive oxygen species (ROS) to release drugs and precipitate in tumor cells, showing high therapeutic efficacy.
Article
Biophysics
Karthik Thangavel, Asha Lakshmikuttyamma, Chellappagounder Thangavel, Sunday A. Shoyele
Summary: The study evaluated the potential of multifunctional nanomedicines targeted towards CD44-positive NSCLC for image-guided drug delivery, showing promising results for their application in imaging and treatment of NSCLC.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Naroa Serna, Victor Pallares, Ugutz Unzueta, Annabel Garcia-Leon, Eric Volta-Duran, Alejandro Sanchez-Chardi, Eloi Parlade, Ariana Rueda, Isolda Casanova, Aida Falgas, Lorena Alba-Castellon, Jorge Sierra, Antonio Villaverde, Esther Vazquez, Ramon Mangues
Summary: Self-assembling non-immunoglobulin scaffold proteins show promise as nanoscale drug carriers and alternatives to antibody-based carriers. This research demonstrates the engineering of human scaffold proteins to target a specific cytokine receptor, CXCR4, and effectively deliver an anti-mitotic drug in a mouse model of acute myeloid leukemia. The protein nanoconjugates showed high efficiency and selectivity in drug delivery, highlighting their potential as alternatives to antibodies in targeted drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Bart Boersma, Karin Moeller, Lisa Wehl, Viola Puddinu, Arnaud Huard, Sebastien Fauteux-Daniel, Carole Bourquin, Gaby Palmer, Thomas Bein
Summary: Inflammation is essential for protective responses, but excessive inflammation can lead to diseases. Porous nanoparticles have been found to effectively deliver anti-inflammatory drugs to macrophages, suppressing inflammatory responses.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Multidisciplinary
Yitong Wang, Hui Chen, Kaili Lin, Ting Ying, Quan Huang, Xiaopan Cai, Jianru Xiao, Qiang Zhang, Yiyun Cheng
Summary: The study demonstrated that polyethylene glycol-conjugated alendronate-functionalized and chloroquine-loaded polydopamine nanoparticles efficiently inhibited tumor growth and osteolysis by breaking the vicious cycle between tumor cell proliferation and bone resorption, highlighting the potential of autophagy inhibition-associated photothermal therapy as a promising strategy for treating malignant bone tumors.
SCIENCE CHINA-MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Jurczyk, Janusz Kasperczyk, Dorota Wrzesniok, Artur Beberok, Katarzyna Jelonek
Summary: There is a growing interest in the use of chemosensitizers and cytostatics in combination to overcome cancer resistance to treatment. To overcome challenges such as poor bioavailability and chemical instability of drugs, attempts have been made to create nanoparticles for the delivery of docetaxel (Dtx) and resveratrol (Res). Recent reports suggest that nano-delivery systems for Dtx and Res exhibit better efficiency in cancer treatment than free drugs, and the simultaneous release of both drugs in cancer cells may help overcome limitations caused by multidrug resistance.
Article
Pharmacology & Pharmacy
Lance T. Dockery, Marie-Christine Daniel
Summary: This study presents the design of dendronized gold nanoparticles coated with poly(propylene imine) dendrons for targeted drug delivery in prostate cancer cells. The dendrons enhance payload density and induce a proton sponge effect for efficient therapeutic delivery. The results showed promising cytotoxicity against PC3 cells, making it a potential system for optimization.
Article
Oncology
Kiranj Kishor Chaudagar, Natalie Landon-Brace, Aniruddh Solanki, Hanna M. Hieromnimon, Emma Hegermiller, Wen Li, Yue Shao, John Joseph, Devan J. Wilkins, Kaela M. Bynoe, Xiang-Ling Li, John G. Clohessy, Soumya Ullas, Jeffrey M. Karp, Akash Patnaik
Summary: The study found that cabozantinib can enhance neutrophil activation and recruitment to facilitate the delivery of BSA-coated polymeric nanoparticles into tumors, showing a promising targeted nanoimmunotherapeutic strategy for enhanced intratumoral drug delivery.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Vanna Sanna, Sandro Satta, Tzung Hsiai, Mario Sechi
Summary: Recently, a novel polymeric nanoparticle (NP) grafted with ligands selectively binding to angiotensin-converting enzyme 2 (ACE2) has been developed as an innovative nanovector for targeted drug delivery. The nanoparticle showed improved antiviral effect compared to traditional drug at the same concentration, indicating its potential as a novel therapy for COVID-19. The study also indicated a basal antiviral activity of the unloaded nanoparticle, potentially due to its direct competition with viral particles for the ACE2 binding site.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Mehrab Pourmadadi, Amirhossein Ghaemi, Amin Shamsabadipour, Maryam Rajabzadeh-Khosroshahi, Meysam Shaghaghi, Abbas Rahdar, Sadanand Pandey
Summary: With the advancement of biotechnology, cutting-edge medical methods have been introduced to treat cancers more efficiently. In chemotherapy, encapsulating anti-cancer drugs in a stimuli-responsive coating can increase biocompatibility and control drug release in a targeted system. Nanoparticles play a crucial role as nanocarriers in chemotherapy, and recent studies have focused on using diverse types of nanoparticles with unique structural features to enhance drug loading and delivery efficacy. This review examines the application of Daunorubicin as an effective anti-cancer drug in novel drug delivery systems, either as a standalone agent or in combination with other drugs using various nanoparticles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Zhaozhao Chen, Lu Tang, Lili Luo, Wenjing Luo, Yingying Li, Xindi Wang, Linlin Huang, Yu Hu, Heng Mei
Summary: This study developed a targeted delivery system for treating uncontrolled inflammation. The system effectively delivered TPCA-1 to inflammatory lesions, reduced infiltration of inflammatory cells, and downregulated the secretion of pro-inflammatory cytokines.
Article
Chemistry, Inorganic & Nuclear
Mehrab Pourmadadi, Shima Ostovar, Gustavo Ruiz-Pulido, Dilawar Hassan, Maryam Souri, Amanda-Lee Ezra Manicum, Razieh Behzadmehr, Sonia Fathi-karkan, Abbas Rahdar, Dora I. Medina, Sadanand Pandey
Summary: Cancer is a global disease that affects millions of people, and in 2023, there are projected to be 1,958,310 new cancer cases and 609,820 cancer fatalities in the United States. Epirubicin is a potential anticancer chemotherapy agent that has shown efficacy against various malignancies. Nanotechnology has been used to develop novel drug delivery systems to enhance the therapeutic efficacy of EPI and overcome its limitations.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Victor Sebastian, Maria Sancho-Albero, Manuel Arruebo, Ana M. Perez-Lopez, Belen Rubio-Ruiz, Pilar Martin-Duque, Asier Unciti-Broceta, Jesus Santamaria
Summary: The use of exosomes as selective delivery vehicles for therapeutic agents is being investigated, but methods used to introduce therapeutic loads often involve membrane disruption, potentially affecting their targeting capabilities. The combination of exosome targeting capabilities and the bio-orthogonal potential of Pd nanoparticles presents a new avenue for therapeutic vectors.
Article
Oncology
S. K. A. Divakar, M. V. Ramana Reddy, S. C. Cosenza, S. J. Baker, D. Perumal, A. C. Antonelli, J. Brody, B. Akula, S. Parekh, E. Premkumar Reddy
Article
Oncology
Deepak Perumal, Pei-Yu Kuo, Violetta V. Leshchenko, Zewei Jiang, Sai Krishna Athaluri Divakar, Hearn Jay Cho, Ajai Chari, Joshua Brody, M. V. Ramana Reddy, Weijia Zhang, E. Premkumar Reddy, Sundar Jagannath, Samir Parekh
Article
Biochemistry & Molecular Biology
Sai Krishna Athuluri-Divakar, Rodrigo Vasquez-Del Carpio, Kaushik Dutta, Stacey J. Baker, Stephen C. Cosenza, Indranil Basu, Yogesh K. Gupta, M. V. Ramana Reddy, Lynn Ueno, Jonathan R. Hart, Peter K. Vogt, David Mulholland, Chandan Guha, Aneel K. Aggarwal, E. Premkumar Reddy
Article
Chemistry, Medicinal
M. V. Ramana Reddy, Balireddy Akula, Stephen C. Cosenza, Saikrishna Athuluridivakar, Muralidhar R. Mallireddigari, Venkat R. Pallela, Vinay K. Billa, D. R. C. Venkata Subbaiah, E. Vijaya Bharathi, Rodrigo Vasquez-Del Carpio, Amol Padgaonkar, Stacey J. Baker, E. Premkumar Reddy
JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Meeting Abstract
Hematology
Deepak Perumal, Violetta V. Leshchenko, Pei-Yu Kuo, Zewei Jiang, Ben Readhead, Caroline Eden, Sai Krishna Athaluri Divakar, Weijia Zhang, Hearn Jay Cho, Ajai Chari, M. V. Ramana Reddy, E. Premkumar Reddy, Joel Dudley, Sundar Jagannath, Samir Parekh
Article
Biochemistry & Molecular Biology
Anand K. Kondapi, Nathamu Satyanarayana, A. D. Saikrishna
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2006)
Article
Biochemistry & Molecular Biology
ADS Krishna, G Panda, AK Kondapi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2005)